Jahn, Olaf

[["dc.bibliographiccitation.firstpage","1409"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The American Journal of Pathology"],["dc.bibliographiccitation.lastpage","1420"],["dc.bibliographiccitation.volume","176"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Hawlik, Andreas"],["dc.contributor.author","Lehnert, Stefan"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Meier, Stephen"],["dc.contributor.author","Görz, Evamaria"],["dc.contributor.author","Braunstein, Kerstin E."],["dc.contributor.author","Krzovska, Marija"],["dc.contributor.author","Schwalenstöcker, Birgit"],["dc.contributor.author","Jesse, Sarah"],["dc.contributor.author","Pröpper, Christian"],["dc.contributor.author","Böckers, Tobias"],["dc.contributor.author","Ludolph, Albert"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2021-04-26T14:11:31Z"],["dc.date.available","2021-04-26T14:11:31Z"],["dc.date.issued","2010-03"],["dc.description.abstract","Transgenic mice expressing human mutated superoxide dismutase 1 (SOD1) linked to familial forms of amyotrophic lateral sclerosis are frequently used as a disease model. We used the SOD1G93A mouse in a cross-breeding strategy to study the function of physiological prion protein (Prp). SOD1G93APrp-/- mice exhibited a significantly reduced life span, and an earlier onset and accelerated progression of disease, as compared with SOD1G93APrp+/+ mice. Additionally, during disease progression, SOD1G93APrp-/- mice showed impaired rotarod performance, lower body weight, and reduced muscle strength. Histologically, SOD1G93APrp-/- mice showed reduced numbers of spinal cord motor neurons and extended areas occupied by large vacuoles early in the course of the disease. Analysis of spinal cord homogenates revealed no differences in SOD1 activity. Using an unbiased proteomic approach, a marked reduction of glial fibrillary acidic protein and enhanced levels of collapsing response mediator protein 2 and creatine kinase were detected in SOD1G93APrp-/- versus SOD1G93A mice. In the course of disease, Bcl-2 decreases, nuclear factor-kappaB increases, and Akt is activated, but these changes were largely unaffected by Prp expression. Exclusively in double-transgenic mice, we detected a significant increase in extracellular signal-regulated kinase 2 activation at clinical onset. We propose that Prp has a beneficial role in the SOD1G93A amyotrophic lateral sclerosis mouse model by influencing neuronal and/or glial factors involved in antioxidative defense, rather than anti-apoptotic signaling."],["dc.identifier.doi","10.2353/ajpath.2010.090355"],["dc.identifier.pmid","20075202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84409"],["dc.language.iso","en"],["dc.relation.eissn","1525-2191"],["dc.relation.issn","0002-9440"],["dc.title","Neuroprotective function of cellular prion protein in a mouse model of amyotrophic lateral sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","901"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Urology"],["dc.bibliographiccitation.lastpage","905"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Merseburger, Axel S."],["dc.contributor.author","Serth, Jürgen"],["dc.contributor.author","Herrmann, Thomas W."],["dc.contributor.author","Becker, Jan U"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Kuczyk, Markus A."],["dc.date.accessioned","2021-04-26T14:11:42Z"],["dc.date.available","2021-04-26T14:11:42Z"],["dc.date.issued","2009-04"],["dc.description.abstract","To provide the first insights into the potential role of urocortin in mammalian spermatogenesis, we studied the expression of urocortin and corticotropin-releasing factor receptors 1 and 2 in the human testis. Urocortin is a bioactive peptide with antiapoptotic and antiproliferative properties. The proper regulation of apoptosis and proliferation is of high physiologic relevance in the control of spermatogenesis in adulthood and of the noncycling stage of gonocytes in fetal life."],["dc.identifier.doi","10.1016/j.urology.2008.12.029"],["dc.identifier.pmid","19232696"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84411"],["dc.language.iso","en"],["dc.relation.eissn","1527-9995"],["dc.relation.issn","0090-4295"],["dc.title","Differential expression of urocortin in human testicular germ cells in course of spermatogenesis: role for urocortin in male fertility?