Diekhof, Esther Kristina

[["dc.bibliographiccitation.firstpage","3325"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","3331"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:23:43Z"],["dc.date.available","2018-11-07T11:23:43Z"],["dc.date.issued","2009"],["dc.description.abstract","The ability to quickly decide on the nature of unexpected environmental changes is vital for adaptive behavior. Converging evidence suggests that the orbitofrontal cortex plays an important role in the rapid assignment of motivational significance and goal relevance to environmental stimuli. However, its putative role as a central part of a network involved in the prioritization of attentional selection, particulary when significant environmental changes Occur unexpectedly or outside of attentional focus, remains to be established. Therefore, we used functional magnetic resonance imaging with a subsequent psychophysiological interaction analysis to reveal the functional connectivity of the right posterior orbitofrontal cortex (pOFC) in a context, in which subjects had to adjust goal-directed behavior to behaviorally relevant events presented outside of the current attentional focus. As expected, an increased functional interaction between pOFC and regions involved in the modulation of selective attention (pulvinar nucleus and inferior parietal lobule) and processing of \"bottom-up\" salience (substantia nigra) could be observed when unattended, but significant changes were relevant for behavior. Moreover, a positive correlation between level of accuracy and an increased functional connectivity between pOFC and extrastriate cortex Suggested that a motivationally-triggered signal from pOFC may have increased visual processing of the relevant but currently unattended stimulus attribute. These data provide evidence that the interplay between the pOFC and these regions underlies a mechanism by which organisms rapidly achieve voluntary control of attentional resources to deal with behaviorally significant changes that occur outside of current attentional focus. Hum Brain Mapp 30:3325-3331, 2009. (C) 2009 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/hbm.20754"],["dc.identifier.isi","000270853700020"],["dc.identifier.pmid","19288466"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Functional Interactions Guiding Adaptive Processing of Behavioral Significance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Fanelli, A."],["dc.contributor.author","Jakob, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Weber, K."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T09:10:04Z"],["dc.date.available","2018-11-07T09:10:04Z"],["dc.date.issued","2012"],["dc.format.extent","214"],["dc.identifier.isi","000209062500785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26410"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","1469-5111"],["dc.relation.issn","1461-1457"],["dc.title","Imaging endophenotypic biomarkers for schizophrenic and affective psychoses in key neural circuits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1703"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","1714"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Kipshagen, Hanne E."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:00:05Z"],["dc.date.available","2018-11-07T09:00:05Z"],["dc.date.issued","2011"],["dc.description.abstract","Expectancies strongly shape our perception of the world and preconceptions about stimulus characteristics can even bias the sensory system for illusory percepts. Here we assessed with functional magnetic resonance imaging how anticipatory mental imagery of a mildly fearful face created a predictive bias that proactively altered perception of highly fearful faces and generated the \"illusion\" of reduced fearfulness. We found that anticipatory activation of the fusiform gyrus (FG) was modulated by the fearfulness of the imagined face. Further during anticipatory imagery, regulatory influences from the lateral and ventromedial prefrontal cortex on the FG primed the perceptual system for a subsequent misperception. This was achieved by increasing perceptual activation in higher-order brain regions for the evaluation of affective valence and contextual framing, while at the same time restricting bottom-up arousal and attention to fearful expressions. Anticipatory mental imagery may thus represent an effective antecedent strategy through which emotional perception can be significantly altered. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Foundation (DFG) [1107, Gr 1950/2-3]"],["dc.identifier.doi","10.1016/j.neuroimage.2010.08.034"],["dc.identifier.isi","000285486000095"],["dc.identifier.pmid","20797441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","The power of imagination - How anticipatory mental imagery alters perceptual processing of fearful facial expressions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1923"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Lewandowski, Mirjana"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:38:30Z"],["dc.date.available","2018-11-07T09:38:30Z"],["dc.date.issued","2014"],["dc.description.abstract","Bipolar disorder (BD) is characterized by recurrent mood episodes ranging from severe depression to acute full-blown mania. Both states of this severe psychiatric disorder have been associated with alterations of reward processing in the brain. Here, we present results of a functional magnetic resonance imaging (fMRI) study on the neural correlates and functional interactions underlying reward gain processing and reward dismissal in favor of a long-term goal in bipolar patients. Sixteen medicated patients diagnosed with bipolar 1 disorder, euthymic to mildly depressed, and sixteen matched healthy controls performed the 'desire-reason dilemma' (DRD) paradigm demanding rejection of priorly conditioned reward stimuli to successfully pursue a superordinate goal. Both groups exhibited significant activations in reward-related brain regions, particularly in the mesolimbic reward system. However, bipolar patients showed reduced neural responses of the ventral striatum (vStr) when exploiting a reward stimulus, and exhibited a decreased suppression of the reward-related activation of the mesolimbic reward system while having to reject immediate reward in favor of the long-term goal. Further, functional interaction between the anteroventral prefrontal cortex and the vStr in the 'DRD' was significantly impaired in the bipolar group. These findings provide evidence for a reduced responsivity of the vStr to reward stimuli in BD, possibly related to clinical features like anhedonia. The disturbed top-down control of mesolimbic reward signals by prefrontal brain regions in BD can be interpreted in terms of a disease-related enhanced impulsivity, a trait marker of BD."],["dc.identifier.doi","10.1038/npp.2014.39"],["dc.identifier.isi","000337550600013"],["dc.identifier.pmid","24535101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33078"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1740-634X"],["dc.relation.issn","0893-133X"],["dc.title","Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2768"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","2784"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Nerenberg, Lesly"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:02:55Z"],["dc.date.available","2018-11-07T09:02:55Z"],["dc.date.issued","2012"],["dc.description.abstract","The ability to resist immediate rewards is crucial for lifetime success and individual well-being. Using functional magnetic resonance imaging, we assessed the association between trait impulsivity and the neural underpinnings of the ability to control immediate reward desiring. Low and high extreme