Koziolek, Michael Johann

[["dc.bibliographiccitation.firstpage","222"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Therapeutic Apheresis and Dialysis"],["dc.bibliographiccitation.lastpage","225"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Fuezesi, Laszlo"],["dc.contributor.author","Koenig, Fatima"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T08:44:57Z"],["dc.date.available","2018-11-07T08:44:57Z"],["dc.date.issued","2010"],["dc.description.abstract","We report a case of a 27-year-old female with thrombotic microangiopathy as an initial presentation of an unexpected disseminated gastric carcinoma. Based on clinical features and laboratory findings, thrombotic thrombocytopenic purpura (TTP) was diagnosed and plasma exchange started. However, she had responded poorly to plasmapheresis, developed multiorgan failure and died 72 h after admission. Autopsy revealed a disseminated gastric adenocarcinoma with metastatic infiltration of dura mater and disseminated tumor cell emboli in the microcirculation of the liver and lungs. Genetic analysis revealed amplification of KRAS oncogene and aberrations in DCC tumor suppressor gene, which can explain the young age and advanced disease at presentation. The role of plasmapheresis in cancer-associated TTP is uncertain. Plasmapheresis delivers fresh coagulation factors and may theoretically promote microthrombi formation and lead to worsening of the disease. Thrombotic thrombocytopenic purpura seems to be a late and prognostically poor manifestation of an underlying malignancy, with majority of patients dying soon after diagnosis. It is important to be aware of this possibility in thrombotic microangiopathy, especially with atypical features and poor response to standard treatment."],["dc.identifier.doi","10.1111/j.1744-9987.2009.00710.x"],["dc.identifier.isi","000276036600014"],["dc.identifier.pmid","20438546"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1744-9979"],["dc.title","Fulminant Plasmapheresis-refractory Thrombotic Microangiopathy Associated With Advanced Gastric Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","A100"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MEDIZINISCHE KLINIK"],["dc.bibliographiccitation.lastpage","A101"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Scheel, A."],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Grone, H. J."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T09:59:01Z"],["dc.date.available","2018-11-07T09:59:01Z"],["dc.date.issued","2006"],["dc.identifier.isi","000237562000323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37491"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0723-5003"],["dc.title","Effective therapy of a hepatitis-C-associated immunocomplex nephritis by means of cryoprecipitate apheresis and interferon-alpha"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Kaempfe, Dietrich"],["dc.contributor.author","Machherndl-Spandl, Sigrid"],["dc.contributor.author","Suessner, Susanne"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.date.accessioned","2018-11-07T09:34:10Z"],["dc.date.available","2018-11-07T09:34:10Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900097"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32120"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Significance of Y-chromosome loss in MDS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","711"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Medical Education"],["dc.bibliographiccitation.lastpage","720"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Raupach, Tobias"],["dc.contributor.author","Andresen, Jil C."],["dc.contributor.author","Meyer, Katharina"],["dc.contributor.author","Strobel, Lisa"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Jung, Wolfram"],["dc.contributor.author","Brown, Jamie"],["dc.contributor.author","Anders, Sven"],["dc.date.accessioned","2018-11-07T10:12:24Z"],["dc.date.available","2018-11-07T10:12:24Z"],["dc.date.issued","2016"],["dc.description.abstract","ContextClinical reasoning is an essential skill, the foundations of which should be acquired during undergraduate medical education. Student performance in clinical reasoning can be assessed using key feature examinations. However, within a paradigm of test-enhanced learning, such examinations may also be used to enhance long-term retention ofprocedural knowledge relevant to clinical reasoning. ObjectivesThis study tested the hypothesis that repeated testing with key feature questions is more effective than repeated case-based learning in fostering clinical reasoning. MethodsIn this randomised crossover trial, Year4 medical students attended 10 weekly computer-based seminars during which patient case histories covering general medical conditions were displayed. The presentation format was switched between groups every