Zilles, David

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","553"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","van Erp, Theo G. M."],["dc.contributor.author","Hibar, D. P."],["dc.contributor.author","Rasmussen, J. M."],["dc.contributor.author","Glahn, D. C."],["dc.contributor.author","Pearlson, G. D."],["dc.contributor.author","Andreassen, Ole A."],["dc.contributor.author","Agartz, Ingrid"],["dc.contributor.author","Westlye, L. T."],["dc.contributor.author","Haukvik, Unn K."],["dc.contributor.author","Dale, Anders M."],["dc.contributor.author","Melle, Ingrid"],["dc.contributor.author","Hartberg, C. B."],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Kraemer, Bernd"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Donohoe, Gary"],["dc.contributor.author","Kelly, S."],["dc.contributor.author","McDonald, Colm"],["dc.contributor.author","Morris, D. W."],["dc.contributor.author","Cannon, Dara M."],["dc.contributor.author","Corvin, Aiden"],["dc.contributor.author","Machielsen, M. W. J."],["dc.contributor.author","Koenders, L."],["dc.contributor.author","de Haan, Laurens"],["dc.contributor.author","Veltman, D. J."],["dc.contributor.author","Satterthwaite, T. D."],["dc.contributor.author","Wolf, D. H."],["dc.contributor.author","Gur, Ruben C."],["dc.contributor.author","Gur, R. E."],["dc.contributor.author","Potkin, Steven G."],["dc.contributor.author","Mathalon, D. H."],["dc.contributor.author","Mueller, B. A."],["dc.contributor.author","Preda, A."],["dc.contributor.author","Macciardi, F."],["dc.contributor.author","Ehrlich, S."],["dc.contributor.author","Walton, E."],["dc.contributor.author","Hass, J."],["dc.contributor.author","Calhoun, V. D."],["dc.contributor.author","Bockholt, H. J."],["dc.contributor.author","Sponheim, S. R."],["dc.contributor.author","Shoemaker, J. M."],["dc.contributor.author","van Haren, Neeltje E. M."],["dc.contributor.author","Pol, H. E. H."],["dc.contributor.author","Ophoff, Roel A."],["dc.contributor.author","Kahn, Rene S."],["dc.contributor.author","Roiz-Santianez, R."],["dc.contributor.author","Crespo-Facorro, B."],["dc.contributor.author","Wang, L."],["dc.contributor.author","Alpert, K. I."],["dc.contributor.author","Jonsson, E. G."],["dc.contributor.author","Dimitrova, R."],["dc.contributor.author","Bois, C."],["dc.contributor.author","Whalley, H. C."],["dc.contributor.author","McIntosh, Andrew M."],["dc.contributor.author","Lawrie, Stephen M."],["dc.contributor.author","Hashimoto, Ryota"],["dc.contributor.author","Thompson, Paul M."],["dc.contributor.author","Turner, Jessica A."],["dc.date.accessioned","2018-11-07T10:16:34Z"],["dc.date.available","2018-11-07T10:16:34Z"],["dc.date.issued","2016"],["dc.description.abstract","The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d = -0.46), amygdala (d = -0.31), thalamus (d = -0.31), accumbens (d = -0.25) and intracranial volumes (d = -0.12), as well as larger pallidum (d = 0.21) and lateral ventricle volumes (d = 0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits scaled with the proportion of unmedicated patients. Worldwide cooperative analyses of brain imaging data support a profile of subcortical abnormalities in schizophrenia, which is consistent with that based on traditional meta-analytic approaches. This first ENIGMA Schizophrenia Working Group study validates that collaborative data analyses can readily be used across brain phenotypes and disorders and encourages analysis and data sharing efforts to further our understanding of severe mental illness."],["dc.identifier.doi","10.1038/mp.2015.63"],["dc.identifier.isi","000372421500014"],["dc.identifier.pmid","26033243"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41060"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","676"],["dc.bibliographiccitation.volume","262"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Meyer, Jobst"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Ekawardhani, Savira"],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:03:05Z"],["dc.date.available","2018-11-07T09:03:05Z"],["dc.date.issued","2012"],["dc.description.abstract","Working memory deficits are found in different psychiatric populations and are most pronounced in schizophrenia. There is preliminary evidence from pharmacological studies that the verbal and visuospatial subcomponents of working memory are subject to differential neurotransmitter modulation. Here, we investigated the impact of well-known polymorphisms of the dopamine transporter gene (SLC6A3, DAT) and the catechol-O-methyl-transferase gene (COMT) as well as the serotonin transporter gene (SLC6A4, 5-HTT) on these specific working memory subcomponents in a mixed sample of patients and healthy individuals. Twenty healthy subjects and 80 patients diagnosed with schizophrenia, bipolar I disorder, or obsessive-compulsive disorder underwent genotyping for the DAT variable number of tandem repeats (VNTR), the COMT val/met-, and the 5-HTT promoter length polymorphism (5-HTTLPR) and neuropsychological testing using a battery of well-characterized, brain circuit-specific working memory tasks. DAT genotype revealed a significant and selective effect on visuospatial working memory, while there was no effect on verbal working memory functioning. 