Diekhof, Esther Kristina

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Weber, Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Depression is a debilitating psychiatric disorder characterized among other aspects by the inability to properly experience or respond to reward. However, it remains unclear whether patients with depression present impaired reward system due to abnormal modulatory mechanisms. We investigated the activation of the nucleus accumbens (NAcc), a crucial region involved in reward processing, with functional magnetic resonance imaging using the desire-reason-dilemma paradigm. This task allows tracking the activity of the NAcc during the acceptance or the rejection of previously conditioned reward stimuli. Patients were assigned into subgroups of lower (LA) or higher (HA) NAcc activation according to beta weights. LA patients presented significant hypoactivation in the ventral tegmental area in addition to bilateral ventral striatum, confirming impairments in the bottom-up input to the NAcc. Conversely, HA patients presented significant hyperactivation in prefrontal areas such as the rostral anterior cingulate cortex and the anterior ventral prefrontal cortex in addition to bilateral ventral striatum, suggesting disturbances in the top-down regulation of the NAcc. Demographic and clinical differences explaining the abnormal co-activations of midbrain and prefrontal regions were not identified. Therefore, we provide evidence for dysfunctional bottom-up processing in one potential neurobiological subtype of depression (LA) and dysfunctional top-down modulation in another subtype (HA). We suggest that the midbrain and prefrontal regions are more specific pathophysiological substrates for each depression subtype. Above all, our results encourage the segregation of patients by similar dysfunctional mechanisms of the dopaminergic system, which would finally contribute to disentangle more specific pathogeneses and guide the development of more personalized targets for future therapies."],["dc.identifier.doi","10.1007/s00406-014-0552-2"],["dc.identifier.gro","3150742"],["dc.identifier.pmid","25327829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7532"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0940-1334"],["dc.title","Dissociating pathomechanisms of depression with fMRI: bottom-up or top-down dysfunctions of the reward system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1703"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","1714"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Kipshagen, Hanne E."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:00:05Z"],["dc.date.available","2018-11-07T09:00:05Z"],["dc.date.issued","2011"],["dc.description.abstract","Expectancies strongly shape our perception of the world and preconceptions about stimulus characteristics can even bias the sensory system for illusory percepts. Here we assessed with functional magnetic resonance imaging how anticipatory mental imagery of a mildly fearful face created a predictive bias that proactively altered perception of highly fearful faces and generated the \"illusion\" of reduced fearfulness. We found that anticipatory activation of the fusiform gyrus (FG) was modulated by the fearfulness of the imagined face. Further during anticipatory imagery, regulatory influences from the lateral and ventromedial prefrontal cortex on the FG primed the perceptual system for a subsequent misperception. This was achieved by increasing perceptual activation in higher-order brain regions for the evaluation of affective valence and contextual framing, while at the same time restricting bottom-up arousal and attention to fearful expressions. Anticipatory mental imagery may thus represent an effective antecedent strategy through which emotional perception can be significantly altered. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Foundation (DFG) [1107, Gr 1950/2-3]"],["dc.identifier.doi","10.1016/j.neuroimage.2010.08.034"],["dc.identifier.isi","000285486000095"],["dc.identifier.pmid","20797441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","The power of imagination - How anticipatory mental imagery alters perceptual processing of fearful facial expressions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1923"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Lewandowski, Mirjana"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:38:30Z"],["dc.date.available","2018-11-07T09:38:30Z"],["dc.date.issued","2014"],["dc.description.abstract","Bipolar disorder (BD) is characterized by recurrent mood episodes ranging from severe depression to acute full-blown mania. Both states of this severe psychiatric disorder have been associated with alterations of reward processing in the brain. Here, we present results of a functional magnetic resonance imaging (fMRI) study on the neural correlates and functional interactions underlying reward gain processing and reward dismissal in favor of a long-term goal in bipolar patients. Sixteen medicated patients diagnosed with bipolar 1 disorder, euthymic to mildly depressed, and sixteen matched healthy controls performed the 'desire-reason dilemma' (DRD) paradigm demanding rejection of priorly conditioned reward stimuli to successfully pursue a superordinate goal. Both groups exhibited significant activations in reward-related brain regions, particularly in the mesolimbic reward system. However, bipolar patients showed reduced neural responses of the ventral striatum (vStr) when exploiting a reward stimulus, and exhibited a decreased suppression of the reward-related activation of the mesolimbic reward system while having to reject immediate reward in favor of the long-term goal. Further, functional interaction between the anteroventral prefrontal cortex and the vStr in the 'DRD' was significantly impaired in the bipolar group. These findings provide evidence for a reduced responsivity of the vStr to reward stimuli in BD, possibly related to clinical features like anhedonia. The disturbed top-down control of mesolimbic reward signals by prefrontal brain regions in BD can be interpreted in terms of a disease-related enhanced impulsivity, a trait marker of BD."],["dc.identifier.doi","10.1038/npp.2014.39"],["dc.identifier.isi","000337550600013"],["dc.identifier.pmid","24535101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33078"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1740-634X"],["dc.relation.issn","0893-133X"],["dc.title","Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2768"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","2784"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Nerenberg, Lesly"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:02:55Z"],["dc.date.available","2018-11-07T09:02:55Z"],["dc.date.issued","2012"],["dc.description.abstract","The ability to resist immediate rewards is crucial for lifetime success and individual well-being. Using functional magnetic resonance imaging, we assessed the association between trait impulsivity and the neural underpinnings of the ability to control immediate reward desiring. Low and high extreme impulsivity groups were compared with regard to their behavioral performance and brain activation in situations, in which they had to forego immediate rewards with varying value to achieve a superordinate long-term goal. We found that highly impulsive (HI) individuals, who successfully compensated for their lack in behavioral self-control, engaged two complementary brain mechanisms when choosing actions in favor of a long-term goal, but at the expense of an immediate reward. First, self-controlled decisions led to a general attenuation of reward-related activation in the nucleus accumbens, which was