Sun, Han

[["dc.bibliographiccitation.firstpage","11983"],["dc.bibliographiccitation.issue","43"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","11986"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Perez-Balado, Carlos"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Lera, Angel R. de"],["dc.contributor.author","Navarro-Vazquez, Armando"],["dc.date.accessioned","2017-09-07T11:43:23Z"],["dc.date.available","2017-09-07T11:43:23Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1002/chem.201101385"],["dc.identifier.gro","3142653"],["dc.identifier.isi","000297316100005"],["dc.identifier.pmid","21922573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0947-6539"],["dc.title","Residual Dipolar Coupling Enhanced NMR Spectroscopy and Chiroptics: A Powerful Combination for the Complete Elucidation of Symmetrical Small Molecules"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S38"],["dc.bibliographiccitation.journal","Magnetic Resonance in Chemistry"],["dc.bibliographiccitation.lastpage","S44"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Schmidt, Manuel"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Leonov, Andrei"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Reinscheid, Uwe M."],["dc.date.accessioned","2017-09-07T11:48:20Z"],["dc.date.available","2017-09-07T11:48:20Z"],["dc.date.issued","2012"],["dc.description.abstract","A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl. Copyright (C) 2012 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/mrc.3886"],["dc.identifier.gro","3142431"],["dc.identifier.isi","000319964200007"],["dc.identifier.pmid","23280659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8207"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0749-1581"],["dc.title","Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5791"],["dc.bibliographiccitation.issue","30"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","5799"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Dinan, Laurence"],["dc.contributor.author","Lafont, Rene"],["dc.contributor.author","Suksamrarn, Apichart"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Reinscheid, Uwe M."],["dc.contributor.author","Lapenna, Silvia"],["dc.date.accessioned","2017-09-07T11:45:14Z"],["dc.date.available","2017-09-07T11:45:14Z"],["dc.date.issued","2010"],["dc.description.abstract","The rare phytoecdysteroid canescensterone is a potent activator of both natural and engineered ecdysteroid receptor (EcR) gene-expression systems. This steroid also shows a remarkable selectivity towards non-lepidopteran compared with lepidopteran EcRs in gene-switch assays, a property that makes it a novel candidate lead compound for use in insecticide discovery and gene-switch design. Canescensterone possesses an unusual ecdysteroid structure, including a pyrrole-2-carboxylate group attached to C-24, a moiety not yet found in any other natural ecdysteroid. We have investigated the ambiguous stereochemistry at C-24 of this steroid by 1D and 2D solution NMR experiments, which resulted in the assignment of the 24R-configuration and determination of the side-chain conformation. The complete stereochemical assignment allowed the generation of docking models of canescensterone in both a lepidopteran EcR and a non-lepidopteran EcR, which helps to explain its selective biological activity."],["dc.identifier.doi","10.1002/ejoc.201000366"],["dc.identifier.gro","3142846"],["dc.identifier.isi","000284237800007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/295"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.eissn","1099-0690"],["dc.relation.issn","1434-193X"],["dc.title","Absolute Configuration and Docking Study of Canescensterone, a Potent Phytoecdysteroid, with Non-Lepidopteran Ecdysteroid Receptor Selectivity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","279"],["dc.bibliographiccitation.lastpage","324"],["dc.contributor.author","Gil, Roberto R."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Navarro-Vázquez, Armando"],["dc.contributor.author","Sun, Han"],["dc.date.accessioned","2017-09-07T11:52:27Z"],["dc.date.available","2017-09-07T11:52:27Z"],["dc.date.issued","2014"],["dc.description.abstract","The use of NMR spectroscopy in anisotropic media, particularly the application of residual dipolar couplings (RDCs) for the structural analysis of small molecules is presented. Experimental procedures such as choice and preparation of alignment media, as well as the selection of the right pulse‐sequences is discussed along with computational techniques for data analysis. Methods for the analysis of flexible molecules are also presented and illustrated with several examples from literature."],["dc.identifier.doi","10.1002/9783527664610.ch8"],["dc.identifier.gro","3144929"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2607"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.publisher","Wiley-VCH"],["dc.publisher.place","Weinheim"],["dc.relation.eisbn","978-3-52766-461-0"],["dc.relation.isbn","978-3-527-33336-3"],["dc.relation.ispartof","Structure Elucidation in Organic Chemistry"],["dc.title","Structural Elucidation of Small Organic Molecules Assistedby NMR in Aligned