Zautner, Andreas Erich

[["dc.bibliographiccitation.artnumber","375681"],["dc.bibliographiccitation.journal","BioMed Research International"],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Masanta, Wycliffe Omurwa"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2018-11-07T09:45:32Z"],["dc.date.available","2018-11-07T09:45:32Z"],["dc.date.issued","2014"],["dc.description.abstract","Atypical and multidrug resistance, especially ESBL and carbapenemase expressing Enterobacteriaceae, is globally spreading. Therefore, it becomes increasingly difficult to achieve therapeutic success by calculated antibiotic therapy. Consequently, rapid antibiotic resistance testing is essential. Various molecular and mass spectrometry-based approaches have been introduced in diagnostic microbiology to speed up the providing of reliable resistance data. PCR- and sequencing-based approaches are the most expensive but the most frequently applied modes of testing, suitable for the detection of resistance genes even from primary material. Next generation sequencing, based either on assessment of allelic single nucleotide polymorphisms or on the detection of nonubiquitous resistance mechanisms might allow for sequence-based bacterial resistance testing comparable to viral resistance testing on the long term. Fluorescence in situ hybridization (FISH), based on specific binding of fluorescence-labeled oligonucleotide probes, provides a less expensive molecular bridging technique. It is particularly useful for detection of resistance mechanisms based on mutations in ribosomal RNA. Approaches based on MALDI-TOFMS, alone or in combination with molecular techniques, like PCR/electrospray ionization MS or minisequencing provide the fastest resistance results from pure colonies or even primary samples with a growing number of protocols. This review details the various approaches of rapid resistance testing, their pros and cons, and their potential use for the diagnostic laboratory."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; Georg August Universitat Gottingen"],["dc.identifier.doi","10.1155/2014/375681"],["dc.identifier.isi","000346708400001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10892"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34641"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corporation"],["dc.relation.issn","2314-6141"],["dc.relation.issn","2314-6133"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Emerging Rapid Resistance Testing Methods for Clinical Microbiology Laboratories and Their Potential Impact on Patient Management"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1"],["dc.bibliographiccitation.journal","Otolaryngology"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.other","Ulualp, Seckin O."],["dc.date.accessioned","2013-01-04T13:06:45Z"],["dc.date.accessioned","2021-10-27T13:19:58Z"],["dc.date.available","2013-01-04T13:06:45Z"],["dc.date.available","2021-10-27T13:19:58Z"],["dc.date.issued","2012"],["dc.description.abstract","The article provides an overview on the current state-of-science of middle ear cholesteatoma, a non-neoplastic, keratinizing lesion that is characterized by the proliferation of epithelium with aberrant micro-architecture. Pathogenetic mechanisms including morphological, immunological, epidemiological and microbiological aspects of the disease are summarized. The importance of penicillinase-expressing anaerobic bacteria and biofilm formation for maintaining the chronic middle ear inflammation is stressed. Nevertheless, the role of the isolated pathogens in the primarily non-sterile compartiment of the middle ear cavity is so far not completely understood and data on the isolated species are contradictious. Heredity was demonstated for some variants of the disease. Therefore, further studies on the etiological role of microbial agents and potential benefits of resistance-adapted antimicrobial therapy seem advisable. Local and systemic complications of the potentially life-threatening disease like conductive and sensorineural hearing loss and cranial abscesses are reported. The prognosis is limited due to frequent recurrence in spite of surgical therapy. Further research is necessary for a better understanding of the pathogenetic mechanisms and to expand the sectrum of therapeutic options."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.4172/2161-119X.S5-001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91926"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2161-119X"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Cholesteatoma – A Potential Consequence of Chronic Middle Ear Inflammation"],["dc.title.alternative","Otilis Media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","40"],["dc.bibliographiccitation.journal","Acta Tropica"],["dc.bibliographiccitation.lastpage","65"],["dc.bibliographiccitation.volume","165"],["dc.contributor.author","Schwarz, Norbert Georg"],["dc.contributor.author","Loderstaedt, Ulrike"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Hinz, Rebecca"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Eibach, Daniel"],["dc.contributor.author","Fischer, Marcellus"],["dc.contributor.author","Hagen, Ralf