Mohr, Alexander

[["dc.bibliographiccitation.firstpage","855"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.lastpage","861"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T11:10:45Z"],["dc.date.available","2018-11-07T11:10:45Z"],["dc.date.issued","2008"],["dc.description.abstract","Introduction Long-term follow-up after coil embolization of intracranial aneurysms is mandatory to monitor coil compacting and aneurysm recurrence. Most centers perform one digital subtraction angiography (DSA) on follow-up continuing with time-of-flight magnetic resonance angiography (TOF-MRA). This study explores the diagnostic value of TOF-MRA at 1.5 T versus 3 T compared to DSA. Materials and methods In 18 patients with 20 aneurysms treated with coil embolization, TOF-MRA at 1.5 and 3 T were performed the day before follow-up DSA, the latter serving as reference. Optimized diagnostic protocols were applied (1.5 T: 0.78 x 0.55 x 0.8 mm, voxel size; acquisition time (TA), 6.37 min; 3 T: 0.56 x 0.45 x 0.65 mm, voxel size; TA, 3.12 min). Three independent neuroradiologists experienced in neuroendovascular therapy rated the occlusion rate (\"complete occlusion\" vs. \"residual neck\" vs. \"residual aneurysm\") and compared the two methods subjectively. Weighted kappa statistics were calculated to assess the level of interobserver agreement. Results Compared to DSA, TOF-MRA was more sensitive in detecting neck remnants, with a slight advantage at 3 T. Regarding artifact load, there are advantages at 1.5 T. Ratings of the occlusion rate correlated highly between all observers (r > 0.85, p < 0.001, respectively). Interobserver agreement was high in all cases (kappa(w) approximate to 0.8, respectively). Conclusion TOF-MRA is a reliable tool for follow-up imaging of cerebral aneurysms after endovascular treatment. Our study shows no advantage of TOF-MRA at 3 T over 1.5 T, when comparable measurement protocols are applied. TOF-MRA at 1.5 T therefore provides appropriate information regarding a therapeutic decision."],["dc.identifier.doi","10.1007/s00234-008-0413-7"],["dc.identifier.isi","000259576300005"],["dc.identifier.pmid","18523761"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3105"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53277"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-3940"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","No advantage of time-of-flight magnetic resonance angiography at 3 Tesla compared to 1.5 Tesla in the follow-up after endovascular treatment of cerebral aneurysms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","430"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","436"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T08:33:01Z"],["dc.date.available","2018-11-07T08:33:01Z"],["dc.date.issued","2009"],["dc.description.abstract","Following coil embolization of intracranial aneurysms, many centers perform at least one digital subtraction angiography (DSA) continuing with time-of-flight magnetic resonance angiography (TOF-MRA). Angiographic computed tomography (ACT) provides high-resolution data from a rotational acquisition of a c-arm-mounted flat panel detector. This study evaluates possible advantages of applying ACT in aneurysm follow-up. In 22 patients DSA examinations with a rotational acquisition were performed. Rotational data were processed into an isotropic high-resolution volume. TOF-MRA was performed the day before DSA. Three experienced neuroradiologists performed a rating of the occlusion rate and a subjective method comparison. Weighted kappa statistics were calculated to assess the level of interobserver agreement. Compared to DSA, the diagnostic value of ACT as well as of TOF-MRA was rated to be inferior, although the sensitivity of detecting residual necks was higher with both techniques. Compared to TOF-MRA, ACT achieves favorable ratings only in aneurysms after stent-remodeling. Interobserver agreement was high for all techniques. Ratings of the occlusion rate correlated highly between all observers (r > 0.85, p < 0.001, respectively). In selected patients ACT can add valuable diagnostic information to DSA. TOF-MRA remains a highly sensitive method for aneurysm follow-up."],["dc.identifier.doi","10.1007/s00330-008-1171-y"],["dc.identifier.isi","000262579000020"],["dc.identifier.pmid","18810455"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17474"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0938-7994"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of angiographic computed tomography in the follow-up after endovascular treatment of cerebral aneurysms-a comparative study with DSA and TOF-MRA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","19"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Pfeifenbring, Sabine"],["dc.contributor.author","Mohr, A."