Overbeck, Tobias R.

[["dc.bibliographiccitation.journal","Frontiers in Public Health"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Schröder, Dominik; 1Department of General Practice, University Medical Center, Göttingen, Germany"],["dc.contributor.affiliation","Heesen, Gloria; 1Department of General Practice, University Medical Center, Göttingen, Germany"],["dc.contributor.affiliation","Heinemann, Stephanie; 1Department of General Practice, University Medical Center, Göttingen, Germany"],["dc.contributor.affiliation","Hummers, Eva; 1Department of General Practice, University Medical Center, Göttingen, Germany"],["dc.contributor.affiliation","Jablonka, Alexandra; 2Department of Rheumatology and Immunology, Hannover Medical School, Hanover, Germany"],["dc.contributor.affiliation","Steffens, Sandra; 2Department of Rheumatology and Immunology, Hannover Medical School, Hanover, Germany"],["dc.contributor.affiliation","Mikuteit, Marie; 2Department of Rheumatology and Immunology, Hannover Medical School, Hanover, Germany"],["dc.contributor.affiliation","Niewolik, Jacqueline; 2Department of Rheumatology and Immunology, Hannover Medical School, Hanover, Germany"],["dc.contributor.affiliation","Overbeck, Tobias R.; 4Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Kallusky, Jonathan; 4Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Müller, Frank; 1Department of General Practice, University Medical Center, Göttingen, Germany"],["dc.contributor.author","Schröder, Dominik"],["dc.contributor.author","Heesen, Gloria"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Hummers, Eva"],["dc.contributor.author","Jablonka, Alexandra"],["dc.contributor.author","Steffens, Sandra"],["dc.contributor.author","Mikuteit, Marie"],["dc.contributor.author","Niewolik, Jacqueline"],["dc.contributor.author","Kallusky, Jonathan"],["dc.contributor.author","Müller, Frank"],["dc.contributor.author","Overbeck, Tobias R."],["dc.date.accessioned","2022-04-26T12:34:44Z"],["dc.date.available","2022-04-26T12:34:44Z"],["dc.date.issued","2022"],["dc.date.updated","2022-05-10T16:09:22Z"],["dc.description.abstract","Background: Restrictions to contain the COVID-19 pandemic affect the social participation of people worldwide. Especially those at high risk for a severe disease tend to abstain from social gatherings. While there are a few questionnaires to measure social participation in elderly or chronic patients, a valid survey instrument that includes pandemic-related social participation is needed. Methods We developed a social participation questionnaire that aims to assess pandemic-related restrictions in social participation. Items were developed using a theory and literature-based approach and then compiled in a discursive process involving experts and lay people. This was followed by the validation of the questionnaire through a cross-sectional survey on 431 individuals. Items with low item-total correlations and low factor loadings using exploratory factor analysis [EFA] were excluded. Using EFA on the remaining items, the factor structure was retrieved and tested with a confirmatory factor analysis [CFA]. Internal consistency was assessed with Chronbachs α. Results Initially, 27 items were developed which were used for validation. 13 items were excluded due to low item-total correlations and factors loadings. EFA of the remaining 14 items revealed three factors which were identified as domains “active social participation,” “wellbeing,” and “restrictions”. CFA showed an acceptable model fit using the three-dimensional structure. Chronbachs α of 0.81 and McDonalds Ω of 0.87 indicate good internal consistency. Correlation analysis showed an association between the developed questionnaire and previously-established participation and mental health scales. Conclusion This study suggests that our 14 item questionnaire is of high reliability and validity and can be used to measure social participation during a pandemic."],["dc.identifier.doi","10.3389/fpubh.2022.831087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106769"],["dc.language.iso","en"],["dc.publisher","Frontiers Media S.A."],["dc.relation","DEFEnse Against COVID-19 STudy"],["dc.relation.issn","2296-2565"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Development and Validation of a Questionnaire to Assess Social Participation of High Risk-Adults in Germany During the COVID-19 Pandemic"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","403"],["dc.bibliographiccitation.firstpage","403"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Infectious