Koziolek, Michael Johann

[["dc.bibliographiccitation.firstpage","e0222102"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Troche-Polzien, Ilka"],["dc.contributor.author","Stock, Johanna"],["dc.contributor.author","Bramlage, Carsten"],["dc.contributor.author","Müller, Gerhard A."],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.editor","Gonzalez Suarez, Maria Lourdes"],["dc.date.accessioned","2020-12-10T18:42:10Z"],["dc.date.available","2020-12-10T18:42:10Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1371/journal.pone.0222102"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77833"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2939"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Clinical Rheumatology"],["dc.bibliographiccitation.lastpage","2946"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Froelich, Britta"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Minguet, Joan"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Deutsch, Cornelia"],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Koziolek, Michael"],["dc.contributor.author","Mueller, Gerhard Anton"],["dc.date.accessioned","2018-11-07T10:05:16Z"],["dc.date.available","2018-11-07T10:05:16Z"],["dc.date.issued","2016"],["dc.description.abstract","In patients with rheumatic diseases, reliable markers for determining disease activity are scarce. One potential parameter is the level of immunoglobulin free light chains (FLCs), which is known to be elevated in the blood of patients with certain rheumatic diseases. Few studies have quantified FLCs in urine, a convenient source of test sample, in patients with different rheumatic diseases. We carried out a retrospective analysis of patients with rheumatic disease attending the University hospital of Goettingen, Germany. Subjects were included if they had urine levels of both kappa and lambda FLCs available and did not have myeloma. Data regarding systemic inflammation and kidney function were recorded, and FLC levels were correlated with inflammatory markers. Of the 382 patients with rheumatic disease, 40.1 % had chronic polyarthritis, 21.2 % connective tissue disease, 18.6 % spondyloarthritis and 15.7 % vasculitis. Elevated levels of kappa FLCs were found for 84 % of patients and elevated lambda for 52.7 %. For the patients with rheumatoid arthritis, FLCs correlated with C-reactive protein (kappa, r = 0.368, p < 0.001; lambda, r = 0.398, p < 0.001) and erythrocyte sedimentation rate (kappa, r = 0.692, p < 0.001; lambda, r = 0.612, p < 0.001). Patients being treated with rituximab displayed FLC levels similar to those of the reference group. There were clear elevations in both kappa and lambda FLCs in patients with rheumatic disease, but not in kappa/lambda ratio. The correlation between FLCs and inflammatory markers in patients with rheumatoid arthritis demonstrates their potential for predicting disease activity."],["dc.identifier.doi","10.1007/s10067-016-3437-0"],["dc.identifier.isi","000388826200010"],["dc.identifier.pmid","27734231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38865"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","London"],["dc.relation.issn","1434-9949"],["dc.relation.issn","0770-3198"],["dc.title","The significance and predictive value of free light chains in the urine of patients with chronic inflammatory rheumatic disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","199"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Nephrology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Delistefani, Fani"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Müller, Gerhard A"],["dc.contributor.author","Koziolek, Michael J"],["dc.contributor.author","Grupp, Clemens"],["dc.date.accessioned","2019-07-09T11:51:45Z"],["dc.date.available","2019-07-09T11:51:45Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of these catheters. Therefore, identification of potential predicting risk factors leading to early infection related complications is valuable, in particular the significance the CRP (C-reactive protein)-value is of interest. Methods In this retrospective study 151 permanent hemodialysis catheters implanted in 130 patients were examined. The following data were collected at the time of catheter implantation: CRP-value, history of catheter-related infection, microbiological status, immunosuppression and diabetes mellitus. The primary outcomes were recorded over the 3 months following the implantation: catheter-related infection, days of hospital stay and death. Catheter removal or revision, rehospitalization and use of antibiotics were identified as secondary outcomes. Results We identified a total of 27 (17.9%) infections (systemic infection: 2.26 episodes/ 1000 catheter days, local infection: 0.6 episodes/ 1000 catheter days). The development of an infection was independent of the CRP-value (p = 0.66) as well as the presence of diabetes mellitus (p = 0.64) or immunosuppression (p = 0.71). Univariate analysis revealed that infection was more frequent in patients with MRSA-carriage (p < 0.001), in case of previous catheter-related infection (p < 0.05) and of bacteremia or bacteriuria in the period of 3 months before catheter implantation (p < 0.001). Catheter removal or revision (p = 0.002), rehospitalization (p = 0.001) and use of antibiotics (p = 0.02) were also more often observed in patients with MRSA-carriage. Conclusions The CRP-value at the time of implantation of a permanent hemodialysis catheter is not associated with the development of early catheter related infections, but an individual history of catheter-related infection, MRSA-carriage and bacteremia or bacteriuria in the period of 3 months prior to catheter implantation are significant risk factors."],["dc.identifier.doi","10.1186/s12882-019-1392-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60004"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Risk factors for catheter-related infections in patients receiving permanent dialysis catheter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","582"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Clinical Hypertension"],["dc.bibliographiccitation.lastpage","588"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Koziolek, Michael J."],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Hoxhold, Kerstin"],["dc.contributor.author","Müller, Gerhard