Leha, Andreas

[["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-03-27T13:37:27Z"],["dc.date.available","2020-03-27T13:37:27Z"],["dc.date.issued","2011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63393"],["dc.title","The Emacs Org-mode: Reproducible Research and Beyond"],["dc.type","report"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9"],["dc.bibliographiccitation.lastpage","100"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-04-02T10:43:45Z"],["dc.date.available","2020-04-02T10:43:45Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.4230/OASIcs.GCB.2013.90"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63516"],["dc.relation.eisbn","978-3-939897-59-0"],["dc.relation.eventlocation","Dagstuhl"],["dc.relation.eventstart","2013"],["dc.relation.ispartof","German Conference on Bioinformatics 2013"],["dc.title","Utilization of ordinal response structures in classification with high-dimensional expression data"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","01"],["dc.bibliographiccitation.journal","Klinische Monatsblätter für Augenheilkunde"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","239"],["dc.contributor.author","Schittkowski, Michael P."],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Horn, Maren"],["dc.contributor.author","Naxer, Sabine"],["dc.date.accessioned","2022-04-01T10:02:44Z"],["dc.date.available","2022-04-01T10:02:44Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung Hintergrund Darstellung der klinischen Befunde der ableitenden Tränenwege bei Patienten mit kongenitalem klinischen Anophthalmus und funktionslosem Mikrophthalmus (MAC-Komplex). Methoden Retrospektive Studie von 207 konsekutiven Patienten, die zwischen 1998 und 2021 mindestens einmal mit hochhydrophilen selbstquellenden Expandern bei MAC operiert wurden. Das Tränenwegssystem wurde in Vollnarkose immer vor allen anderen operativen Maßnahmen sondiert und gespült. Ergebnisse 64 Patienten wurden wegen möglicher Fehldiagnosen aufgrund vorheriger Lid- oder Orbitachirurgie an anderer Stelle oder wegen fehlender Daten ausgeschlossen. Die Analyse umfasste daher 67 Mädchen und 76 Jungen im Alter zwischen 1 und 126 Monaten (medianes Alter: 5 Monate). 72 Patienten wiesen einen unilateralen und 42 einen bilateralen Anophthalmus auf, 24 einen unilateralen und 5 einen bilateralen Mikrophthalmus; somit standen 286 Augenhöhlen (davon 190 mit Pathologie) zur Beurteilung zur Verfügung. Bei einseitigen Fällen war das Tränenwegssystem auf der normalen Seite nie betroffen. Auf der anophthalmischen oder mikrophthalmischen Seite war das Tränenwegssystem nur in 68 Augenhöhlen (35,8%) unauffällig. Der häufigste Befund war eine Kanalikulusstenose (91 Augenhöhlen; 48%). Eine Stenose des Canaliculus communis wurde in 12 Augenhöhlen (6,3%) und eine Obstruktion des Ductus nasolacrimalis in 9 Augenhöhlen (4,7%) festgestellt. Es gab 4 Fälle von Aplasie beider Tränenpünktchen, andere Anomalien waren nicht auffällig. Beim einseitigen Anophthalmus ließ sich bei pathologischen Befunden der Tränenwegssondierung ein signifikanter Zusammenhang mit einer Lippen-Kiefer-Gaumen-Spalte feststellen, was in den 3 anderen Gruppen nicht der Fall war. Schlussfolgerungen Beim kongenitalen klinischen Anophthalmus ist das Tränensystem in bis zu 66,5% der Fälle betroffen, meist aufgrund einer Kanalikulusstenose. Auch wenn es keine eindeutigen Hinweise auf einen embryologischen Zusammenhang gibt, ist diese Assoziation sicher kein Zufallsbefund."],["dc.identifier.doi","10.1055/a-1721-2375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105993"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-3999"],["dc.relation.issn","0023-2165"],["dc.title","Tränenwegsbefunde von 143 Kindern mit Mikrophthalmus-Anophthalmus-Komplex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Experimental and Clinical Endocrinology & Diabetes"],["dc.contributor.author","Witzel, Judith Charlotte"],["dc.contributor.author","Giessel, Anna"],["dc.contributor.author","Heppner, Christina"],["dc.contributor.author","Lamersdorf, Annette"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Glueer, Claus"],["dc.contributor.author","Siggelkow, Heide"],["dc.date.accessioned","2022-12-01T08:31:03Z"],["dc.date.available","2022-12-01T08:31:03Z"],["dc.description.abstract","Introduction: Established scores estimate 10-year fracture risk in osteoporosis to assist with treatment recommendations. This study compares and contrasts the risk probabilities of major osteoporotic and hip fractures calculated by the FRAX tool with those of the DVO score, established in German-speaking countries.\nMaterial and methods: This seven-year retrospective study analyzes data of 125 male patients (mean age: 59.2±10.7 years) evaluated for osteoporosis. For the DVO score, the therapy threshold of >30% for vertebral and hip fractures suggested by DVO guidelines was implemented. We calculated fracture risks based on FRAX scores with aBMD and applied a common therapy threshold of ≥3% for hip fracture and subsequently determined the “DVO-equivalent risk level” for FRAX-based assessment that would identify as many male patients as identified by the DVO score. \nResults: Based on DVO score, 60.0% of patients had a 10-year risk of hip and vertebral fractures >30%. The recommendations for individuals based on FRAX scores for hip fracture with aBMD with risk ≥ 3% overlapped with those based on DVO score in 40.8% of patients. Patients identified for treatment only by DVO score presented a higher percentage of spine fractures (65% vs. 41%). The thresholds for this “DVO-equivalent risk level” for ‘FRAX with aBMD’ would be ≥ 6.9% for MOF and ≥ 2.1% for HF.