Wiltfang, Jens

[["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Hansen, Niels; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Singh, Aditya; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Bartels, Claudia; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Brosseron, Frederic; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Buerger, Katharina; 5German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany"],["dc.contributor.affiliation","Cetindag, Arda C.; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Dobisch, Laura; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Dechent, Peter; 10MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Ertl-Wagner, Birgit B.; 11Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany"],["dc.contributor.affiliation","Fliessbach, Klaus; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Haynes, John D.; 12Bernstein Center for Computational Neuroscience, Charité—Universitätsmedizin, Berlin, Germany"],["dc.contributor.affiliation","Heneka, Michael T.; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Janowitz, Daniel; 6Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Kilimann, Ingo; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Laske, Christoph; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Metzger, Coraline D.; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Munk, Matthias H.; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Peters, Oliver; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Priller, Josef; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Roy, Nina; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Scheffler, Klaus; 21Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany"],["dc.contributor.affiliation","Schneider, Anja; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spottke, Annika; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spruth, Eike J.; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Teipel, Stefan; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Tscheuschler, Maike; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Vukovich, Ruth; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Wiltfang, Jens; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Duezel, Emrah; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Jessen, Frank; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Goya-Maldonado, Roberto; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cetindag, Arda C."],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Ertl-Wagner, Birgit B."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Haynes, John D."],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Tscheuschler, Maike"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.date.accessioned","2021-06-01T09:42:25Z"],["dc.date.available","2021-06-01T09:42:25Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:10Z"],["dc.description.abstract","Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups."],["dc.identifier.doi","10.3389/fnagi.2021.626974"],["dc.identifier.eissn","1663-4365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85247"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","455"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Alzheimer's Disease"],["dc.bibliographiccitation.lastpage","465"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Kuper-Smith, Jan O."],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buchmann, Martina"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Fließbach, Klaus"],["dc.contributor.author","Haynes, John-Dylan"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Li, Siyao"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Pross, Verena"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Dyrba, Martin"],["dc.contributor.editor","Zhou, Juan Helen"],["dc.date.accessioned","2020-12-10T18:44:13Z"],["dc.date.available","2020-12-10T18:44:13Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3233/JAD-190446"],["dc.identifier.eissn","1875-8908"],["dc.identifier.issn","1387-2877"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16953"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78366"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer’s Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sannemann, Lena"],["dc.contributor.author","Schild, Ann-Katrin"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cosma, Nicoleta Carmen"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Freiesleben, Silka Dawn"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Kobeleva, Xenia"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H. J."],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Polcher, Alexandra"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Rauchmann, Boris"],["dc.contributor.author","Rösch, Christina"],["dc.contributor.author","Rudolph, Janna"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike Jakob"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.date.accessioned","2021-04-14T08:31:19Z"],["dc.date.available","2021-04-14T08:31:19Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s13195-020-00701-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1758-9193"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Miebach, Lisa"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Polcher, Alexandra"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Luther, Katja"],["dc.contributor.author","Incesoy, Enise"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Spruth, Eike"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Utecht, Julia"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Buchmann, Martina"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Kalbhen, Pascal"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Metzger, Coraline"],["dc.contributor.author","Meiberth, Dix"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Wagner, Michael"],["dc.date.accessioned","2020-12-10T18:39:08Z"],["dc.date.available","2020-12-10T18:39:08Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s13195-019-0515-y"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16326"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77551"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Müller, Stephan"],["dc.contributor.author","Preische, Oliver"],["dc.contributor.author","Göpfert, Jens