Thoms, Kai-Martin

[["dc.bibliographiccitation.firstpage","1085"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","1090"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, Sajjad"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:29:15Z"],["dc.date.available","2018-11-07T10:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with the rare DNA repair deficiency syndrome xeroderma pigmentosum (XP) are sensitive to the sun and exhibit a 1000-fold increased risk for developing skin cancers, including cutaneous melanoma. Inherited polymorphisms of XP genes may contribute to subtle variations in DNA repair capacity and genetic susceptibility to melanoma. We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area. We confirmed that the XPC intron 9 PAT+, intron 11 -6A, and the exon 15 2920C polymorphisms are in a linkage disequilibrium. Only 1.6% of the 669 donors genotyped were discordant for these three polymorphisms. The allele frequencies (cases: controls) were for intron 9 PAT+ 41.7%:36.9%, for intron 11 -6A 41.8%:37.0% and for exon 15 2920C 41.3%:37.3%. Using multivariate logistic regression analyses to control for age, skin type and number of nevi, the three polymorphisms were significantly associated with increased risks of melanoma: OR 1.87 (95% CI: 1.10-3.19; P = 0.022), OR 1.83 (95% CI: 1.07-3.11; P = 0.026), and OR 1.82 (95% CI: 1.07-3.08; P = 0.026), respectively. Exploratory multivariate analyses of distinct subgroups revealed that these polymorphisms were associated with increased risks for the development of multiple primary melanomas (n = 28). The results of our case-control study support the hypothesis that the intron 9 PAT+, intron 11 -6A and exon 15 2920C haplotype may contribute to the risk of developing cutaneous melanoma by increasing the rate of an alternatively spliced XPC mRNA isoform that skips exon 12 and leads to reduced DNA repair. Our results should be validated in independent samples in order to guard against false positive findings."],["dc.description.sponsorship","Intramural NIH HHS [Z01 BC004517-31]"],["dc.identifier.doi","10.1093/carcin/bgi055"],["dc.identifier.isi","000229700100008"],["dc.identifier.pmid","15731165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0143-3334"],["dc.title","Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","154"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","155"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Mori, T."],["dc.contributor.author","Kobayashi, Nobuhiko"],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T08:29:22Z"],["dc.date.available","2018-11-07T08:29:22Z"],["dc.date.issued","2009"],["dc.identifier.isi","000268960300506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16637"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Cyclosporin A but not everolimus inhibits the DNA-repair"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hofmann, L."],["dc.contributor.author","Brauns, B."],["dc.contributor.author","Kraus, S."],["dc.contributor.author","Wolff, Christian"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.date.accessioned","2018-11-07T09:20:50Z"],["dc.date.available","2018-11-07T09:20:50Z"],["dc.date.issued","2013"],["dc.format.extent","927"],["dc.identifier.isi","000323202300082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28966"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0379"],["dc.title","The in vivo confocal Laser-scanning Microscopy increases the pre-operative diagnostic Accuracy in cutaneous Neoplasia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","580"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Scandinavian Journal of Clinical and Laboratory Investigation"],["dc.bibliographiccitation.lastpage","588"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Emmert, Birgit"],["dc.contributor.author","Hermann, J."],["dc.contributor.author","Roedling, T."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Leibeling, Diana"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T11:07:34Z"],["dc.date.available","2018-11-07T11:07:34Z"],["dc.date.issued","2007"],["dc.description.abstract","Deficiencies in individual DNA repair systems are involved in both de novo and therapy-related acute myeloid leukaemia (t-AML), as indicated by genetic markers involving nucleotide excision repair (NER gene polymorphisms), double-strand-break (DSB) or mismatch repair (microsatellite instability (MSI)). We modified a host cell reactivation (HCR) assay for functional DNA repair system analysis of living primary haematopoietic cells; 2 x 10(5) normal peripheral blood lymphocytes (PBLs) and cord blood CD34+ progenitor cells were cryopreserved, thawed and transfected with 