Havemann-Reinecke, Ursula

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T10:48:30Z"],["dc.date.available","2018-11-07T10:48:30Z"],["dc.date.issued","2004"],["dc.format.extent","S458"],["dc.identifier.isi","000224663002518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","24th CINP Congress"],["dc.relation.eventlocation","Paris, FRANCE"],["dc.relation.issn","1461-1457"],["dc.title","Chronic psychosocial stress in rats as a model of depression - Behavioral and pharmacological studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cannabis and Cannabinoid Research"],["dc.bibliographiccitation.lastpage","61"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Bouter, Yvonne"],["dc.contributor.author","Brzózka, Magdalena M."],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Pahlisch, Franziska"],["dc.contributor.author","Leweke, F. Markus"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Rohleder, Cathrin"],["dc.date.accessioned","2021-04-14T08:27:08Z"],["dc.date.available","2021-04-14T08:27:08Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1089/can.2019.0041"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82180"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2378-8763"],["dc.relation.issn","2578-5125"],["dc.title","Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57B l /6J Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","19"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Behavioural Pharmacology"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T10:20:40Z"],["dc.date.available","2018-11-07T10:20:40Z"],["dc.date.issued","2006"],["dc.description.abstract","Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological validation of this model. Animals were socially stressed for 5 weeks and, in parallel, after the first week of stress, they were subjected to chronic (4 weeks) treatment with the antidepressant drug citalopram. The drug was administered via drinking water (30 mg/kg). The optimal dose of citalopram was determined in a pilot study. After 4 weeks of treatment, plasma levels of citalopram and its metabolite were found to be within the human therapeutic range. The effects of social stress and citalopram treatment were assessed by behavioural tests. Chronically stressed rats showed reduced locomotor and exploratory activity, reduced sucrose preference and increased immobility time in the forced swimming test. Chronic oral administration of citalopram abolished those effects and normalized behaviours related to motivation and reward sensitivity. These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats."],["dc.identifier.doi","10.1097/01.fbp.0000186631.53851.71"],["dc.identifier.isi","000238089900003"],["dc.identifier.pmid","16377960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41936"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0955-8810"],["dc.title","Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Behavioural Pharmacology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T10:55:55Z"],["dc.date.available","2018-11-07T10:55:55Z"],["dc.date.issued","2005"],["dc.format.extent","S90"],["dc.identifier.doi","10.1097/00008877-200509001-00282"],["dc.identifier.isi","000232603300279"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49895"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","11th Biennial Meeting of the European-Behavioral-Pharmacology-Society"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0955-8810"],["dc.title","Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","371"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Ruether, Eckhart"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T08:29:48Z"],["dc.date.available","2018-11-07T08:29:48Z"],["dc.date.issued","2005"],["dc.format.extent","R146"],["dc.identifier.isi","000229046800607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16747"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","46th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Citalopram counteracts behavioural and molecular alternations evoked by chronic psychosocial stress in rats."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","369"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T10:50:54Z"],["dc.date.available","2018-11-07T10:50:54Z"],["dc.date.issued","2004"],["dc.format.extent","R153"],["dc.identifier.isi","000220592800612"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48756"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","45th Spring Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Chronic psychosocial stress as a model of depression-first results from behavioural and pharmacological studies in rats"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","134"],["dc.bibliographiccitation.volume","162"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T08:53:43Z"],["dc.date.available","2018-11-07T08:53:43Z"],["dc.date.issued","2005"],["dc.description.abstract","Stress, especially chronic stress, is one of the most important factors responsible for precipitation of affective disorders in humans. The animal models commonly used in the investigation of stress effects are based mainly on powerful physical stressors. In the majority of cases, these models are not relevant to situations that human beings encounter in everyday life. In our study, an animal model for chronic social stress has been developed for rats using a resident-intruder paradigm. This paradigm is considered a model of social defeat or subordination, and therefore may mimic situations occurring in humans. Rats were subjected daily to subordination stress for a period of five weeks and, in parallel, tested with a battery of behavioural tests. Chronically stressed rats showed behavioural changes, including decreased motility and exploratory activity, increased immobility in a forced swim test, and reduced preference for sweet sucrose solution (anhedonia). Reduced locomotor and exploratory activity represents a loss of interest in new stimulating situations; implying a deficit in motivation. Increased immobility in the forced swim test indicates behavioural despair, a characteristic of depressive disorders. Decreased sucrose preference may indicate desensitisation of the brain reward mechanism. Since anhedonia is one of the core symptoms of depression in humans, our findings suggest that the rat chronic social stress model may be an appropriate model for depressive disorders. (C) 2005 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2005.03.009"],["dc.identifier.isi","000229795800013"],["dc.identifier.pmid","15922073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22490"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.title","Anhedonia and motivational deficits in rats: Impact of chronic social stress"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Ruether, Eckhart"],["dc.contributor.author","Chiemke, C."],["dc.contributor.author","Zernig, Gerald"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Fluegge, Gabriele"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T11:13:31Z"],["dc.date.available","2018-11-07T11:13:31Z"],["dc.date.issued","2008"],["dc.format.extent","127"],["dc.identifier.isi","000258855500524"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1461-1457"],["dc.title","Pharmacological validation of a chronic social stress model of anhedonia in rats: Effects of reboxetine, haloperidol and diazepam"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.date.accessioned","2018-11-07T11:04:22Z"],["dc.date.available","2018-11-07T11:04:22Z"],["dc.date.issued","2007"],["dc.format.extent","S245"],["dc.identifier.doi","10.1016/j.eurpsy.2007.01.819"],["dc.identifier.isi","000245473000850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51827"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","0924-9338"],["dc.title","Pharmacological validation of a chronic social stress model in rats: effects of citalopram, reboxetine, haloperidol and diazepam"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","417"],["dc.bibliographiccitation.issue","6-7"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","429"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Abumaria, Nashat"],["dc.contributor.author","Rygula, Rafal"],["dc.contributor.author","Hiemke, Christoph"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Havemann-Reinecke, Ursula"],["dc.contributor.author","Ruether, Eckart"],["dc.contributor.author","Fluegge, Gabriele"],["dc.date.accessioned","2018-11-07T11:02:41Z"],["dc.date.available","2018-11-07T11:02:41Z"],["dc.date.issued","2007"],["dc.description.abstract","Using a model of depression in which chronic social stress induces depressive-like symptoms, we investigated effects of the selective serotonin-reuptake inhibitor (SSRI) citalopram on gene expression in the dorsal raphe nucleus of mate rats. Expression of tryptophan hydroxylase (TPH) protein was found to be upregulated by the stress and normalized by citalopram, while mRNAs for genes TPH 1 and 2 were differentially affected. Citalopram had no effect on serotonin transporter mRNA but reduced serotonin-1A autoreceptor mRNA in stressed animals. The SSRI prevented the stress-induced upregulation of mRNA for CREB binding protein, synaptic vesicle glycoprotein 2b and the glial N-myc downstream-regulated gene 2, but increased mRNA for neuron-specific enolase (NSE) in both stressed and unstressed animals having no effect on stress-induced upregulation of NSE protein. These findings demonstrate that in the dorsal raphe nucleus of chronically stressed rats, citatopram normalizes TPH expression and blocks stress effects on distinct genes related to neurotransmitter release and neuroplasticity. (C) 2006 Elsevier B. V. and ECPN. All rights reserved."],["dc.identifier.doi","10.1016/j.euroneuro.2006.08.009"],["dc.identifier.isi","000246200000006"],["dc.identifier.pmid","17182223"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51442"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1873-7862"],["dc.relation.issn","0924-977X"],["dc.title","Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]