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","142"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","161"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kratzke, Manuel"],["dc.contributor.author","Candiello, Ermes"],["dc.contributor.author","Schmidt, Bernhard"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Schu, Peter"],["dc.date.accessioned","2018-11-07T09:54:05Z"],["dc.date.available","2018-11-07T09:54:05Z"],["dc.date.issued","2015"],["dc.description.abstract","Adaptor protein (AP)-1/sigma 1B(-/-) mice have reduced synaptic-vesicle (SV) recycling and increased endosomes. Mutant mice have impaired spatial memory, and sigma 1B-deficient humans have a severe mental retardation. In order to define these sigma 1B(-/-) 'bulk' endosomes and to determine their functions in SV recycling, we developed a protocol to separate them from the majority of the neuronal endosomes. The sigma 1B(-/-) 'bulk' endosomes proved to be classic early endosomes with an increase in the phospholipid phosphatidylinositol 3-phosphate (PI-3-P), which recruits proteins mediating protein sorting out of early endosomes into different routes. sigma 1B deficiency induced alterations in the endosomal proteome reveals two major functions: SV protein storage and sorting into endolysosomes. Alternative endosomal recycling pathways are not up-regulated, but certain SV proteins are misrouted. Tetraspanins are enriched in sigma 1B(-/-) synaptosomes, but not in their endosomes or in their clathrin-coated-vesicles (CCVs), indicating AP-1/sigma 1B-dependent sorting. Synapses contain also more AP-2 CCV, although it is expected that they contain less due to reduced SV recycling. Coat composition of these AP-2 CCVs is altered, and thus, they represent a subpopulation of AP-2 CCVs. Association of calmodulin-dependent protein kinase (CaMK)-II alpha, -delta and casein kinase (CK)-II alpha with the endosome/SV pool is altered, as well as 14-3-3 eta, indicating changes in specific signalling pathways regulating synaptic plasticity. The accumulation of early endosomes and endocytotic AP-2 CCV indicates the regulation of SV recycling via early endosomes by the interdependent regulation of AP-2-mediated endocytosis and AP-1/sigma 1B-mediated SV reformation."],["dc.description.sponsorship","DFG [Schu 802/3-1, 802/3-2]"],["dc.identifier.doi","10.1007/s12035-014-8852-0"],["dc.identifier.isi","000358341600014"],["dc.identifier.pmid","25128028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36465"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Humana Press Inc"],["dc.relation.issn","1559-1182"],["dc.relation.issn","0893-7648"],["dc.title","AP-1/sigma 1B-Dependent SV Protein Recycling Is Regulated in Early Endosomes and Is Coupled to AP-2 Endocytosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","527"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","International Journal of Mass Spectrometry"],["dc.bibliographiccitation.lastpage","540"],["dc.bibliographiccitation.volume","228"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Eckart, Klaus"],["dc.date.accessioned","2021-04-26T14:12:49Z"],["dc.date.available","2021-04-26T14:12:49Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1016/S1387-3806(03)00159-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84422"],["dc.relation.issn","1387-3806"],["dc.title","Tandem mass spectrometric characterization of branched peptides derived from photoaffinity labeling"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Eckart, Klaus"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Radulovic, Marko"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Blank, Thomas"],["dc.contributor.author","Stiedl, Oliver"],["dc.contributor.author","Spiess, Joachim"],["dc.date.accessioned","2021-12-08T12:28:35Z"],["dc.date.available","2021-12-08T12:28:35Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199952286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95748"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Actions of CRF and Its Analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","849"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Alzheimer's