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:18:18Z"],["dc.date.available","2018-11-07T10:18:18Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Leukoencephalopathy with calcifications and cysts (LCC or Labrune disease) is a relatively recently defined and exceptionally rare disease in which parenchymal cysts and calcifications within a widespread leukoencephalopathy can cause a broad spectrum of neurological symptoms. The cause of the disease is unknown. Manifestation is usually in childhood or adolescence, while onset in adulthood has been described in 19 cases. Case presentation: Here we report a case of an adult-onset LCC of a Caucasian woman who became symptomatic at age 70 as confirmed by typical neuroimaging and neuropathological findings. After resection of left mesioparietal space-occupying cystic brain tissue the patient has so far remained clinically stable during one year of follow-up with a continuous treatment with glucocorticosteroids. Conclusion: To our knowledge this report of a patient who became symptomatic at age 70 represents the oldest age-at-onset case of LCC described so far."],["dc.identifier.doi","10.1186/s12883-016-0543-1"],["dc.identifier.isi","000369361200001"],["dc.identifier.pmid","26852234"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12818"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41411"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Late-onset leukoencephalopathy with cerebral calcifications and cysts: case report and review of the literature"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","359"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.lastpage","365"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Froelich, Andreas M. J."],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Psychogios, Marios Nikos"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T08:56:46Z"],["dc.date.available","2018-11-07T08:56:46Z"],["dc.date.issued","2011"],["dc.description.abstract","Carotid artery stenting (CAS) requires adequate follow-up imaging to assess complications such as in-stent stenosis or occlusion. Options include digital subtraction angiography, CT angiography, ultrasound, and MR angiography (MRA), which may offer a non-invasive option for CAS follow-up imaging. The aim of this study was to assess contrast-enhanced MRA (CE-MRA) and three-dimensional time-of-flight MRA (3D-TOF) for visualization of the in-stent lumen in different carotid stents. In this study, we compared CE-MRA and 3D-TOF of five different carotid stents (Guidant AcculinkA (R), Cordis PreciseA (R), Boston WallstentA (R), Abbot Vascular XactA (R), Cook ZilverA (R)) in three diameters (4, 6, and 8 mm) using a vascular flow model at 3.0 T with the help of a recently developed carotid surface coil. Stent-related artifacts were objectively assessed by calculating artificial lumen narrowing (ALN) and relative in-stent signal (RIS). RIS and ALN depended heavily on stent type, stent diameter, and the employed MR sequence. ALN and RIS were relatively favorable for AcculinkA (R), PreciseA (R), and ZilverA (R) stents with both CE-MRA and 3D-TOF. CE-MRA provided better results for the Wallstent, while the Xact stent was difficult to visualize with both MRA protocols. Both CE-MRA and 3D-TOF are viable options for depicting the in-stent lumen in carotid stents. For specific stents, 3D-TOF provided image quality comparable to CE-MRA and may thus be suitable for in vivo assessment. Development of stent-specific pathways for follow-up imaging seems advisable to address stent-related differences in image quality."],["dc.identifier.doi","10.1007/s00234-010-0753-y"],["dc.identifier.isi","000289569100007"],["dc.identifier.pmid","20721544"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6598"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23231"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1920"],["dc.relation.issn","0028-3940"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Comparing different MR angiography strategies of carotid stents in a vascular flow model: toward stent-specific recommendations in MR follow-up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","202"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pituitary"],["dc.bibliographiccitation.lastpage","208"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gutenberg, Angelika"],["dc.contributor.author","Caturegli, Patrizio"],["dc.contributor.author","Metz, Imke"],["dc.contributor.author","Martinez, Ramon"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:09:54Z"],["dc.date.available","2018-11-07T09:09:54Z"],["dc.date.issued","2012"],["dc.description.abstract","We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulo-hypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed."],["dc.identifier.doi","10.1007/s11102-011-0307-2"],["dc.identifier.isi","000304405400013"],["dc.identifier.pmid","21479815"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26377"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1386-341X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Necrotizing infundibulo-hypophysitis: an entity too rare to be true?