Kollmar, Otto

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Schäfer, T."],["dc.contributor.author","Sperling, J."],["dc.contributor.author","Slotta, J. E."],["dc.contributor.author","Kollmar, O."],["dc.contributor.author","Schilling, M. K."],["dc.contributor.author","Menger, M. D."],["dc.contributor.author","Richter, S."],["dc.date.accessioned","2019-07-09T11:40:02Z"],["dc.date.available","2019-07-09T11:40:02Z"],["dc.date.issued","2012"],["dc.description.abstract","BACKGROUND: Hepatic arterial infusion (HAI) has been developed for high-dose regional chemotherapy of unresectable liver metastases or primary liver malignancies. While it is well known that high concentrations of tumor necrosis factor (TNF)-α damage tumor blood perfusion, there is no information on whether autochthonous liver perfusion is affected by HAI with TNF-α. Therefore, we investigated the effects of HAI with TNF-α on hepatic macro- and microvascular perfusion. METHODS: Swabian Hall pigs were randomized into three groups. HAI was performed with either 20 or 40 µg/kg body weight TNF-α (n = 6 each group). Saline-treated animals served as controls (n = 6). Analyses during a 2-hour post-HAI observation period included systemic hemodynamics, portal venous and hepatic arterial blood flow, portal venous pressure, and the blood flow in the hepatic microcirculation. RESULTS: HAI with TNF-α caused a slight decrease of mean arterial blood pressure (p < 0.001), which was compensated by a moderate increase of heart rate (p < 0.001). No further systemic side effects of TNF-α were observed. HAI with TNF-α further caused a slight but not significant decrease of portal venous blood flow (p = 0.737) in both experimental groups, paralleled by an increase of hepatic arterial blood flow (p = 0.023, 20 µg/kg; p = 0.034, 40 µg/kg) resulting in an overall hepatic hyperperfusion. The hepatic hyperperfusion after HAI with 20 µg/kg TNF-α was more pronounced and associated with a 40% decrease of the blood flow in the hepatic microcirculation (p = 0.009). HAI with 40 µg/kg TNF-α was only associated with a temporary and moderate total hepatic hyperperfusion and did not affect the blood flow in the hepatic microcirculation. CONCLUSION: HAI with TNF-α causes a decrease of portal venous flow; however, this is overcompensated by an increased hepatic arterial blood flow, resulting in a total hepatic hyperperfusion. Moderate total hepatic hyperperfusion does not affect the blood flow in the hepatic microcirculation, while a persistent and more pronounced hyperperfusion may cause hepatic microcirculatory disturbances."],["dc.identifier.doi","10.1159/000339306"],["dc.identifier.fs","594196"],["dc.identifier.pmid","22739241"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10601"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58078"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1421-9921"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Blood Pressure"],["dc.subject.mesh","Female"],["dc.subject.mesh","Heart Rate"],["dc.subject.mesh","Hepatic Artery"],["dc.subject.mesh","Liver Circulation"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Portal Vein"],["dc.subject.mesh","Swine"],["dc.subject.mesh","Tumor Necrosis Factor-alpha"],["dc.subject.mesh","Venous Pressure"],["dc.title","Hepatic arterial infusion with tumor necrosis factor-α induces early hepatic hyperperfusion."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]