week. In the control condition, students studied long case narratives. The intervention condition used the same content but augmented case presentation with a sequence of key feature questions. Using a within-subjects design, student performance on intervention and control items was assessed at 13weeks (exit examination) and 9months (retention test) after the first day of term. ResultsA total of 87 of 124 eligible students provided complete data for the longitudinal analysis (response rate: 70.2%). In the retention test, meanstandard deviation student scores on intervention items were significantly higher than those on control items (56.025.8% versus 48.8 +/- 24.7%; p<0.001). The results remained unchanged after accounting for exposure time in a linear regression analysis that also adjusted for sex and general student performance levels. ConclusionsThis is the first study to demonstrate an effect of test-enhanced learning on clinical reasoning as assessed with key feature questions. In this randomised trial, repeated testing was more effective than repeated case-based learning alone. Curricular implementation of longitudinal key feature testing may considerably enhance student learning outcomes in relevant aspects of clinical medicine."],["dc.identifier.doi","10.1111/medu.13069"],["dc.identifier.isi","000378731000006"],["dc.identifier.pmid","27295475"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40228"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2923"],["dc.relation.issn","0308-0110"],["dc.title","Test-enhanced learning of clinical reasoning: a crossover randomised trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e42"],["dc.bibliographiccitation.issue","06"],["dc.bibliographiccitation.journal","Deutsche medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","e50"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Lüders, Stephan"],["dc.contributor.author","Schrader, Bastian"],["dc.contributor.author","Bäsecke, Jörg"],["dc.contributor.author","Haller, Hermann"],["dc.contributor.author","Elsässer, Albrecht"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Schrader, Joachim"],["dc.date.accessioned","2020-12-10T18:12:04Z"],["dc.date.available","2020-12-10T18:12:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1055/a-0714-3835"],["dc.identifier.eissn","1439-4413"],["dc.identifier.issn","0012-0472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74237"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","ELITE-Studie – Ernährung, Lebensstil und individuelle Information zur Verhinderung von Schlaganfall, Demenz und Herzinfarkt – Studiendesign und kardiovaskuläre Aufnahmedate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Clinical Apheresis"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Patschan, Daniel"],["dc.contributor.author","Patschan, Susann A."],["dc.contributor.author","Henze, Elvira"],["dc.contributor.author","Wessels, Johannes Theodor"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Mueller, Georg Anton"],["dc.date.accessioned","2018-11-07T08:34:48Z"],["dc.date.available","2018-11-07T08:34:48Z"],["dc.date.issued","2009"],["dc.description.abstract","Background and Aim: Endothelial progenitor cells (EPCs) have been shown to promote neovascularization under physiologic and pathologic conditions. Statins have been documented to increase the total number of circulating EPCs in long-term treated patients. Lipid apheresis is used to treat patient with refractory hyperlipidemia. The aim of our study was to evaluate whether lipid apheresis is associated with EPC mobilization. Methods: Thirteen patients with refractory hyperlipidemia (analysis at the beginning and at the end of a single lipid apheresis treatment) and 10 healthy controls were included into the study. For quantifying total peripheral EPCs, CD133+/Flk-1+ myelo-monocytic blood cells were enumerated by flow cytometry. The proliferative potential of EPCs was evaluated by a \"colony-forming unit\" assay. In some patients, EPC eNOS expression was evaluated before and after treatment. Results: Circulating EPCs and the cells' proliferative activity were lower in hyperlipidemia patients as compared to controls (0.14 +/- 0.07 vs. 0.6 +/- 0.14, P = 0.01, and 13.9 +/- 4.9 vs. 45.6 +/- + 8.1. P = 0.0007). Lipid apheresis treatment was not associated with an increase in total EPCs. The cells' proliferative activity was strongly stimulated by lipid apheresis as reflected by an increase in the number of EPC colonies (13.9 +/- 4.9 to 34.1 +/- 7.1 P = 0.035). Analysis of EPC eNOS expression revealed a threefold increase in the cellular expression intensity after lipid apheresis. Conclusions: Patients with refractory hyperlipidemia exhibit lower peripheral EPC numbers and a lower proliferative activity of circulating EPCs than healthy controls. A single lipid apheresis treatment significantly stimulates EPC proliferation. it furthermore increases cellular eNOS. In summary, these results show that lipid apheresis mediates beneficial effects on the EPC system as an essential element in the process of vascular repair in the human organism. J. Clin. Apheresis 24:180-185. 