Diseases"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Dopfer-Jablonka, Alexandra"],["dc.contributor.author","Steffens, Sandra"],["dc.contributor.author","Müller, Frank"],["dc.contributor.author","Mikuteit, Marie"],["dc.contributor.author","Niewolik, Jacqueline"],["dc.contributor.author","Cossmann, Anne"],["dc.contributor.author","Stankov, Metodi V."],["dc.contributor.author","Behrens, Georg M. N."],["dc.contributor.author","Hummers, Eva"],["dc.contributor.author","Heesen, Gloria"],["dc.contributor.author","Schröder, Dominik"],["dc.contributor.author","Roder, Sascha"],["dc.contributor.author","Klawonn, Frank"],["dc.contributor.author","Vahldiek, Kai"],["dc.contributor.author","Hasenkamp, Justin"],["dc.contributor.author","Kallusky, Jonathan"],["dc.contributor.author","Falk, Christine S."],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Heinemann, Stephanie"],["dc.date.accessioned","2022-04-29T07:33:23Z"],["dc.date.accessioned","2022-08-12T12:57:45Z"],["dc.date.available","2022-04-29T07:33:23Z"],["dc.date.available","2022-08-12T12:57:45Z"],["dc.date.issued","2022-04-25"],["dc.date.updated","2022-07-29T12:00:25Z"],["dc.description.abstract","Background\r\n Immunocompromised people (ICP) and elderly individuals (older than 80 years) are at increased risk for severe coronavirus infections. To protect against serious infection with SARS-CoV-2, ICP are taking precautions that may include a reduction of social contacts and participation in activities which they normally enjoy. Furthermore, for these people, there is an uncertainty regarding the effectiveness of the vaccination. The COVID-19 Contact (CoCo) Immune study strives to characterize the immune response to COVID-19 vaccination in immunocompromised, elderly people, and patients with hematological or oncological diseases. The study uses blood-based screenings to monitor the humoral and cellular immune response in these groups after vaccination. Questionnaires and qualitative interviews are used to describe the level of social participation.\r\n \r\n \r\n Methods\r\n The CoCo Immune Study is a mixed methods prospective, longitudinal, observational study at two large university hospitals in Northern Germany. Starting in March 2021, it monitors anti-SARS-CoV-2 immune responses and collects information on social participation in more than 600 participants, at least 18 years old. Inclusion criteria and subcohorts: Participants with (1) regularly intake of immunosuppressive medication (ICP-cohort) or (2) age ≥ 80 years (80 + -cohort). Additionally, patients with current or former (3) myeloid, (4) lymphatic disease or (5) solid tumor under checkpoint inhibition (3–5: HO-cohort). Exclusion criteria: (1) refusal to give informed consent, (2) contraindication to blood testing, (3) inability to declare consent. Participants complete a questionnaire at four different time points: prior to full vaccination, and 1, 6 and 12 months after completed vaccination. In addition, participants draw blood samples themselves or through a local health care provider and send them with their questionnaires per post at the respective time points after vaccination. Patients of the HO cohort dispense additional blood samples at week 3 to 12 and at month 6 to 9 after 2nd vaccination to gain additional knowledge in B and T cell responses. Selected participants are invited to qualitative interviews about social participation.\r\n \r\n \r\n Discussion\r\n This observational study is designed to gain insight into the immune response of people with weakened immune systems and to find out how social participation is affected after COVID-19 vaccination.\r\n Trial registration: This study was registered with German Clinical Trial Registry (registration number: DRKS00023972) on 30th December 2020."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Infectious Diseases. 2022 Apr 25;22(1):403"],["dc.identifier.doi","10.1186/s12879-022-07347-w"],["dc.identifier.pmid","35468758"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106987"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112723"],["dc.language.iso","en"],["dc.relation","DEFEnse Against COVID-19 STudy"],["dc.relation.eissn","1471-2334"],["dc.relation.issn","1471-2334"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","SARS-CoV-2"],["dc.subject","COVID-19"],["dc.subject","Pandemic"],["dc.subject","Humoral and cellular immunity"],["dc.subject","Immunocompromised people"],["dc.subject","Elderly"],["dc.subject","Hematology"],["dc.subject","Solid tumor"],["dc.subject","Checkpoint inhibition"],["dc.subject","Serological testing"],["dc.subject","Coronavirus"],["dc.subject","Social participation"],["dc.subject","Immunogenicity"],["dc.title","SARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]