75 250 ng luciferase reporter plasmid (pCMVLuc) using DEAE-dextran (0.1 mg/mL) in a transfection volume of 250 mu L. We obtained luciferase activities of similar to 300-fold above background in CD34+ progenitor cells and similar to 2000-fold in PBLs, thus rendering these cells applicable for DNA repair analysis. We then evaluated the NER (UV-irradiated pCMVLuc) and DSB repair capacity (linearized pCMVLuc) of normal lymphocytes and several leukaemic cell lineages. Kasumi-1 and HL-60 AML cells exhibited a reduced NER capacity compared to normal GM03715 lymphocytes, PBLs and CD34+ progenitor cells (6.2 +/- 0.9 %, 6.5 +/- 0.9% vs. 12.3 +/- 1.8 %, 13.5 +/- 0.7% and 13.5 +/- 2.0 %, respectively). Kasumi-1 AML cells exhibited a reduced DSB repair capacity compared to AG10107 and GM03715 normal lymphocytes as well as CEM acute T-cell lymphoblastic leukaemia cells (6.4 +/- 0.8% vs. 10.8 +/- 0.7 %, 27.3 +/- 1.1% and 20.5 +/- 1.6 %, respectively). The modified HCR assay can be used for functional DNA repair analysis in living cells of patients with pre- and post-leukaemic conditions as well as in leukaemic blasts to elucidate the role of DNA repair in de novo and t-AML leukaemogenesis and to determine the individual susceptibility to t-AML prior to chemotherapy."],["dc.identifier.doi","10.1080/00365510701230481"],["dc.identifier.isi","000249644300003"],["dc.identifier.pmid","17852814"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52592"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis As"],["dc.relation.issn","0036-5513"],["dc.title","Functional DNA repair system analysis in haematopoietic progenitor cells using host cell reactivation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","337"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","341"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Kaune, Kjell Matthias"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Padeken, Michael"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T08:27:21Z"],["dc.date.available","2018-11-07T08:27:21Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Nevus spilus (NS) defines a cafe-au-lait macule with superimposed maculopapular speckles. Although the cafe-au-lait macule often presents at birth, the darker pigmented speckles increase in number and size during a period of several years. The need for close follow-Lip of patients with NS is underlined by reports of several cases of cutaneous melanoma developing within Such lesions. Methods: We followed up 4 adult patients (3 male, one female; mean age 38 years) with Unilateral segmental NS of the thoracic or abdominal region. The NS was present at birth in all 4 patients. Follow-up by sequential digital dermatoscopy and digital overview images was scheduled every 6 to 12 months. Results: During surveillance (mean follow-up time, 8.1.5 years), 3 melanocytic lesions were excised. in one patient focal enlargement prompted excision of two dysplastic compound nevi. In another patient new black dots and focal peripheral hyperpign-lentation were detected by comparison with previous images. Histologic analysis confirmed the diagnosis of invasive melanoma (Breslow thickness, 0.6 mm). Limitations: This observational clinical study included a small number of patients. Sequential digital dermatoscopy of large NS in children may lead to Unnecessary excisions because of physiologic changes. Conclusion: We suggest close follow-up of patients with segmental NS whenever complete excision is not possible. In adults, follow-tip by digital dermatoscopy and excision of lesions with dynamic changes may assist in the early detection of melanoma. (J Am Acad Dermatol 2009;61:337-41.)"],["dc.identifier.doi","10.1016/j.jaad.2008.12.035"],["dc.identifier.isi","000268775500020"],["dc.identifier.pmid","19233509"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16191"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0190-9622"],["dc.title","Melanoma arising in segmental nevus spilus: Detection by sequential digital dermatoscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Nickel, A."],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Schaefer, A."],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Schoen, M."],["dc.contributor.author","Thomale, Juergen"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T08:59:32Z"],["dc.date.available","2018-11-07T08:59:32Z"],["dc.date.issued","2011"],["dc.format.extent","194"],["dc.identifier.isi","000286468200219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23926"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","38th Annual Meeting of the Arbeitsgemeinschaft-Dermatologishche-Forschung"],["dc.relation.eventlocation","Tuebingen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Temozolomide