Pöhlmann, Stefan

[["dc.bibliographiccitation.firstpage","11727"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Journal of virology"],["dc.bibliographiccitation.lastpage","11733"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Karsten, Christina B."],["dc.contributor.author","Buettner, Falk F. R."],["dc.contributor.author","Cajic, Samanta"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Reichl, Udo"],["dc.contributor.author","Gerardy-Schahn, Rita"],["dc.contributor.author","Rapp, Erdmann"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2016-08-25T12:14:40Z"],["dc.date.accessioned","2021-10-27T13:13:01Z"],["dc.date.available","2016-08-25T12:14:40Z"],["dc.date.available","2021-10-27T13:13:01Z"],["dc.date.issued","2015-11-01"],["dc.description.abstract","Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission."],["dc.identifier.doi","10.1128/JVI.01358-15"],["dc.identifier.fs","620621"],["dc.identifier.pmid","26355090"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91745"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.euproject","HighGlycan"],["dc.relation.issn","1098-5514"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Cell Line"],["dc.subject.mesh","Gene Products, env"],["dc.subject.mesh","HIV Infections"],["dc.subject.mesh","HIV-1"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Macaca mulatta"],["dc.subject.mesh","Mannose"],["dc.subject.mesh","Mucous Membrane"],["dc.subject.mesh","Polysaccharides"],["dc.subject.mesh","Simian Acquired Immunodeficiency Syndrome"],["dc.subject.mesh","Simian Immunodeficiency Virus"],["dc.title","Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S210"],["dc.bibliographiccitation.issue","suppl 2"],["dc.bibliographiccitation.journal","Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","S218"],["dc.bibliographiccitation.volume","212"],["dc.contributor.author","Wrensch, Florian"],["dc.contributor.author","Karsten, Christina B."],["dc.contributor.author","Gnirß, Kerstin"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Lu, Kai"],["dc.contributor.author","Takada, Ayato"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Simmons, Graham"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2022-10-06T13:35:09Z"],["dc.date.available","2022-10-06T13:35:09Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1093/infdis/jiv255"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116027"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1537-6613"],["dc.relation.issn","0022-1899"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Interferon-Induced Transmembrane Protein–Mediated Inhibition of Host Cell Entry of Ebolaviruses"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e43337"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Bertram, Stephanie"],["dc.contributor.author","Gnirß, Kerstin"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Gawanbacht, Ali"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Ehrhardt, Christina"],["dc.contributor.author","Ludwig, Stephan"],["dc.contributor.author","Kiene, Miriam"],["dc.contributor.author","Moldenhauer, Anna-Sophie"],["dc.contributor.author","Goedecke, Ulrike"],["dc.contributor.author","Karsten, Christina B."],["dc.contributor.author","Kühl, Annika"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2019-07-09T11:53:44Z"],["dc.date.available","2019-07-09T11:53:44Z"],["dc.date.issued","2012"],["dc.description.abstract","The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu. Influenza A virus (FLUAV) also buds from the plasma membrane and is not inhibited by tetherin. Here, we investigated if FLUAV encodes a functional equivalent of Vpu for tetherin antagonism. We found that expression of the FLUAV protein NS1, which antagonizes the interferon (IFN) response, did not block the tetherin-mediated restriction of HIV release, which was rescued by Vpu. Similarly, tetherinmediated inhibition of HIV release was not rescued by FLUAV infection. In contrast, FLUAV infection induced tetherin expression on target cells in an IFN-dependent manner. These results suggest that FLUAV escapes the antiviral effects of tetherin without encoding a tetherin antagonist with Vpu-like activity."],["dc.identifier.doi","10.1371/journal.pone.0043337"],["dc.identifier.fs","588509"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7923"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60484"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Influenza A Virus Does Not Encode a Tetherin Antagonist with Vpu-Like Activity and Induces IFN-Dependent Tetherin Expression in Infected Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]