\nThis study demonstrates that the DVO score was more sensitive than the FRAX score for patients with spinal fractures. We suggest considering the appropriate score and therapy threshold carefully in the daily care of male patients."],["dc.identifier.doi","10.1055/a-1977-4413"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118056"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1439-3646"],["dc.relation.issn","0947-7349"],["dc.title","Discrepancies between osteoporotic fracture evaluations in men based on German (DVO) osteoporosis guidelines or the FRAX score"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Statland, Jeffrey M."],["dc.contributor.author","Hussain, Sumaira"],["dc.contributor.author","Hennecke, Christiane"],["dc.contributor.author","Wuu, Joanne"],["dc.contributor.author","Langbein, Thomas"],["dc.contributor.author","Ahmed, Raees"],["dc.contributor.author","Günther, René"],["dc.contributor.author","Ilse, Benjamin"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kollewe, Katja"],["dc.contributor.author","Kuttler, Josua"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Lengenfeld, Teresa"],["dc.contributor.author","Meyer, Thomas"],["dc.contributor.author","Neuwirth, Christoph"],["dc.contributor.author","Tostmann, Ralf"],["dc.contributor.author","Benatar, Michael"],["dc.date.accessioned","2021-04-14T08:30:11Z"],["dc.date.available","2021-04-14T08:30:11Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1080/21678421.2021.1879866"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83141"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2167-9223"],["dc.relation.issn","2167-8421"],["dc.title","Challenges and opportunities for Multi-National Investigator-Initiated clinical trials for ALS: European and United States collaborations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.contributor.author","Rinke, Sven"],["dc.contributor.author","Zuck, Tanja"],["dc.contributor.author","Hausdörfer, Tim"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2021-09-01T06:42:27Z"],["dc.date.available","2021-09-01T06:42:27Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Objectives A university-based randomized clinical study evaluated the 5-year performance of chairside-fabricated zirconia-reinforced lithium silicate (ZLS)-ceramic partial crowns. Material and methods Forty-five patients were restored with 61 chairside-fabricated ZLS-restorations (Cerec SW 4.2, Dentsply Sirona, Germany; Vita Suprinity, Vita Zahnfabrik, Germany). Deviating from the manufacturers’ recommendations, restorations with reduced minimum material thicknesses (MMT) were fabricated: group 1, MMT = 0.5–0.74 mm ( n  = 31); group 2, MMT = 0.75–1.0 mm ( n  = 30). For luting, a self-adhesive cement (SAC) or a total-etch technique with a composite cement (TEC) was applied. Statistical evaluation was performed by time-to-event analysis (Kaplan–Meier). Possible covariates of the survival (SVR) and success rates (SCR), evaluated in a Cox regression model, were MMT, restoration position (premolar/molar), and cementation technique (SAC vs. TEC). Results Forty patients (54 restorations, premolars, n  = 23; molars, n  = 31) participated in the 5-year follow-up. Five losses due to ceramic fractures occurred in group 1 ( n  = 28) (SVR: 83.0% [95% confidence interval (CI): 0.71–0.96]). Group 2 ( n  = 26) showed no losses (SVR: 100%). The success rate for partial crowns placed on premolars was 100% and 69% (95% CI: 0.54–0.84) for molar restorations. Recementation was required in 4 restorations with SAC (SCR: 86% [95% CI: 0.73–0.99]; SCR-DC: 100%). Restorations in group 2 showed a significantly reduced risk of material fracture hazard ratio (HR) = 0.09, p  = 0.0292) compared with the restorations in group 1. Molar partial crowns showed an increased risk for a clinical intervention (HR = 5.26, p  = 0.0222) compared to premolar restorations. Conclusions Material thickness and position of the restoration are risk factors influencing the survival and success rate of ZLS-ceramic partial crowns. Clinical relevance Observation of an MMT of at least 0.75–1.0 mm for ZLS-ceramics is essential to avoid material-related fractures. Clinical trial registration : German Clinical Trails Register (trial number: DRKS00005611)"],["dc.description.abstract","Abstract Objectives A university-based randomized clinical study evaluated the 5-year performance of chairside-fabricated zirconia-reinforced lithium silicate (ZLS)-ceramic partial crowns. Material and methods Forty-five patients were restored with 61 chairside-fabricated ZLS-restorations (Cerec SW 4.2, Dentsply Sirona, Germany; Vita Suprinity, Vita Zahnfabrik, Germany). Deviating from the manufacturers’ recommendations, restorations with reduced minimum material thicknesses (MMT) were fabricated: group 1, MMT = 0.5–0.74 