Pfeifenbring, Sabine

[["dc.bibliographiccitation.firstpage","807"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","815"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Haider, Lukas"],["dc.contributor.author","Zrzavy, Tobias"],["dc.contributor.author","Hametner, Simon"],["dc.contributor.author","Hoeftberger, Romana"],["dc.contributor.author","Bagnato, Francesca"],["dc.contributor.author","Grabner, Guenther"],["dc.contributor.author","Trattnig, Siegfried"],["dc.contributor.author","Pfeifenbring, Sabine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Lassmann, Hans"],["dc.date.accessioned","2018-11-07T10:17:40Z"],["dc.date.available","2018-11-07T10:17:40Z"],["dc.date.issued","2016"],["dc.description.abstract","Multiple sclerosis is characterized by widespread primary demyelination and progressive degeneration, driven by heterogeneous mechanisms. Haider et al. provide a topographic map of the frequency with which different brain regions are affected by these processes, and show that demyelination and neurodegeneration involve inflammatory as well as vascular changes.Multiple sclerosis is characterized by widespread primary demyelination and progressive degeneration, driven by heterogeneous mechanisms. Haider et al. provide a topographic map of the frequency with which different brain regions are affected by these processes, and show that demyelination and neurodegeneration involve inflammatory as well as vascular changes.Multiple sclerosis is a chronic inflammatory disease with primary demyelination and neurodegeneration in the central nervous system. In our study we analysed demyelination and neurodegeneration in a large series of multiple sclerosis brains and provide a map that displays the frequency of different brain areas to be affected by these processes. Demyelination in the cerebral cortex was related to inflammatory infiltrates in the meninges, which was pronounced in invaginations of the brain surface (sulci) and possibly promoted by low flow of the cerebrospinal fluid in these areas. Focal demyelinated lesions in the white matter occurred at sites with high venous density and additionally accumulated in watershed areas of low arterial blood supply. Two different patterns of neurodegeneration in the cortex were identified: oxidative injury of cortical neurons and retrograde neurodegeneration due to axonal injury in the white matter. While oxidative injury was related to the inflammatory process in the meninges and pronounced in actively demyelinating cortical lesions, retrograde degeneration was mainly related to demyelinated lesions and axonal loss in the white matter. Our data show that accumulation of lesions and neurodegeneration in the multiple sclerosis brain does not affect all brain regions equally and provides the pathological basis for the selection of brain areas for monitoring regional injury and atrophy development in future magnetic resonance imaging studies."],["dc.identifier.doi","10.1093/brain/awv398"],["dc.identifier.isi","000371694600023"],["dc.identifier.pmid","26912645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2156"],["dc.relation.issn","0006-8950"],["dc.title","The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Hametner, Simon"],["dc.contributor.author","Wimmer, Isabella"],["dc.contributor.author","Haider, L."],["dc.contributor.author","Pfeifenbring, Sabine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Lassmann, Hans"],["dc.date.accessioned","2018-11-07T09:18:49Z"],["dc.date.available","2018-11-07T09:18:49Z"],["dc.date.issued","2013"],["dc.format.extent","9"],["dc.identifier.isi","000328751400004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28488"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.conference","29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS"],["dc.relation.eventlocation","Copenhagen, DENMARK"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Iron and oxidative damage in the multiple sclerosis brain"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1196"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","1209"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Bergner, Caroline G."],["dc.contributor.author","Meer, Franziska"],["dc.contributor.author","Winkler, Anne"],["dc.contributor.author","Wrzos, Claudia"],["dc.contributor.author","Türkmen, Mevlude"],["dc.contributor.author","Valizada, Emil"],["dc.contributor.author","Fitzner, Dirk"],["dc.contributor.author","Hametner, Simon"],["dc.contributor.author","Hartmann, Christian"],["dc.contributor.author","Pfeifenbring, Sabine"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2022-03-01T11:45:41Z"],["dc.date.available","2022-03-01T11:45:41Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/glia.23598"],["dc.identifier.eissn","1098-1136"],["dc.identifier.issn","0894-1491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103412"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Microglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","848"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Annals of Neurology"],["dc.bibliographiccitation.lastpage","861"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Hametner, Simon"],["dc.contributor.author","Wimmer, Isabella"],["dc.contributor.author","Haider, Lukas"],["dc.contributor.author","Pfeifenbring, Sabine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Lassmann, Hans"],["dc.date.accessioned","2018-11-07T09:16:47Z"],["dc.date.available","2018-11-07T09:16:47Z"],["dc.date.issued","2013"],["dc.description.abstract","ObjectiveIron may contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain with age. Our study focused on nonheme iron distribution and the expression of the iron-related proteins ferritin, hephaestin, and ceruloplasmin in relation to oxidative damage in the brain tissue of 33 MS and 30 control cases. MethodsWe performed (1) whole-genome microarrays including 4 MS and 3 control cases to analyze the expression of iron-related genes, (2) nonheme iron histochemistry, (3) immunohistochemistry for proteins of iron metabolism, and (4) quantitative analysis by digital densitometry and cell counting in regions representing different stages of lesion maturation. ResultsWe found an age-related increase of iron in the white matter of controls as well as in patients with short disease duration. In chronic MS, however, there was a significant decrease of iron in the normal-appearing white matter (NAWM) corresponding with disease duration, when corrected for age. This decrease of iron in oligodendrocytes and myelin was associated with an upregulation of iron-exporting ferroxidases. In active MS lesions, iron was apparently released from dying oligodendrocytes, resulting in extracellular accumulation of iron and uptake into microglia and macrophages. Iron-containing microglia showed signs of cell degeneration. At lesion edges and within centers of lesions, iron accumulated in astrocytes and axons. InterpretationIron decreases in the NAWM of MS patients with increasing disease duration. Cellular degeneration in MS lesions leads to waves of iron liberation, which may propagate neurodegeneration together with inflammatory oxidative burst. Ann Neurol 2013;74:848-861"],["dc.description.sponsorship","Austrian Science Fund [P24245-B19]"],["dc.identifier.doi","10.1002/ana.23974"],["dc.identifier.isi","000329891100015"],["dc.identifier.pmid","23868451"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28011"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1531-8249"],["dc.relation.issn","0364-5134"],["dc.title","Iron and Neurodegeneration in the Multiple Sclerosis Brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]