Matthias"],["dc.contributor.author","Frickmann, Hagen"],["dc.date.accessioned","2018-11-07T10:29:30Z"],["dc.date.available","2018-11-07T10:29:30Z"],["dc.date.issued","2017"],["dc.description.abstract","This review reports on laboratory diagnostic approaches for selected, highly pathogenic neglected zoonotic diseases, i.e. anthrax, bovine tuberculosis, brucellosis, echinococcosis, leishmaniasis, rabies, Taenia solium-associated diseases (neuro-/cysticercosis & taeniasis) and trypanosomiasis. Diagnostic options, including microscopy, culture, matrix-assisted laser-desorption-ionisation time of-flight mass spectrometry, molecular approaches and serology are introduced. These procedures are critically discussed regarding their diagnostic reliability and state of evaluation. For rare diseases reliable evaluation data are scarce due to the rarity of samples. If bio-safety level 3 is required for cultural growth, but such high standards of laboratory infrastructure are not available, serological and molecular approaches from inactivated sample material might be alternatives. Multiple subsequent testing using various test platforms in a stepwise approach may improve sensitivity and specificity. Cheap and easy to use tests, usually called \"rapid diagnostic tests\" (RDTs) may impact disease control measures, but should not preclude developing countries from state of the art diagnostics. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license."],["dc.identifier.doi","10.1016/j.actatropica.2015.09.003"],["dc.identifier.isi","000390973400008"],["dc.identifier.pmid","26391646"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43653"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1873-6254"],["dc.relation.issn","0001-706X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Microbiological laboratory diagnostics of neglected zoonotic diseases (NZDs)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","720"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Microorganisms"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Hasdemir, Ufuk"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Pfeifer, Yvonne"],["dc.contributor.author","Bunk, Boyke"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Spröer, Cathrin"],["dc.contributor.author","Overmann, Jörg"],["dc.contributor.author","Zautner, Andreas E."],["dc.contributor.author","Frickmann, Hagen"],["dc.date.accessioned","2021-06-01T09:42:39Z"],["dc.date.available","2021-06-01T09:42:39Z"],["dc.date.issued","2021"],["dc.description.abstract","Mobile genetic elements, such as plasmids, facilitate the spread of antibiotic resistance genes in Enterobacterales. In line with this, we investigated the plasmid-resistome of seven blaOXA-48 gene-carrying Klebsiella pneumoniae isolates, which were isolated between 2013 and 2014 at the University Medical Center in Göttingen, Germany. All isolates were subjected to complete genome sequencing including the reconstruction of entire plasmid sequences. In addition, phenotypic resistance testing was conducted. The seven isolates comprised both disease-associated isolates and colonizers isolated from five patients. They fell into two clusters of three sequence type (ST)101 and two ST11 isolates, respectively; and ST15 and ST23 singletons. The seven isolates harbored various plasmids of the incompatibility (Inc) groups IncF, IncL/M, IncN, IncR, and a novel plasmid chimera. All blaOXA-48 genes were encoded on the IncL/M plasmids. Of note, distinct phenotypical resistance patterns associated with different sets of resistance genes encoded by IncL/M and IncR plasmids were observed among isolates of the ST101 cluster in spite of high phylogenetic relatedness of the bacterial chromosomes, suggesting nosocomial transmission. This highlights the importance of plasmid uptake and plasmid recombination events for the fast generation of resistance variability after clonal transmission. In conclusion, this study contributes a piece in the puzzle of molecular epidemiology of resistance gene-carrying plasmids in K. pneumoniae in Germany."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/microorganisms9040720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85312"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2076-2607"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","CC BY 4.0"],["dc.title","Detection of a New Resistance-Mediating Plasmid Chimera in a blaOXA-48-Positive Klebsiella pneumoniae Strain at a German University Hospital"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","481"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Antibiotics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tilkorn, Friederike K. M. T."],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Simon, Isabel S."],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Horn, Sebastian"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2020-08-06T06:04:43Z"],["dc.date.available","2020-08-06T06:04:43Z"],["dc.date.issued","2020"],["dc.description.abstract","Young children are frequently colonized with Clostridioides (C.) difficile. Depending on their resistance patterns, antibiotic treatment can