Pöhlmann, Stefan

[["dc.bibliographiccitation.firstpage","4738"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","4742"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Guo, Yuan"],["dc.contributor.author","Sakonsinsiri, Chadamas"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Fascione, Martin A."],["dc.contributor.author","Zhang, Haiyan"],["dc.contributor.author","Wang, Weili"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Turnbull, W. Bruce"],["dc.contributor.author","Zhou, Dejian"],["dc.date.accessioned","2022-10-06T13:34:57Z"],["dc.date.available","2022-10-06T13:34:57Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1002/anie.201600593"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116020"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","1433-7851"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein-Ligand Interactions"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","S2211124721008287"],["dc.bibliographiccitation.firstpage","109415"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Hofmann-Winkler, Heike"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Kempf, Amy"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Graichen, Luise"],["dc.contributor.author","Arora, Prerna"],["dc.contributor.author","Sidarovich, Anzhalika"],["dc.contributor.author","Moldenhauer, Anna-Sophie"],["dc.contributor.author","Winkler, Martin S."],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2021-09-01T06:42:36Z"],["dc.date.available","2021-09-01T06:42:36Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.celrep.2021.109415"],["dc.identifier.pii","S2211124721008287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89097"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.issn","2211-1247"],["dc.title","SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Virology Journal"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Lambertz, Ruth Lydia Olga"],["dc.contributor.author","Gerhauser, Ingo"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Gärtner, Sabine"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Leist, Sarah Rebecca"],["dc.contributor.author","Kollmus, Heike"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Schughart, Klaus"],["dc.date.accessioned","2020-12-10T18:39:01Z"],["dc.date.available","2020-12-10T18:39:01Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12985-020-01323-z"],["dc.identifier.eissn","1743-422X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77513"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0224082"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Gärtner, Sabine"],["dc.contributor.author","Markus, Lara"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Krawczak, Michael"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2019-11-05T08:51:28Z"],["dc.date.accessioned","2021-10-27T13:13:08Z"],["dc.date.available","2019-11-05T08:51:28Z"],["dc.date.available","2021-10-27T13:13:08Z"],["dc.date.issued","2019"],["dc.description.abstract","The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFITM3) inhibits HIV and SIV infection at the stage of host cell entry. However, it is still unclear to what extent the antiviral activity of IFITM3 observed in cell culture translates into inhibition of HIV/SIV spread in the infected host. We have shown previously that although rhIFITM3 inhibits SIV entry into cultured cells, polymorphisms in the rhIFITM3 gene are not strongly associated with viral load or disease progression in SIV infected macaques. Here, we examined whether rhIFITM3(2), which is closely related to rhIFITM3 at the sequence level, exerts antiviral activity and whether polymorphisms in the rhIFITM3(2) gene impact the course of SIV infection. We show that expression of rhIFITM3(2) is interferon-inducible and inhibits SIV entry into cells, although with reduced efficiency as compared to rhIFITM3. We further report the identification of 19 polymorphisms in the rhIFITM3(2) gene. However, analysis of a well characterized cohort of SIV infected macaques revealed that none of the polymorphisms had a significant impact upon the course of SIV infection. These results and our previous work suggest that polymorphisms in the rhIFITM3 and rhIFITM3(2) genes do not strongly modulate the course of SIV infection in macaques."],["dc.identifier.doi","10.1371/journal.pone.0224082"],["dc.identifier.pmid","31682595"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16596"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91754"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1932-6203"],["dc.relation.issn","1932-6203"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","599"],["dc.title","Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18022"],["dc.bibliographiccitation.issue","42"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","18034"],["dc.bibliographiccitation.volume","142"],["dc.contributor.author","Budhadev, Darshita"],["dc.contributor.author","Poole, Emma"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Liu, Yuanyuan"],["dc.contributor.author","Hooper, James"],["dc.contributor.author","Kalverda, Elizabeth"],["dc.contributor.author","Akshath, Uchangi Satyaprasad"],["dc.contributor.author","Hondow, Nicole"],["dc.contributor.author","Turnbull, W. Bruce"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Guo, Yuan"],["dc.contributor.author","Zhou, Dejian"],["dc.date.accessioned","2021-04-14T08:31:53Z"],["dc.date.available","2021-04-14T08:31:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1021/jacs.0c06793"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83741"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1520-5126"],["dc.relation.issn","0002-7863"],["dc.title","Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin–Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e01488-16"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Wrensch, Florian"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Gärtner, Sabine"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.editor","Ross, Susan R."],["dc.date.accessioned","2022-10-06T13:25:35Z"],["dc.date.available","2022-10-06T13:25:35Z"],["dc.date.issued","2017"],["dc.description.abstract","ABSTRACT\n Interferon-induced transmembrane proteins (IFITMs) can inhibit the cellular entry of several enveloped viruses, including simian immunodeficiency virus (SIV). The blockade of SIV by IFITMs is isolate specific, raising the question of which parameters impact sensitivity to IFITM. We show that the virion context in which SIV-Env is presented and the efficiency of virion incorporation determine Env susceptibility to inhibition by IFITMs. Thus, determinants other than the nature of the envelope protein can impact the IFITM sensitivity of viral entry.