Lehmann, Wolfgang

[["dc.bibliographiccitation.firstpage","1422"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Personalized Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Fieseler, George; 1Clinic for Orthopedic and Trauma Surgery, Sports Medicine, Clinic Hannoversch Münden, 34346 Hannoversch Münden, Germany"],["dc.contributor.affiliation","Schwesig, René; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Sendler, Julia; 1Clinic for Orthopedic and Trauma Surgery, Sports Medicine, Clinic Hannoversch Münden, 34346 Hannoversch Münden, Germany"],["dc.contributor.affiliation","Cornelius, Jakob; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Schulze, Stephan; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Lehmann, Wolfgang; 3Clinic for Orthopedic, Trauma and Reconstructive Surgery, Georg August University Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Hermassi, Souhail; 4Physical Education Department, College of Education, Qatar University, Doha 2713, Qatar"],["dc.contributor.affiliation","Delank, Karl-Stefan; 2Department of Orthopedic and Trauma Surgery, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany"],["dc.contributor.affiliation","Laudner, Kevin; 5Department of Health Sciences, University of Colorado Colorado Springs, Colorado Springs, CO 80918, USA"],["dc.contributor.author","Fieseler, George"],["dc.contributor.author","Schwesig, René"],["dc.contributor.author","Sendler, Julia"],["dc.contributor.author","Cornelius, Jakob"],["dc.contributor.author","Schulze, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hermassi, Souhail"],["dc.contributor.author","Delank, Karl-Stefan"],["dc.contributor.author","Laudner, Kevin"],["dc.contributor.editor","Gesslein, Markus"],["dc.contributor.editor","Kurz, Eduard"],["dc.date.accessioned","2022-10-04T10:21:08Z"],["dc.date.available","2022-10-04T10:21:08Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:45Z"],["dc.description.abstract","To determine how the internal rotation and shift (IRO/shift) test compares to the gold standard of clinical tests (Jobe test) for diagnosing supraspinatus lesions and to confirm these clinical results with surgical findings, 100 symptomatic patients were clinically examined between October 2018 and November 2019. All 100 patients were evaluated using both the IRO/shift test and Jobe test. A total of 48 of these patients received surgical intervention. Based on these data, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for both the IRO/shift test and Jobe test were calculated. The IRO/shift test had a sensitivity of 96% (95% CI: 82–100%), specificity of 50% (95% CI: 27–73%), PPV of 73% (95% CI: 56–86%), NPV of 91% (95% CI: 59–100%), and an accuracy of 77% (95% CI: 63–88%). The Jobe test had a sensitivity of 89% (95% CI: 72–98%), specificity of 60% (95% CI: 36–81%), PPV of 76% (95% CI: 58–89%), NPV of 80% (95% CI: 52–96%), and an accuracy of 77% (95% CI: 54–81%). These results suggest that the IRO/shift test is comparable to the Jobe test, which is often viewed as the gold standard clinical examination for assessing supraspinatus lesions. This study was approved by the Ethics Commission of the Martin Luther University Halle-Wittenberg (reference number: 2018-05)."],["dc.identifier.doi","10.3390/jpm12091422"],["dc.identifier.pii","jpm12091422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114337"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","MDPI"],["dc.relation.eissn","2075-4426"],["dc.rights","Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."],["dc.title","IRO/Shift Test Is Comparable to the Jobe Test for Detection of Supraspinatus Lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0243306"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Buchhorn, Gottfried"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.editor","de Araújo, Gabriel"],["dc.date.accessioned","2021-04-14T08:31:45Z"],["dc.date.available","2021-04-14T08:31:45Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0243306"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83704"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Comparison of the double loop knot stitch and Kessler stitch for Achilles tendon repair: A biomechanical cadaver study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0609-5"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70360"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pedikelsubtraktionsosteotomie zur Korrektur rigider Deformitäten"],["dc.title.alternative","Pedicle subtraction osteotomy to correct rigid deformities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0615-7"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70363"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Dorsale Stabilisation der Halswirbelkörper HWK1/HWK2 modifiziert nach Goel-Harms mit HWK-1-Pedikelschrauben"],["dc.title.alternative","Dorsal stabilization of C1/C2 modified according to Goel-Harms with C1 pedicle screws"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","292"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0608-6"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70359"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Techniken zur Steigerung der Pedikelschraubenstabilität im osteoporotischen Knochen"],["dc.title.alternative","Techniques to increase