Brück, Wolfgang

[["dc.bibliographiccitation.firstpage","793"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Annals of Neurology"],["dc.bibliographiccitation.lastpage","796"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Bitsch, Annette"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Lassmann, Hans"],["dc.contributor.author","Lucchinetti, C."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.date.accessioned","2018-11-07T08:59:26Z"],["dc.date.available","2018-11-07T08:59:26Z"],["dc.date.issued","2001"],["dc.description.abstract","Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time."],["dc.identifier.doi","10.1002/ana.1053"],["dc.identifier.isi","000169091400016"],["dc.identifier.pmid","11409432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23896"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0364-5134"],["dc.title","A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Luerbke, Alexander"],["dc.contributor.author","Cui, Qiao-Ling"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Antel, Jack P."],["dc.date.accessioned","2018-11-07T08:51:34Z"],["dc.date.available","2018-11-07T08:51:34Z"],["dc.date.issued","2011"],["dc.format.extent","S89"],["dc.identifier.isi","000294178900348"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21963"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","0894-1491"],["dc.title","TCF7L2 EXPRESSION IS PRESENT IN EARLY BUT NOT IN CHRONIC MS LESIONS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","91"],["dc.bibliographiccitation.volume","286"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Goldschmidt, Thomas"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Wegner, C."],["dc.contributor.author","Koenig, Fatima Barbara"],["dc.contributor.author","Metz, Imke"],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T11:22:05Z"],["dc.date.available","2018-11-07T11:22:05Z"],["dc.date.issued","2009"],["dc.description.abstract","Multiple sclerosis (MS) lesions are histopathologically characterized by inflammation, demyelination/remyelination, axonal damage and gliosis. Animal experimental and in vitro studies suggest that sex hormones influence the immune system and contribute to the increased likelihood in women of developing MS. However, a variety of studies have also shown that remyelination is more marked in female rodents or that female sex hormones are beneficial for myelin repair. To determine whether gender influences the histopathology of MS lesions, we compared the extent of inflammation, axonal damage and remyelination in MS lesions of female and male MS patients. We observed no differences in the composition of inflammatory infiltrates, axonal damage or cortical pathology. Similar numbers of oligodendroglial progenitor cells and mature oligodendrocytes were present in MS lesions. Remyelination is slightly, but not significantly, more extensive in women than men in early MS lesions. The absence of significant differences in lesion pathology between female and male MS patients might be explained by a lack of a gender influence, but also might be due to the limited number of tissue samples available for histopathological analysis. (C) 2009 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jns.2009.07.014"],["dc.identifier.isi","000271621800020"],["dc.identifier.pmid","19674757"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55923"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","14th European-Charcot-Foundation Symposium"],["dc.relation.eventlocation","Taormina, ITALY"],["dc.relation.issn","0022-510X"],["dc.title","Gender differences in the histopathology of MS?"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T10:58:19Z"],["dc.date.available","2018-11-07T10:58:19Z"],["dc.date.issued","2007"],["dc.format.extent","S16"],["dc.identifier.isi","000251423400028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50452"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.conference","23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS"],["dc.relation.eventlocation","Prague, CZECH REPUBLIC"],["dc.relation.issn","1352-4585"],["dc.title","Oligodendroglial progenitor differentiation is effective in early but deficient in chronic multiple sclerosis lesions"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","186"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Der Pathologe"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Brunn, A."],["dc.contributor.author","Klapper, Wolfram"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Metz, Imke"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Deckert, M."],["dc.date.accessioned","2018-11-07T09:25:09Z"],["dc.date.available","2018-11-07T09:25:09Z"],["dc.date.issued","2013"],["dc.description.abstract","The differential diagnosis of lymphoid lesions in the central nervous system covers a broad spectrum of neoplastic and inflammatory disorders. Complex cases benefit from the combined expertise in the fields of hematopoietic and neuroepithelial tumors as well as neuroimmunology. The Network Lymphomas and Lymphomatoid Lesions in the Nervous System (NLLLN) recommends performing a biopsy prior to any therapeutic intervention as a precise diagnosis was impossible in approximately 50 % of patients pretreated with corticosteroids. This is based on the analysis of approximately 1,000 cases in the past 4 years. In addition to total NLLLN experiences the characteristics, pathogenesis and differential diagnosis of primary lymphoma of the central nervous system are discussed."],["dc.identifier.doi","10.1007/s00292-013-1742-9"],["dc.identifier.isi","000318894800002"],["dc.identifier.pmid","23471726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29998"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0172-8113"],["dc.title","Differential diagnosis of lymphoid infiltrates in the central nervous system. Experience of the Network Lymphomas and Lymphomatoid Lesions in the Nervous System"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2202"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","2212"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Lingfeld, G."],["dc.contributor.author","Bitsch, Annette"],["dc.contributor.author","Schuchardt, J."