2009. (C) 2009 Wiley-Liss, Inc."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [PA1530/2-1, PA1530/3-1]"],["dc.identifier.doi","10.1002/jca.20208"],["dc.identifier.isi","000271446400002"],["dc.identifier.pmid","19753649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17907"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0733-2459"],["dc.title","LDL Lipid Apheresis Rapidly Increases Peripheral Endothelial Progenitor Cell Competence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","HNO"],["dc.contributor.author","Schuppe, Marie Charlotte"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Olgemüller, Ulrike"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Gupta, Sidhi"],["dc.contributor.author","Dombrowski, Tobias"],["dc.contributor.author","Czech-Zechmeister, Bozena A."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2022-11-01T10:17:33Z"],["dc.date.available","2022-11-01T10:17:33Z"],["dc.date.issued","2022"],["dc.description.abstract","Zusammenfassung\n \n Hintergrund\n Obwohl allergologische Erkrankungen zu den wichtigen Gesundheitsstörungen laut ärztlicher Approbationsordnung zählen, ist die Allergologie in Deutschland nicht als selbstständiges Fach im Studium der Humanmedizin verankert.\n \n \n Ziel der Arbeit\n Da sämtliche Universitäts- und Hochschulstandorte mit dieser Herausforderung umgehen müssen, war es Ziel unseres Lehrprojekts, eine exemplarische und mit allen beteiligten Kliniken und Instituten abgestimmte Koordination und Verzahnung der allergologischen Lehre an einem Standort zu etablieren. Insbesondere Comprehensive Allergy Centers (CAC) bieten eine bereits vorhandene Infrastruktur, in der diese Neukonzeption der allergologischen Lehre auf andere Standorte übertragen werden könnte.\n \n \n Material und Methoden\n Nach umfangreicher Bestandsaufnahme der aktuellen allergologischen Lehre an der Universitätsmedizin Göttingen wurde im interdisziplinären Konsens ein neues Lehrkonzept entwickelt, durch die Bereitstellung zusätzlicher digitaler Lehr- und Lernanteile ergänzt („blended learning“) und schließlich evaluiert.\n \n \n Ergebnisse\n Die allergologische Lehre im klinischen Studienabschnitt zeigte eine starke Fragmentierung, die ohne Koordination der zwölf beteiligten Kliniken/Institute und ohne Abstimmung der jeweiligen Lerninhalte stattfand. In der etablierten Struktur des interdisziplinären CAC erfolgte eine Neukonzeption, Koordination und Schwerpunktsetzung der studentischen Lehre zur klinischen Allergologie. Die Bereitstellung von neuen interaktiven Lerneinheiten sowie ergänzender Materialien zum Selbststudium wurden von den Studierenden positiv bewertet. Eine vergleichende Evaluation von Studierenden nach Absolvieren der unterschiedlichen Curricula zeigte signifikante Verbesserungen im Erreichen der gewünschten Lernziele."],["dc.description.abstract","Abstract\n \n Background\n Although allergic diseases are among the most important health disorders, allergology is not anchored as an independent subject in the clinical part of medical studies in Germany.\n \n \n Objective\n As all universities and institutes face the same challenge, the aim of our project was to establish exemplary coordination and networking of education in allergology at one location in agreement with all involved departments and institutes. Particularly, Comprehensive Allergy Centers (CAC) offer an established infrastructure via which the revised allergology education program can be transferred to other universities.\n \n \n Materials and methods\n After an extensive inventory of the current allergological curriculum at the University Medical Center Göttingen, a new teaching concept was developed in interdisciplinary consensus, supplemented by first-time provision of additional digital contents (“blended learning”), and finally evaluated.