Brelie, Christian von der

[["dc.bibliographiccitation.firstpage","E16"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurosurgical Focus"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Melich, Patrick"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2021-04-14T08:23:53Z"],["dc.date.available","2021-04-14T08:23:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3171/2020.5.FOCUS20267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81082"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1092-0684"],["dc.title","Do we underdiagnose osteoporosis in patients with pyogenic spondylodiscitis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e74"],["dc.bibliographiccitation.journal","World Neurosurgery"],["dc.bibliographiccitation.lastpage","e80"],["dc.bibliographiccitation.volume","131"],["dc.contributor.author","Müller, Sebastian J."],["dc.contributor.author","Freimann, Florian B."],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2020-12-10T15:21:43Z"],["dc.date.available","2020-12-10T15:21:43Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.wneu.2019.07.014"],["dc.identifier.issn","1878-8750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73130"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Test-Retest Reliability of Outpatient Telemetric Intracranial Pressure Measurements in Shunt-Dependent Patients with Hydrocephalus and Idiopathic Intracranial Hypertension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Hernández-Durán, Silvia"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2021-08-12T07:46:11Z"],["dc.date.available","2021-08-12T07:46:11Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The Subdural Hematoma in the Elderly (SHE) score was developed as a model to predict 30-day mortality from acute, chronic, and mixed subdural hematoma in the elderly population after minor or no trauma. Emerging evidence suggests frailty to be predictive of mortality and morbidity in the elderly. In this study, we aim to externally validate the SHE for chronic subdural hematoma (CSDH) alone, and we hypothesize that the incorporation of frailty into the SHE may increase its predictive power. A retrospective cohort of elderly patients with CSDH after minor or no trauma being treated at our institution was evaluated with the SHE. Thirty-day mortality and outcome were documented. Patients were assessed with the Clinical Frailty Scale (CFS), which was incorporated into a modified SHE (mSHE). Both the SHE and the mSHE were then assessed in their predictive powers through receiver operating characteristic statistics. We included 168 patients. Most (n = 124, 74%) had a favorable outcome at 30 days. Mortality was low at n = 7, 4%. The SHE failed to predict mortality (AUC = .564, p = .565). Contrarily, the mSHE performed well in both mortality (AUC = .749, p = .026) and outcome (AUC = .862, p < .001). A threshold of mSHE = 3 is predictive of mortality with a sensitivity of 50% and a specificity of 75% and of poor outcome with a sensitivity of 88% and a specificity of 64%. Frailty should be routinely evaluated in elderly individuals, as it can predict outcome and mortality, providing the possibility for medical, surgical, nutritional, cognitive, and physical exercise interventions."],["dc.description.abstract","Abstract The Subdural Hematoma in the Elderly (SHE) score was developed as a model to predict 30-day mortality from acute, chronic, and mixed subdural hematoma in the elderly population after minor or no trauma. Emerging evidence suggests frailty to be predictive of mortality and morbidity in the elderly. In this study, we aim to externally validate the SHE for chronic subdural hematoma (CSDH) alone, and we hypothesize that the incorporation of frailty into the SHE may increase its predictive power. A retrospective cohort of elderly patients with CSDH after minor or no trauma being treated at our institution was evaluated with the SHE. Thirty-day mortality and outcome were documented. Patients were assessed with the Clinical Frailty Scale (CFS), which was incorporated into a modified SHE (mSHE). Both the SHE and the mSHE were then assessed in their predictive powers through receiver operating characteristic statistics. We included 168 patients. Most (n = 124, 74%) had a favorable outcome at 30 days. Mortality was low at n = 7, 4%. The SHE failed to predict mortality (AUC = .564, p = .565). Contrarily, the mSHE performed well in both mortality (AUC = .749, p = .026) and outcome (AUC = .862, p < .001). A threshold of mSHE = 3 is predictive of mortality with a sensitivity of 50% and a specificity of 75% and of poor outcome with a sensitivity of 88% and a specificity of 64%. Frailty should be routinely evaluated in elderly individuals, as it can predict outcome and mortality, providing the possibility for medical, surgical, nutritional, cognitive, and physical exercise interventions."],["dc.identifier.doi","10.1007/s10143-021-01586-2"],["dc.identifier.pii","1586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88639"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1437-2320"],["dc.relation.issn","0344-5607"],["dc.title","A matter of frailty: the modified Subdural Hematoma in the Elderly (mSHE) score"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1321"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1324"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Hernandez-Duran, S."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2018-11-07T10:22:12Z"],["dc.date.available","2018-11-07T10:22:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Posterior reversible encephalopathy syndrome (PRES) is thought to result from endothelial dysfunction and breakdown of the blood-brain barrier with subsequent vasogenic edema. Abrupt hypertension has been identified as one of its risk factors. We present a rare case of PRES in the anterior circulation with sudden onset of left hemiparesis and rapid neurological deterioration on the basis of hypertensive crisis. Due to refractory intracranial hypertension, the patient required emergent right decompressive craniectomy. Further investigations, including a biopsy, revealed an atypical form of PRES. This case illustrates the importance of aggressive medical and early surgical management to prevent permanent neurological deficits."],["dc.identifier.doi","10.1007/s00701-017-3197-x"],["dc.identifier.isi","000403508400022"],["dc.identifier.pmid","28516363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Posterior reversible encephalopathy syndrome presenting in the anterior circulation with malignant