Pöhlmann, Stefan

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.volume","93"],["dc.contributor.author","Kleine-Weber, Hannah"],["dc.contributor.author","Elzayat, Mahmoud Tarek"],["dc.contributor.author","Wang, Lingshu"],["dc.contributor.author","Graham, Barney S."],["dc.contributor.author","Müller, Marcel A."],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.editor","Gallagher, Tom"],["dc.date.accessioned","2020-12-10T18:37:02Z"],["dc.date.available","2020-12-10T18:37:02Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1128/JVI.01381-18"],["dc.identifier.eissn","1098-5514"],["dc.identifier.issn","0022-538X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76822"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Antimicrobial Agents and Chemotherapy"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Schroeder, Simon"],["dc.contributor.author","Kleine-Weber, Hannah"],["dc.contributor.author","Müller, Marcel A."],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2021-04-14T08:25:20Z"],["dc.date.available","2021-04-14T08:25:20Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1128/AAC.00754-20"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81600"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1098-6596"],["dc.relation.issn","0066-4804"],["dc.title","Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5502"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","5511"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Gierer, Stefanie"],["dc.contributor.author","Bertram, Stephanie"],["dc.contributor.author","Kaup, Franziska"],["dc.contributor.author","Wrensch, Florian"],["dc.contributor.author","Heurich, Adeline"],["dc.contributor.author","Krämer-Kühl, Annika"],["dc.contributor.author","Welsch, Kathrin"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Meyer, Benjamin"],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2022-10-06T13:25:31Z"],["dc.date.available","2022-10-06T13:25:31Z"],["dc.date.issued","2013"],["dc.description.abstract","ABSTRACT\n The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose a significant threat to public health. The elucidation of hCoV-EMC interactions with host cells is critical to our understanding of the pathogenesis of this virus and to the identification of targets for antiviral intervention. Here we investigated the viral and cellular determinants governing hCoV-EMC entry into host cells. We found that the spike protein of hCoV-EMC (EMC-S) is incorporated into lentiviral particles and mediates transduction of human cell lines derived from different organs, including the lungs, kidneys, and colon, as well as primary human macrophages. Expression of the known coronavirus receptors ACE2, CD13, and CEACAM1 did not facilitate EMC-S-driven transduction, suggesting that hCoV-EMC uses a novel receptor for entry. Directed protease expression and inhibition analyses revealed that TMPRSS2 and endosomal cathepsins activate EMC-S for virus-cell fusion and constitute potential targets for antiviral intervention. Finally, EMC-S-driven transduction was abrogated by serum from an hCoV-EMC-infected patient, indicating that EMC-S-specific neutralizing antibodies can be generated in patients. Collectively, our results indicate that hCoV-EMC uses a novel receptor for protease-activated entry into human cells and might be capable of extrapulmonary spread. In addition, they define TMPRSS2 and cathepsins B and L as potential targets for intervention and suggest that neutralizing antibodies contribute to the control of hCoV-EMC infection."],["dc.identifier.doi","10.1128/JVI.00128-13"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114860"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","155"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Emerging Microbes & Infections"],["dc.bibliographiccitation.lastpage","168"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kleine-Weber, Hannah"],["dc.contributor.author","Schroeder, Simon"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Prokscha, Alexander"],["dc.contributor.author","Naim, Hassan Y."],["dc.contributor.author","Müller, Marcel A."],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Hoffmann, Markus"],["dc.date.accessioned","2020-12-10T18:15:34Z"],["dc.date.available","2020-12-10T18:15:34Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1080/22221751.2020.1713705"],["dc.identifier.eissn","2222-1751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74887"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","588"],["dc.bibliographiccitation.issue","7826"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","590"],["dc.bibliographiccitation.volume","585"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Mösbauer, Kirstin"],["dc.contributor.author","Hofmann-Winkler, Heike"],["dc.contributor.author","Kaul, Artur"],["dc.contributor.author","Kleine-Weber, Hannah"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Gassen, Nils C."],["dc.contributor.author","Müller, Marcel A."],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2021-04-14T08:24:28Z"],["dc.date.available","2021-04-14T08:24:28Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41586-020-2575-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81295"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1476-4687"],["dc.relation.issn","0028-0836"],["dc.title","Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","271"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","280.e8"],["dc.bibliographiccitation.volume","181"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Kleine-Weber, Hannah"],["dc.contributor.author","Schroeder, Simon"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Herrler, Tanja"],["dc.contributor.author","Erichsen, Sandra"],["dc.contributor.author","Schiergens, Tobias S."],["dc.contributor.author","Herrler, Georg"],["dc.contributor.author","Wu, Nai-Huei"],["dc.contributor.author","Nitsche, Andreas"],["dc.contributor.author","Müller, Marcel A."],["dc.contributor.author","Drosten, Christian"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2020-12-10T14:22:59Z"],["dc.date.available","2020-12-10T14:22:59Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.cell.2020.02.052"],["dc.identifier.issn","0092-8674"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71797"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]