\n \n \n Results\n Initially, we observed a high level of fragmentation in the teaching of allergology in the clinical study sections of human medicine, with no coordination between the 12 clinical departments/institutes involved and no coherent framework for the specific learning content. Within the established structure of the interdisciplinary CAC, we revised, coordinated, and defined key areas for improved student education in clinical allergology. The allocation of new interactive learning elements as well as supplementary materials for self-studies was welcomed by the students and positively evaluated. A survey among students after completing the former vs. current curricula showed significant improvements in achieving the desired educational objectives."],["dc.identifier.doi","10.1007/s00106-022-01222-5"],["dc.identifier.pii","1222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116840"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-605"],["dc.relation.eissn","1433-0458"],["dc.relation.issn","0017-6192"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Interdisziplinäre Neukonzeption der Lehre im Querschnittsfach „Allergologie“ im Studiengang Humanmedizin"],["dc.title.translated","New interdisciplinary teaching concept for the cross-sectional subject of allergology in human medicine studies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","257"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Hypertension"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Heusser, Karsten"],["dc.contributor.author","Thöne, Arvo"],["dc.contributor.author","Lipp, Axel"],["dc.contributor.author","Menne, Jan"],["dc.contributor.author","Beige, Joachim"],["dc.contributor.author","Reuter, Hannes"],["dc.contributor.author","Hoffmann, Fabian"],["dc.contributor.author","Halbach, Marcel"],["dc.contributor.author","Eckert, Siegfried"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Haarmann, Helge"],["dc.contributor.author","Joyner, Michael J."],["dc.contributor.author","Paton, Julian F.R."],["dc.contributor.author","Diedrich, André"],["dc.contributor.author","Haller, Hermann"],["dc.contributor.author","Jordan, Jens"],["dc.contributor.author","Tank, Jens"],["dc.date.accessioned","2020-12-10T18:38:04Z"],["dc.date.available","2020-12-10T18:38:04Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1161/HYPERTENSIONAHA.119.13925"],["dc.identifier.eissn","1524-4563"],["dc.identifier.issn","0194-911X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77177"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Efficacy of Electrical Baroreflex Activation Is Independent of Peripheral Chemoreceptor Modulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","314A"],["dc.bibliographiccitation.journal","Journal of the American Society of Nephrology"],["dc.bibliographiccitation.lastpage","315A"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Blaschke, S."],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T10:06:57Z"],["dc.date.available","2018-11-07T10:06:57Z"],["dc.date.issued","2002"],["dc.identifier.isi","000177757501553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39194"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","1046-6673"],["dc.title","Role of fractalkine (CX3C-L) and its receptor (CX3C-R) in renal fibrogenesis."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1215"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Mini Reviews in Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","1228"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Koziolek, M."],["dc.contributor.author","Vasko, R."],["dc.contributor.author","Bramlage, C."],["dc.contributor.author","Muller, G."],["dc.contributor.author","Strutz, F."],["dc.date.accessioned","2021-06-01T10:48:35Z"],["dc.date.available","2021-06-01T10:48:35Z"],["dc.date.issued","2009"],["dc.description.abstract","The chemokine CX3C-L/FKN is expressed in both soluble and transmembrane/mucin hybrid forms, thus combining chemoattractant functions together with receptor/adhesion molecule properties. In contrast to other chemokine receptors, CX3C-R is expressed not only on lymphoid cell populations, but also on several intrinsic cells including tubular epithelial cells and renal fibroblasts where it regulates various aspects of cell viability, matrix synthesis and degradation, migration, inflammation as well as oxidative stress. In the kidney, the chemokines/receptor pair has been shown to play a role in nephrogenesis as well as in the pathogenesis primary and secondary nephropathies. In several animal models and human specimens with acute and chronic renal failure including allograft nephropathy, CX3C-L/CX3C-R has been shown to exert immune and non-immune mediated renal damages. A blockade of this chemokine system ameliorated acute and chronic renal damages, though the latter to a more robust extent. There seems to a role of the CX3C-L/CX3C-R pair in mediating acute renal inflammation as well as in progressive chronic renal failure. However, functional studies are lacking for many aspects and further studies are necessary to better define the functional properties of CX3 C-L/FKN and its receptor."],["dc.identifier.doi","10.2174/138955709789055252"],["dc.identifier.isi","000271619500007"],["dc.identifier.pmid","19817712"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85989"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bentham Science Publ Ltd"],["dc.relation.issn","1389-5575"],["dc.title","The CX3C-Chemokine Fractalkine in Kidney Diseases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]