Hornung, Daniel

[["dc.bibliographiccitation.artnumber","042920"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Physical Review. E"],["dc.bibliographiccitation.volume","92"],["dc.contributor.author","Spreckelsen, Florian"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Steinbock, Oliver"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T09:50:03Z"],["dc.date.available","2018-11-07T09:50:03Z"],["dc.date.issued","2015"],["dc.description.abstract","Scroll waves in a three-dimensional medium with negative filament tension may break up and display spatiotemporal chaos. The presence of heterogeneities can influence the evolution of the medium, in particular scroll waves may pin to such heterogeneities. We show that as a result the medium may be stabilized by heterogeneities of a suitably chosen geometry. Thin rodlike heterogeneities suppress otherwise developing spatiotemporal chaos and additionally clear out already existing chaotic excitation patterns."],["dc.identifier.doi","10.1103/PhysRevE.92.042920"],["dc.identifier.isi","000363242700008"],["dc.identifier.pmid","26565317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35630"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/95"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2470-0053"],["dc.relation.issn","2470-0045"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Stabilization of three-dimensional scroll waves and suppression of spatiotemporal chaos by heterogeneities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","170024"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Royal Society Open Science"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Biktashev, V. N."],["dc.contributor.author","Otani, N. F."],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Baig, T."],["dc.contributor.author","Berg, S."],["dc.contributor.author","Han, Sang Who"],["dc.contributor.author","Krinsky, V. I."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T10:26:28Z"],["dc.date.available","2018-11-07T10:26:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation."],["dc.identifier.doi","10.1098/rsos.170024"],["dc.identifier.isi","000398107700049"],["dc.identifier.pmid","28405398"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14953"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43052"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/167"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241526/EU//EUTRIGTREAT"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2054-5703"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Mechanisms of vortices termination in the cardiac muscle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Fitschen, Timm"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","tom Wörden, Henrik"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-05-13T10:03:07Z"],["dc.date.available","2022-05-13T10:03:07Z"],["dc.date.issued","2018-01-23"],["dc.description.abstract","Here we present CaosDB, a Research Data Management System (RDMS) designed to ensure seamless integration of inhomogeneous data sources and repositories of legacy data. Its primary purpose is the management of data from biomedical sciences, both from simulations and experiments during the complete research data lifecycle. An RDMS for this domain faces particular challenges: Research data arise in huge amounts, from a wide variety of sources, and traverse a highly branched path of further processing. To be accepted by its users, an RDMS must be built around workflows of the scientists and practices and thus support changes in workflow and data structure. Nevertheless it should encourage and support the development and observation of standards and furthermore facilitate the automation of data acquisition and processing with specialized software. The storage data model of an RDMS must reflect these complexities with appropriate semantics and ontologies while offering simple methods for finding, retrieving, and understanding relevant data. We show how CaosDB responds to these challenges and give an overview of the CaosDB Server, its data model and its easy-to-learn CaosDB Query Language. We briefly discuss the status of the implementation, how we currently use CaosDB, and how we plan to use and extend it."],["dc.identifier.arxiv","1801.07653"],["dc.identifier.doi","10.3390/data4020083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107868"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/199"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","CaosDB - Research Data Management for Complex, Changing, and Automated Research Workflows"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","153a"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","154a"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hörning, Marcel"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-03-01T11:44:57Z"],["dc.date.available","2022-03-01T11:44:57Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.bpj.2012.11.869"],["dc.identifier.pii","S0006349512021157"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103171"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-3495"],["dc.title","Electric-Field-Based Control Strategies for Cardiac Tissue"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","83"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Data"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Fitschen, Timm"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","tom Wörden, Henrik"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2020-12-10T18:47:01Z"],["dc.date.available","2020-12-10T18:47:01Z"],["dc.date.issued","2019"],["dc.description.abstract","Here we present CaosDB, a Research Data Management System (RDMS) designed to ensure seamless integration of inhomogeneous data sources and repositories of legacy data. Its primary purpose is the management of data from biomedical sciences, both from simulations and experiments during the complete research data lifecycle. An RDMS for this domain faces particular challenges: Research data arise in huge amounts, from a wide variety of sources, and traverse a highly branched path of further processing. To be accepted by its users, an RDMS must be built around workflows of the scientists and practices and thus support changes in workflow and data structure. Nevertheless it should encourage and support the development and observation of standards and furthermore facilitate the automation of data acquisition and processing with specialized software. The storage data model of an RDMS must reflect these complexities with appropriate semantics and ontologies while offering simple methods for finding, retrieving, and understanding relevant data. We show how CaosDB responds to these challenges and give an overview of the CaosDB Server, its data model and its easy-to-learn CaosDB Query Language. We briefly discuss the status of the implementation, how we currently use CaosDB, and how we plan to use and extend it."],["dc.identifier.doi","10.3390/data4020083"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78611"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/275"],["dc.language.iso","en"],["dc.notes","GRO-Red/ SW 8.5.2020: Geprüft. Keine Anpassung erforderlich, da Preprint im Volltext verfügbar."],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.eissn","2306-5729"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","CaosDB—Research Data Management for Complex, Changing, and Automated Research Workflows"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","7355"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","U152"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Kornreich, Bruce G."],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Zabel, Markus"],["dc.contributor.author","Flanders, James"],["dc.contributor.author","Gladuli, Andrea"],["dc.contributor.author","Campoy, Luis"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Luther, Gisa"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Krinsky, Valentin I."],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Gilmour, Robert F. Jr."],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2017-09-07T11:44:07Z"],["dc.date.available","2017-09-07T11:44:07Z"],["dc.date.issued","2011"],["dc.description.abstract","Controlling the complex spatio-temporal dynamics underlying life-threatening cardiac arrhythmias such as fibrillation is extremely difficult, because of the nonlinear interaction of excitation waves in a heterogeneous anatomical substrate(1-4). In the absence of a better strategy, strong, globally resetting electrical shocks remain the only reliable treatment for cardiac fibrillation(5-7). Here we establish the relationship between the response of the tissue to an electric field and the spatial distribution of heterogeneities in the scale-free coronary vascular structure. We show that in response to a pulsed electric field, E, these heterogeneities serve as nucleation sites for the generation of intramural electrical waves with a source density rho(E) and a characteristic time, tau, for tissue depolarization that obeys the power law tau proportional to E(alpha). These intramural wave sources permit targeting of electrical turbulence near the cores of the vortices of electrical activity that drive complex fibrillatory dynamics. Weshow in vitro that simultaneous and direct access to multiple vortex cores results in rapid synchronization of cardiac tissue and therefore, efficient termination of fibrillation. Using this control strategy, we demonstrate low-energy termination of fibrillation in vivo. Our results give new insights into the mechanisms and dynamics underlying the control of spatio-temporal chaos in heterogeneous excitable media and provide new research perspectives towards alternative, life-saving low-energy defibrillation techniques."],["dc.identifier.doi","10.1038/nature10216"],["dc.identifier.gro","3142697"],["dc.identifier.isi","000292690500052"],["dc.identifier.pmid","21753855"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/130"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0028-0836"],["dc.title","Low-energy control of electrical turbulence in the heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Uzelac, Ilija"],["dc.contributor.author","Ji, Yanyan C."],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Schröder-Scheteling, Johannes"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Gray, Richard A."],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Fenton, Flavio H."],["dc.date.accessioned","2022-03-01T11:44:24Z"],["dc.date.available","2022-03-01T11:44:24Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3389/fphys.2017.00819"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103016"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1664-042X"],["dc.title","Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]