facilitate gastrointestinal spreading in colonized individuals, potentially leading to transmission to others. C. difficile was isolated from stool samples from infants born in two hospitals in Göttingen and Darmstadt, Germany. All isolates were subjected to phenotypic antimicrobial resistance testing, PCR-based screening for toxin genes and mass spectrometry-based exclusion of ribotypes 027 and 176. Within an initial cohort of 324 neonates with a longitudinal survey of C. difficile, 137 strains were isolated from 48 individuals. Antimicrobial resistance was recorded against metronidazole in one (0.7%), erythromycin in 16 (11.7%) and moxifloxacin in 2 (1.5%) of the strains, whereas no resistance was observed against vancomycin (0.0%) or rifampicin (0.0%). Newly observed resistance against erythromycin in children with detection of previously completely sensitive isolates was reported for C. difficile isolates from 2 out of 48 children. In 20 children (42%), non-toxigenic strains were detected, and from 27 children (56%), toxigenic strains were isolated, while both toxigenic and non-toxigenic strains were recorded for 1 child (2%). Ribotypes 027 or 176 were not observed. In conclusion, the German C. difficile strains isolated from the children showed mild to moderate resistance with predominance of macrolide resistance, a substance class which is frequently applied in children. The observed switches to the dominance of macrolide-resistant isolates suggests likely selection of resistant C. difficile strains already in children"],["dc.identifier.doi","10.3390/antibiotics9080481"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17510"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67527"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2079-6382"],["dc.relation.issn","2079-6382"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.gro","C. difficile"],["dc.subject.gro","Rifaximin"],["dc.title","Antimicrobial Resistance Patterns in Clostridioides difficile Strains Isolated from Neonates in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","78"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Diagnostics"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Dörschug, Anja"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Hillebrecht, Anke"],["dc.contributor.author","Blaschke, Sabine"],["dc.contributor.author","Mese, Kemal"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Dierks, Sascha"],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Zautner, Andreas E."],["dc.date.accessioned","2021-04-14T08:29:44Z"],["dc.date.available","2021-04-14T08:29:44Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/diagnostics11010078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82978"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2075-4418"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","CC BY 4.0"],["dc.title","Comparison of Five Serological Assays for the Detection of SARS-CoV-2 Antibodies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","17"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Military Medical Research"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Zautner, Andreas E."],["dc.contributor.author","Masanta, Wycliffe O."],["dc.contributor.author","Hinz, Rebecca"],["dc.contributor.author","Hagen, Ralf M."],["dc.contributor.author","Frickmann, Hagen"],["dc.date.accessioned","2019-07-09T11:41:51Z"],["dc.date.available","2019-07-09T11:41:51Z"],["dc.date.issued","2015"],["dc.description.abstract","Abstract Diagnostic microbial isolates of bio-safety levels 3 and 4 are difficult to handle in medical field camps under military deployment settings. International transport of such isolates is challenging due to restrictions by the International Air Transport Association. An alternative option might be inactivation and sequencing of the pathogen at the deployment site with subsequent sequence-based revitalization in well-equipped laboratories in the home country for further scientific assessment. A literature review was written based on a PubMed search. First described for poliovirus in 2002, de novo synthesis of pathogens based on their sequence information has become a well-established procedure in science. Successful syntheses have been demonstrated for both viruses and prokaryotes. However, the technology is not yet available for routine diagnostic purposes. Due to the potential utility of diagnostic sequencing and sequence-based de novo synthesis of pathogens, it seems worthwhile to establish the technology for diagnostic purposes over the intermediate term. This is particularly true for resource-restricted deployment settings, where safe handling of harmful pathogens cannot always be guaranteed."],["dc.identifier.doi","10.1186/s40779-015-0045-2"],["dc.identifier.pmid","26157585"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12481"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58532"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Artificially designed pathogens – a diagnostic option for future military