Schild, Detlev

[["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Rabba, J."],["dc.contributor.author","Czesnik, D."],["dc.contributor.author","Nezlin, L."],["dc.contributor.author","Mueller, B."],["dc.contributor.author","Schild, Detlev"],["dc.date.accessioned","2018-11-07T11:04:38Z"],["dc.date.available","2018-11-07T11:04:38Z"],["dc.date.issued","2000"],["dc.format.extent","374"],["dc.identifier.isi","000088236602132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51886"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","0953-816X"],["dc.title","Alpha-2-receptors modulate calcium currents and synaptic transmission in the olfactory bulb of Xenopus laevis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0736-0266(02)00143-2"],["dc.bibliographiccitation.firstpage","213"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Orthopaedic Research"],["dc.bibliographiccitation.lastpage","223"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Frosch, Karl-Heinz"],["dc.contributor.author","Sondergeld, I."],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Rudy, T."],["dc.contributor.author","Lohmann, Christoph H."],["dc.contributor.author","Rabba, J."],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Breme, J."],["dc.contributor.author","Stuermer, Klaus-Michael"],["dc.date.accessioned","2018-11-07T10:40:38Z"],["dc.date.available","2018-11-07T10:40:38Z"],["dc.date.issued","2003"],["dc.description.abstract","The goal of this study was to assess the osseointegration of porous titanium implants by means of coating with autologous osteoblasts. Titanium implants (8 x 5 x 4 mm) having drill channels with diameters of 400, 500, and 600 mum were coated with autologous osteoblasts obtained from spongiosa chips. The implants were inserted into the distal femora of 17 adult Chinchilla Bastard rabbits (group 1). Uncoated implants were inserted as controls in the contralateral femur (group II). The animals were sacrificed after 5, 11, and 42 days. Intravital fluorochrome labeling and microradiography were used for the assessment of bone ingrowth into the titanium channels. In both groups, no bone tissue was formed in the channels up to day 5. On day 11, group I exhibited significantly more (p < 0.05) bone tissue (19.8 +/- 14.0% vs. 5.8 +/- 9.1%) with greater bone-implant contact (13.3 +/- 15.1% vs. 5.7 +/- 5.3%, p < 0.05) at the channel mouths than group II. Bone tissue was formed mainly between day 15 and 30 in group 1, in group 11 between day 25 and 40. Six weeks after implantation, bone tissue filled on an average 68.8 +/- 15.1% of the mouths of the drill channels in implants in group 1, the filling for group 11 was 49.8 +/- 18.1% (p < 0.05). The average bone-implant contact at the channel mouths after six weeks was 56.5 +/- 13.5% in group 1, 40.2 +/- 21.9% in group 11 (p < 0.05). 600-mum channels showed at this time point the best osseous integration (p < 0.05). Coating with autologous osteoblasts accelerates and enhances the osseointegration of titanium implants and could be a successful biotechnology for future clinical applications. (C) 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0736-0266(02)00143-2"],["dc.identifier.isi","000181251900004"],["dc.identifier.pmid","12568951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46347"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0736-0266"],["dc.title","Autologous osteoblasts enhance osseointegration of porous titanium implants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1093"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The European journal of neuroscience"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Czesnik, D."],["dc.contributor.author","Nezlin, L."],["dc.contributor.author","Rabba, J."],["dc.contributor.author","Müller, B."],["dc.contributor.author","Schild, D."],["dc.date.accessioned","2019-07-10T08:14:11Z"],["dc.date.available","2019-07-10T08:14:11Z"],["dc.date.issued","2001-03-01"],["dc.description.abstract","Norepinephrine (NE) has various modulatory roles in both the peripheral and the central nervous systems. Here we investigate the function of the locus coeruleus efferent fibres in the olfactory bulb of Xenopus laevis tadpoles. In order to distinguish unambiguously between mitral cells and granule cells of the main olfactory bulb and the accessory olfactory bulb, we used a slice preparation. The two neuron types were distinguished on the basis of their location in the slice, their typical branching pattern and by electrophysiological criteria. At NE concentrations lower than 5 microM there was only one effect of NE upon voltage-gated conductances; NE blocked a high-voltage-activated Ca(2+)-current in mitral cells of both the main and the accessory olfactory bulbs. No such effect was observed in granule cells. The effect of NE upon mitral cell Ca(2+)-currents was mimicked by the alpha(2)-receptor agonists clonidine and alpha-methyl-NE. As a second effect, NE or clonidine blocked spontaneous synaptic activity in granule cells of both the main and the accessory olfactory bulbs. NE or clonidine also blocked the spontaneous synaptic activity in mitral cells of either olfactory bulb. The amplitude of glutamate-induced currents in granule cells was modulated neither by clonidine nor by alpha-methyl-NE. Taken together, the main effect of the noradrenergic, presynaptic, alpha(2)-receptor-mediated block of Ca(2)+-currents in mitral cells appeared to be a wide-spread disinhibition of mitral cells in the accessory olfactory bulb as well as in the main olfactory bulb."],["dc.identifier.fs","2568"],["dc.identifier.pmid","11285006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9909"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61458"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0953-816X"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Calcium Channel Blockers"],["dc.subject.mesh","Calcium Channels"],["dc.subject.mesh","Clonidine"],["dc.subject.mesh","Electric Conductivity"],["dc.subject.mesh","Larva"],["dc.subject.mesh","Neurons"],["dc.subject.mesh","Norepinephrine"],["dc.subject.mesh","Olfactory Bulb"],["dc.subject.mesh","Synapses"],["dc.subject.mesh","Synaptic Transmission"],["dc.subject.mesh","Xenopus laevis"],["dc.title","Noradrenergic modulation of calcium currents and synaptic transmission in the olfactory bulb of Xenopus laevis tadpoles."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Chemical senses"],["dc.bibliographiccitation.lastpage","407"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Scheidweiler, U."],["dc.contributor.author","Nezlin, L."],["dc.contributor.author","Rabba, J."],["dc.contributor.author","Müller, B."],["dc.contributor.author","Schild, D."],["dc.date.accessioned","2019-07-10T08:14:10Z"],["dc.date.available","2019-07-10T08:14:10Z"],["dc.date.issued","2001-05-01"],["dc.description.abstract","We report on the development of a slice culture of amphibian brain tissue. In particular, we cultured slices from Xenopus laevis tadpoles that contain the olfactory mucosae, the olfactory nerves, the olfactory bulb and the telencephalon. During 6 days in roller tubes the slices flattened, starting from 250 microm and decreasing to approximately 40 microm, corresponding to about three cell layers. Dendritic processes could be followed over distances as long as 200 microm. Neurons in the cultured slice could be recorded using the patch clamp technique and simultaneously imaged using an inverted laser scanning microscope. We characterized the main neuron types of the olfactory bulb, i.e. mitral cells and granule cells, by correlating their typical morphological features in the acute slice with the electrophysiological properties in both the acute slice and slice culture. This correlation allowed unambiguous identification of mitral cells and granule cells in the slice culture."],["dc.identifier.fs","2567"],["dc.identifier.pmid","11369674"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9907"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61456"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0379-864X"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Culture Techniques"],["dc.subject.mesh","Electrophysiology"],["dc.subject.mesh","Larva"],["dc.subject.mesh","Microscopy, Confocal"],["dc.subject.mesh","Neurons"],["dc.subject.mesh","Neurons, Afferent"],["dc.subject.mesh","Olfactory Bulb"],["dc.subject.mesh","Patch-Clamp Techniques"],["dc.subject.mesh","Xenopus laevis"],["dc.title","Slice culture of the olfactory bulb of Xenopus laevis tadpoles."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]