chemoresistance in prolonged melanoma treatment regimens: assessment of mechanisms"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e000333"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal for Immunotherapy of Cancer"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Amaral, Teresa"],["dc.contributor.author","Kiecker, Felix"],["dc.contributor.author","Schaefer, Sarah"],["dc.contributor.author","Stege, Henner"],["dc.contributor.author","Kaehler, Katharina"],["dc.contributor.author","Terheyden, Patrick"],["dc.contributor.author","Gesierich, Anja"],["dc.contributor.author","Gutzmer, Ralf"],["dc.contributor.author","Haferkamp, Sebastian"],["dc.contributor.author","Uttikal, Jochen"],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Rafei-Shamsabadi, David"],["dc.contributor.author","Reinhardt, Lydia"],["dc.contributor.author","Meier, Friedegund"],["dc.contributor.author","Karoglan, Ante"],["dc.contributor.author","Posch, Christian"],["dc.contributor.author","Gambichler, Thilo"],["dc.contributor.author","Pfoehler, Claudia"],["dc.contributor.author","Thoms, Kai"],["dc.contributor.author","Tietze, Julia"],["dc.contributor.author","Debus, Dirk"],["dc.contributor.author","Herbst, Rudolf"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Loquai, Carmen"],["dc.contributor.author","Hassel, Jessica C"],["dc.contributor.author","Meiss, Frank"],["dc.contributor.author","Tueting, Thomas"],["dc.contributor.author","Heinrich, Vanessa"],["dc.contributor.author","Eigentler, Thomas"],["dc.contributor.author","Garbe, Claus"],["dc.contributor.author","Zimmer, Lisa"],["dc.date.accessioned","2020-12-10T18:37:15Z"],["dc.date.available","2020-12-10T18:37:15Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1136/jitc-2019-000333"],["dc.identifier.eissn","2051-1426"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76892"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG study in 380 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Bueckmann, L."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Apel, Antje"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T08:44:37Z"],["dc.date.available","2018-11-07T08:44:37Z"],["dc.date.issued","2010"],["dc.format.extent","S23"],["dc.identifier.isi","000276455100134"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20242"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","Annual Meeting of the Society-for-Investigative-Dermatology"],["dc.relation.eventlocation","Atlanta, GA"],["dc.relation.issn","0022-202X"],["dc.title","Nucleotide excision repair is inhibited by Cyclosporin A via calcineurin-mediated down-regulation of the xeroderma pigmentosum group A and C proteins"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","586"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genes and Immunity"],["dc.bibliographiccitation.lastpage","590"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Schoof, Nils"],["dc.contributor.author","von Bonin, Frederike"],["dc.contributor.author","Koenig, Inke R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Kube, Dieter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T11:24:52Z"],["dc.date.available","2018-11-07T11:24:52Z"],["dc.date.issued","2009"],["dc.description.abstract","Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5'-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma ( adjusted P = 0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma. Genes and Immunity ( 2009) 10, 586-590; doi:10.1038/gene.2009.40; published online 21 May 2009"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft DFG [GRK1034]"],["dc.identifier.doi","10.1038/gene.2009.40"],["dc.identifier.isi","000269493400005"],["dc.identifier.pmid","19458621"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56507"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1466-4879"],["dc.title","Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Journal of Gene Medicine"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:40:35Z"],["dc.date.available","2018-11-07T10:40:35Z"],["dc.date.issued","2003"],["dc.format.extent","S17"],["dc.identifier.isi","000181972700056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Ltd"],["dc.publisher.place","Chichester"],["dc.relation.conference","2nd International Symposium on Molecular Diagnostics and Skin Gene therapy"],["dc.relation.eventlocation","DUSSELDORF, GERMANY"],["dc.relation.issn","1099-498X"],["dc.title","Effective DEAE dextran mediated transfection of primary blood lymphocytes, dendritic cells, and immature hematopoietic cells for use in functional DNA repair assays"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]