Frauendorf, Holm

[["dc.bibliographiccitation.firstpage","1139"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Analytical and Bioanalytical Chemistry"],["dc.bibliographiccitation.lastpage","1147"],["dc.bibliographiccitation.volume","390"],["dc.contributor.author","Fitzner, Ansgar"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Diederichsen, Ulf"],["dc.date.accessioned","2018-11-07T11:18:24Z"],["dc.date.available","2018-11-07T11:18:24Z"],["dc.date.issued","2008"],["dc.description.abstract","Formation and fragmentation of recognition complexes between trioxacarcin A and various DNA sequences were examined by temperature-dependent UV and CD spectroscopy, HPLC analysis, and ESI mass spectrometry with regard to reaction conditions, intermediates, products, mechanism, and sequence specificity. Cleavage of the trioxacarcin-DNA complexes provided the natural product gutingimycin by guanine abstraction. The resulting DNA with an abasic site was further cleaved into a DNA fragment with a furanyl unit at the 3'-end and an oligonucleotide with a phosphorylated 5'-end."],["dc.identifier.doi","10.1007/s00216-007-1737-6"],["dc.identifier.isi","000252918100017"],["dc.identifier.pmid","18210096"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3482"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55029"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1618-2642"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Formation of gutingimycin: analytical investigation of trioxacarcin A-mediated alkylation of dsDNA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Biotechnology"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Sajid, Imran"],["dc.contributor.author","Shaaban, Khaled Attia"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Hasnain, Shahida"],["dc.contributor.author","Laatsch, Hartmut G."],["dc.date.accessioned","2018-11-07T11:10:37Z"],["dc.date.available","2018-11-07T11:10:37Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.jbiotec.2008.07.169"],["dc.identifier.isi","000208979400175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53245"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.title","Val-Geninthiocin: A thiopeptide antibiotic produced by Streptomyces sp RSF18"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","736"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","The Journal of Antibiotics"],["dc.bibliographiccitation.lastpage","746"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Shaaban, Khaled Attia"],["dc.contributor.author","Shaaban, Mohamed"],["dc.contributor.author","Facey, Petrea"],["dc.contributor.author","Fotso, Serge"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Helmke, Elisabeth"],["dc.contributor.author","Maier, Armin"],["dc.contributor.author","Fiebig, Heinz-Herbert"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T11:08:35Z"],["dc.date.available","2018-11-07T11:08:35Z"],["dc.date.issued","2008"],["dc.description.abstract","Chemical investigation of the marine-derived Streptomyces sp. Act8015 led to the isolation of two cyclic peptide antibiotics, piperazimycins A and B (1a, 1b). Their structures were confirmed on the basis of a detailed HRESI-MS/MS analysis. Additionally, a new butanolide, 4,10-dihydroxy-10-methyl-dodecan-4-olide (2), and the respective acid, 4,10-dihydroxy-10-methyl-dodecanoic acid (3a) were identified. Further isolated compounds were staurosporin, adenine, indole-3-carboxylic acid, ferulic acid, tryptophol, and three gamma-butyrolactones: virginiae butanolide E (4e) and Graefe's Factors I (4f) and III (4g). The structures of 2 and 3a were confirmed by detailed 1 D and 2D NMR studies and MS spectra and by comparison with related structures. A full signal assignment of virginiae butanolide E (4e) is reported here for the first time."],["dc.description.sponsorship","Alexander von Humboldt Foundation (AvH); BMBF [03F0415A]"],["dc.identifier.isi","000263144400003"],["dc.identifier.pmid","19194032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52819"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Antibiotics Research Assoc"],["dc.relation.issn","0021-8820"],["dc.title","Electrospray Ionization Mass Spectra of Piperazimycins A and B and gamma-Butyrolactones from a Marine-derived Streptomyces sp."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Natural Products"],["dc.bibliographiccitation.lastpage","8"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Zendah, Imene"],["dc.contributor.author","Riaz, Naheed"],["dc.contributor.author","Nasr, Hamdi"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Schueffler, Anja"],["dc.contributor.author","Raies, Aly"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T09:15:39Z"],["dc.date.available","2018-11-07T09:15:39Z"],["dc.date.issued","2012"],["dc.description.abstract","The new chromophenazines A-F [9-methyl-5-(3'-methylbut-2'-enyl)-5H-benzo[a]phenazin-7-one (la), 9-methyl-5-(3'-methylbut-2'-enyl)-7-oxo-5,7-dihydrobenzo [a]phenazine-1-carboxylic acid (1b), 5-(3'-methylbut-2'-eny1)-7-oxo-5,7-dihydrophenazine-l-carboxamide (2), 3-benzoyl-5-(3'-methylbut-2'-enyl)-5,10-dihydrophenazine-1-carboxylic acid (5a), 3,7-dibenzoyl-5-(3'-methylbut-2'-enyl)-5,10-dihydrophenazine-1-carboxylic acid (5b), and 3,7-dibenzoyl-5-(3'-methylbut-2'-enyl)-5,10-dihydrophenazine-1-carboxamide (5c)], together with phenazine-1-carboxylic acid, 1-phenazinecarboxamide, 1-phenazinol, tryptophol, and anthranilic acid, were isolated from Streptomyces sp. Ank 315. The structures of the new compounds