impulsivity groups were compared with regard to their behavioral performance and brain activation in situations, in which they had to forego immediate rewards with varying value to achieve a superordinate long-term goal. We found that highly impulsive (HI) individuals, who successfully compensated for their lack in behavioral self-control, engaged two complementary brain mechanisms when choosing actions in favor of a long-term goal, but at the expense of an immediate reward. First, self-controlled decisions led to a general attenuation of reward-related activation in the nucleus accumbens, which was accompanied by an increased inverse connectivity with the anteroventral prefrontal cortex. Second, HI subjects controlled their desire for increasingly valuable, but suboptimal rewards through a linear reduction of activation in the ventromedial prefrontal cortex (VMPFC). This was achieved by an increased inverse coupling between the VMPFC and the ventral striatum. Importantly, the neural mechanisms observed in the HI group differed from those in extremely controlled individuals, despite similar behavioral performance. Collectively, these results suggest trait-specific neural mechanisms that allow HI individuals to control their desire for immediate reward. Hum Brain Mapp 33:2768-2784, 2012. (c) 2011 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.21398"],["dc.identifier.isi","000310798800002"],["dc.identifier.pmid","21938756"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24787"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Impulsive personality and the ability to resist immediate reward: An fMRI study examining interindividual differences in the neural mechanisms underlying self-control"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","559"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain and Cognition"],["dc.bibliographiccitation.lastpage","564"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Melcher, Tobias"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Karch, Susanne"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Goschke, Thomas"],["dc.date.accessioned","2018-11-07T08:30:55Z"],["dc.date.available","2018-11-07T08:30:55Z"],["dc.date.issued","2009"],["dc.description.abstract","Background monitoring is a necessary prerequisite to detect unexpected changes in the environment, while being involved in a primary task. Here, we used fMRI to investigate the neural mechanisms that underlie adaptive goal-directed behavior in a cued task switching paradigm during real response conflict or, more generally, when expectations on the repetitive features of the environment were violated. Unexpected changes in sensory stimulus attributes in the currently unattended stimulus dimension thereby led to activations in a bilateral network comprising inferior lateral frontal, intraparietal, and posterior medial frontal brain regions, independent of whether these attributes elicited a factual response conflict or not. This fronto-parietal network may thus play an important role in adaptive responding to potentially significant events outside the current focus of attention. (C) 2008 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Council (DFG) [Gr 1950/1-1, Gr 1950/1-3, Go 720/3-1]"],["dc.identifier.doi","10.1016/j.bandc.2008.11.008"],["dc.identifier.isi","000264220800014"],["dc.identifier.pmid","19135767"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17003"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0278-2626"],["dc.title","Brain mechanisms associated with background monitoring of the environment for potentially significant sensory events"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","174"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T11:17:39Z"],["dc.date.available","2018-11-07T11:17:39Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1055/s-2007-980145"],["dc.identifier.isi","000254238600009"],["dc.identifier.pmid","18311694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54857"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0720-4299"],["dc.title","Functional organisation of frontal cortex - Part 2: Relevance for neuropsychiatric disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Diekhof, E."],["dc.date.accessioned","2018-11-07T08:52:01Z"],["dc.date.available","2018-11-07T08:52:01Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292556"],["dc.identifier.isi","000296086300140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","The influence of satiety on decision-making and functional interaction of neuronal systems: A task to access self-control in obese subjects."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Weber, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Melcher, T."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:52:00Z"],["dc.date.available","2018-11-07T08:52:00Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1055/s-0031-1292483"],["dc.identifier.isi","000296086300067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22064"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","27th Symposium of the AGNP"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Multi-functional MRI studies of disordered brain circuits in schizophrenic and affective psychoses"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","1473"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Obst, Katrin U."],["dc.contributor.author","Henseler, Ilona"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:05:53Z"],["dc.date.available","2018-11-07T09:05:53Z"],["dc.date.issued","2012"],["dc.description.abstract","There is ample evidence of gender differences in neural processes and behavior. Differences in reward-related behaviors have been linked to either temporary or permanent organizational influences of gonadal hormones on the mesolimbic dopamine system and reward-related activation. Still, little is known about the association between biological gender and the neural underpinnings of the ability to resist reward-related impulses. Here we assessed with functional magnetic resonance imaging which neural processes enable men and women to successfully control their desire for immediate reward when this is required by a higher-order goal (i.e., during a 'desire-reason dilemma'; Dielchof and Gruber, 2010). Thirty-two participants (16 females) were closely matched for age, personality characteristics (e.g., novelty seeking) and behavioral performance in the 'desire-reason task'. On the neural level, men and women showed similarities in the general response of the nucleus accumbens and of the ventral tegmental area to predictors of immediate reward, but they differed in additional brain mechanisms that enabled self-controlled decisions against the preference for immediate reward. Firstly, men exhibited a stronger reduction of activation in the ventral pallidum, putamen, temporal pole and pregenual anterior cingulate cortex during the 'desire-reason dilemma'. Secondly, connectivity analyses revealed a significant change in the direction of the connectivity between anteroventral prefrontal cortex and nucleus accumbens during decisions counteracting the reward-related impulse when comparing men and women. Together, these findings support the view of a sexual dimorphism that manifested in the recruitment of gender-specific neural resources during the successful deployment of self-control. (c) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2012.07.010"],["dc.identifier.isi","000309145100008"],["dc.identifier.pmid","22814146"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","A functional neuroimaging study assessing gender differences in the neural mechanisms underlying the ability to resist impulsive desires"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]