Fortuna, Michal G.

[["dc.bibliographiccitation.journal","Anesthesia & Analgesia"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Kugler, Sebastian"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T09:41:05Z"],["dc.date.available","2018-11-07T09:41:05Z"],["dc.date.issued","2014"],["dc.format.extent","S178"],["dc.identifier.isi","000209827600153"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33649"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0003-2999"],["dc.title","OPTOGENETIC DISSECTION OF THE NEURONAL CIRCUITS OF THE MOUSE RESPIRATORY NETWORK"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","173"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","191"],["dc.bibliographiccitation.volume","597"],["dc.contributor.author","Hülsmann, Swen"],["dc.contributor.author","Oke, Yoshihiko"],["dc.contributor.author","Mesuret, Guillaume"],["dc.contributor.author","Latal, A. Tobias"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Niebert, Marcus"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Fischer, Julia"],["dc.contributor.author","Hammerschmidt, Kurt"],["dc.date.accessioned","2019-07-30T07:09:26Z"],["dc.date.available","2019-07-30T07:09:26Z"],["dc.date.issued","2019"],["dc.description.abstract","Newborn mice produce ultrasonic vocalization to communicate with their mother. The neuronal glycine transporter (GlyT2) is required for efficient loading of synaptic vesicles in glycinergic neurons. Mice lacking GlyT2 develop a phenotype that resembles human hyperekplexia and the mice die in the second postnatal week. In the present study, we show that GlyT2-knockout mice do not acquire adult ultrasonic vocalization-associated breathing patterns. Despite the strong impairment of glycinergic inhibition, they can produce sufficient expiratory airflow to produce ultrasonic vocalization. Because mouse ultrasonic vocalization is a valuable read-out in translational research, these data are highly relevant for a broad range of research fields."],["dc.identifier.doi","10.1113/JP276976"],["dc.identifier.pmid","30296333"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62159"],["dc.language.iso","en"],["dc.relation.eissn","1469-7793"],["dc.relation.issn","0022-3751"],["dc.relation.issn","1469-7793"],["dc.title","The postnatal development of ultrasonic vocalization-associated breathing is altered in glycine transporter 2-deficient mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","141"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Hülsmann, Swen"],["dc.date.accessioned","2020-12-10T15:21:04Z"],["dc.date.available","2020-12-10T15:21:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.resp.2018.10.008"],["dc.identifier.issn","1569-9048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72908"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Probing the function of glycinergic neurons in the mouse respiratory network using optogenetics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","68"],["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","210"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Bischoff, A.-M."],["dc.contributor.author","Kuegler, Sebastian"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T09:42:47Z"],["dc.date.available","2018-11-07T09:42:47Z"],["dc.date.issued","2014"],["dc.identifier.isi","000332259900177"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34034"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","The effect of optogenetic stimulation of the Glycinergic neurons of the mammalian respiratory network"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","Hüer, Janina"],["dc.contributor.author","Guo, Hao"],["dc.contributor.author","Gruber, Jens"],["dc.contributor.author","Gruber-Dujardin, Eva"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Scherberger, Hansjörg"],["dc.contributor.author","Treue, Stefan"],["dc.contributor.author","Gail, Alexander"],["dc.date.accessioned","2021-04-14T08:24:27Z"],["dc.date.available","2021-04-14T08:24:27Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41598-020-67752-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81290"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2045-2322"],["dc.title","Histological assessment of optogenetic tools to study fronto-visual and fronto-parietal cortical networks in the rhesus macaque"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2506"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","The Journal of Neuroscience : the official journal of the Society for Neuroscience"],["dc.bibliographiccitation.lastpage","2515"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Fortuna, Michal G."],["dc.contributor.author","West, Gavin H."],["dc.contributor.author","Stornetta, Ruth L."],["dc.contributor.author","Guyenet, Patrice G."],["dc.date.accessioned","2019-07-30T08:35:44Z"],["dc.date.available","2019-07-30T08:35:44Z"],["dc.date.issued","2008"],["dc.description.abstract","In neonatal rat brains in vitro, the rostral ventral respiratory column (rVRC) contains neurons that burst just before the phrenic nerve discharge (PND) and rebound after inspiration (pre-I neurons). These neurons, called parafacial respiratory group (pfRG), have been interpreted as a master inspiratory oscillator, an expiratory rhythm generator or simply as neonatal precursors of retrotrapezoid (RTN) chemoreceptor neurons. pfRG neurons have not been identified in adults, and their phenotype is unknown. Here, we confirm that the rVRC normally lacks pre-I neurons in adult anesthetized rats. However, we show that, during hypercapnic hypoxia, a population of rVRC expiratory-augmenting (E-AUG) neurons consistently develops a pre-I discharge. These cells reside in the Bötzinger region of the rVRC, they express glycine-transporter-2, and their axons arborize throughout the VRC. Hypoxia triggers an identical pre-I pattern in retroambigual expiratory bulbospinal neurons, but this pattern is not elicited in Bötzinger expiratory-decrementing neurons, Bötzinger inspiratory neurons, RTN neurons, and blood pressure-regulating neurons. In conclusion, under hypoxia in vivo, abdominal expiratory premotor neurons of adult rats develop a pre-I pattern reminiscent of that observed in neonate brainstems in vitro. In the rVRC of adult rats, pre-I cells include selected rhythmogenic neurons (glycinergic Bötzinger neurons) but not RTN chemoreceptors. We suggest that the pfRG may not be an independent rhythm generator but a heterogeneous collection of E-AUG neurons (glycinergic Bötzinger neurons, possibly facial motor and premotor neurons), the discharge of which becomes preinspiratory under specific experimental conditions resulting from, in part, a prolonged and intensified activity of postinspiratory neurons."],["dc.identifier.doi","10.1523/JNEUROSCI.5595-07.2008"],["dc.identifier.pmid","18322095"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62186"],["dc.language.iso","en"],["dc.relation.eissn","1529-2401"],["dc.relation.issn","0270-6474"],["dc.relation.issn","1529-2401"],["dc.title","Botzinger expiratory-augmenting neurons and the parafacial respiratory group"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]