Bergmann, Ingo

[["dc.bibliographiccitation.artnumber","50"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Janssen, Hauke"],["dc.contributor.author","von Stosch, Roland"],["dc.contributor.author","Poeschl, Rupert"],["dc.contributor.author","Buettner, Benedikt"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Bergmann, Ingo"],["dc.date.accessioned","2018-11-07T09:38:44Z"],["dc.date.available","2018-11-07T09:38:44Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Shoulder surgery is often performed in the beach-chair position, a position associated with arterial hypotension and subsequent risk of cerebral ischaemia. It can be performed under general anaesthesia or with an interscalene brachial plexus block, each of which has specific advantages but also specific negative effects on blood pressure control. It would be worthwhile to combine the advantages of the two, but the effects of the combination on the circulation are not well investigated. We studied blood pressure, heart rate, and incidence of adverse circulatory events in patients undergoing shoulder surgery in general anaesthesia with or without an interscalene block. Methods: Prospective, randomised, blinded study in outpatients (age 18 to 80 years) undergoing shoulder arthroscopy. General anaesthesia was with propofol/opioid, interscalene block with 40 ml 1% mepivacaine. Hypotension requiring treatment was defined as a mean arterial pressure < 60 mmHg or a systolic pressure < 80% of baseline; relevant bradycardia was a heart rate < 50 bpm with a decrease in blood pressure. Results: Forty-two patients had general anaesthesia alone, 41 had general anaesthesia plus interscalene block. The average systolic blood pressure under anaesthesia in the beach-chair position was 114 +/- 7.3 vs. 116 +/- 8.3 mmHg (p = 0.09; all comparisons General vs. General-Regional). The incidence of a mean arterial pressure under 60 mmHg or a decrease in systolic pressure of more than 20% from baseline was 64% vs. 76% (p = 0.45). The number of patients with a heart rate lower than 50 and a concomitant blood pressure decrease was 8 vs. 5 (p = 0.30). Conclusion: One can safely combine interscalene block with general anaesthesia for surgery in the beach-chair position in ASA I and II patients."],["dc.description.sponsorship","departmental funds"],["dc.identifier.doi","10.1186/1471-2253-14-50"],["dc.identifier.isi","000338572300001"],["dc.identifier.pmid","25002832"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10431"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33130"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2253"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Blood pressure response to combined general anaesthesia/interscalene brachial plexus block for outpatient shoulder arthroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","436"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Central European Journal of Medicine"],["dc.bibliographiccitation.lastpage","442"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Heetfeld, Maximilian"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Schafdecker, Hans G."],["dc.contributor.author","Poeschl, Rupert"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, Jose Maria"],["dc.date.accessioned","2018-11-07T09:22:14Z"],["dc.date.available","2018-11-07T09:22:14Z"],["dc.date.issued","2013"],["dc.description.abstract","Outpatient surgery is increasingly being performed on patients with pre-existing cardiovascular and pulmonary disorders. These are relevant for anesthesia because of the inherent risk of hemodynamic instability. This study compared the hemodynamic course in ASA III patients undergoing knee arthroscopy with either peripheral block of the femoral and sciatic nerves or general anesthesia. We searched our patient database for ASA III patients who had undergone knee arthroscopy between 2005 and 2010. This is routinely performed in either regional or general anesthesia, and the patients were stratified according to the anesthetic. Hemodynamic parameters, process times, complications and postoperative pain documented in the charts were evaluated and compared. 130 ASA III outpatients underwent knee arthroscopy during the observation period. Regional anesthesia alone (n=65) was sufficient in 96%. Heart rate was more stable and blood pressure decreased less under regional than under general anesthesia (systolic pressure - 11 +/- 8% versus - 28 +/- 9%; p < 0.001). Patients with general anesthesia (n=65) required more circulatory support. Establishing the nerve block takes longer than inducing general anesthesia, but this was performed ahead of time and thus had no effect on work flow. The groups did not differ with regard to complication rates, and intensity of postoperative pain or satisfaction with the anesthetic. No patient showed evidence of nerve damage or neurological deficits. Peripheral nerve block provides a more stable hemodynamic course than general anesthesia in ASA III patients undergoing knee arthroscopy. (C) Versita Sp. z o.o."],["dc.identifier.doi","10.2478/s11536-012-0143-4"],["dc.identifier.isi","000320283200013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29292"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Versita"],["dc.relation.issn","1644-3640"],["dc.relation.issn","1895-1058"],["dc.title","Peripheral nerve blocks give greater hemodynamic stability than general anesthesia for ASA III patients undergoing outpatient knee arthroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2035"],["dc.bibliographiccitation.issue","45"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Ameen, Abu