Now showing 1 - 3 of 3
  • 2012Conference Abstract
    [["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Schmidt, P."],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, U."],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2012"],["dc.format.extent","143"],["dc.identifier.isi","000305069800445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26326"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Karyotypic and phenotypic plasticity of the Candida glabrata strain CBS138/ATCC2001"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2012Journal Article
    [["dc.bibliographiccitation.artnumber","e52218"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanchuleeporn, Marut"],["dc.contributor.author","Schmidt, Pia"],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:02:13Z"],["dc.date.available","2018-11-07T09:02:13Z"],["dc.date.issued","2012"],["dc.description.abstract","Genomic plasticity is a mechanism for adaptation to environmental cues such as host responses and antifungal drug pressure in many fungi including the human pathogenic yeast Candida glabrata. In this study we evaluated the phenotypic and genotypic stability of the world-wide used C. glabrata reference strain CBS138/ ATCC2001 under laboratory conditions. A set of ten lineages of this wild type strain and genetically modified progenies were obtained from different scientific laboratories, and analyzed for genotypic and phenotypic alterations. Even though the derivates were indistinguishable by multi locus sequence typing, different phenotypic groups that correlated with specific karyotypic changes were observed. In addition, modifications in the adherence capacity to plastic surface emerged that were shown to correlate with quantitative changes in adhesin gene expression rather than subtelomeric gene loss or differences in the number of macrosatellite repeats within adhesin genes. These results confirm the genomic plasticity of C. glabrata and show that chromosomal aberrations and functional adaptations may occur not only during infection and under antimicrobial therapy, but also under laboratory conditions without extreme selective pressures. These alterations can significantly affect phenotypic properties such as cell surface attributes including adhesion and the cell wall carbohydrate composition and therefore, if unnoticed, may adulterate the outcome of genetic studies."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1371/journal.pone.0052218"],["dc.identifier.isi","000312794500117"],["dc.identifier.pmid","23284942"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24630"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Gross Karyotypic and Phenotypic Alterations among Different Progenies of the Candida glabrata CBS138/ATCC2001 Reference Strain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2013Conference Abstract
    [["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","303"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Schwarzmueller, T."],["dc.contributor.author","Kuchler, K."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:20:05Z"],["dc.date.available","2018-11-07T09:20:05Z"],["dc.date.issued","2013"],["dc.format.extent","15"],["dc.identifier.isi","000331497600047"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28793"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","65th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM) e V / Annual Meeting of the German-Society-for-Infectious-Diseases (DGI) e V"],["dc.relation.eventlocation","Univ Rostock, Rostock, GERMANY"],["dc.relation.issn","1618-0607"],["dc.relation.issn","1438-4221"],["dc.title","Studies on the role of the GPI-anchored Ecm33 protein family in Candida glabrata"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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