Disease"],["dc.bibliographiccitation.lastpage","858"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Hornung, Karen"],["dc.contributor.author","Zampar, Silvia"],["dc.contributor.author","Engel, Nadine"],["dc.contributor.author","Klafki, Hans"],["dc.contributor.author","Liepold, Thomas"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Wirths, Oliver"],["dc.date.accessioned","2020-12-10T18:44:12Z"],["dc.date.available","2020-12-10T18:44:12Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3233/JAD-181134"],["dc.identifier.eissn","1875-8908"],["dc.identifier.issn","1387-2877"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78365"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The European Physical Journal A"],["dc.bibliographiccitation.lastpage","140"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Ahrens, J."],["dc.contributor.author","Altieri, S."],["dc.contributor.author","Annand, JRM"],["dc.contributor.author","Arends, H. J."],["dc.contributor.author","Beck, R."],["dc.contributor.author","Braghieri, A."],["dc.contributor.author","d'Hose, N."],["dc.contributor.author","Dutz, H."],["dc.contributor.author","Goertz, S."],["dc.contributor.author","Grabmayr, P."],["dc.contributor.author","Hasegawa, S."],["dc.contributor.author","Heid, E."],["dc.contributor.author","Holvoet, H."],["dc.contributor.author","van Hoorebeke, L."],["dc.contributor.author","Horikawa, N."],["dc.contributor.author","Iwata, T."],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Jennewein, P."],["dc.contributor.author","Kondratiev, R."],["dc.contributor.author","Krimmer, J."],["dc.contributor.author","Lang, M."],["dc.contributor.author","Lannoy, B."],["dc.contributor.author","Livingston, K."],["dc.contributor.author","McGeorge, J. C."],["dc.contributor.author","Meyer, Werner"],["dc.contributor.author","Panzeri, A."],["dc.contributor.author","Pedroni, P."],["dc.contributor.author","Pinelli, T."],["dc.contributor.author","Preobrajenski, I."],["dc.contributor.author","Reicherz, G."],["dc.contributor.author","Rosner, G."],["dc.contributor.author","Rost, M."],["dc.contributor.author","Rostomyan, T."],["dc.contributor.author","Ryckbosch, D."],["dc.contributor.author","Schumacher, M."],["dc.contributor.author","Seitz, Bjoern"],["dc.contributor.author","Tamas, Gabor"],["dc.contributor.author","Thomas, Andy"],["dc.contributor.author","de Vyver, R."],["dc.contributor.author","Walcher, T."],["dc.contributor.author","Zapadtka, F."],["dc.date.accessioned","2018-11-07T10:55:18Z"],["dc.date.available","2018-11-07T10:55:18Z"],["dc.date.issued","2005"],["dc.description.abstract","The G asymmetry of the gamma p -> N pi reaction has been measured for the first time for E gamma = 340 +/- 14 MeV. This observable, for which very scarce published data exist, plays an important role to disentangle the contributions of the various nucleon resonances. The experiment, performed at the Mainz microtron MAIM, used a 4 pi-detector system, a linearly polarized, tagged photon beam, and a longitudinally polarized proton target."],["dc.identifier.doi","10.1140/epja/i2005-10158-3"],["dc.identifier.isi","000234051900016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49755"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1434-601X"],["dc.relation.issn","1434-6001"],["dc.title","Measurement of the G asymmetry for the gamma p -> N pi channels in the Delta(1232) resonance region"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","202303"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Ahrens, J."],["dc.contributor.author","Altieri, S."],["dc.contributor.author","Annand, J. R. M."],["dc.contributor.author","Arends, H.-J."],["dc.contributor.author","Beck, R."],["dc.contributor.author","Bradtke, C."],["dc.contributor.author","Braghieri, A."],["dc.contributor.author","d'Hose, N."],["dc.contributor.author","Dutz, H."],["dc.contributor.author","Goertz, S."],["dc.contributor.author","Grabmayr, P."],["dc.contributor.author","Hasegawa, S."],["dc.contributor.author","Heid, E."],["dc.contributor.author","Holvoet, H."],["dc.contributor.author","van Hoorebeke, L."],["dc.contributor.author","Horikawa, N."],["dc.contributor.author","Iwata, T."],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Jennewein, P."],["dc.contributor.author","Klein, F."],["dc.contributor.author","Kondratiev, R."],["dc.contributor.author","Lang, M."],["dc.contributor.author","Lannoy, B."],["dc.contributor.author","Lisin, V."],["dc.contributor.author","Martinez-Fabregate, M."],["dc.contributor.author","McGeorge, J. C."],["dc.contributor.author","Meyer, Werner"],["dc.contributor.author","Panzeri, A."],["dc.contributor.author","Pedroni, P."],["dc.contributor.author","Pinelli, T."],["dc.contributor.author","Preobrajenski, I."],["dc.contributor.author","Reicherz, G."],["dc.contributor.author","Rohlof, Ch."],["dc.contributor.author","Rosner, G."],["dc.contributor.author","Rost, M."],["dc.contributor.author","Rostomyan, T."],["dc.contributor.author","Ryckbosch, D."],["dc.contributor.author","Schumacher, M."],["dc.contributor.author","Seitz, Bjoern"],["dc.contributor.author","Tamas, Gabor"],["dc.contributor.author","Thomas, Andy"],["dc.contributor.author","van