intracranial hypertension requiring surgical decompression: a case report and literature review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","236"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurocritical Care"],["dc.bibliographiccitation.lastpage","247"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Hernández-Durán, Silvia"],["dc.contributor.author","Salfelder, Clara"],["dc.contributor.author","Schaeper, Joern"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2021-04-14T08:26:05Z"],["dc.date.available","2021-04-14T08:26:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s12028-020-01029-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81829"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1556-0961"],["dc.relation.issn","1541-6933"],["dc.title","Mechanical Ventilation, Sedation and Neuromonitoring of Patients with Aneurysmal Subarachnoid Hemorrhage in Germany: Results of a Nationwide Survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Chacón-Quesada, T."],["dc.contributor.author","Rohde, V."],["dc.contributor.author","von der Brelie, C."],["dc.date.accessioned","2021-04-14T08:29:10Z"],["dc.date.available","2021-04-14T08:29:10Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s10143-021-01513-5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82818"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1437-2320"],["dc.relation.issn","0344-5607"],["dc.title","Less surgical site infections in neurosurgery during COVID-19 times—one potential benefit of the pandemic?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e166"],["dc.bibliographiccitation.journal","World Neurosurgery"],["dc.bibliographiccitation.lastpage","e174"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Gutowski, Pawel"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2020-12-10T15:21:42Z"],["dc.date.available","2020-12-10T15:21:42Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.wneu.2018.06.147"],["dc.identifier.issn","1878-8750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73125"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Clinical Outcome of Epidural Hematoma Treated Surgically in the Era of Modern Resuscitation and Trauma Care"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Treiber, Hannes"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Chapuy, Claudia Ilse"],["dc.date.accessioned","2022-07-01T07:35:36Z"],["dc.date.available","2022-07-01T07:35:36Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract We describe here 11 consecutive patients with recurrence of high-grade glioma treated with regorafenib at our university medical center. The majority of patients had MGMT promoter methylation (9/11 cases). Regorafenib was given as 2nd line systemic treatment in 6/11 patients and 3rd or higher line treatment in 5/11 patients. The median number of applied cycles was 2 with dosage reductions in 5/11. Response to treatment was observed in 4/11 (PR in 1/11, and SD in 3/11). Median overall survival for the cohort was 16.1 months, median progression-free survival 9.0 months, and median time to treatment failure 3.3 months. Side effects of any CTCAE grade were noted in all patients, hereby 6/11 with CTCAE °III-IV reactions. High-grade side effects were of dermatologic, cardiovascular, and hematologic nature. A mean treatment delay of 57.5 days (range 23–119) was noted between tumor board recommendation and treatment initiation due to the application process for off-label use in this indication. In conclusion, treatment with regorafenib in relapsed high-grade glioma is a feasible treatment option but has to be considered carefully due to the significant side effect profile."],["dc.identifier.doi","10.1007/s10143-022-01826-z"],["dc.identifier.pii","1826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112216"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","1437-2320"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Regorafenib for recurrent high-grade glioma: a unicentric retrospective analysis of feasibility, efficacy, and toxicity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","707"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","711"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Hernández-Durán, Silvia"],["dc.contributor.author","Meinen, Leonie"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2021-06-01T09:42:12Z"],["dc.date.available","2021-06-01T09:42:12Z"],["dc.date.issued","2021"],["dc.description.abstract","Background and Purpose: The role of decompressive hemicraniectomy (DC) in malignant cerebral infarction (MCI) has clearly been established, but little is known about the course of intracranial pressure (ICP) in patients undergoing this surgical measure. In this study, we investigated the role of invasive ICP monitoring in patients after DC for MCI, postulating that postoperative ICP predicts mortality. Methods: In this retrospective observational study of MCI patients undergoing DC, ICP were recorded continuously in hourly intervals for the first 72 hours after DC. For every hour, mean ICP was calculated, pooling ICP of every patient. A receiver operating characteristic analysis was performed for hourly mean ICP. A subgroup analysis by age (≥60 years and <60 years) was also performed. Results: A total of 111 patients were analyzed, with 29% mortality rate in patients <60 years, and 41% in patients ≥60 years. A threshold of 10 mm Hg within the first 72 postoperative hours was a reliable predictor of mortality in MCI, with an acceptable sensitivity of 70% and high specificity of 97%. Established predictors of mortality failed to predict mortality. Conclusions: Our study suggests the need to reevaluate postoperative ICP after DC in MCI and calls for a redefinition of ICP thresholds in these patients to indicate further therapy."],["dc.identifier.doi","10.1161/STROKEAHA.120.032390"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85174"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","Invasive Monitoring of Intracranial Pressure After Decompressive Craniectomy in Malignant Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","von der Brelie, Christian"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Bettag, Chistoph"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2020-12-10T14:11:13Z"],["dc.date.available","2020-12-10T14:11:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s10143-020-01250-1"],["dc.identifier.eissn","1437-2320"],["dc.identifier.issn","0344-5607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71005"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]