\n \n IMPORTANCE\n The host cell-encoded IFITM proteins can block viral entry and are an important component of the innate defenses against viral infection. However, the determinants controlling whether a virus is susceptible to blockade by IFITM proteins are incompletely understood. Our study shows that the amount of envelope proteins incorporated into virions as well as the nature of the virion particle itself can impact the sensitivity of viral entry to IFITMs. These results show for the first time that determinants other than the viral envelope protein can impact sensitivity to IFITM and have implications for the interpretation of previously published data on inhibition of viruses by IFITM proteins. Moreover, our findings might help to define the mechanism underlying the antiviral activity of IFITM proteins."],["dc.description.sponsorship"," Leibniz-Gemeinschaft https://doi.org/10.13039/501100001664"],["dc.identifier.doi","10.1128/JVI.01488-16"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114874"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.volume","93"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Brinkmann, Constantin"],["dc.contributor.author","Krähling, Verena"],["dc.contributor.author","Behner, Laura"],["dc.contributor.author","Moldenhauer, Anna-Sophie"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Nehls, Julia"],["dc.contributor.author","Schindler, Michael"],["dc.contributor.author","Hoenen, Thomas"],["dc.contributor.author","Maisner, Andrea"],["dc.contributor.author","Becker, Stephan"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.editor","Dermody, Terence S."],["dc.date.accessioned","2020-12-10T18:37:03Z"],["dc.date.available","2020-12-10T18:37:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1128/JVI.01821-18"],["dc.identifier.eissn","1098-5514"],["dc.identifier.issn","0022-538X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76825"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1073"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of General Virology"],["dc.bibliographiccitation.lastpage","1078"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Lambertz, Ruth L. O."],["dc.contributor.author","Gerhauser, Ingo"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Leist, Sarah R."],["dc.contributor.author","Kollmus, Heike"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Schughart, Klaus"],["dc.date.accessioned","2020-12-10T18:20:19Z"],["dc.date.available","2020-12-10T18:20:19Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1099/jgv.0.001274"],["dc.identifier.eissn","1465-2099"],["dc.identifier.issn","0022-1317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75522"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","447"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","456.e11"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Krüger, Nadine"],["dc.contributor.author","Schulz, Sebastian"],["dc.contributor.author","Cossmann, Anne"],["dc.contributor.author","Rocha, Cheila"],["dc.contributor.author","Kempf, Amy"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Graichen, Luise"],["dc.contributor.author","Moldenhauer, Anna-Sophie"],["dc.contributor.author","Winkler, Martin S."],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2022-04-01T10:00:59Z"],["dc.date.available","2022-04-01T10:00:59Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.cell.2021.12.032"],["dc.identifier.pii","S0092867421014951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105571"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.issn","0092-8674"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11727"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Journal of virology"],["dc.bibliographiccitation.lastpage","11733"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Karsten, Christina B."],["dc.contributor.author","Buettner, Falk F. R."],["dc.contributor.author","Cajic, Samanta"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Reichl, Udo"],["dc.contributor.author","Gerardy-Schahn, Rita"],["dc.contributor.author","Rapp, Erdmann"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2016-08-25T12:14:40Z"],["dc.date.accessioned","2021-10-27T13:13:01Z"],["dc.date.available","2016-08-25T12:14:40Z"],["dc.date.available","2021-10-27T13:13:01Z"],["dc.date.issued","2015-11-01"],["dc.description.abstract","Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission."],["dc.identifier.doi","10.1128/JVI.01358-15"],["dc.identifier.fs","620621"],["dc.identifier.pmid","26355090"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91745"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.euproject","HighGlycan"],["dc.relation.issn","1098-5514"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Cell Line"],["dc.subject.mesh","Gene Products, env"],["dc.subject.mesh","HIV Infections"],["dc.subject.mesh","HIV-1"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Macaca mulatta"],["dc.subject.mesh","Mannose"],["dc.subject.mesh","Mucous Membrane"],["dc.subject.mesh","Polysaccharides"],["dc.subject.mesh","Simian Acquired Immunodeficiency Syndrome"],["dc.subject.mesh","Simian Immunodeficiency Virus"],["dc.title","Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]