Lehmann, Wolfgang

[["dc.bibliographiccitation.firstpage","1224"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Klockner, Friederike"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Reinhold, Maximilian"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2022-01-11T14:07:53Z"],["dc.date.available","2022-01-11T14:07:53Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-03T16:52:39Z"],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/medicina57111224"],["dc.identifier.pii","medicina57111224"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1648-9144"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1035"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Musculoskeletal Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Seitz, Mark-Tilmann"],["dc.contributor.author","Höller, Sebastian"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.author","Acharya, Mehool R."],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2022-01-11T14:05:45Z"],["dc.date.accessioned","2022-08-18T12:36:24Z"],["dc.date.available","2022-01-11T14:05:45Z"],["dc.date.available","2022-08-18T12:36:24Z"],["dc.date.issued","2021-12-13"],["dc.date.updated","2022-07-29T12:17:23Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Fragility fractures without significant trauma of the pelvic ring in older patients were often treated conservatively. An alternative treatment is surgery involving percutaneous screw fixation to stabilize the posterior pelvic ring. This surgical treatment enables patients to be mobilized quickly and complications associated with bedrest and temporary immobility are reduced. However, the functional outcome following surgery and quality of life of the patients have not yet been investigated. Here, we present a comprehensive study addressing the long-term well-being and the quality of life of patients with fragility pelvic ring fractures after surgical treatment.\r\n \r\n \r\n Methods\r\n Between 2011–2019, 215 geriatric patients with pelvic ring fractures were surgically treated at the university hospital in Göttingen (Germany). Of these, 94 patients had fragility fractures for which complete sets of computer tomography (CT) and radiological images were available. Fractures were classified according to Tile and according to the FFP classification of Rommens and Hofmann. The functional outcome of surgical treatment was evaluated using the Majeed pelvic score and the Short Form Health Survey-36 (SF-36).\r\n \r\n \r\n Results\r\n Thirty five tile type C and 48 type B classified patients were included in the study. After surgery eighty-three patients scored in average 85.92 points (± 23.39) of a maximum of 100 points using the Majeed score questionnaire and a mean of 1.60 points on the numerical rating scale ranging between 0 and 10 points where 0 points refers to “no pain” and 10 means “strongest pain”. Also, the SF-36 survey shows that surgical treatment positively effects patients with respect to their general health status and by restoring vitality, reducing bodily pain and an increase of their general mental health.\r\n \r\n \r\n Conclusions\r\n Patients who received a percutaneous screw fixation of fragility fractures of the posterior pelvic ring reported an overall positive outcome concerning their long-term well-being. In particular, older patients appear to benefit from surgical treatment.\r\n \r\n \r\n Trial registration\r\n Functional outcome and quality of life after surgical treatment of fragility fractures of the posterior pelvic ring, DRKS00024768. Registered 8th March 2021 - Retrospectively registered. Trial registration number \r\n DRKS00024768\r\n \r\n ."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Musculoskeletal Disorders. 2021 Dec 13;22(1):1035"],["dc.identifier.doi","10.1186/s12891-021-04925-y"],["dc.identifier.pii","4925"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97739"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112951"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2474"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Fragility fractures"],["dc.subject","Percutaneous screw fixation"],["dc.subject","Long-term outcome"],["dc.subject","Quality of life"],["dc.title","A retrospective study about functional outcome and quality of life after surgical fixation of insufficiency pelvic ring injuries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4985"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Bauer, Ina Juliana"],["dc.contributor.author","Maheshwari, Arvind K."],["dc.contributor.author","Husen, Martin"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Saul, Dominik"],["dc.date.accessioned","2021-12-01T09:22:51Z"],["dc.date.available","2021-12-01T09:22:51Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/jcm10214985"],["dc.identifier.pii","jcm10214985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94497"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2077-0383"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Predicting the Exception—CRP and Primary Hip Arthroplasty"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10257"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Wagener, Nele; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.affiliation","Lehmann, Wolfgang; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.affiliation","Weiser, Lukas; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.affiliation","Jäckle, Katharina; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.affiliation","Di Fazio, Pietro; 2Department of Visceral Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstraße, 35043 Marburg, Germany"],["dc.contributor.affiliation","Schilling, Arndt F.; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.affiliation","Böker, Kai O.; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany"],["dc.contributor.author","Wagener, Nele"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Di Fazio, Pietro"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Böker, Kai O."],["dc.contributor.editor","Kim, Jung Eun"],["dc.date.accessioned","2022-10-04T10:21:19Z"],["dc.date.available","2022-10-04T10:21:19Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:03Z"],["dc.description.abstract","Attention deficit hyperactivity disorder (ADHD) is one of the most common worldwide mental disorders in children, young and adults. If left untreated, the disorder can continue into adulthood. The abuse of ADHD-related drugs to improve mental performance