Diekhof, Esther Kristina

[["dc.bibliographiccitation.firstpage","3325"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","3331"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T11:23:43Z"],["dc.date.available","2018-11-07T11:23:43Z"],["dc.date.issued","2009"],["dc.description.abstract","The ability to quickly decide on the nature of unexpected environmental changes is vital for adaptive behavior. Converging evidence suggests that the orbitofrontal cortex plays an important role in the rapid assignment of motivational significance and goal relevance to environmental stimuli. However, its putative role as a central part of a network involved in the prioritization of attentional selection, particulary when significant environmental changes Occur unexpectedly or outside of attentional focus, remains to be established. Therefore, we used functional magnetic resonance imaging with a subsequent psychophysiological interaction analysis to reveal the functional connectivity of the right posterior orbitofrontal cortex (pOFC) in a context, in which subjects had to adjust goal-directed behavior to behaviorally relevant events presented outside of the current attentional focus. As expected, an increased functional interaction between pOFC and regions involved in the modulation of selective attention (pulvinar nucleus and inferior parietal lobule) and processing of \"bottom-up\" salience (substantia nigra) could be observed when unattended, but significant changes were relevant for behavior. Moreover, a positive correlation between level of accuracy and an increased functional connectivity between pOFC and extrastriate cortex Suggested that a motivationally-triggered signal from pOFC may have increased visual processing of the relevant but currently unattended stimulus attribute. These data provide evidence that the interplay between the pOFC and these regions underlies a mechanism by which organisms rapidly achieve voluntary control of attentional resources to deal with behaviorally significant changes that occur outside of current attentional focus. Hum Brain Mapp 30:3325-3331, 2009. (C) 2009 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/hbm.20754"],["dc.identifier.isi","000270853700020"],["dc.identifier.pmid","19288466"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Functional Interactions Guiding Adaptive Processing of Behavioral Significance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Weber, Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Depression is a debilitating psychiatric disorder characterized among other aspects by the inability to properly experience or respond to reward. However, it remains unclear whether patients with depression present impaired reward system due to abnormal modulatory mechanisms. We investigated the activation of the nucleus accumbens (NAcc), a crucial region involved in reward processing, with functional magnetic resonance imaging using the desire-reason-dilemma paradigm. This task allows tracking the activity of the NAcc during the acceptance or the rejection of previously conditioned reward stimuli. Patients were assigned into subgroups of lower (LA) or higher (HA) NAcc activation according to beta weights. LA patients presented significant hypoactivation in the ventral tegmental area in addition to bilateral ventral striatum, confirming impairments in the bottom-up input to the NAcc. Conversely, HA patients presented significant hyperactivation in prefrontal areas such as the rostral anterior cingulate cortex and the anterior ventral prefrontal cortex in addition to bilateral ventral striatum, suggesting disturbances in the top-down regulation of the NAcc. Demographic and clinical differences explaining the abnormal co-activations of midbrain and prefrontal regions were not identified. Therefore, we provide evidence for dysfunctional bottom-up processing in one potential neurobiological subtype of depression (LA) and dysfunctional top-down modulation in another subtype (HA). We suggest that the midbrain and prefrontal regions are more specific pathophysiological substrates for each depression subtype. Above all, our results encourage the segregation of patients by similar dysfunctional mechanisms of the dopaminergic system, which would finally contribute to disentangle more specific pathogeneses and guide the development of more personalized targets for future therapies."],["dc.identifier.doi","10.1007/s00406-014-0552-2"],["dc.identifier.gro","3150742"],["dc.identifier.pmid","25327829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7532"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0940-1334"],["dc.title","Dissociating pathomechanisms of depression with fMRI: bottom-up or top-down dysfunctions of the reward system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.date.accessioned","2018-11-07T11:25:23Z"],["dc.date.available","2018-11-07T11:25:23Z"],["dc.date.issued","2009"],["dc.format.extent","220"],["dc.identifier.isi","000270507200060"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56609"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","26th Symposium of the Association-of-Neuropsychopharmacology-and-Pharmacopsychiatry (AGNP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","When desire collides with reason: functional interactions between anteroventral prefrontal cortex and nucleus accumbens underlie the human ability to resist impulsive desires"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Fanelli, A."],["dc.contributor.author","Jakob, K."],["dc.contributor.author","Petrovic, A."],["dc.contributor.author","Weber, K."],["dc.contributor.author","Keil, M."