Zautner, Andreas Erich

[["dc.bibliographiccitation.firstpage","728"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],["dc.bibliographiccitation.lastpage","734"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Alter, T."],["dc.contributor.author","Bereswill, S."],["dc.contributor.author","Gluender, G."],["dc.contributor.author","Haag, L.-M."],["dc.contributor.author","Haenel, I."],["dc.contributor.author","Heimesaat, Markus M."],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Rautenschlein, Silke"],["dc.contributor.author","Weber, R. M."],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T08:55:46Z"],["dc.date.available","2018-11-07T08:55:46Z"],["dc.date.issued","2011"],["dc.description.abstract","Over the last few years, infections with Campylobacter have significantly increased in Europe and Germany and these bacteria have even surpassed Salmonella as the most prevalent bacteria, causing gastroenteritis. Especially contamination during the handling and consumption of meat products seems to be the most important risk factor which plays a prominent role for transmission to man. In addition, contact with pets and other animals, drinking raw or improperly pasteurized milk, and the tenacity of Campylobacter in different environments, especially water, have also to be considered for an adequate risk assessment. Besides gastroenteritis, arthralgia, and Guillain-Barre syndrome are important clinical complications of Campylobacter infections in man. At the same time, it is mostly unclear why the course of infection in man and in reservoir animals differs significantly, especially as only a few classical bacterial virulence factors have been identified so far. For these reasons, the development of efficient prevention strategies is of utmost importance in order to control campylobacteriosis."],["dc.identifier.doi","10.1007/s00103-011-1289-y"],["dc.identifier.isi","000292038500010"],["dc.identifier.pmid","21626378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1436-9990"],["dc.title","Campylobacteriosis of man. Livestock as reservoir for Campylobacter species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Food Safety and Food Quality"],["dc.bibliographiccitation.lastpage","101"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Herrmann, Sahra"],["dc.contributor.author","Gross, Uwe"],["dc.date.accessioned","2018-11-07T08:43:22Z"],["dc.date.available","2018-11-07T08:43:22Z"],["dc.date.issued","2010"],["dc.description.abstract","In recent years Campylobacter jejuni replaced Salmonella spp. as the most common bacterial cause of food-borne gastroenteritis worldwide. Noticeable is the fact that no classical enterotoxins are known for C. jejuni. The sequencing of the complete genome revealed that C. jejuni possesses one single trimeric cytotoxin, called cytolethal distending toxin (CdtABC). Other previously suspected toxins could not be confirmed by sequence analysis. However, a number of alternative virulence-associated factors have been identified so far. The multidrug efflux pump CmeABC faciliates, by \"neutralization\" of bile salts, the survival of C. jejuni in the avian as well as in the human intestine. Furthermore it is responsible for resistance to heavy metal ions and to certain antibiotics. The flagellum of C. jejuni mediates not only the targeted motility directed by three families of chemo- and aerotaxis receptors. A homologue of a type-III-secretion-system integrated in the flagellar apparatus is functionally involved in the cell-invasion process. Thus, a whole group of proteins termed Campylobacter invasion antigens (Cia) is injected into the host cell via the flagellar transport mechanism during the process of host cell invasion. Further pathogenicity-associated determinants are the polysaccharide capsule and specific glycosylation of the lipooligosaccharide (LOS). It has been shown that C. jejuni strains with sialylation of the lipooligosaccharide display increased invasiveness. These strains are also responsible for the development of the Guillain-Barre-syndrome, through molecular mimicry with gangliosides of the central nervous system. In the past, many colonization-related factors have been identified with the help of transposon-induced mutagenesis and chicken colonization models. Using this and other modern molecular biology methods, combined with appropriate animal models such as gnotobiotic mice in which symptomatic campylobacteriosis can be established, it is hoped to identify additional virulence-associated factors."],["dc.identifier.doi","10.2376/0003-925X-61-91"],["dc.identifier.isi","000280167900003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19946"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","M H Schaper Gmbh Co Kg"],["dc.relation.issn","0003-925X"],["dc.title","Campylobacter jejuni - The Search for virulence-associated factors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Folba, Claudia"],["dc.contributor.author","Ichsan, Ichsan"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2018-11-07T09:20:59Z"],["dc.date.available","2018-11-07T09:20:59Z"],["dc.date.issued","2013"],["dc.format.extent","5"],["dc.identifier.isi","000322918300017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29007"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Mass Spectrometry as a new