for studying, working and everyday life is also rising. The potentially high number of subjects with controlled or uncontrolled use of such substances increases the impact of possible side effects. It has been shown before that the early ADHD drug methylphenidate influences bone metabolism negatively. This study focused on the influence of three more recent cognitive enhancers, modafinil, atomoxetine and guanfacine, on the differentiation of mesenchymal stem cells to osteoblasts and on their cell functions, including migration. Human mesenchymal stem cells (hMSCs) were incubated with a therapeutic plasma dosage of modafinil, atomoxetine and guanfacine. Gene expression analyses revealed a high beta-2 adrenoreceptor expression in hMSC, suggesting it as a possible pathway to stimulate action. In bone formation assays, all three cognitive enhancers caused a significant decrease in the mineralized matrix and an early slight reduction of cell viability without triggering apoptosis or necrosis. While there was no effect of the three substances on early differentiation, they showed differing effects on the expression of osterix (OSX), receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in the later stages of osteoblast development, suggesting alternative modes of action. All three substances significantly inhibited hMSC migration. This effect could be rescued by a selective beta-blocker (Imperial Chemical Industries ICI-118,551) in modafinil and atomoxetine, suggesting mediation via beta-2 receptor stimulation. In conclusion, modafinil, atomoxetine and guanfacine negatively influence hMSC differentiation to bone-forming osteoblasts and cell migration through different intracellular pathways."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/ijms231810257"],["dc.identifier.pii","ijms231810257"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114378"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","MDPI"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","786"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Brix, Theresa"],["dc.contributor.author","Oberthür, Swantje"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2021-10-01T09:58:29Z"],["dc.date.available","2021-10-01T09:58:29Z"],["dc.date.issued","2021"],["dc.description.abstract","Background and Objectives: Stabilization of the spine by cage implantation or autologous pelvic bone graft are surgical methods for the treatment of traumatic spine fractures. These methods serve to stably re-adjust the spine and to prevent late detrimental effects such as pain or increasing kyphosis. They both involve ventral interventions using interbody fusion to replace the intervertebral disc space between the vertebral bodies either by cages or autologous pelvic bone grafts. We examined which of these methods serves the patients better in terms of bone fusion and the long-term clinical outcome. Materials and Methods: Forty-six patients with traumatic fractures (12 cages; mean age: 54.08/34 pelvic bone grafts; mean age: 42.18) who received an anterior fusion in the thoracic or lumbar spine were included in the study. Postoperative X-ray images were evaluated, and fusion of the stabilized segment was inspected by two experienced spine surgeons. The time to discharge from hospital and gender differences were evaluated. Results: There was a significant difference of the bone fusion rate of patients with autologous pelvic bone grafts in favor of cage implantation (p = 0.0216). Also, the stationary phase of patients who received cage implantations was clearly shorter (17.50 days vs. 23.85 days; p = 0.0089). In addition, we observed a significant gender difference with respect to the bony fusion rate in favor of females treated with cage implantations (p < 0.0001). Conclusions: Cage implantations after spinal fractures result in better bony fusion rates as compared to autologous pelvic bone grafts and a shorter stay of the patients in the hospital. Thus, we conclude that cage implantations rather than autologous pelvic bone grafts should be the preferred surgical treatment for stabilizing the spine after fracture."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/medicina57080786"],["dc.identifier.pii","medicina57080786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90071"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1648-9144"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.title","Cage or Pelvic Graft—Study on Bony Fusion of the Ventral Thoracic and Lumbar Spine in Traumatic Vertebral Fractures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3975"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Materials"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Böker, Kai O."],["dc.contributor.author","Richter, Katharina"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Grunwald, Ingo"],["dc.contributor.author","Borcherding, Kai"],["dc.contributor.author","von Byern, Janek"],["dc.contributor.author","Hartwig, Andreas"],["dc.contributor.author","Wildemann, Britt"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T18:47:15Z"],["dc.date.available","2020-12-10T18:47:15Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3390/ma12233975"],["dc.identifier.eissn","1996-1944"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78693"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","1996-1944"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Current State of Bone Adhesives—Necessities and Hurdles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3526"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Materials"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Böker, Kai Oliver"],["dc.contributor.author","Kleinwort, Frederick"],["dc.contributor.author","Klein-Wiele, Jan-Hendrick"],["dc.contributor.author","Simon, Peter"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Schilling, Arndt F."],["dc.date.accessioned","2021-04-14T08:23:46Z"],["dc.date.available","2021-04-14T08:23:46Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/ma13163526"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17507"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81039"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","1996-1944"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Laser Ablated Periodic Nanostructures on Titanium and Steel Implants Influence Adhesion and Osteogenic Differentiation of Mesenchymal Stem Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]