Pöhlmann, Stefan

[["dc.bibliographiccitation.firstpage","11727"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Journal of virology"],["dc.bibliographiccitation.lastpage","11733"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Karsten, Christina B."],["dc.contributor.author","Buettner, Falk F. R."],["dc.contributor.author","Cajic, Samanta"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Reichl, Udo"],["dc.contributor.author","Gerardy-Schahn, Rita"],["dc.contributor.author","Rapp, Erdmann"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2016-08-25T12:14:40Z"],["dc.date.accessioned","2021-10-27T13:13:01Z"],["dc.date.available","2016-08-25T12:14:40Z"],["dc.date.available","2021-10-27T13:13:01Z"],["dc.date.issued","2015-11-01"],["dc.description.abstract","Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission."],["dc.identifier.doi","10.1128/JVI.01358-15"],["dc.identifier.fs","620621"],["dc.identifier.pmid","26355090"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91745"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.euproject","HighGlycan"],["dc.relation.issn","1098-5514"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Cell Line"],["dc.subject.mesh","Gene Products, env"],["dc.subject.mesh","HIV Infections"],["dc.subject.mesh","HIV-1"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Macaca mulatta"],["dc.subject.mesh","Mannose"],["dc.subject.mesh","Mucous Membrane"],["dc.subject.mesh","Polysaccharides"],["dc.subject.mesh","Simian Acquired Immunodeficiency Syndrome"],["dc.subject.mesh","Simian Immunodeficiency Virus"],["dc.title","Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]