Thomssen, Reiner

[["dc.bibliographiccitation.firstpage","154"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","155"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Schettler, Volker"],["dc.contributor.author","Monazahian, M."],["dc.contributor.author","Wieland, Eberhard"],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Grunewald, Rolf W."],["dc.contributor.author","Thomssen, R."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T09:23:53Z"],["dc.date.available","2018-11-07T09:23:53Z"],["dc.date.issued","2001"],["dc.description.abstract","Background The association of HCV with apolipoprotein B containing lipoproteins has been observed and this led to the assumption that the LDL receptor may also serve as a candidate receptor for HCV. H.E.L.P.-LDL apheresis is suggested to be an effective and rapid tool to safely eliminate apolipoprotein B containing lipoproteins. Materials and methods In this pilot study, we have investigated whether H.E.L.P. treatment would reduce HCV load in five patients, all infected for more than 4 years with HCV and resistant against established anti-HCV therapy (interferon, ribaverin). HCV-RNA was determined by RT-PCR in plasma immediately before the start of apheresis (SA) and after treatment of 2500 mL plasma (AA). Results H.E.L.P. apheresis led to a mean decrease of 77.3% (16th percentile 36.5%, 84 th percentile 89.6%) of HCV-RNA when AA values were compared to SA values. This decline was reproducible during nine treatment procedures, but was not correlated to the decrease in LDL cholesterol. Conclusions This investigation shows for the first time that HCV load can be reduced by H.E.L.P. apheresis, which is an established and approved therapy for hypercholesterolemia. Even though the efficiency of viral load reduction varied between single procedures and did not correlate to LDL removal, this extracorporeal therapy opens the possibility to treat patients with established immune modulatory and antiviral therapy in the interval between two apheresis procedures."],["dc.identifier.doi","10.1046/j.1365-2362.2001.00758.x"],["dc.identifier.isi","000167703900011"],["dc.identifier.pmid","11168454"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29690"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Ltd"],["dc.relation.issn","0014-2972"],["dc.title","Reduction of hepatitis C virus load by HELP-LDL apheresis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","384"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","THERAPEUTIC APHERESIS"],["dc.bibliographiccitation.lastpage","386"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Schettler, Volker"],["dc.contributor.author","Monazahian, M."],["dc.contributor.author","Wieland, Eberhard"],["dc.contributor.author","Thomssen, R."],["dc.contributor.author","Mueller, Gerhard A."],["dc.date.accessioned","2018-11-07T08:38:03Z"],["dc.date.available","2018-11-07T08:38:03Z"],["dc.date.issued","2001"],["dc.description.abstract","Association of the hepatitis C virus (HCV) with apolipoprotein B containing lipoproteins has been suggested, and this led to the concept that the low-density lipoprotein (LDL) receptor may also serve as a candidate receptor for HCV uptake into the liver. We have investigated whether heparin-induced extracorporeal LDL precipitation (HELP) LDL apheresis treatment reduces HCV plasma load in 6 patients, all infected for more than 4 years with HCV and resistant against established anti-HCV therapy. HELP apheresis treatment caused an HCV-RNA decrease of 77.3% in mean. This decline was not correlated with LDL-cholesterol reduction. HCV-RNA was retained on the HELP filter as shown for 1 patient. The effect of RNA lowering was only transient due to the high turnover of HCV. However, HELP apheresis may open a window of opportunity for an immune-modulating and antiviral therapy in the interval between two apheresis procedures in patients with high virus load."],["dc.identifier.doi","10.1046/j.1526-0968.2001.00374.x"],["dc.identifier.isi","000174293700011"],["dc.identifier.pmid","11778924"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18683"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.relation.issn","1091-6660"],["dc.title","Effect of heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) apheresis on hepatitis C plasma virus load"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]