mm ( n  = 31); group 2, MMT = 0.75–1.0 mm ( n  = 30). For luting, a self-adhesive cement (SAC) or a total-etch technique with a composite cement (TEC) was applied. Statistical evaluation was performed by time-to-event analysis (Kaplan–Meier). Possible covariates of the survival (SVR) and success rates (SCR), evaluated in a Cox regression model, were MMT, restoration position (premolar/molar), and cementation technique (SAC vs. TEC). Results Forty patients (54 restorations, premolars, n  = 23; molars, n  = 31) participated in the 5-year follow-up. Five losses due to ceramic fractures occurred in group 1 ( n  = 28) (SVR: 83.0% [95% confidence interval (CI): 0.71–0.96]). Group 2 ( n  = 26) showed no losses (SVR: 100%). The success rate for partial crowns placed on premolars was 100% and 69% (95% CI: 0.54–0.84) for molar restorations. Recementation was required in 4 restorations with SAC (SCR: 86% [95% CI: 0.73–0.99]; SCR-DC: 100%). Restorations in group 2 showed a significantly reduced risk of material fracture hazard ratio (HR) = 0.09, p  = 0.0292) compared with the restorations in group 1. Molar partial crowns showed an increased risk for a clinical intervention (HR = 5.26, p  = 0.0222) compared to premolar restorations. Conclusions Material thickness and position of the restoration are risk factors influencing the survival and success rate of ZLS-ceramic partial crowns. Clinical relevance Observation of an MMT of at least 0.75–1.0 mm for ZLS-ceramics is essential to avoid material-related fractures. Clinical trial registration : German Clinical Trails Register (trial number: DRKS00005611)"],["dc.identifier.doi","10.1007/s00784-021-04132-y"],["dc.identifier.pii","4132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89055"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Prospective clinical evaluation of chairside-fabricated zirconia-reinforced lithium silicate ceramic partial crowns—5-year results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2223225"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","JAMA Network Open"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Rühlmann, Felix"],["dc.contributor.author","Tichelbäcker, Tobias"],["dc.contributor.author","Mackert, Alma Franziska"],["dc.contributor.author","Engelhardt, Deborah"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Bernhardt, Markus"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Azizian, Azadeh"],["dc.contributor.author","Gaedcke, Jochen"],["dc.date.accessioned","2022-09-01T09:49:15Z"],["dc.date.available","2022-09-01T09:49:15Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1001/jamanetworkopen.2022.23225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113381"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2574-3805"],["dc.title","Incidence, Associated Risk Factors, and Outcomes of Postoperative Arrhythmia After Upper Gastrointestinal Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","769"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Immunotherapy"],["dc.bibliographiccitation.lastpage","782"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Schiwitza, Annett"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.contributor.author","Zwerger, Birgit"],["dc.contributor.author","Rüschoff, Josef"],["dc.contributor.author","Reinhardt, Christian"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Rittmeyer, Achim"],["dc.date.accessioned","2020-12-10T18:43:39Z"],["dc.date.available","2020-12-10T18:43:39Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.2217/imt-2019-0039"],["dc.identifier.eissn","1750-7448"],["dc.identifier.issn","1750-743X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78202"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Monitoring efficacy of checkpoint inhibitor therapy in patients with non-small-cell lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","16.e13"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Konietzka, Jan"],["dc.contributor.author","Fritz, Maximilian"],["dc.contributor.author","Spiri, Silvan"],["dc.contributor.author","McWhirter, Rebecca"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Palumbos, Sierra"],["dc.contributor.author","Costa, Wagner Steuer"],["dc.contributor.author","Oranth, Alexandra"],["dc.contributor.author","Gottschalk, Alexander"],["dc.contributor.author","Miller, David M."],["dc.contributor.author","Hajnal, Alex"],["dc.contributor.author","Bringmann, Henrik"],["dc.date.accessioned","2020-12-10T14:23:22Z"],["dc.date.available","2020-12-10T14:23:22Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.cub.2019.10.048"],["dc.identifier.issn","0960-9822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71913"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Artmann, Stephan"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Klemm, E."],["dc.date.accessioned","2018-11-07T09:19:06Z"],["dc.date.available","2018-11-07T09:19:06Z"],["dc.date.issued","2013"],["dc.identifier.isi","000326360900431"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28557"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.title","Identification of prognostic miRNAs in breast cancer through profiling of tumor educated macrophages"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]