Thoms, Kai-Martin

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Nuehnen, V. P."],["dc.contributor.author","Henneke, Marco"],["dc.contributor.author","Freiberg, Clemens"],["dc.contributor.author","Hensen, J."],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Lippert, Undine"],["dc.date.accessioned","2018-11-07T10:25:22Z"],["dc.date.available","2018-11-07T10:25:22Z"],["dc.date.issued","2017"],["dc.identifier.isi","000400154800456"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42845"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Idiopathic Calcinosis Cutis in a Ten-year-old Girl"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1085"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","1090"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, Sajjad"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:29:15Z"],["dc.date.available","2018-11-07T10:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with the rare DNA repair deficiency syndrome xeroderma pigmentosum (XP) are sensitive to the sun and exhibit a 1000-fold increased risk for developing skin cancers, including cutaneous melanoma. Inherited polymorphisms of XP genes may contribute to subtle variations in DNA repair capacity and genetic susceptibility to melanoma. We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area. We confirmed that the XPC intron 9 PAT+, intron 11 -6A, and the exon 15 2920C polymorphisms are in a linkage disequilibrium. Only 1.6% of the 669 donors genotyped were discordant for these three polymorphisms. The allele frequencies (cases: controls) were for intron 9 PAT+ 41.7%:36.9%, for intron 11 -6A 41.8%:37.0% and for exon 15 2920C 41.3%:37.3%. Using multivariate logistic regression analyses to control for age, skin type and number of nevi, the three polymorphisms were significantly associated with increased risks of melanoma: OR 1.87 (95% CI: 1.10-3.19; P = 0.022), OR 1.83 (95% CI: 1.07-3.11; P = 0.026), and OR 1.82 (95% CI: 1.07-3.08; P = 0.026), respectively. Exploratory multivariate analyses of distinct subgroups revealed that these polymorphisms were associated with increased risks for the development of multiple primary melanomas (n = 28). The results of our case-control study support the hypothesis that the intron 9 PAT+, intron 11 -6A and exon 15 2920C haplotype may contribute to the risk of developing cutaneous melanoma by increasing the rate of an alternatively spliced XPC mRNA isoform that skips exon 12 and leads to reduced DNA repair. Our results should be validated in independent samples in order to guard against false positive findings."],["dc.description.sponsorship","Intramural NIH HHS [Z01 BC004517-31]"],["dc.identifier.doi","10.1093/carcin/bgi055"],["dc.identifier.isi","000229700100008"],["dc.identifier.pmid","15731165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0143-3334"],["dc.title","Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","451"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","452"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:08:39Z"],["dc.date.available","2018-11-07T09:08:39Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1111/j.1610-0387.2012.07977.x"],["dc.identifier.isi","000305605300001"],["dc.identifier.pmid","22916350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26083"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0379"],["dc.title","Dermatological Side effects in Tumor Therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","884"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","888"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Hoffmann, Johanna C."],["dc.contributor.author","Thoms, Kai‐Martin"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Mitteldorf, Christina"],["dc.date.accessioned","2022-07-01T07:35:11Z"],["dc.date.available","2022-07-01T07:35:11Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/ddg.14755_g"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112105"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","Gelblicher Knoten mit Hypertrichose an der Oberlippe"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","154"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","155"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Mori, T."],["dc.contributor.author","Kobayashi, Nobuhiko"],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Boeckmann, L."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T08:29:22Z"],["dc.date.available","2018-11-07T08:29:22Z"],["dc.date.issued","2009"],["dc.identifier.isi","000268960300506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16637"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Cyclosporin A but not everolimus inhibits the DNA-repair"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","982"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","British Journal of Pharmacology"],["dc.bibliographiccitation.lastpage","993"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Oetjen, Elke"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Laufer, Y."],["dc.contributor.author","Pape, D."],["dc.contributor.author","Blume, Roland"],["dc.contributor.author","Li, P. F."],["dc.contributor.author","Knepel, Willhart"],["dc.date.accessioned","2018-11-07T11:10:10Z"],["dc.date.available","2018-11-07T11:10:10Z"],["dc.date.issued","2005"],["dc.description.abstract","1 Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs directly targeting the transcription factor nuclear factor of activated T cells ( NFAT). Through inhibition of calcineurin phosphatase activity they block the dephosphorylation and thus activation of NFAT. Cyclosporin A and tacrolimus also inhibit other calcineurin-dependent transcription factors including the ubiquitously expressed cAMP response element-binding protein ( CREB). Membrane depolarization by phosphorylating CREB on Ser119 leads to the recruitment of its coactivator CREB-binding protein (CBP) that stimulates initiation of transcription. 