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T09:10:04Z"],["dc.date.available","2018-11-07T09:10:04Z"],["dc.date.issued","2012"],["dc.format.extent","214"],["dc.identifier.isi","000209062500785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26410"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","1469-5111"],["dc.relation.issn","1461-1457"],["dc.title","Imaging endophenotypic biomarkers for schizophrenic and affective psychoses in key neural circuits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1703"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","1714"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Kipshagen, Hanne E."],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:00:05Z"],["dc.date.available","2018-11-07T09:00:05Z"],["dc.date.issued","2011"],["dc.description.abstract","Expectancies strongly shape our perception of the world and preconceptions about stimulus characteristics can even bias the sensory system for illusory percepts. Here we assessed with functional magnetic resonance imaging how anticipatory mental imagery of a mildly fearful face created a predictive bias that proactively altered perception of highly fearful faces and generated the \"illusion\" of reduced fearfulness. We found that anticipatory activation of the fusiform gyrus (FG) was modulated by the fearfulness of the imagined face. Further during anticipatory imagery, regulatory influences from the lateral and ventromedial prefrontal cortex on the FG primed the perceptual system for a subsequent misperception. This was achieved by increasing perceptual activation in higher-order brain regions for the evaluation of affective valence and contextual framing, while at the same time restricting bottom-up arousal and attention to fearful expressions. Anticipatory mental imagery may thus represent an effective antecedent strategy through which emotional perception can be significantly altered. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Foundation (DFG) [1107, Gr 1950/2-3]"],["dc.identifier.doi","10.1016/j.neuroimage.2010.08.034"],["dc.identifier.isi","000285486000095"],["dc.identifier.pmid","20797441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24067"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","The power of imagination - How anticipatory mental imagery alters perceptual processing of fearful facial expressions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","1923"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Zvonik, Kerstin"],["dc.contributor.author","Lewandowski, Mirjana"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:38:30Z"],["dc.date.available","2018-11-07T09:38:30Z"],["dc.date.issued","2014"],["dc.description.abstract","Bipolar disorder (BD) is characterized by recurrent mood episodes ranging from severe depression to acute full-blown mania. Both states of this severe psychiatric disorder have been associated with alterations of reward processing in the brain. Here, we present results of a functional magnetic resonance imaging (fMRI) study on the neural correlates and functional interactions underlying reward gain processing and reward dismissal in favor of a long-term goal in bipolar patients. Sixteen medicated patients diagnosed with bipolar 1 disorder, euthymic to mildly depressed, and sixteen matched healthy controls performed the 'desire-reason dilemma' (DRD) paradigm demanding rejection of priorly conditioned reward stimuli to successfully pursue a superordinate goal. Both groups exhibited significant activations in reward-related brain regions, particularly in the mesolimbic reward system. However, bipolar patients showed reduced neural responses of the ventral striatum (vStr) when exploiting a reward stimulus, and exhibited a decreased suppression of the reward-related activation of the mesolimbic reward system while having to reject immediate reward in favor of the long-term goal. Further, functional interaction between the anteroventral prefrontal cortex and the vStr in the 'DRD' was significantly impaired in the bipolar group. These findings provide evidence for a reduced responsivity of the vStr to reward stimuli in BD, possibly related to clinical features like anhedonia. The disturbed top-down control of mesolimbic reward signals by prefrontal brain regions in BD can be interpreted in terms of a disease-related enhanced impulsivity, a trait marker of BD."],["dc.identifier.doi","10.1038/npp.2014.39"],["dc.identifier.isi","000337550600013"],["dc.identifier.pmid","24535101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33078"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1740-634X"],["dc.relation.issn","0893-133X"],["dc.title","Disturbed Anterior Prefrontal Control of the Mesolimbic Reward System and Increased Impulsivity in Bipolar Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2768"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","2784"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Nerenberg, Lesly"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:02:55Z"],["dc.date.available","2018-11-07T09:02:55Z"],["dc.date.issued","2012"],["dc.description.abstract","The ability to resist immediate rewards is crucial for lifetime success and