Wiltfang, Jens

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[["dc.bibliographiccitation.journal","Frontiers in Aging Neuroscience"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Hansen, Niels; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Singh, Aditya; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Bartels, Claudia; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Brosseron, Frederic; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Buerger, Katharina; 5German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany"],["dc.contributor.affiliation","Cetindag, Arda C.; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Dobisch, Laura; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Dechent, Peter; 10MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Ertl-Wagner, Birgit B.; 11Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany"],["dc.contributor.affiliation","Fliessbach, Klaus; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Haynes, John D.; 12Bernstein Center for Computational Neuroscience, Charité—Universitätsmedizin, Berlin, Germany"],["dc.contributor.affiliation","Heneka, Michael T.; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Janowitz, Daniel; 6Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Kilimann, Ingo; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Laske, Christoph; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Metzger, Coraline D.; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Munk, Matthias H.; 15German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany"],["dc.contributor.affiliation","Peters, Oliver; 7Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany"],["dc.contributor.affiliation","Priller, Josef; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Roy, Nina; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Scheffler, Klaus; 21Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany"],["dc.contributor.affiliation","Schneider, Anja; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spottke, Annika; 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],["dc.contributor.affiliation","Spruth, Eike J.; 8German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"],["dc.contributor.affiliation","Teipel, Stefan; 13German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"],["dc.contributor.affiliation","Tscheuschler, Maike; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Vukovich, Ruth; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Wiltfang, Jens; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.affiliation","Duezel, Emrah; 9German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"],["dc.contributor.affiliation","Jessen, Frank; 23Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany"],["dc.contributor.affiliation","Goya-Maldonado, Roberto; 1Department of Psychiatry and Psychotherapy, Göttingen, Germany"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Singh, Aditya"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cetindag, Arda C."],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Ertl-Wagner, Birgit B."],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Haynes, John D."],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Tscheuschler, Maike"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.date.accessioned","2021-06-01T09:42:25Z"],["dc.date.available","2021-06-01T09:42:25Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:10Z"],["dc.description.abstract","Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups."],["dc.identifier.doi","10.3389/fnagi.2021.626974"],["dc.identifier.eissn","1663-4365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85247"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1663-4365"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Müller, Stephan"],["dc.contributor.author","Preische, Oliver"],["dc.contributor.author","Göpfert, Jens C."],["dc.contributor.author","Yañez, Viviana A. Carcamo"],["dc.contributor.author","Joos, Thomas O."],["dc.contributor.author","Boecker, Henning"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Nestor, Peter"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Schipke, Carola G."],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Fließbach, Klaus"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Laske, Christoph"],["dc.date.accessioned","2019-07-09T11:43:49Z"],["dc.date.available","2019-07-09T11:43:49Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1038/s41598-017-08779-0"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14687"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58976"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Tau plasma levels in subjective cognitive decline: Results from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Boecker, Henning"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Franke, Christiana"],["dc.contributor.author","Fuentes, Manuel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Nestor, Peter"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Pross, Verena"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Speck, Oliver"],["dc.contributor.author","Spruth, Eike Jakob"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Westerteicher, Christine"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Düzel, Emrah"],["dc.date.accessioned","2020-12-10T18:39:07Z"],["dc.date.available","2020-12-10T18:39:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1186/s13195-017-0314-2"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15507"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77548"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15156 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1025"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","1044"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Kleineidam, Luca"],["dc.contributor.author","Chouraki, Vincent"],["dc.contributor.author","Próchnicki, Tomasz"],["dc.contributor.author","van der Lee, Sven J."],["dc.contributor.author","Madrid-Márquez, Laura"],["dc.contributor.author","Wagner-Thelen, Holger"],["dc.contributor.author","Karaca, Ilker"],["dc.contributor.author","Weinhold, Leonie"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Boland, Anne"],["dc.contributor.author","Martino