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","36"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wüstenberg, Torsten"],["dc.contributor.author","Begemann, Martin"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Stawicki, S."],["dc.contributor.author","Hinze-Selch, D."],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Aldenhoff, Josef B."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Ehrenreich, Hanhelore"],["dc.date.accessioned","2017-09-07T11:46:27Z"],["dc.date.available","2017-09-07T11:46:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Neurodevelopmental abnormalities together with neurodegenerative processes contribute to schizophrenia, an etiologically heterogeneous, complex disease phenotype that has been difficult to model in animals. The neurodegenerative component of schizophrenia is best documented by magnetic resonance imaging (MRI), demonstrating progressive cortical gray matter loss over time. No treatment exists to counteract this slowly proceeding atrophy. The hematopoietic growth factor erythropoietin (EPO) is neuroprotective in animals. Here, we show by voxel-based morphometry in 32 human subjects in a placebo-controlled study that weekly high-dose EPO for as little as 3 months halts the progressive atrophy in brain areas typically affected in schizophrenia, including hippocampus, amygdala, nucleus accumbens, and several neocortical areas. Specifically, gray matter protection is highly associated with improvement in attention and memory functions. These findings suggest that a neuroprotective strategy is effective against common pathophysiological features of schizophrenic patients, and strongly encourage follow-up studies to optimize EPO treatment dose and duration."],["dc.identifier.doi","10.1038/mp.2010.51"],["dc.identifier.gro","3150516"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7289"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","hematopoietic growth factor; neuroregeneration; neuroprotection; voxel-based morphometry; brain atrophy; cognition; schizophrenia"],["dc.title","Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","29254"],["dc.bibliographiccitation.issue","30"],["dc.bibliographiccitation.journal","Oncotarget"],["dc.bibliographiccitation.lastpage","29267"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Siam, Laila"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Chaung, Han-Ning"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Klemm, Florian"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Blazquez, Raquel"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Lueke, Florian"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Pukrop, Tobias"],["dc.date.accessioned","2018-11-07T09:50:20Z"],["dc.date.available","2018-11-07T09:50:20Z"],["dc.date.issued","2015"],["dc.description.abstract","The current approach to brain metastases resection is macroscopic removal of metastasis until reaching the glial pseudo-capsule (gross total resection (GTR)). However, autopsy studies demonstrated infiltrating metastatic cells into the parenchyma at the metastasis/brain parenchyma (M/BP)-interface. Aims/Methods: To analyze the astrocyte reaction and metastatic infiltration pattern at the M/BP-interface with an organotypic brain slice coculture system. Secondly, to evaluate the significance of infiltrating metastatic tumor cells in a prospective biopsy study. Therefore, after GTR, biopsies were obtained from the brain parenchyma beyond the glial pseudo-capsule and analyzed histomorphologically. Results: The coculture revealed three types of cancer cell infiltration. Interestingly, the astrocyte reaction was significantly different in the coculture with a benign, neuroectodermal-derived cell line. In the prospective biopsy study 58/167 (34.7%) samples revealed infiltrating metastatic cells. Altogether, 25/39 patients (64.1%) had proven to exhibit infiltration in at least one biopsy specimen with significant impact on survival (OS) (3.4 HR; p = 0.009; 2-year OS was 6.6% versus 43.5%). Exceptionally, in the non-infiltrating cohort three patients were long-term survivors. Conclusions: Metastatic infiltration has a significant impact on prognosis. Secondly, the astrocyte reaction at the M/BP-interface is heterogeneous and supports our previous concept of the organ-specific defense against metastatic (organ-foreign) cells."],["dc.identifier.doi","10.18632/oncotarget.4201"],["dc.identifier.isi","000363183200062"],["dc.identifier.pmid","26299612"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13618"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35687"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Impact Journals Llc"],["dc.relation.issn","1949-2553"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]