pedicle screw stability in osteoporotic vertebrae"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1224"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Klockner, Friederike"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Reinhold, Maximilian"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Weiser, Lukas"],["dc.date.accessioned","2022-01-11T14:07:53Z"],["dc.date.available","2022-01-11T14:07:53Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-03T16:52:39Z"],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.abstract","Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/medicina57111224"],["dc.identifier.pii","medicina57111224"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97886"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1648-9144"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1035"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Musculoskeletal Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Seitz, Mark-Tilmann"],["dc.contributor.author","Höller, Sebastian"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.author","Acharya, Mehool R."],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2022-01-11T14:05:45Z"],["dc.date.accessioned","2022-08-18T12:36:24Z"],["dc.date.available","2022-01-11T14:05:45Z"],["dc.date.available","2022-08-18T12:36:24Z"],["dc.date.issued","2021-12-13"],["dc.date.updated","2022-07-29T12:17:23Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Fragility fractures without significant trauma of the pelvic ring in older patients were often treated conservatively. An alternative treatment is surgery involving percutaneous screw fixation to stabilize the posterior pelvic ring. This surgical treatment enables patients to be mobilized quickly and complications associated with bedrest and temporary immobility are reduced. However, the functional outcome following surgery and quality of life of the patients have not yet been investigated. Here, we present a comprehensive study addressing the long-term well-being and the quality of life of patients with fragility pelvic ring fractures after surgical treatment.\r\n \r\n \r\n Methods\r\n Between 2011–2019, 215 geriatric patients with pelvic ring fractures were surgically treated at the university hospital in Göttingen (Germany). Of these, 94 patients had fragility fractures for which complete sets of computer tomography (CT) and radiological images were available. Fractures were classified according to Tile and according to the FFP classification of Rommens and Hofmann. The functional outcome of surgical treatment was evaluated using the Majeed pelvic score and the Short Form Health Survey-36 (SF-36).\r\n \r\n \r\n Results\r\n Thirty five tile type C and 48 type B classified patients were included in the study. After surgery eighty-three patients scored in average 85.92 points (± 23.39) of a maximum of 100 points using the Majeed score questionnaire and a mean of 1.60 points on the numerical rating scale ranging between 0 and 10 points where 0 points refers to “no pain” and 10 means “strongest pain”. Also, the SF-36 survey shows that surgical treatment positively effects patients with respect to their general health status and by restoring vitality, reducing bodily pain and an increase of their general mental health.\r\n \r\n \r\n Conclusions\r\n Patients who received a percutaneous screw fixation of fragility fractures of the posterior pelvic ring reported an overall positive outcome concerning their long-term well-being. In particular, older patients appear to benefit from surgical treatment.\r\n \r\n \r\n Trial registration\r\n Functional outcome and quality of life after surgical treatment of fragility fractures of the posterior pelvic ring, DRKS00024768. Registered 8th March 2021 - Retrospectively registered. Trial registration number \r\n DRKS00024768\r\n \r\n ."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Musculoskeletal Disorders. 2021 Dec 13;22(1):1035"],["dc.identifier.doi","10.1186/s12891-021-04925-y"],["dc.identifier.pii","4925"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97739"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112951"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2474"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Fragility fractures"],["dc.subject","Percutaneous screw fixation"],["dc.subject","Long-term outcome"],["dc.subject","Quality of life"],["dc.title","A retrospective study about functional outcome and quality of life after surgical fixation of insufficiency pelvic ring injuries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nutrition & Metabolism"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Weber, Marie"],["dc.contributor.author","Zimmermann, Marc Hendrik"],["dc.contributor.author","Kosinsky, Robyn Laura"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Menger, Björn"],["dc.contributor.author","Taudien, Stefan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2019-07-09T11:49:50Z"],["dc.date.accessioned","2020-06-09T07:03:29Z"],["dc.date.available","2019-07-09T11:49:50Z"],["dc.date.available","2020-06-09T07:03:29Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Osteoporosis is one of the world’s major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Results Biomechanical properties were unchanged in