Adami, Pamela V."],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Popp, Julius"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Jansen, Iris E."],["dc.contributor.author","Hulsman, Marc"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Berr, Claudine"],["dc.contributor.author","Heun, Reinhard"],["dc.contributor.author","Frölich, Lutz"],["dc.contributor.author","Tzourio, Christophe"],["dc.contributor.author","Dartigues, Jean-François"],["dc.contributor.author","Hüll, Michael"],["dc.contributor.author","Espinosa, Ana"],["dc.contributor.author","Hernández, Isabel"],["dc.contributor.author","de Rojas, Itziar"],["dc.contributor.author","Orellana, Adelina"],["dc.contributor.author","Valero, Sergi"],["dc.contributor.author","Stringa, Najada"],["dc.contributor.author","van Schoor, Natasja M."],["dc.contributor.author","Huisman, Martijn"],["dc.contributor.author","Scheltens, Philip"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Deleuze, Jean-Francois"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Tarraga, Lluis"],["dc.contributor.author","Schmid, Matthias"],["dc.contributor.author","Scherer, Martin"],["dc.contributor.author","Riedel-Heller, Steffi"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Amouyel, Philippe"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Boada, Merce"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","González-Pérez, Antonio"],["dc.contributor.author","van der Flier, Wiesje M."],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Lambert, Jean-Charles"],["dc.contributor.author","Holstege, Henne"],["dc.contributor.author","Sáez, Mª Eugenia"],["dc.contributor.author","Latz, Eicke"],["dc.contributor.author","Ruiz, Agustin"],["dc.contributor.author","Ramirez, Alfredo"],["dc.date.accessioned","2020-12-10T14:10:28Z"],["dc.date.available","2020-12-10T14:10:28Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00401-020-02138-6"],["dc.identifier.eissn","1432-0533"],["dc.identifier.issn","0001-6322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70767"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Alzheimer's Disease"],["dc.bibliographiccitation.lastpage","64"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Lelental, Natalia"],["dc.contributor.author","Brandner, Sebastian"],["dc.contributor.author","Kofanova, Olga"],["dc.contributor.author","Blennow, Kaj"],["dc.contributor.author","Zetterberg, Henrik"],["dc.contributor.author","Andreasson, Ulf"],["dc.contributor.author","Engelborghs, Sebastiaan"],["dc.contributor.author","Mroczko, Barbara"],["dc.contributor.author","Gabryelewicz, Tomasz"],["dc.contributor.author","Teunissen, Charlotte E."],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Parnetti, Lucilla"],["dc.contributor.author","Chiasserini, Davide"],["dc.contributor.author","Molinuevo, Jose Luis"],["dc.contributor.author","Perret-Liaudet, Armand"],["dc.contributor.author","Verbeek, Marcel M."],["dc.contributor.author","Andreasen, Niels"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Bahl, Justyna M. C."],["dc.contributor.author","Herukka, Sanna-Kaisa"],["dc.contributor.author","Hausner, Lucrezia"],["dc.contributor.author","Frölich, Lutz"],["dc.contributor.author","Labonte, Anne"],["dc.contributor.author","Poirier, Judes"],["dc.contributor.author","Miller, Anne-Marie"],["dc.contributor.author","Zilka, Norbert"],["dc.contributor.author","Kovacech, Branislav"],["dc.contributor.author","Urbani, Andrea"],["dc.contributor.author","Suardi, Silvia"],["dc.contributor.author","Oliveira, Catarina"],["dc.contributor.author","Baldeiras, Ines"],["dc.contributor.author","Dubois, Bruno"],["dc.contributor.author","Rot, Uros"],["dc.contributor.author","Lehmann, Sylvain"],["dc.contributor.author","Skinningsrud, Anders"],["dc.contributor.author","Betsou, Fay"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Gkatzima, Olymbia"],["dc.contributor.author","Winblad, Bengt"],["dc.contributor.author","Buchfelder, Michael"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Lewczuk, Piotr"],["dc.date.accessioned","2017-09-07T11:44:24Z"],["dc.date.available","2017-09-07T11:44:24Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Assay-vendor independent quality control (QC) samples for neurochemical dementia diagnostics (NDD) biomarkers are so far commercially unavailable. This requires that NDD laboratories prepare their own QC samples, for example by pooling leftover cerebrospinal fluid (CSF) samples. Objective: To prepare and test alternative matrices for QC samples that could facilitate intra- and inter-laboratory QC of the NDD biomarkers. Methods: Three matrices were validated in this study: (A) human pooled CSF, (B) Aβ peptides spiked into human prediluted plasma, and (C) Aβ peptides spiked into solution of bovine serum albumin in phosphate-buffered saline. All matrices were tested also after supplementation with an antibacterial agent (sodium azide). We analyzed short- and long-term stability of the biomarkers with ELISA and chemiluminescence (Fujirebio Europe, MSD, IBL International), and performed an inter-laboratory variability study. Results: NDD biomarkers turned out to be stable in almost all samples stored at the tested conditions for up to 14 days as well as in samples stored deep-frozen (at – 80°C) for up to one year. Sodium azide did not influence biomarker stability. Inter-center variability of the samples sent at room temperature (pooled CSF, freeze-dried CSF, and four artificial matrices) was comparable to the results obtained on deep-frozen samples in other large-scale projects. Conclusion: Our results suggest that it is possible to replace self-made, CSF-based QC samples with large-scale volumes of QC materials prepared with artificial peptides and matrices. This would greatly facilitate intra- and inter-laboratory QC schedules for NDD measurements."],["dc.identifier.doi","10.3233/jad-150883"],["dc.identifier.gro","3151642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8458"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","1387-2877"],["dc.title","Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]