2 It was unknown at what step in CREB-mediated transcription cyclosporin A and tacrolimus interfere. 3 In transient transfection experiments, using GAL4-CREB fusion proteins and a pancreatic islet beta-cell line, cyclosporin A inhibited depolarization-induced activation of CREB proteins which carried various deletions or mutations throughout their sequence providing no evidence for the existence of a distinct CREB domain conferring cyclosporin A sensitivity. In a mammalian two-hybrid assay, cyclosporin A did not inhibit Ser119-dependent interaction of CREB with its coactivator CBP. 4 Using GAL4-CBP fusion proteins, cyclosporin A inhibited depolarization-induced CBP activity, with cyclosporin A-sensitive domains mapped to both the N- ( aa 1 - 451) and C-terminal ( aa 2040 2305) ends of CBP. The depolarization-induced transcriptional activity of the CBP C-terminus was enhanced by overexpression of calcineurin and was inhibited by cyclosporin A and tacrolimus in a concentration-dependent manner with IC50 values ( 10 and 1 nM, respectively) consistent with their known IC50 values for inhibition of calcineurin. 5 These data suggest that, in contrast to NFAT, cyclosporin A and tacrolimus inhibit CREB transcriptional activity at the coactivator level."],["dc.identifier.doi","10.1038/sj.bjp.0706127"],["dc.identifier.isi","000228649700013"],["dc.identifier.pmid","15711594"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53159"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0007-1188"],["dc.title","The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T08:52:30Z"],["dc.date.available","2018-11-07T08:52:30Z"],["dc.date.issued","2011"],["dc.format.extent","7"],["dc.identifier.isi","000294842800023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22182"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Percutaneous transluminal Angioplasty (PTA) in Ulcus cruris mixtum"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hofmann, L."],["dc.contributor.author","Brauns, B."],["dc.contributor.author","Kraus, S."],["dc.contributor.author","Wolff, Christian"],["dc.contributor.author","Thoms, K-M"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.date.accessioned","2018-11-07T09:20:50Z"],["dc.date.available","2018-11-07T09:20:50Z"],["dc.date.issued","2013"],["dc.format.extent","927"],["dc.identifier.isi","000323202300082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28966"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0379"],["dc.title","The in vivo confocal Laser-scanning Microscopy increases the pre-operative diagnostic Accuracy in cutaneous Neoplasia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Kraus, Sophie Luise"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T09:05:25Z"],["dc.date.available","2018-11-07T09:05:25Z"],["dc.date.issued","2012"],["dc.format.extent","E2"],["dc.identifier.doi","10.1111/j.1610-0387.2012.08012_suppl.x"],["dc.identifier.isi","000309186700005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25308"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0379"],["dc.title","Successful treatment of severe cutaneous leishmaniasis with sodium Stibugluconat perilesional injections"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1107"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","1109"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Ritter, K."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:56:30Z"],["dc.date.available","2018-11-07T08:56:30Z"],["dc.date.issued","2011"],["dc.description.abstract","P>Background Infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of proliferating endothelial cells. It expresses markers associated with endothelial, haematopoietic and mesenchymal lineages. We have previously shown that the cells forming the capillary endothelium of proliferating IH express cell surface markers and transcriptions factors consistent with it being a haemogenic endothelium. Objectives We wished to determine whether the expression of transcription factors associated with the erythroid lineage was of physiological relevance and sufficient for IH tissue cultured in vitro to undergo erythropoiesis. Methods Immunohistochemical staining of paraffin-embedded sections of proliferating IHs was undertaken and expression of the embryonically associated haemoglobin zeta (HBZ) chain and the erythropoietin receptor (EPO-R) was determined. Relative expression of mRNA encoding these proteins was determined by quantitative reverse transcription-polymerase chain reaction using snap-frozen biopsy samples. Differentiation towards erythrocytes was investigated using freshly resected tissue cultured as explants in Matrigel. Results The endothelium of the microvessels, but not the pericyte layer, was strongly immunoreactive for the EPO-R and the embryonically associated HBZ chain. Abundant expression of transcripts encoding these proteins was also detected, corroborating the immunohistochemical staining. When tissue was grown in culture the cells emanating from IH explants were able to generate enucleated erythrocytes in vitro. The erythrocytes were immunoreactive for the erythrocyte-specific marker glycophorin A. Conclusions The microvessels in IH are a functional haemogenic endothelium that expresses the embryonically associated HBZ chain and is able to form erythrocytes in vitro. IH thus represents a possible extramedullary site for tumour-associated primitive erythropoiesis."],["dc.identifier.doi","10.1111/j.1365-2133.2010.10188.x"],["dc.identifier.isi","000289898200028"],["dc.identifier.pmid","21166659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0007-0963"],["dc.title","Successful treatment of classic kaposi sarcoma with low-dose intramuscular immunoglobulins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]