accompanied by an increased inverse connectivity with the anteroventral prefrontal cortex. Second, HI subjects controlled their desire for increasingly valuable, but suboptimal rewards through a linear reduction of activation in the ventromedial prefrontal cortex (VMPFC). This was achieved by an increased inverse coupling between the VMPFC and the ventral striatum. Importantly, the neural mechanisms observed in the HI group differed from those in extremely controlled individuals, despite similar behavioral performance. Collectively, these results suggest trait-specific neural mechanisms that allow HI individuals to control their desire for immediate reward. Hum Brain Mapp 33:2768-2784, 2012. (c) 2011 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.21398"],["dc.identifier.isi","000310798800002"],["dc.identifier.pmid","21938756"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24787"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Impulsive personality and the ability to resist immediate reward: An fMRI study examining interindividual differences in the neural mechanisms underlying self-control"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Diekhof, E."],["dc.date.accessioned","2018-11-07T08:52:01Z"],["dc.date.available","2018-11-07T08:52:01Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292556"],["dc.identifier.isi","000296086300140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","The influence of satiety on decision-making and functional interaction of neuronal systems: A task to access self-control in obese subjects."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Weber, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Melcher, T."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:52:00Z"],["dc.date.available","2018-11-07T08:52:00Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292483"],["dc.identifier.isi","000296086300067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22064"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Multi-functional MRI studies of disordered brain circuits in schizophrenic and affective psychoses"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","1473"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:05:53Z"],["dc.date.available","2018-11-07T09:05:53Z"],["dc.date.issued","2012"],["dc.description.abstract","There is ample evidence of gender differences in neural processes and behavior. Differences in reward-related behaviors have been linked to either temporary or permanent organizational influences of gonadal hormones on the mesolimbic dopamine system and reward-related activation. Still, little is known about the association between biological gender and the neural underpinnings of the ability to resist reward-related impulses. Here we assessed with functional magnetic resonance imaging which neural processes enable men and women to successfully control their desire for immediate reward when this is required by a higher-order goal (i.e., during a 'desire-reason dilemma'; Dielchof and Gruber, 2010). Thirty-two participants (16 females) were closely matched for age, personality characteristics (e.g., novelty seeking) and behavioral performance in the 'desire-reason task'. On the neural level, men and women showed similarities in the general response of the nucleus accumbens and of the ventral tegmental area to predictors of immediate reward, but they differed in additional brain mechanisms that enabled self-controlled decisions against the preference for immediate reward. Firstly, men exhibited a stronger reduction of activation in the ventral pallidum, putamen, temporal pole and pregenual anterior cingulate cortex during the 'desire-reason dilemma'. Secondly, connectivity analyses revealed a significant change in the direction of the connectivity between anteroventral prefrontal cortex and nucleus accumbens during decisions counteracting the reward-related impulse when comparing men and women. Together, these findings support the view of a sexual dimorphism that manifested in the recruitment of gender-specific neural resources during the successful deployment of self-control. (c) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2012.07.010"],["dc.identifier.isi","000309145100008"],["dc.identifier.pmid","22814146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2679"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","2687"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Mohr, Holger"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Kraemer, Bernd"],["dc.contributor.author","Wolf', Claudia"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Binder, Elisabeth B."],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:08:12Z"],["dc.date.available","2018-11-07T10:08:12Z"],["dc.date.issued","2016"],["dc.description.abstract","Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like I) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipolar disorder and schizophrenia, are linked to functional alterations in the reward system. We aimed at investigating possible effects of the MAD1L1 rs11764590 risk allele on reward systems functioning in healthy adults. A large homogenous sample of 224 young (aged 18-31 years) participants was genotyped and underwent functional magnetic resonance imaging (fMR1). All participants performed the 'Desire-Reason Dilemma' paradigm investigating the neural correlates that underlie reward processing and active reward dismissal in favor of a long-term goal. We found significant hypoactivations of the ventral tegmental area (VTA), the bilateral striatum and bilateral frontal and parietal cortices in response to conditioned reward stimuli in the risk allele carriers compared with major allele carriers. In the dilemma situation, functional connectivity between prefrontal brain regions and the ventral striatum was significantly diminished in the risk allele carriers. Healthy risk allele carriers showed a significant deficit of their bottom-up response to conditioned reward stimuli in the bilateral VTA and striatum. Furthermore, functional connectivity between the ventral striatum and prefrontal areas exerting top-down control on the mesolimbic reward system was reduced in this group. Similar alterations in reward processing and disturbances of prefrontal control mechanisms on mesolimbic brain circuits have also been reported in bipolar disorder and schizophrenia. Together, these findings suggest the existence of an intermediate phenotype associated with MAD1L1."],["dc.description.sponsorship","Servier"],["dc.identifier.doi","10.1038/npp.2016.70"],["dc.identifier.isi","000382901900007"],["dc.identifier.pmid","27184339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39428"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1740-634X"],["dc.relation.issn","0893-133X"],["dc.title","Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Bipolar Disorders"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, E."],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Lewandowski, Mirjana"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Keil, M."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:24:19Z"],["dc.date.available","2018-11-07T09:24:19Z"],["dc.date.issued","2013"],["dc.format.extent","122"],["dc.identifier.isi","000319826800286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29796"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th International Conference on Bipolar Disorder of the International-Society-for-Bipolar-Disorders"],["dc.relation.eventlocation","Miami Beach, FL"],["dc.relation.issn","1398-5647"],["dc.title","Disturbed anterior prefrontal control of the dopaminergic reward system and increased impulsivity in bipolar disorder"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]