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.date.accessioned","2018-11-07T09:57:36Z"],["dc.date.available","2018-11-07T09:57:36Z"],["dc.date.issued","2002"],["dc.description.abstract","Multiple sclerosis is characterized morphologically by the key features demyelination, inflammation, gliosis and axonal damage. In recent years, it has become more evident that axonal damage is the major morphological substrate of permanent clinical disability. In our study, we investigated the occurrence of acute axonal damage determined by immunocytochemistry for amyloid precursor protein (APP) which is produced in neurones and accumulates at sites of recent axon transection or damage. The numbers of APP-positive axons in multiple sclerosis lesions were correlated with the disease duration and course. Most APP-positive axons were detected within the first year after disease onset, but acute axonal damage was also detected to a minor degree in lesions of patients with a disease duration of 10 years and more. This effect was not due to the lack of active demyelinating lesions in the chronic disease stage. Late remyelinated lesions (so-called shadow plaques) did not show signs of axon destruction. The number of inflammatory cells showed a decrease over time similar to that of the number of APP-positive axons. There was a significant correlation between the extent of axon damage and the numbers of CD8-positive cytotoxic T cells and macrophages/microglia. Our results indicate that a putative axon-protective treatment should start as early as possible and include strategies preventing T cell/macrophage-mediated axon destruction and leading to remyelination of axons."],["dc.identifier.doi","10.1093/brain/awf235"],["dc.identifier.isi","000178613700004"],["dc.identifier.pmid","12244078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0006-8950"],["dc.title","Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2270"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.lastpage","2276"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Burgmaier, G."],["dc.contributor.author","Schonrock, L. M."],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Richter-Landsberg, C."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.date.accessioned","2018-11-07T10:44:08Z"],["dc.date.available","2018-11-07T10:44:08Z"],["dc.date.issued","2000"],["dc.description.abstract","The present study investigated the effects of flupirtine (Katadolon) on tumor necrosis factor (TNF)-alpha -mediated cell death and Bcl-2 expression in the permanent rat oligodendrocyte cell line OLN-93 (OLN cells). TNF-alpha (500 U/ml) induced apoptosis of OLN cells, which was confirmed by DNA fragmentation using an in situ end-labeling technique and ultrastructural analysis. Flupirtine significantly reduced the rate of spontaneous cell death of OLN cells already at low concentrations; TNF-alpha -mediated apoptosis was suppressed only with higher concentrations of flupirtine (100 muM). Expression of Bcl-2 protein and mRNA in OLN cells was detected by immunocytochemistry, western blot, and RT-PCR. Quantitative analysis of western blots revealed an similar to2.5-fold upregulation of Bcl-2 protein during TNF-alpha treatment. Furthermore, addition of 10 or 100 muM flupirtine before incubation with TNF-alpha led to an approximately threefold increase of Bcl-2 expression. Exposure of OLN cells to flupirtine alone moderately augmented the expression of Bcl-2 protein. Our data demonstrate that flupirtine upregulates the expression of Bcl-2 protein in OLN cells; this Bcl-2 induction is associated with a reduced rate of TNF-alpha -induced cell death."],["dc.identifier.doi","10.1046/j.1471-4159.2000.0752270.x"],["dc.identifier.isi","000165298900005"],["dc.identifier.pmid","11080178"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47205"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0022-3042"],["dc.title","Association of increased Bcl-2 expression with rescue from tumor necrosis factor-alpha-induced cell death in the oligodendrocyte cell line OLN-93"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Luerbke, Alexander"],["dc.contributor.author","Cui, Qiao-Ling"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Kuhlmann, T."],["dc.date.accessioned","2018-11-07T08:51:28Z"],["dc.date.available","2018-11-07T08:51:28Z"],["dc.date.issued","2011"],["dc.format.extent","S97"],["dc.identifier.isi","000209137300182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21941"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","TCF7L2 expression is observed in early but not in chronic MS lesions"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1914"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1921"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Goldschmidt, Thomas"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Koenig, Fatima Barbara"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Kuhlmann, T."],["dc.date.accessioned","2018-11-07T08:28:49Z"],["dc.date.available","2018-11-07T08:28:49Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: To analyze and compare the extent of remyelination in lesions from patients with multiple sclerosis (MS) who have a short (early MS lesions) or a long (chronic MS lesions) disease duration and to determine the influence of anatomic localization on the extent of remyelination. In early MS lesions, remyelination has been described as a relatively frequent event, in contrast to chronic MS lesions, where remyelination is absent or limited to the lesion border in the majority of lesions. However, no studies have been published that have quantified and compared the extent of remyelination in early and chronic MS lesions. Methods: We analyzed the occurrence of remyelination in 52 biopsies from 51 patients (early MS) and in 174 lesions from 36 autopsy cases (chronic MS) by immunohistochemistry for myelin proteins, and correlated our findings with anatomic localization, sex, age, and disease duration. Results: Significantly more lesions were remyelinated in early than in chronicMS (80.7% vs 60%). In chronic MS, subcortical lesions showed more extensive remyelination than periventricular lesions. The majority of cerebellar lesions were completely demyelinated. Conclusion: In summary, our data demonstrate that remyelination is a frequent event in early multiple sclerosis lesions. Furthermore, the anatomic localization of a lesion might influence the extent of remyelination. Neurology (R) 2009; 72: 1914-1921"],["dc.identifier.doi","10.1212/WNL.0b013e3181a8260a"],["dc.identifier.isi","000266524600007"],["dc.identifier.pmid","19487649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16511"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0028-3878"],["dc.title","Remyelination capacity of the MS brain decreases with disease chronicity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Kuhlmann, T."],["dc.contributor.author","Bitsch, Annette"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Siebert, Heike"],["dc.contributor.author","Bruck, Wolfgang W."],["dc.date.accessioned","2018-11-07T11:24:45Z"],["dc.date.available","2018-11-07T11:24:45Z"],["dc.date.issued","2001"],["dc.format.extent","532"],["dc.identifier.isi","000171662200082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56477"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0001-6322"],["dc.title","Evidence for local and systemic elimination of macrophages from the injured peripheral nervous system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]