deployments"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","426"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Diagnostics"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Dörschug, Anja"],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Yilmaz, Elif"],["dc.contributor.author","Mese, Kemal"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Zautner, Andreas E."],["dc.date.accessioned","2021-04-14T08:27:55Z"],["dc.date.available","2021-04-14T08:27:55Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/diagnostics11030426"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82450"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2075-4418"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","CC BY 4.0"],["dc.title","Comparative Assessment of Sera from Individuals after S-Gene RNA-Based SARS-CoV-2 Vaccination with Spike-Protein-Based and Nucleocapsid-Based Serological Assays"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2404"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Dierks, Sascha"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Mese, Kemal"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Zautner, Andreas"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Torkieh, Setare"],["dc.contributor.author","Denker, Fenja"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Storch, Marcus"],["dc.contributor.author","Frickmann, Hagen"],["dc.date.accessioned","2021-07-05T15:00:47Z"],["dc.date.available","2021-07-05T15:00:47Z"],["dc.date.issued","2021"],["dc.description.abstract","This study was performed as a head-to-head comparison of the performance characteristics of (1) two SARS-CoV-2-specific rapid antigen assays with real-time PCR as gold standard as well as (2) a fully automated high-throughput transcription-mediated amplification (TMA) assay and real-time PCR in a latent class analysis-based test comparison without a gold standard with several hundred samples in a low prevalence “real world” setting. Recorded sensitivity and specificity of the NADAL and the LumiraDx antigen assays and the Hologic Aptima SARS-CoV-2 TMA assay were 0.1429 (0.0194, 0.5835), 0.7644 (0.7016, 0.8174), and 0.7157 (0, 1) as well as 0.4545 (0.2022, 0.7326), 0.9954 (0.9817, 0.9988), and 0.9997 (not estimable), respectively. Agreement kappa between the positive results of the two antigen-based assays was 0.060 (0.002, 0.167) and 0.659 (0.492, 0.825) for TMA and real-time PCR. Samples with low viral load as indicated by cycle threshold (Ct) values > 30 were generally missed by both antigen assays, while 1:10 pooling suggested higher sensitivity of TMA compared to real-time PCR. In conclusion, both sensitivity and specificity speak in favor of the use of the LumiraDx rather than the NADAL antigen assay, while TMA results are comparably as accurate as PCR, when applied in a low prevalence setting."],["dc.description.abstract","This study was performed as a head-to-head comparison of the performance characteristics of (1) two SARS-CoV-2-specific rapid antigen assays with real-time PCR as gold standard as well as (2) a fully automated high-throughput transcription-mediated amplification (TMA) assay and real-time PCR in a latent class analysis-based test comparison without a gold standard with several hundred samples in a low prevalence “real world” setting. Recorded sensitivity and specificity of the NADAL and the LumiraDx antigen assays and the Hologic Aptima SARS-CoV-2 TMA assay were 0.1429 (0.0194, 0.5835), 0.7644 (0.7016, 0.8174), and 0.7157 (0, 1) as well as 0.4545 (0.2022, 0.7326), 0.9954 (0.9817, 0.9988), and 0.9997 (not estimable), respectively. Agreement kappa between the positive results of the two antigen-based assays was 0.060 (0.002, 0.167) and 0.659 (0.492, 0.825) for TMA and real-time PCR. Samples with low viral load as indicated by cycle threshold (Ct) values > 30 were generally missed by both antigen assays, while 1:10 pooling suggested higher sensitivity of TMA compared to real-time PCR. In conclusion, both sensitivity and specificity speak in favor of the use of the LumiraDx rather than the NADAL antigen assay, while TMA results are comparably as accurate as PCR, when applied in a low prevalence setting."],["dc.identifier.doi","10.3390/jcm10112404"],["dc.identifier.pii","jcm10112404"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87903"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Diagnosing SARS-CoV-2 with Antigen Testing, Transcription-Mediated Amplification and Real-Time PCR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","379"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Antibiotics"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Frickmann, Hagen"],["dc.contributor.author","Zautner, Andreas E."],["dc.date.accessioned","2021-04-14T08:25:08Z"],["dc.date.available","2021-04-14T08:25:08Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/antibiotics9070379"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17476"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81532"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2079-6382"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Impact of Case Definitions on Efficacy Estimation in Clinical Trials—A Proof-of-Principle Based on Historical Examples"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]