Lizé, Muriel

[["dc.bibliographiccitation.firstpage","10"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Cancer : EJC Supplements"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Lizé, Muriel"],["dc.contributor.author","Herr, C."],["dc.contributor.author","Bals, R."],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2022-03-01T11:45:36Z"],["dc.date.available","2022-03-01T11:45:36Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1016/S1359-6349(10)70847-8"],["dc.identifier.pii","S1359634910708478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103385"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1359-6349"],["dc.title","38 miR-449 induces apoptosis while triggering a stress and DNA damage response"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1088"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","1104"],["dc.bibliographiccitation.volume","202"],["dc.contributor.author","Zysman, Maéva"],["dc.contributor.author","Baptista, Bruno Ribeiro"],["dc.contributor.author","Essari, Laure-Aléa"],["dc.contributor.author","Taghizadeh, Sara"],["dc.contributor.author","Thibault de Ménonville, Charlotte"],["dc.contributor.author","Giffard, Clément"],["dc.contributor.author","Issa, Amelle"],["dc.contributor.author","Franco-Montoya, Marie-Laure"],["dc.contributor.author","Breau, Marielle"],["dc.contributor.author","Souktani, Rachid"],["dc.contributor.author","Aissat, Abdel"],["dc.contributor.author","Caeymaex, Laurence"],["dc.contributor.author","Lizé, Muriel"],["dc.contributor.author","Van Nhieu, Jeanne Tran"],["dc.contributor.author","Jung, Camille"],["dc.contributor.author","Rottier, Robert"],["dc.contributor.author","Cruzeiro, Marcio Do"],["dc.contributor.author","Adnot, Serge"],["dc.contributor.author","Epaud, Ralph"],["dc.contributor.author","Chabot, François"],["dc.contributor.author","Lanone, Sophie"],["dc.contributor.author","Boczkowski, Jorge"],["dc.contributor.author","Boyer, Laurent"],["dc.date.accessioned","2021-04-14T08:31:22Z"],["dc.date.available","2021-04-14T08:31:22Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1164/rccm.201908-1573OC"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83575"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1535-4970"],["dc.relation.issn","1073-449X"],["dc.title","Targeting p16 INK4a Promotes Lipofibroblasts and Alveolar Regeneration after Early-Life Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2740"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cell Death and Differentiation"],["dc.bibliographiccitation.lastpage","2757"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wildung, Merit"],["dc.contributor.author","Esser, Tilman Uli"],["dc.contributor.author","Grausam, Katie Baker"],["dc.contributor.author","Wiedwald, Cornelia"],["dc.contributor.author","Volceanov-Hahn, Larisa"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Beuermann, Sabine"],["dc.contributor.author","Li, Li"],["dc.contributor.author","Zylla, Jessica"],["dc.contributor.author","Guenther, Ann-Kathrin"],["dc.contributor.author","Wienken, Magdalena"],["dc.contributor.author","Ercetin, Evrim"],["dc.contributor.author","Han, Zhiyuan"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Zhao, Haotian"],["dc.contributor.author","Lizé, Muriel"],["dc.date.accessioned","2020-12-10T18:09:42Z"],["dc.date.available","2020-12-10T18:09:42Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41418-019-0332-7"],["dc.identifier.eissn","1476-5403"],["dc.identifier.issn","1350-9047"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73732"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4579"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Cell Cycle"],["dc.bibliographiccitation.lastpage","4583"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Lize, Muriel"],["dc.contributor.author","Herr, Christian"],["dc.contributor.author","Klimke, Alexander"],["dc.contributor.author","Bals, Robert"],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2018-11-07T08:36:50Z"],["dc.date.available","2018-11-07T08:36:50Z"],["dc.date.issued","2010"],["dc.description.abstract","MicroRNAs of the miR-34/449 family mediate cell cycle arrest and tumor suppression. Here we show that the expression of microRNA miR-449a, unlike its paralog miR-34a, is highly tissue specific and largely restricted to pulmonary and testicular tissue. MiR-449a levels in the murine lung are particularly high shortly before and after birth, coinciding with terminal differentiation of lung epithelia. Strikingly, miR-449a