C."],["dc.contributor.author","Yañez, Viviana A. Carcamo"],["dc.contributor.author","Joos, Thomas O."],["dc.contributor.author","Boecker, Henning"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Nestor, Peter"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Schipke, Carola G."],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Fließbach, Klaus"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Laske, Christoph"],["dc.date.accessioned","2019-07-09T11:43:49Z"],["dc.date.available","2019-07-09T11:43:49Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1038/s41598-017-08779-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14687"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58976"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Tau plasma levels in subjective cognitive decline: Results from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Boecker, Henning"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Franke, Christiana"],["dc.contributor.author","Fuentes, Manuel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Nestor, Peter"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Pross, Verena"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Speck, Oliver"],["dc.contributor.author","Spruth, Eike Jakob"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Westerteicher, Christine"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Düzel, Emrah"],["dc.date.accessioned","2020-12-10T18:39:07Z"],["dc.date.available","2020-12-10T18:39:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1186/s13195-017-0314-2"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15507"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77548"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15156 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1186"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain: A Journal of Neurology"],["dc.bibliographiccitation.lastpage","1200"],["dc.bibliographiccitation.volume","141"],["dc.contributor.author","Franzmeier, Nicolai"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Duering, Marco"],["dc.contributor.author","Dichgans, Martin"],["dc.contributor.author","Haass, Christian"],["dc.contributor.author","Suárez-Calvet, Marc"],["dc.contributor.author","Fagan, Anne M"],["dc.contributor.author","Paumier, Katrina"],["dc.contributor.author","Benzinger, Tammie"],["dc.contributor.author","Masters, Colin L"],["dc.contributor.author","Morris, John C"],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Rossor, Martin"],["dc.contributor.author","Jucker, Mathias"],["dc.contributor.author","Chhatwal, Jasmeer"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Boecker, Henning"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Heneka, Michael T"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Nestor, Peter"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Fuentes, Manuel"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Spruth, Eike J"],["dc.contributor.author","Franke, Christiana"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Kofler, Barbara"],["dc.contributor.author","Westerteicher, Christine"],["dc.contributor.author","Speck, Oliver"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Araque Caballero, Miguel Ángel"],["dc.contributor.author","Metzger, Coraline"],["dc.contributor.author","Bittner, Daniel"],["dc.contributor.author","Weiner, Michael"],["dc.contributor.author","Lee, Jae-Hong"],["dc.contributor.author","Salloway, Stephen"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Goate, Alison"],["dc.contributor.author","Schofield, Peter R"],["dc.contributor.author","Bateman, Randall J"],["dc.contributor.author","Ewers, Michael"],["dc.date.accessioned","2020-12-10T18:18:09Z"],["dc.date.available","2020-12-10T18:18:09Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1093/brain/awy008"],["dc.identifier.eissn","1460-2156"],["dc.identifier.issn","0006-8950"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15454"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75085"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Dyrba, Martin"],["dc.contributor.author","Hanzig, Moritz"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bader, Sebastian"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cantré, Daniel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Ewers, Michael"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Haynes, John-Dylan"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Keles, Deniz B."],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Maier, Franziska"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Preis, Lukas"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Rauchmann, Boris"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schott, Björn H."],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Weber, Marc-André"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.authorgroup","for the ADNI, AIBL, DELCODE study groups"],["dc.date.accessioned","2021-12-01T09:23:04Z"],["dc.date.accessioned","2022-08-18T12:39:17Z"],["dc.date.available","2021-12-01T09:23:04Z"],["dc.date.available","2022-08-18T12:39:17Z"],["dc.date.issued","2021-11-23"],["dc.date.updated","2022-07-29T12:17:50Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined by prior knowledge.\r\n \r\n \r\n Methods\r\n We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection.\r\n \r\n \r\n Results\r\n Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001).\r\n \r\n \r\n Conclusion\r\n The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia."],["dc.identifier.citation","Alzheimer's Research & Therapy. 2021 Nov 23;13(1):191"],["dc.identifier.doi","10.1186/s13195-021-00924-2"],["dc.identifier.pii","924"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94551"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112968"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1758-9193"],["dc.rights.holder","The Author(s)"],["dc.subject","Alzheimer’s disease"],["dc.subject","Deep learning"],["dc.subject","Convolutional neural network"],["dc.subject","MRI"],["dc.subject","Layer-wise relevance propagation"],["dc.title","Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]