5-HTT genotype, by contrast, exerted a significant and selective effect on verbal working memory task performance. COMT genotype did not show any influence on either working memory domain. The results of the present study provide evidence for a differential impact of genetic polymorphisms of the dopaminergic and serotonergic systems on verbal and visuospatial working memory functioning. Together with prior evidence suggesting the existence of subgroups of schizophrenia patients exhibiting isolated deficits in only one working memory domain, this finding further supports the idea of endophenotypically and pathophysiologically distinct subgroups of schizophrenia with implications for personalized therapeutic approaches."],["dc.identifier.doi","10.1007/s00406-012-0312-0"],["dc.identifier.isi","000310812800005"],["dc.identifier.pmid","22454241"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9471"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24827"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","86"],["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Zilles, David"],["dc.date.accessioned","2019-07-09T11:50:05Z"],["dc.date.available","2019-07-09T11:50:05Z"],["dc.date.issued","2019"],["dc.description.abstract","Background: Catatonia is a syndrome comprising psychomotor, behavioral, and autonomous symptoms which may occur in the context of severe schizophrenic, affective, and other mental disorders or medical conditions. Treatment options include high dose benzodiazepines (lorazepam) and electroconvulsive therapy (ECT) with some evidence for the effectiveness of glutamate antagonists. However, due to a lack of randomized controlled studies in this severely ill population, evidence base is weak. Methods: On occasion of the case of a patient with treatment resistant catatonia in schizoaffective disorder, we developed the hypothesis of vagus nerve stimulation (VNS) being a potential therapy for treatment resistant catatonia. Results: Based on a selective literature search, we found a remarkable overlap of the pathophysiology of catatonia on the one hand and the putative mechanisms of action of VNS on the other hand in several domains: functional brain imaging, involved neurotransmitter systems, clinical, and theoretical. We thus decided to use VNS as a single subject clinical trial. During the 1-year-follow-up, we observed a fluctuating, but ultimately marked improvement of both catatonic symptoms and general psychopathology. Conclusions: We assume there is a sufficient hypothetical corroboration for the potential effectiveness of VNS as a long-term treatment in predominantly catatonic syndromes. This hypothesis could be tested in proof-of-concept clinical trials."],["dc.identifier.doi","10.3389/fpsyt.2019.00086"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15856"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59700"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Vagus Nerve Stimulation as a Treatment for Catatonia: A Hypothesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","179"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","261"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Kennel, Jennifer"],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T08:57:31Z"],["dc.date.available","2018-11-07T08:57:31Z"],["dc.date.issued","2011"],["dc.description.abstract","Verbal and visuospatial working memory (WM) impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression (MDD) the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies. Eighteen MDD patients and 18 healthy controls matched with regard to age, gender and education were tested using process- and circuit-specific WM tasks for which clear brain-behaviour relationships had been established in prior functional neuroimaging studies. Patients suffering from acute MDD showed a selective impairment in articulatory rehearsal of verbal information in working memory. By contrast, visuospatial WM was unimpaired in this sample. There were no significant correlations between symptom severity and WM performance. These data indicate a dysfunction of a specific