Hanna"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:49:09Z"],["dc.date.available","2018-11-07T09:49:09Z"],["dc.date.issued","2015"],["dc.description.abstract","Hyperglycemia is common during and after Coronary Artery Bypass Graft Surgery (CABGS) and has been shown to be associated with poor clinical outcomes. In this study, we hypothesized that a moderate perioperative mean blood glucose level of<150mg/dL improves long-term survival in cardiac surgery patients. We conducted a prospective, observational cohort study in the heart center of the University Medical Center of Goettingen, Germany. Patients undergoing on-pump cardiac surgery were enrolled in this investigation. After evaluating perioperative blood glucose levels, patients were classified into 2 groups based on mean glucose levels: Glucose 150mg/dL and Glucose<150mg/dL. Patients were followed up for 5 years, and mortality within this period was recorded as the primary outcome parameter. Secondary outcome parameters included the length of ICU stay, the use of inotropic agents, the length of hospital stay, and the in-hospital mortality. A total of 455 consecutive patients who underwent cardiac surgery with cardiopulmonary bypass were enrolled in this investigation. A Kaplan-Meier survival analysis of the 5-year mortality risk revealed a higher mortality risk among patients with glucose levels 150mg/dL (P=0.0043, log-rank test). After adjustment for confounders in a multivariate Cox regression model, the association between glucose 150mg/dL and 5-year mortality remained significant (hazard ratio, 2.10; 95% CI, 1.30-3.39; P=0.0023). This association was corroborated by propensity score matching, in which Kaplan-Meier survival analysis demonstrated significant improvement in the 5-year survival of patients with glucose levels<150mg/dL (P=0.0339). Similarly, in-hospital mortality was significantly higher in patients with glucose 150mg/dL compared with patients with glucose<150mg/dL. Moreover, patients in the Glucose 150mg/dL group required significantly higher doses of the inotropic agent Dobutamine (mg/d) compared with patients in the Glucose<150mg/dL group (20.6 +/- 62.3 and 10.5 +/- 40.7, respectively; P=0.0104). Moreover, patients in the Glucose 150mg/dL group showed a significantly longer hospital stay compared with patients in the Glucose<150mg/dL group (28 +/- 23 and 24 +/- 19, respectively; P=0.0297). We conclude that perioperative blood glucose levels<150mg/dL are associated with improved 5-year survival in patients undergoing cardiac surgery. More studies are warranted to explain this effect."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1097/MD.0000000000002035"],["dc.identifier.isi","000369537400066"],["dc.identifier.pmid","26559310"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35449"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Perioperative Blood Glucose Levels < 150 mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery A Prospective, Observational Cohort Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0127761"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Liese, Benjamin"],["dc.contributor.author","Steinau, Maximilian"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:57:00Z"],["dc.date.available","2018-11-07T09:57:00Z"],["dc.date.issued","2015"],["dc.description.abstract","According to previous investigations, CD14 is suggested to play a pivotal role in initiating and perpetuating the pro-inflammatory response during sepsis. A functional polymorphism within the CD14 gene, rs2569190, has been shown to impact the pro-inflammatory response upon stimulation with lipopolysaccharide, a central mediator of inflammation in sepsis. In this study, we hypothesized that the strong pro-inflammatory response induced by the TT genotype of CD14 rs2569190 may have a beneficial effect on survival (30-day) in patients with sepsis. A total of 417 adult patients with sepsis (and of western European descent) were enrolled into this observational study. Blood samples were collected for rs2569190 genotyping. Patients were followed over the course of their stay in the ICU, and the 30-day mortality risk was recorded as the primary outcome parameter. Sepsis-related organ failure assessment (SOFA) scores were quantified at sepsis onset and throughout the observational period to monitor organ failure as a secondary variable. Moreover, organ support-free days were evaluated as a secondary outcome parameter. TT-homozygous patients were compared to C-allele carriers. Kaplan-Meier survival analysis revealed a higher 30-day mortality risk among C-allele carriers compared with T homozygotes (p = 0.0261). To exclude the effect of potential confounders (age, gender, BMI and type of infection) and covariates that varied at baseline with a p-value < 0.2 (e.g., comorbidities), we performed multivariate Cox regression analysis to examine the survival time. The CD14 rs2569190 C allele remained a significant covariate for the 30-day mortality risk in the multivariate analysis (hazard ratio, 2.11; 95% CI, 1.08-4.12; p = 0.0282). The 30-day mortality rate among C allele carriers was 23%, whereas the T homozygotes had a mortality rate of 13%. Additionally, an analysis of organ-specific SOFA scores revealed a significantly higher SOFA-Central nervous system score among patients carrying the C allele compared with T-homozygous patients (1.9 +/- 1.1 and 1.6 +/- 1.0, respectively; p = 0.0311). In conclusion, CD14 rs2569190 may act as a prognostic variable for the short-term outcome (30-day survival) in patients with