Tool for Subtyping in Fungi"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","302"],["dc.contributor.author","Vu, C. H."],["dc.contributor.author","Stentzel, S."],["dc.contributor.author","Kolata, J."],["dc.contributor.author","Steil, Leif"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Classen, Carl Friedrich"],["dc.contributor.author","Voelker, Uwe"],["dc.contributor.author","Broeker, Barbara"],["dc.date.accessioned","2018-11-07T09:06:03Z"],["dc.date.available","2018-11-07T09:06:03Z"],["dc.date.issued","2012"],["dc.format.extent","39"],["dc.identifier.isi","000311593300132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25467"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","64th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM)"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Human IgG Response to Staphylococcus aureus-Induced Furunculosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","302"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Johann, C."],["dc.contributor.author","Strubel, A."],["dc.contributor.author","Busse, C."],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Schmidt-Ott, Ruprecht"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T09:06:02Z"],["dc.date.available","2018-11-07T09:06:02Z"],["dc.date.issued","2012"],["dc.identifier.isi","000311593300082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","64th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM)"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Serodiagnostic and Seroprevalence of Campylobacteriosis and post-Campylobacter-sequelae"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Antimicrobial Chemotherapy"],["dc.bibliographiccitation.lastpage","10"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Laukien, Friederike"],["dc.contributor.author","Schober, Isabel"],["dc.contributor.author","Oehmig, Ines"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Overmann, Jörg"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Zautner, Andreas E."],["dc.contributor.author","Bohne, Wolfgang"],["dc.date.accessioned","2020-08-06T06:17:51Z"],["dc.date.available","2020-08-06T06:17:51Z"],["dc.date.issued","2019"],["dc.description.abstract","The identification and characterization of clinical Clostridioides difficile isolates with reduced fidaxomicin susceptibility."],["dc.identifier.doi","10.1093/jac/dky375"],["dc.identifier.pmid","30247587"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67529"],["dc.language.iso","en"],["dc.relation.eissn","1460-2091"],["dc.relation.issn","0305-7453"],["dc.title","Characterization of a clinical Clostridioides difficile isolate with markedly reduced fidaxomicin susceptibility and a V1143D mutation in rpoB"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","302"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Welcker, F."],["dc.contributor.author","Edel, B."],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Kuhns, Martin"],["dc.contributor.author","Gross, U."],["dc.contributor.author","Kappe, R."],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Rimek, D."],["dc.date.accessioned","2018-11-07T09:06:05Z"],["dc.date.available","2018-11-07T09:06:05Z"],["dc.date.issued","2012"],["dc.format.extent","117"],["dc.identifier.isi","000311593300422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25475"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","64th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM)"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Use of MALDI-TOF mass spectrometry for typing Aspergillus flavus in a potential hospital outbreak scenario"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Oehmig, Ines"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Zautner, Andreas E."],["dc.contributor.author","Bohne, Wolfgang"],["dc.date.accessioned","2021-09-01T06:38:18Z"],["dc.date.available","2021-09-01T06:38:18Z"],["dc.date.issued","2021"],["dc.description.abstract","Flagellar motility is important for the pathogenesis of many intestinal pathogens, allowing bacteria to move to their preferred ecological niche. Clostridioides difficile is currently the major cause for bacterial health care-associated intestinal infections in the western world. Most clinical strains produce peritrichous flagella and are motile in soft-agar. However, little knowledge exists on the C. difficile swimming behaviour and its regulation at the level of individual cells. We report here on the swimming strategy of C. difficile at the single cell level and its dependency on environmental parameters. A comprehensive analysis of motility parameters from several thousand bacteria was achieved with the aid of a recently developed bacterial tracking programme. C. difficile motility was found to be strongly dependent on the matrix elasticity of the medium. Long run phases of all four motile C. difficile clades were only observed in the presence of high molecular weight molecules such as polyvinylpyrrolidone (PVP) and mucin, which suggests an adaptation of the motility apparatus to the mucin-rich intestinal environment. Increasing mucin or PVP concentrations lead to longer and straighter runs with increased travelled distance per run and fewer turnarounds that result in a higher net displacement of the bacteria. The observed C. difficile swimming pattern under these