de Vyver, R."],["dc.contributor.author","Zapadtka, F."],["dc.date.accessioned","2018-11-07T08:57:26Z"],["dc.date.available","2018-11-07T08:57:26Z"],["dc.date.issued","2006"],["dc.description.abstract","A measurement of the helicity dependence of the total inclusive photoabsorption cross section on the deuteron was carried out at MAMI (Mainz) in the energy range 200 < E-gamma < 800 MeV. The experiment used a 4 pi detection system, a circularly polarized tagged photon beam and a frozen-spin target which provided longitudinally polarized deuterons. The contribution to the Gerasimov-Drell-Hearn sum rule for the deuteron determined from the data is 407 +/- 20(stat)+/- 24(syst) mu b for 200 < E-gamma < 800 MeV."],["dc.identifier.doi","10.1103/PhysRevLett.97.202303"],["dc.identifier.isi","000242101600017"],["dc.identifier.pmid","17155680"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23402"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","0031-9007"],["dc.title","Measurement of the Gerasimov-Drell-Hearn integrand for H-2 from 200 to 800 MeV"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuropharmacology"],["dc.bibliographiccitation.lastpage","242"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Tezval, Hossein"],["dc.contributor.author","van Werven, Lars"],["dc.contributor.author","Eckart, Klaus"],["dc.contributor.author","Spiess, Joachim"],["dc.date.accessioned","2021-04-26T14:12:25Z"],["dc.date.available","2021-04-26T14:12:25Z"],["dc.date.issued","2004-08"],["dc.description.abstract","Corticotropin-releasing factor (CRF) and the CRF-like peptide urocortin I (UcnI) exert their activity through two different CRF receptors, CRF1 and CRF2. Recently, UcnII and UcnIII have been discovered as potential endogenous agonists selective for CRF2 known to be involved in brain functions such as learning and anxiety, as well as in cardiovascular functions. A structure-affinity relationship study using chimeric peptides was designed to characterize mouse UcnII (mUcnII) and mUcnIII further and to investigate the structural basis of their receptor subtype selectivity. In the framework of this study, mUcnII (IC50 = 4.4 nM) but not mUcnIII was identified as high-affinity ligand for the rat CRF binding protein. Such affinity had previously not been observed for the human version of this protein. On the basis of secondary structure predictions, it was hypothesized that the amino acid motifs Pro-Ile-Gly of mUcnII and Pro-Thr-Asn of mUcnIII decrease alpha-helicity and thereby impair binding to CRF1. In support of this hypothesis, binding affinity to CRF1 of the chimeric peptides [Pro11Ile12Gly13]h/rCRF, [Pro11Thr12Asn13]h/rCRF, and the corresponding rUcnI analogs was found to be decreased by three orders of magnitude, whereas binding affinity to CRF2 was much less affected. The dramatic decrease in binding affinity to CRF1 correlated with a decrease in alpha-helicity as indicated by the data of circular dichroism spectroscopy."],["dc.identifier.doi","10.1016/j.neuropharm.2004.03.018"],["dc.identifier.pmid","15223302"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84419"],["dc.language.iso","en"],["dc.relation.issn","0028-3908"],["dc.title","Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","159"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Expert Review of Proteomics"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Werner, Hauke B."],["dc.contributor.author","Jahn, Olaf"],["dc.date.accessioned","2021-04-26T14:11:27Z"],["dc.date.available","2021-04-26T14:11:27Z"],["dc.date.issued","2010-04"],["dc.identifier.doi","10.1586/epr.09.105"],["dc.identifier.pmid","20377380"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84408"],["dc.language.iso","en"],["dc.relation.eissn","1744-8387"],["dc.relation.issn","1478-9450"],["dc.title","Myelin matters: proteomic insights into white matter disorders"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]