were established on the basis of spectroscopic data, 1D NOE, 2D NMR, and ESIMS measurements and comparison with literature values."],["dc.identifier.doi","10.1021/np100818d"],["dc.identifier.isi","000300762100002"],["dc.identifier.pmid","22220635"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27745"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0163-3864"],["dc.title","Chromophenazines from the Terrestrial Streptomyces sp Ank 315"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Zeitschrift für Naturforschung B"],["dc.bibliographiccitation.lastpage","1230"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Sajid, Imran"],["dc.contributor.author","Shaaban, Khaled Attia"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Hasnain, Shahida"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T11:10:53Z"],["dc.date.available","2018-11-07T11:10:53Z"],["dc.date.issued","2008"],["dc.description.abstract","Val-Geninthiocin (2), a new member of thiopeptide antibiotics, was isolated from the mycelium of Streptomyces sp. RSF18, along with the closely related geninthiocin (1) and the macrolide, chalcomycin. By intensive NMR and MS studies, Val-geninthiocin (2) was identified as desoxygeninthiocin, a thiopeptide, containing several oxazole and thiazole units and a number of unusual amino acids. Compound 2 shows potent activity against Gram-positive bacteria and minor antifungal activity, while it is not effective against Gram-negative bacteria or microalgae. Here we describe the fermentation, isolation and structure elucidation as well as the biological activity of 2."],["dc.identifier.isi","000260353100014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53307"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Z Naturforsch"],["dc.relation.issn","0932-0776"],["dc.title","Val-Geninthiocin: Structure Elucidation and MSn Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp RSF18"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7641"],["dc.bibliographiccitation.issue","69"],["dc.bibliographiccitation.journal","Chemical Communications"],["dc.bibliographiccitation.lastpage","7643"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Kenla, Timothee J. Nwemeguela"],["dc.contributor.author","Tatong, Michel D. Kongue"],["dc.contributor.author","Talontsi, Ferdinand Mouafo"],["dc.contributor.author","Dittrich, Birger"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Laatsch, Hartmut"],["dc.date.accessioned","2018-11-07T09:29:42Z"],["dc.date.available","2018-11-07T09:29:42Z"],["dc.date.issued","2013"],["dc.description.abstract","Si-enterobactin (2a), a hexacoordinated complex of the siderophore enterobactin (2b) with silicon as the central atom, was isolated from an endophytic Streptomyces sp. occurring in Piper guinensis roots. The structure and absolute configuration were determined from NMR and MS data, and by X-ray diffraction. The orientation of the molecule along the pseudo-3-fold axis shows that the coordination environment of the silicon atom complexed with three bidentate ligands is Delta. We assume that 2a or related complexes may be involved in the transport of silicon in plants, diatoms, or other silicon-dependent organisms."],["dc.identifier.doi","10.1039/c3cc44437f"],["dc.identifier.isi","000322594900022"],["dc.identifier.pmid","23872808"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31108"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1364-548X"],["dc.relation.issn","1359-7345"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Si-enterobactin from the endophytic Streptomyces sp KT-S1-B5-a potential silicon transporter in Nature?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.journal","Phytochemistry"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Talontsi, Ferdinand Mouafo"],["dc.contributor.author","Facey, Petrea"],["dc.contributor.author","Tatong, Michel D. Kongue"],["dc.contributor.author","Islam, Mohammad Tofazzal"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Draeger, Siegfried"],["dc.contributor.author","Tiedemann, Andreas von"],["dc.contributor.author","Laatsch, Hartmut G."],["dc.date.accessioned","2018-11-07T09:04:13Z"],["dc.date.available","2018-11-07T09:04:13Z"],["dc.date.issued","2012"],["dc.description.abstract","Two polyketides, cryptosporiopsin A (1) and hydroxypropan-2',3'-diol orsellinate (3), and a natural cyclic pentapeptide (4), together with two known compounds were isolated from the culture of Cryptosporiopsis sp., an endophytic fungus from leaves and branches of Zanthoxylum leprieurii (Rutaceae). The structures of these metabolites were elucidated on the basis of their spectroscopic and spectrometric data. Cryptosporiopsin A and the other metabolites exhibited motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola at 10-25 mu g/mL. In addition, the isolated compounds displayed potent inhibitory activity against mycelial growth of two other peronosporomycete phytopathogens, Pythium ultimum, Aphanomyces cochlioides and a basidiomycetous fungus Rhizoctonia solani. Weak cytotoxic activity on brine shrimp larvae was observed. (C) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.phytochem.2012.06.006"],["dc.identifier.isi","310421100010"],["dc.identifier.pmid","22883958"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25066"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0031-9422"],["dc.title","Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp of Zanthoxylum leprieurii"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]