Media"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9487"],["dc.bibliographiccitation.issue","40"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","9490"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Hallwass, Fernando"],["dc.contributor.author","Schmidt, Manuel"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Mazur, Adam"],["dc.contributor.author","Kummerloewe, Grit"],["dc.contributor.author","Luy, Burkhard"],["dc.contributor.author","Navarro-Vazquez, Armando"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Reinscheid, Uwe M."],["dc.date.accessioned","2017-09-07T11:45:04Z"],["dc.date.available","2017-09-07T11:45:04Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1002/anie.201101784"],["dc.identifier.gro","3142793"],["dc.identifier.isi","000296071700043"],["dc.identifier.pmid","21915963"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/237"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1433-7851"],["dc.title","Residual Chemical Shift Anisotropy (RCSA): A Tool for the Analysis of the Configuration of Small Molecules"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5213"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","5221"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Ge, Hui Ming"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Jiang, Nan"],["dc.contributor.author","Qin, Yan Hua"],["dc.contributor.author","Dou, Huan"],["dc.contributor.author","Yan, Tong"],["dc.contributor.author","Hou, Ya Yi"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Tan, Ren Xiang"],["dc.date.accessioned","2017-09-07T11:48:55Z"],["dc.date.available","2017-09-07T11:48:55Z"],["dc.date.issued","2012"],["dc.description.abstract","Bioactive natural products offer multiple opportunities for the discovery of novel chemical entities with potential pharmaceutical, nutraceutical and agrochemical applications. Many new organic compounds with novel scaffolds are isolated in small quantities and established methods often fail to determine the structure and bioactivity of such novel natural products. To meet this challenge, we present here a new methodology combining RDC (residual dipolar coupling)-based NMR spectroscopy in microtubes, with a motif-inspired biological assessment strategy. Using only one milligram (ca. 1.5 mu mol) of sample, the new protocol established the bioactivity as well as the relative and absolute configuration of vatiparol obtained from Vatica parvifolia. Vatiparol is unique in its unprecedented carbon skeleton and selective inhibitory effect on the expression of monocyte chemo-attractant protein-1 (MCP-1, also known as CCL2). The plausible biosynthetic pathway of vatiparol is briefly discussed. The approach introduced here promises to be widely applicable to the determination of the structure and bioactivity of structurally unknown organic samples available in very limited amounts."],["dc.identifier.doi","10.1002/chem.201104078"],["dc.identifier.gro","3142553"],["dc.identifier.isi","000302868100013"],["dc.identifier.pmid","22434621"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8917"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","0947-6539"],["dc.title","Relative and Absolute Configuration of Vatiparol (1mg): A Novel Anti-inflammatory Polyphenol"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11280"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Journal of the American Chemical Society"],["dc.bibliographiccitation.lastpage","11283"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Lei, Xinxiang"],["dc.contributor.author","Xu, Zhen"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Wang, Shun"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Peng, Li"],["dc.contributor.author","Gao, Chao"],["dc.contributor.author","Tan, Ren X."],["dc.date.accessioned","2017-09-07T11:45:39Z"],["dc.date.available","2017-09-07T11:45:39Z"],["dc.date.issued","2014"],["dc.description.abstract","Residual dipolar couplings (RDCs) have proven to be an invaluable anisotropic NMR parameter for the structural elucidation of complex biopolymers and organic molecules. However, a remaining bottleneck limiting its wider use by organic and natural product chemists is the lack of a range of easily applicable aligning media for diverse organic solvents. In this study, graphene oxide (GO) liquid crystals (LCs) were developed to induce partial orientation of organic molecules to allow RDC measurements. These LCs were determined to be maintainable at very low concentrations (as low as 1 mg/mL, corresponding to quadrupolar H-2 splittings ranging from 2.8 to 30 Hz and maximum C-13-H-1 dipolar couplings of 20 Hz for camphor in a CH3COCH3/water system) and to be remarkably stable and broadly compatible with aqueous and organic solvents such as dimethyl sulfoxide, CH3COCH3, and CH3CN. Moreover, compared with those for other alignment media, very clean and high-quality NMR spectra were acquired with the GO molecules in solution because of their rigidity and high molecular weight. The developed medium offers a versatile and robust method for RDC measurements that may routinize the RDC-based structure determination of organic