conditions is characterised by bidirectional, alternating back and forth run phases, interrupted by a short stop without an apparent reorientation or tumbling phase. This motility type was not described before for peritrichous bacteria and is more similar to some previously described polar monotrichous bacteria."],["dc.description.abstract","Flagellar motility is important for the pathogenesis of many intestinal pathogens, allowing bacteria to move to their preferred ecological niche. Clostridioides difficile is currently the major cause for bacterial health care-associated intestinal infections in the western world. Most clinical strains produce peritrichous flagella and are motile in soft-agar. However, little knowledge exists on the C. difficile swimming behaviour and its regulation at the level of individual cells. We report here on the swimming strategy of C. difficile at the single cell level and its dependency on environmental parameters. A comprehensive analysis of motility parameters from several thousand bacteria was achieved with the aid of a recently developed bacterial tracking programme. C. difficile motility was found to be strongly dependent on the matrix elasticity of the medium. Long run phases of all four motile C. difficile clades were only observed in the presence of high molecular weight molecules such as polyvinylpyrrolidone (PVP) and mucin, which suggests an adaptation of the motility apparatus to the mucin-rich intestinal environment. Increasing mucin or PVP concentrations lead to longer and straighter runs with increased travelled distance per run and fewer turnarounds that result in a higher net displacement of the bacteria. The observed C. difficile swimming pattern under these conditions is characterised by bidirectional, alternating back and forth run phases, interrupted by a short stop without an apparent reorientation or tumbling phase. This motility type was not described before for peritrichous bacteria and is more similar to some previously described polar monotrichous bacteria."],["dc.identifier.doi","10.3389/fmicb.2021.715220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88905"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1664-302X"],["dc.title","Clostridioides difficile Single Cell Swimming Strategy: A Novel Motility Pattern Regulated by Viscoelastic Properties of the Environment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4163"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Clinical Microbiology"],["dc.bibliographiccitation.lastpage","4167"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Bernhard, Mareike"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2018-11-07T09:32:15Z"],["dc.date.available","2018-11-07T09:32:15Z"],["dc.date.issued","2014"],["dc.description.abstract","Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based species identification has become a reliable and fast tool for use in clinical diagnostics, including in mycology. To identify yeasts in the MALDI Biotyper system, a multistep extraction protocol, which is also used to generate the reference spectra, is recommended. Sample preparation by on-target lysis (OTL) requires significantly less hands-on time and is therefore highly desirable, but it results in too-low MALDI Biotyper log score values to allow automated species identification. To overcome this problem, we developed a procedure for generating and validating an OTL spectrum data set for the most relevant and frequently occurring yeast species in clinical specimens. The performance was evaluated against a set of OTL spectra derived during clinical routine procedures and from a set of closely related yeasts. In the diagnostic setting, the OTL procedure significantly decreased the workload but allowed species identification with high specificity and sensitivity. False identifications were not observed. The use of in-house-generated OTL reference spectra can highly accelerate MALDI-TOF MS-based yeast species identification using the MALDI Biotyper."],["dc.description.sponsorship","Bruker Daltonics"],["dc.identifier.doi","10.1128/JCM.02128-14"],["dc.identifier.isi","345222900007"],["dc.identifier.pmid","25232169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31711"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","1098-660X"],["dc.relation.issn","0095-1137"],["dc.title","Yeast On-Target Lysis (YOTL), a Procedure for Making Auxiliary Mass Spectrum Data Sets for Clinical Routine Identification of Yeasts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","267"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Microbiology and Immunology"],["dc.bibliographiccitation.lastpage","273"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Masanta, Wycliffe O."],["dc.contributor.author","Linsel, Gunter"],["dc.contributor.author","Heutelbeck, Astrid"],["dc.contributor.author","Zautner, Andreas E."],["dc.date.accessioned","2020-12-10T18:42:43Z"],["dc.date.available","2020-12-10T18:42:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1556/1886.2017.00024"],["dc.identifier.eissn","2062-8633"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78057"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Seroprevalence of Chlamydophila psittaci among employees of two German duck farms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]