tibiae and reduced in femora. In tibiae, C1 treatment enhanced callus density and cortical width and decreased callus area. In the C3 group, callus formation was reduced during the first 3 weeks after osteotomy, correlating to a higher mRNA expression of Osteocalcin, Tartrate-resistant acid phosphatase and Rankl. In femora, baicalein treatments did not alter bone parameters. Conclusions Baicalein enhanced callus density and cortical width but impaired early callus formation in tibiae. In femora, it diminished the biomechanical properties and calcium-to-phosphate ratio. Thus, it is not advisable to apply baicalein to treat early bone fractures. To determine the exact effects on bone healing, further studies in which baicalein treatments are started at different stages of healing are needed."],["dc.identifier.doi","10.1186/s12986-018-0327-2"],["dc.identifier.pmid","30651746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15789"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66212"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1743-7075"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effect of the Lipoxygenase Inhibitor Baicalein on Bone Tissue and Bone Healing in Ovariectomized Rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","100224"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Komrakova, M."],["dc.contributor.author","Rechholtz, C."],["dc.contributor.author","Pohlmann, N."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Schilling, A. F."],["dc.contributor.author","Wigger, R."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Hoffmann, D. B."],["dc.date.accessioned","2019-09-24T08:05:04Z"],["dc.date.available","2019-09-24T08:05:04Z"],["dc.date.issued","2019"],["dc.description.abstract","Bisphosphonate alendronate (ALN), phytoestrogen 8-prenylnaringenin (8-PN) and the whole body vibration exert a favorable effect on osteoporotic bone. However, the impact of these treatments and the combination of pharmacological therapies with biomechanical stimulation on muscle and bone has not yet been explored in detail. The effect of ALN and 8-PN and their combination with the vibration (Vib) on skeletal muscle and bone healing was investigated in ovariectomized (Ovx) rats. Three-month old rats were Ovx (n = 78), or left intact (Non-Ovx; n = 12). Five weeks after Ovx, all rats were treated according to the group assignment (n = 12/13): 1) Non-Ovx; 2) Ovx; 3) Ovx + Vib; 4) Ovx + ALN; 5) Ovx + ALN + Vib; 6): Ovx + 8-PN; 7) Ovx + 8-PN + Vib. Treatments with ALN (0.58 mg/kg BW, in food), 8-PN (1.77 mg/kg BW, daily s.c. injections) and/or with vertical vibration (0.5 mm, 35 Hz, 1 g, 15 min, 2×/day, 5×/week) were conducted for ten weeks. Nine weeks after Ovx, all rats underwent bilateral tibia osteotomy with plate osteosynthesis and were sacrificed six weeks later. Vibration increased fiber size and capillary density in muscle, enlarged callus area and width, and decreased callus density in tibia, and elevated alkaline phosphatase in serum. ALN and ALN + Vib enhanced capillarization and lactate dehydrogenase activity in muscle. In tibia, ALN slowed bone healing, ALN + Vib increased callus width and density, enhanced callus formation rate and expression of osteogenic genes. 8-PN and 8-PN + Vib decreased fiber size and increased capillary density in muscle; callus density and cortical width were reduced in tibia. Vibration worsened 8-PN effect on bone healing decreasing the callus width and area. Our data suggest that Vib, ALN, 8-PN, or 8-PN + Vib do not appear to aid bone healing. ALN + Vib improved bone healing; however application is questionable since single treatments impaired bone healing. Muscle responds to the anti-osteoporosis treatments and should be included in the evaluation of the drugs."],["dc.identifier.doi","10.1016/j.bonr.2019.100224"],["dc.identifier.pmid","31516917"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62450"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Effect of alendronate or 8-prenylnaringenin applied as a single therapy or in combination with vibration on muscle structure and bone healing in ovariectomized rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","293"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Open Medicine"],["dc.bibliographiccitation.lastpage","298"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Buchhorn, Gottfried"],["dc.contributor.author","Kück, Fabian"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Spering, Christopher"],["dc.creator.author","Frosch S"],["dc.creator.author","Buchhorn G"],["dc.creator.author","Kück F"],["dc.creator.author","Walde TA"],["dc.creator.author","Lehmann W"],["dc.creator.author","Spering C"],["dc.date.accessioned","2021-04-14T08:29:54Z"],["dc.date.available","2021-04-14T08:29:54Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1515/med-2021-0211"],["dc.identifier.pmcid","PMC7892937"],["dc.identifier.pmid","33628945"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83027"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2391-5463"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.title","Biomechanical evaluation of self-cinching stitch techniques in rotator cuff repair: The single-loop and double-loop knot stitches"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]