A."],["dc.contributor.author","Bramlage, Carsten"],["dc.date.accessioned","2020-12-10T18:28:56Z"],["dc.date.available","2020-12-10T18:28:56Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/jch.13212"],["dc.identifier.issn","1524-6175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76465"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Difference between renal and splenic resistive index as a novel criterion in Doppler evaluation of renal artery stenosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","143"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Therapeutic Apheresis and Dialysis"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Hennig, Ulrich"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Bramlage, Carsten"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Strutz, Frank M."],["dc.contributor.author","Mueller, Georg Anton"],["dc.date.accessioned","2018-11-07T08:44:57Z"],["dc.date.available","2018-11-07T08:44:57Z"],["dc.date.issued","2010"],["dc.description.abstract","We retrospectively analyzed 10 906 lipid apheresis sessions (heparin-induced lipoprotein precipitation, direct adsorption of lipoproteins, double filtration plasmapheresis, dextran sulfate adsorption, and immunoadsorption) in 38 patients who were consecutively treated in our department during the last 20 years. The incidences of major cardiovascular events (MACE) (death, cerebrovascular accident, myocardial infarction, limb amputation, and renal vascular involvement) were taken separately as primary end-points or as a combined end-point. The time-course of secondary end-points (coronary and extracranial status of arteries, left ventricular function, occlusive artery disease, and calculated glomerular filtration rate [cGFR]) were also evaluated, as well as the extent of the reduction in plasma lipids and lipoproteins and the incidence of therapy associated side-effects. MACE decreased from 7.02% events per patient per year at the start of lipid apheresis to 1.17% during lipid apheresis and the rate of myocardial revascularization decreased from 22.8% to 3.8% per patient per year. Classical (diabetes mellitus, arterial hypertension, and smoking history), as well as novel risk factors (cGFR < 60 mL/min, statin withdrawal, mixed hyperlipoproteinemia, and elevated lipoprotein (a)) were associated with an elevated risk for MACE. All applied methods had comparable effects. All lipid apheresis methods proved to be safe and suitable for long-term treatment. The present data demonstrate that treatment with lipid apheresis is very effective and leads to long-term reduction in cardiovascular mortality and morbidity."],["dc.identifier.doi","10.1111/j.1744-9987.2009.00747.x"],["dc.identifier.isi","000276036600003"],["dc.identifier.pmid","20438535"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20314"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1744-9979"],["dc.title","Retrospective Analysis of Long-term Lipid Apheresis at a Single Center"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Rheumatology International"],["dc.bibliographiccitation.lastpage","605"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Froelich, Britta"],["dc.contributor.author","Wallbach, Manuel"],["dc.contributor.author","Minguet, Joan"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Deutsch, Cornelia"],["dc.contributor.author","Bramlage, Peter"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Koziolek, Michael"],["dc.date.accessioned","2018-11-07T10:25:49Z"],["dc.date.available","2018-11-07T10:25:49Z"],["dc.date.issued","2017"],["dc.description.abstract","The risk of infection in patients with rheumatic diseases is elevated, but a clear marker to differentiate the cause of the systemic inflammation is missing. We assessed the ability urinary immunoglobulin free light chains (FLCs) to indicate the presence of infection in patients with rheumatic disease. We performed a retrospective analysis of patients with rheumatic disease attending the Georg-August University Hospital in Goettingen, Germany, from January 2011 to December 2013. Subjects were included if they had urine levels of kappa and lambda FLCs available. A reference group of patients without autoimmune disease, but with documented infection, was constructed. A total of 1500 patients had their urinary FLCs quantified during the study period. Of the 382 patients with rheumatic disease, 172 (45%) displayed no systemic inflammation, 162 (42%) had inflammation due to the underlying disease activity, and 48 (13%) had inflammation due to a confirmed infection. Urinary FLC concentrations were much higher in patients with rheumatic diseases and infection (kappa 68.8 +/- 81.8 mg/L, lambda 31.4 +/- 53.5 mg/L) compared to those with inflammation due to rheumatic disease activity (kappa 22.7 +/- 26.3 mg/L, lambda 8.1 +/- 9.1 mg/L, kappa p < 0.001, lambda p = 0.004). Urinary kappa FLCs demonstrated good ability to predict infection, with a sensitivity of 63% and specificity of 84%. Urinary lambda FLCs gave similar values, with a sensitivity of 65% and specificity of 81%. FLCs may be useful for distinguishing inflammation due to rheumatic disease activity from that due to the additional presence of infection. The ability to quantify these proteins in urine provides a simple alternative to the use of blood."],["dc.identifier.doi","10.1007/s00296-017-3666-9"],["dc.identifier.isi","000398591600015"],["dc.identifier.pmid","28214923"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42931"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1437-160X"],["dc.relation.issn","0172-8172"],["dc.title","Urinary free light chains may help to identify infection in patients with elevated systemic inflammation due to rheumatic disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1681"],["dc.bibliographiccitation.issue","34-35"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","1685"],["dc.bibliographiccitation.volume","134"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Grupp, Clemens"],["dc.contributor.author","Mueller, Georg Anton"],["dc.date.accessioned","2018-11-07T11:25:37Z"],["dc.date.available","2018-11-07T11:25:37Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1055/s-0029-1234000"],["dc.identifier.isi","000269482900005"],["dc.identifier.pmid","19707964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56662"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Microalbuminuria and albuminuria: differential diagnosis and consequences for treatment"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]