individual well-being. Using functional magnetic resonance imaging, we assessed the association between trait impulsivity and the neural underpinnings of the ability to control immediate reward desiring. Low and high extreme impulsivity groups were compared with regard to their behavioral performance and brain activation in situations, in which they had to forego immediate rewards with varying value to achieve a superordinate long-term goal. We found that highly impulsive (HI) individuals, who successfully compensated for their lack in behavioral self-control, engaged two complementary brain mechanisms when choosing actions in favor of a long-term goal, but at the expense of an immediate reward. First, self-controlled decisions led to a general attenuation of reward-related activation in the nucleus accumbens, which was accompanied by an increased inverse connectivity with the anteroventral prefrontal cortex. Second, HI subjects controlled their desire for increasingly valuable, but suboptimal rewards through a linear reduction of activation in the ventromedial prefrontal cortex (VMPFC). This was achieved by an increased inverse coupling between the VMPFC and the ventral striatum. Importantly, the neural mechanisms observed in the HI group differed from those in extremely controlled individuals, despite similar behavioral performance. Collectively, these results suggest trait-specific neural mechanisms that allow HI individuals to control their desire for immediate reward. Hum Brain Mapp 33:2768-2784, 2012. (c) 2011 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.21398"],["dc.identifier.isi","000310798800002"],["dc.identifier.pmid","21938756"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24787"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1065-9471"],["dc.title","Impulsive personality and the ability to resist immediate reward: An fMRI study examining interindividual differences in the neural mechanisms underlying self-control"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Bipolar Disorders"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Lewandowski, Mirjana"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.date.accessioned","2018-11-07T08:28:57Z"],["dc.date.available","2018-11-07T08:28:57Z"],["dc.date.issued","2009"],["dc.format.extent","46"],["dc.identifier.isi","000268963500123"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16539"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","8th International Conference on Bipolar Disorder"],["dc.relation.eventlocation","Pittsburgh, PA"],["dc.relation.issn","1398-5647"],["dc.title","Hyper- or hyporesponsivity of prefrontal cortices in bipolar affective disorder? - A meta-analysis using activation likelihood estimation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","559"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain and Cognition"],["dc.bibliographiccitation.lastpage","564"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Melcher, Tobias"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Karch, Susanne"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Goschke, Thomas"],["dc.date.accessioned","2018-11-07T08:30:55Z"],["dc.date.available","2018-11-07T08:30:55Z"],["dc.date.issued","2009"],["dc.description.abstract","Background monitoring is a necessary prerequisite to detect unexpected changes in the environment, while being involved in a primary task. Here, we used fMRI to investigate the neural mechanisms that underlie adaptive goal-directed behavior in a cued task switching paradigm during real response conflict or, more generally, when expectations on the repetitive features of the environment were violated. Unexpected changes in sensory stimulus attributes in the currently unattended stimulus dimension thereby led to activations in a bilateral network comprising inferior lateral frontal, intraparietal, and posterior medial frontal brain regions, independent of whether these attributes elicited a factual response conflict or not. This fronto-parietal network may thus play an important role in adaptive responding to potentially significant events outside the current focus of attention. (C) 2008 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","German Research Council (DFG) [Gr 1950/1-1, Gr 1950/1-3, Go 720/3-1]"],["dc.identifier.doi","10.1016/j.bandc.2008.11.008"],["dc.identifier.isi","000264220800014"],["dc.identifier.pmid","19135767"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17003"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0278-2626"],["dc.title","Brain mechanisms associated with background monitoring of the environment for potentially significant sensory events"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","174"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Fortschritte der Neurologie · Psychiatrie"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Diekhof, Esther Kristina"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T11:17:39Z"],["dc.date.available","2018-11-07T11:17:39Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1055/s-2007-980145"],["dc.identifier.isi","000254238600009"],["dc.identifier.pmid","18311694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54857"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0720-4299"],["dc.title","Functional organisation of frontal cortex - Part 2: Relevance for neuropsychiatric disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]