Leha, Andreas

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","JBMR Plus"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Wilde, Deborah"],["dc.contributor.author","Wilken, Lara"],["dc.contributor.author","Stamm, Bettina"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Chavanon, Mira‐Lynn"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Herrmann‐Lingen, Christoph"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2021-06-01T10:50:47Z"],["dc.date.available","2021-06-01T10:50:47Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/jbm4.10245"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17136"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86788"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2473-4039"],["dc.relation.issn","2473-4039"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The HPQ—Development and First Administration of a Questionnaire for Hypoparathyroid Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Experimental and Clinical Endocrinology & Diabetes"],["dc.contributor.author","Witzel, Judith Charlotte"],["dc.contributor.author","Giessel, Anna"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Lamersdorf, Annette"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Glueer, Claus"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2022-12-01T08:31:03Z"],["dc.date.available","2022-12-01T08:31:03Z"],["dc.description.abstract","Introduction: Established scores estimate 10-year fracture risk in osteoporosis to assist with treatment recommendations. This study compares and contrasts the risk probabilities of major osteoporotic and hip fractures calculated by the FRAX tool with those of the DVO score, established in German-speaking countries.\nMaterial and methods: This seven-year retrospective study analyzes data of 125 male patients (mean age: 59.2±10.7 years) evaluated for osteoporosis. For the DVO score, the therapy threshold of >30% for vertebral and hip fractures suggested by DVO guidelines was implemented. We calculated fracture risks based on FRAX scores with aBMD and applied a common therapy threshold of ≥3% for hip fracture and subsequently determined the “DVO-equivalent risk level” for FRAX-based assessment that would identify as many male patients as identified by the DVO score. \nResults: Based on DVO score, 60.0% of patients had a 10-year risk of hip and vertebral fractures >30%. The recommendations for individuals based on FRAX scores for hip fracture with aBMD with risk ≥ 3% overlapped with those based on DVO score in 40.8% of patients. Patients identified for treatment only by DVO score presented a higher percentage of spine fractures (65% vs. 41%). The thresholds for this “DVO-equivalent risk level” for ‘FRAX with aBMD’ would be ≥ 6.9% for MOF and ≥ 2.1% for HF.\nThis study demonstrates that the DVO score was more sensitive than the FRAX score for patients with spinal fractures. We suggest considering the appropriate score and therapy threshold carefully in the daily care of male patients."],["dc.identifier.doi","10.1055/a-1977-4413"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118056"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1439-3646"],["dc.relation.issn","0947-7349"],["dc.title","Discrepancies between osteoporotic fracture evaluations in men based on German (DVO) osteoporosis guidelines or the FRAX score"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","JBMR Plus"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Stamm, Bettina"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Wilken, Lara"],["dc.contributor.author","Wilde, Deborah"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Herrmann‐Lingen, Christoph"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2022-04-01T10:01:30Z"],["dc.date.available","2022-04-01T10:01:30Z"],["dc.date.issued","2022"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/jbm4.10586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105677"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2473-4039"],["dc.relation.issn","2473-4039"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","The Influence of Conventional Treatment on Symptoms and Complaints in Patients With Chronic Postsurgical Hypoparathyroidism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Endocrine Abstracts"],["dc.contributor.author","Wilde, Deborah"],["dc.contributor.author","Wilken, Lara"],["dc.contributor.author","Stamm, Bettina"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2019-10-14T07:11:37Z"],["dc.date.available","2019-10-14T07:11:37Z"],["dc.date.issued","2018"],["dc.description.abstract","Introduction: Hypoparathyroidism (hypoPT) is characterized by inadequately low circulating concentrations of parathyroid hormone (PTH) followed by low calcium and increased phosphate levels in the blood. Patients with hypoPT suffer from a number of complications and complaints including infections, neuro-psychiatric diseases, abnormal bone architecture impaired muscle function and reduced quality of life. Due to the complexity of the various clinical manifestations there is a demand for a disease-sensitive control instrument to be able to monitor symptoms beside biochemical values. We used a new disease-characteristic questionnaire to investigate hypoPT patients’ complaints and contributing factors. Methods: This prospective study was conducted in two endocrinological centers in Germany over one year. Patients with postsurgical hypoPT (n=49) were matched for sex and age ±3 years and compared to patients with thyroid surgery without hypoPT (ThySu, n=39)) and patients with (former) primary hyperparathyroidism (pHPT, n=35). The Hypoparathyroid Patient Questionnaire (HPQ 40) was filled in during the patient’s visit at the center. Information was completed by clinical background information (e.g. disease complications), blood tests and current medication. The influence of these clinical data on patients’ complaints represented as subscales of the HPQ 40 (pain and cramps, depression and anxiety, gastrointestinal symptoms, vitality, neuro-vegetative symptoms) was analyzed. Results: In hypoPT patients 87% had serum calcium-levels within the target range. Serum-phosphate-levels and calcium-phosphate-product were within reference range in 95.7% of patients, or 100% respectively. The scores for pain and cramps and neuro-vegetative symptoms were significantly elevated in comparison with one (neuro-vegetative symptoms; P=0.002) or both (pain and cramps; P=0.001) control groups. No laboratory parameter correlated with patients’ complaints after Bonferroni correction. In contrast, treatment with alfacalcidol or calcitriol significantly influenced results on different subscales (P=0.002 and P=0.021, respectively). Conclusions: This study identified pain and cramps and neuro-vegetative symptoms as relevant areas of complaints in predominantly well controlled patients with hypoPT. Our data suggest that different active vitamin D agents may influence certain disease manifestations. The impact of different treatment regimen on clinical manifestations of hypoPT patients should be more intensively investigated."],["dc.identifier.doi","10.1530/endoabs.56.GP182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62490"],["dc.language.iso","en"],["dc.relation.issn","1479-6848"],["dc.title","Use of a Disease-Characteristic Questionnaire identified pain and cramps and neuro-vegetative symptoms as significantly elevated and affected by Medication in mainly well-controlled hypoparathyroid patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","JBMR Plus"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Wilde, Deborah"],["dc.contributor.author","Wilken, Lara"],["dc.contributor.author","Stamm, Bettina"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Blaschke, Martina"],["dc.contributor.author","Herrmann‐Lingen, Christoph"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2021-06-01T10:50:50Z"],["dc.date.available","2021-06-01T10:50:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/jbm4.10368"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17513"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86799"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2473-4039"],["dc.relation.issn","2473-4039"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Quantification of Symptom Load by a Disease‐Specific Questionnaire HPQ 28 and Analysis of Associated Biochemical Parameters in Patients With Postsurgical Hypoparathyroidism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]