is upregulated by more than 1,000-fold when epithelial cells from human airways are lifted from a liquid environment to air, allowing them to undergo mucociliary differentiation. The induction of miR-449a occurs in parallel to its host gene CDC20B and the transcription factor FoxJ1. Exposure to tobacco smoke induces a moderate further increase in the levels of miR-449a, and also miR-34a, in differentiated airway epithelia. We propose that miR-449a can serve as an exquisitely sensitive and specific biomarker for the differentiation of bronchial epithelia. Moreover, miR-449a may actively promote mucociliary differentiation through its ability to block cell cycle progression, and it may conribute to a first line of defence against genotoxic stress by its proapoptotic functions."],["dc.identifier.doi","10.4161/cc.9.22.13870"],["dc.identifier.isi","000285002800031"],["dc.identifier.pmid","21088493"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18400"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1538-4101"],["dc.title","microRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2874"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Cell Cycle"],["dc.bibliographiccitation.lastpage","2882"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Lize, Muriel"],["dc.contributor.author","Klimke, Alexander"],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2018-11-07T08:52:42Z"],["dc.date.available","2018-11-07T08:52:42Z"],["dc.date.issued","2011"],["dc.description.abstract","The microRNAs 449a, b and c (miR-449) are potent inducers of cell death, cell cycle arrest, and/or cell differentiation. They belong to the same family as the p53-responsive microRNAs miR-34. Instead of p53, however, the cell cycle regulatory transcription factor E2F1 induces miR-449. All members of this microRNA family are capable of mediating cell cycle arrest and apoptosis and might thereby contribute to tumor suppression. Underlying mechanisms include the downregulation of histone acetyl transferases and consecutive activation of p53, but also the targeting of cyclin dependent kinases and their association partners. Thus, miR-34 and miR-449 provide an asymmetric feedback loop to balance E2F and p53 activities. More recently, it was discovered that miR-449 displays strong tissue specificity, with high levels in lung and testes. Two model systems (Xenopus embryos and cultured human cells) revealed that miR-449 is essential for the development of ciliated epithelia, and this appears to depend on miR-449-mediated modulation of the Notch signaling pathway. Here we summarize our current knowledge on cell fate determination by miR-449, and we propose future directions to explore the function of miR-449 in cell regulation and organismal development. MiR-449 helps to ensure proper cell function but also to avoid cancer, marking a close link between cell differentiation and tumor suppression."],["dc.identifier.doi","10.4161/cc.10.17.17181"],["dc.identifier.isi","000294480700022"],["dc.identifier.pmid","21857159"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22233"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1538-4101"],["dc.title","MicroRNA-449 in cell fate determination"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1300"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Genes & Development"],["dc.bibliographiccitation.lastpage","1312"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Nemajerova, Alice"],["dc.contributor.author","Kramer, Daniela"],["dc.contributor.author","Siller, Saul S."],["dc.contributor.author","Herr, Christian"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Pena, Tonatiuh"],["dc.contributor.author","Suazo, Cristina Gallinas"],["dc.contributor.author","Glaser, Katharina"],["dc.contributor.author","Wildung, Merit"],["dc.contributor.author","Steffen, Henrik"],["dc.contributor.author","Sriraman, Anusha"],["dc.contributor.author","Oberle, Fabian"],["dc.contributor.author","Wienken, Magdalena"],["dc.contributor.author","Hennion, Magali"],["dc.contributor.author","Vidal, Ramon"],["dc.contributor.author","Royen, Bettina"],["dc.contributor.author","Alevra, Mihai"],["dc.contributor.author","Schild, Detlev"],["dc.contributor.author","Bals, Robert"],["dc.contributor.author","Doenitz, Juergen"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Bonn, Stefan"],["dc.contributor.author","Takemaru, Ken-Ichi"],["dc.contributor.author","Moll, Ute