verbal WM system in acutely ill patients with MDD. As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients."],["dc.identifier.doi","10.1007/s00406-010-0165-3"],["dc.identifier.isi","000289257000006"],["dc.identifier.pmid","21063718"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6617"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23416"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","519"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","525"],["dc.bibliographiccitation.volume","260"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Gruber, Eva"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T08:38:24Z"],["dc.date.available","2018-11-07T08:38:24Z"],["dc.date.issued","2010"],["dc.description.abstract","Working memory (WM) deficits are a neuropsychological core finding in patients with schizophrenia and also supposed to be a potential endophenotype of schizophrenia. Yet, there is a large heterogeneity between different WM tasks which is partly due to the lack of process specificity of the tasks applied. Therefore, we investigated WM functioning in patients with schizophrenia using process- and circuit-specific tasks. Thirty-one patients with schizophrenia and 47 controls were tested with respect to different aspects of verbal and visuospatial working memory using modified Sternberg paradigms in a computer-based behavioural experiment. Total group analysis revealed significant impairment of patients with schizophrenia in each of the tested WM components. Furthermore, we were able to identify subgroups of patients showing different patterns of selective deficits. Patients with schizophrenia exhibit specific and, in part, selective WM deficits with indirect but conclusive evidence of dysfunctions of the underlying neural networks. These deficits are present in tasks requiring only maintenance of verbal or visuospatial information. In contrast to a seemingly global working memory deficit, individual analysis revealed differential patterns of working memory impairments in patients with schizophrenia."],["dc.identifier.doi","10.1007/s00406-010-0107-0"],["dc.identifier.isi","000282872700003"],["dc.identifier.pmid","20169354"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18760"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Patients with schizophrenia show deficits of working memory maintenance components in circuit-specific tasks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","309"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","315"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Burke, Sarah"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:24:43Z"],["dc.date.available","2018-11-07T11:24:43Z"],["dc.date.issued","2009"],["dc.description.abstract","Working memory disturbances are a frequently replicated finding in schizophrenia and less consistent also in schizoaffective disorder. Working memory dysfunctions have been shown to be heritable and have been proposed to represent a promising endophenotype of schizophrenic psychoses. In the present study, we investigated the effects of familial loading on performance rates in circuit-specific verbal and visuospatial working memory tasks in matched samples of schizophrenic patients (from multiply affected or uniaffected families), schizoaffective patients (from multiply affected or uniaffected families), and healthy subjects. We found a significant interaction effect between familial loading and diagnosis in terms of a diagnosis-specific detrimental effect of familial loading on the performance of schizophrenic (but not schizoaffective) patients in the articulatory rehearsal task. This finding of a circuit-specific verbal working memory deficit in schizophrenic patients with additional familial loading is consistent with prior studies, which provided evidence for the existence of specific subgroups of schizophrenic patients with selective working memory impairments and for diagnosis-specific dysfunctions of the articulatory rehearsal mechanism in schizophrenic, but not in schizoaffective patients. Together, these findings suggest that the genetic risk for (a subtype of) schizophrenia may be associated with dysfunctions of the brain system, which underlies the articulatory rehearsal mechanism, the probably phylogenetically youngest part of human working memory."],["dc.identifier.doi","10.1007/s00406-009-0001-9"],["dc.identifier.isi","000269000500001"],["dc.identifier.pmid","19274424"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3522"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56468"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0940-1334"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]