molecules."],["dc.identifier.doi","10.1021/ja506074a"],["dc.identifier.gro","3142076"],["dc.identifier.isi","000340442700019"],["dc.identifier.pmid","25075756"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4278"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0002-7863"],["dc.title","Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1811"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","1817"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","D'Auvergne, E. J."],["dc.contributor.author","Reinscheid, Uwe M."],["dc.contributor.author","Dias, Luiz Carlos"],["dc.contributor.author","Andrade, Carlos Kleber Z."],["dc.contributor.author","Rocha, Rafael Oliveira"],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2017-09-07T11:45:04Z"],["dc.date.available","2017-09-07T11:45:04Z"],["dc.date.issued","2011"],["dc.description.abstract","The absolute configuration of small crystallizable molecules can be determined with anomalous X-ray diffraction as shown by Bijvoet in 1951. For the majority of compounds that can neither be crystallized nor easily be converted into crystallizable derivatives, stereocontrolled organic synthesis is still required to establish their absolute configuration. In this contribution, a new fundamental methodology for resolving the absolute configuration will be presented that does not require crystallization. With residual dipolar coupling enhanced NMR spectroscopy, ensembles of a limited number of structures are created reflecting the correct conformations and relative configuration. Subsequently, from these ensembles, optical rotation dispersion"],["dc.identifier.doi","10.1002/chem.201002520"],["dc.identifier.gro","3142796"],["dc.identifier.isi","000287787100012"],["dc.identifier.pmid","21274932"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/240"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0947-6539"],["dc.title","Bijvoet in Solution Reveals Unexpected Stereoselectivity in a Michael Addition"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Natural Products and Bioprospecting"],["dc.bibliographiccitation.lastpage","48"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Liu, Liang-Yan"],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Liu, Ji-Kai"],["dc.date.accessioned","2017-09-07T11:52:24Z"],["dc.date.available","2017-09-07T11:52:24Z"],["dc.date.issued","2016"],["dc.description.abstract","A new alkylpyrrole derivative, fusariumin A (1), was isolated from the culture broth of the fungus Fusarium sp. The absolute configuration of fuasiumin A has been established as (2'R,3'R) using a combination of RDC (residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy. It is worth to note that in this study without the aid of the RDC analysis, an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound."],["dc.identifier.doi","10.1007/s13659-015-0084-0"],["dc.identifier.gro","3144919"],["dc.identifier.pmid","26791752"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2596"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","2192-2195"],["dc.title","The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp."],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","394"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Natural Products"],["dc.bibliographiccitation.lastpage","399"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Whitson, Emily L."],["dc.contributor.author","Sun, Han"],["dc.contributor.author","Thomas, Cheryl L."],["dc.contributor.author","Henrich, Curtis J."],["dc.contributor.author","Sayers, Thomas J."],["dc.contributor.author","McMahon, James B."],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","McKee, Tawnya C."],["dc.date.accessioned","2017-09-07T11:48:57Z"],["dc.date.available","2017-09-07T11:48:57Z"],["dc.date.issued","2012"],["dc.description.abstract","Barleria alluaudii and Diospyros maritima were both investigated as part of an ongoing search for synergistic TRAIL (tumor necrosis factor-alpha-related apoptosis-inducing ligand) sensitizers. As a result of this study, two naphthoquinone epoxides, 2,3-epoxy-2,3-dihydrolapachol (1) and 2,3-epoxy-2,3-dihydro-8-hydroxylapachol (2), both not previously isolated from natural sources, and the known 2-methylanthraquinone (3) were identified from B. alluaudii. Time-dependent density functional theory (TD-DFT) calculations of electronic circular dichroism (ECD) spectra were utilized to establish the absolute configuration of 1 and 2. Additionally, five known naphthoquinone derivatives, maritinone (4), elliptinone (5), plumbagin (6), (+)-cis-isoshinanolone (7), and ethylidene-6,6'-biplumbagin (8), were isolated from D. maritima. Compounds 1, 2, and 4-6 showed varying levels of synergy with TRAIL. Maritinone (4) and elliptinone (5) showed the highest synergistic effect, with more than a 3-fold increase in activity observed with TRAIL than with compound alone."],["dc.identifier.doi","10.1021/np200805z"],["dc.identifier.gro","3142569"],["dc.identifier.isi","000301810700010"],["dc.identifier.pmid","22313254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8934"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0163-3864"],["dc.title","Synergistic TRAIL Sensitizers from Barleria alluaudii and Diospyros maritima"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]