M."],["dc.contributor.author","Lize, Muriel"],["dc.date.accessioned","2018-11-07T10:13:24Z"],["dc.date.available","2018-11-07T10:13:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and are essential for cleaning inhaled pollutants and pathogens from airways. Despite their significance for human disease, the transcriptional control that governs multiciliogenesis remains poorly understood. Here we identify TP73, a p53 homolog, as governing the program for airway multiciliogenesis. Mice with TP73 deficiency suffer from chronic respiratory tract infections due to profound defects in ciliogenesis and complete loss of mucociliary clearance. Organotypic airway cultures pinpoint TAp73 as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of MCC progenitors. Mechanistically, cross-species genomic analyses and complete ciliary rescue of knockout MCCs identify TAp73 as the conserved central transcriptional integrator of multiciliogenesis. TAp73 directly activates the key regulators FoxJ1, Rfx2, Rfx3, and miR34bc plus nearly 50 structural and functional ciliary genes, some of which are associated with human ciliopathies. Our results position TAp73 as a novel central regulator of MCC differentiation."],["dc.identifier.doi","10.1101/gad.279836.116"],["dc.identifier.isi","000378084000006"],["dc.identifier.pmid","27257214"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40428"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","1549-5477"],["dc.relation.issn","0890-9369"],["dc.title","TAp73 is a central transcriptional regulator of airway multiciliogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","00635-2020"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ERJ Open Research"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Wagner, Willi"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Andreas, Stefan"],["dc.contributor.author","Lizé, Muriel"],["dc.date.accessioned","2021-06-01T10:47:58Z"],["dc.date.available","2021-06-01T10:47:58Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1183/23120541.00635-2020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85780"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2312-0541"],["dc.title","Three-dimensional assessment of bronchiectasis in a mouse model of mucociliary clearance disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5842"],["dc.bibliographiccitation.issue","30"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","5860"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Markworth, Ronja"],["dc.contributor.author","Adolfs, Youri"],["dc.contributor.author","Dambeck, Vivian"],["dc.contributor.author","Steinbeck, Lars M."],["dc.contributor.author","Lizé, Muriel"],["dc.contributor.author","Pasterkamp, R. Jeroen"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Dean, Camin"],["dc.contributor.author","Burk, Katja"],["dc.date.accessioned","2020-12-10T18:42:33Z"],["dc.date.available","2020-12-10T18:42:33Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1523/JNEUROSCI.0027-19.2019"],["dc.identifier.eissn","1529-2401"],["dc.identifier.issn","0270-6474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78005"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","EJC SUPPLEMENTS"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Lize, M."],["dc.contributor.author","Herr, Christian"],["dc.contributor.author","Bals, R."],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2018-11-07T08:42:32Z"],["dc.date.available","2018-11-07T08:42:32Z"],["dc.date.issued","2010"],["dc.identifier.isi","000288603100036"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19722"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","21st Meeting of the European-Association-for-Cancer-Research"],["dc.relation.eventlocation","Oslo, NORWAY"],["dc.title","miR-449 induces apoptosis while triggering a stress and DNA damage response"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Suazo, C. Gallinas"],["dc.contributor.author","Klimke, Alexander"],["dc.contributor.author","Lize, M."],["dc.contributor.author","Kessel, Michael"],["dc.contributor.author","Dobbelstein, Matthias"],["dc.date.accessioned","2018-11-07T09:37:50Z"],["dc.date.available","2018-11-07T09:37:50Z"],["dc.date.issued","2014"],["dc.format.extent","S84"],["dc.identifier.isi","000351589700308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32930"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","1879-0852"],["dc.relation.issn","0959-8049"],["dc.title","microRNA-449 acts as a barrier to stemness"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]