sepsis."],["dc.description.sponsorship","Open Access Publikationsfonds 2015"],["dc.identifier.doi","10.1371/journal.pone.0127761"],["dc.identifier.isi","000355187300054"],["dc.identifier.pmid","26020644"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11869"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37077"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e12958"],["dc.bibliographiccitation.issue","43"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Büttner, Benedikt"],["dc.contributor.author","Dracklé, Joschka"],["dc.contributor.author","Kristof, Katalin"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Schwarz, Alexander"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Bergmann, Ingo"],["dc.date.accessioned","2020-12-10T18:20:05Z"],["dc.date.available","2020-12-10T18:20:05Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/MD.0000000000012958"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15719"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75456"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Paths of femoral nerve catheters placed using ultrasound-guided in plane vs out of plane techniques"],["dc.title.alternative","A randomized controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Crozier, Thomas Allen"],["dc.contributor.author","Roessler, Markus"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Buettner, Benedikt"],["dc.contributor.author","Hinz, Jose Maria"],["dc.contributor.author","Bauer, Martin"],["dc.date.accessioned","2018-11-07T09:45:14Z"],["dc.date.available","2018-11-07T09:45:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: The conventional sequence when using supraglottic airway devices is insertion, cuff inflation and fixation. Our hypothesis was that a tighter fit of the cuff and tip could be achieved with a consequently lower incidence of air leak, better separation of gastrointestinal and respiratory tracts and less airway morbidity if the device were first affixed and the cuff then inflated. Methods: Our clinical review board approved the study (public registry number DRKS00003174). An LMA Supreme r was inserted into 184 patients undergoing lower limb arthroscopy in propofol-remifentanil anaesthesia who were randomly assigned to either the control (inflation then fixation; n = 92) or study group (fixation then inflation; n = 92). The cuff was inflated to 60 cmH2O. The patients' lungs were ventilated in pressure-controlled mode with 5 cmH2O PEEP, Pmax to give 6 ml kg-1 tidal volume, and respiratory rate adjusted to end-tidal CO2 of 4.8 and 5.6 kPa. Correct cuff and tip position were determined by leak detection, capnometry trace, oropharyngeal leak pressure, suprasternal notch test, and lube-tube test. Bowl and cuff position and the presence of glottic narrowing were assessed by fiberscopic examination. Postoperative dysphagia, hoarseness and sore throat were assessed with a questionnaire. Ventilatory impairment was defined as a tidal volume < 6 ml kg-1 with Pmax at oropharyngeal leak pressure, glottic narrowing was defined as an angle between the vocal cords under 16 degrees. Results: The incidence of incorrect device position (18% vs. 21%), failed ventilation (10% vs. 9%), leak pressure (24.8 vs. 25.2 cmH2O, p = 0.63), failed lube-tube test (16.3% vs. 17.6%) and glottic narrowing (19.3% vs. 14.1%, p = 0.35) was similar in both groups (control vs. study, resp.). When glottic narrowing occurred, it was more frequently associated with ventilatory impairment in the control group (77% vs. 39%; p = 0.04). Airway morbidity was more common in the control group (33% vs. 19%; p < 0.05). Conclusions: Altering the sequence of cuff inflation and device fixation does not affect device position, oropharyngeal leak pressures or separation of gastrointestinal and respiratory tracts. It reduces the incidence of glottic narrowing with impaired ventilation and also perioperative airway morbidity."],["dc.identifier.doi","10.1186/1471-2253-14-2"],["dc.identifier.isi","000329575600001"],["dc.identifier.pmid","24387685"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9652"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34569"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2253"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","The effect of changing the sequence of cuff inflation and device fixation with the LMA-Supreme (R) on device position, ventilatory complications, and airway morbidity: a clinical and fiberscopic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Szabanowski, Torsten"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, Jose Maria"],["dc.date.accessioned","2018-11-07T10:02:06Z"],["dc.date.available","2018-11-07T10:02:06Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Even extremely high-doses of the potent opioid, sufentanil, cannot reliably suppress stress responses to intense surgical stimuli such as sternotomy. The chemically related opioid remifentanil with its different pharmacokinetics and binding affinities for delta-and kappa-opioid receptors might be more effective in attenuating these responses. Methods: ASA I-III patients scheduled for a surgical procedure with sternotomy under balanced anesthesia (sevoflurane and sufentanil 3 mu g center dot kg(-1) bolus, 0.017 mu g center dot kg(-1) center dot min(-1) infusion) were randomized into two groups. Patients in the study group were supplemented with remifentanil (2 mu g center dot kg(-1) bolus, 2-7 mu g center dot kg(-1) center dot min(-1) infusion) starting ten minutes before sternotomy. Heart rate, arterial blood pressures, cardiac index, ejection fraction, systemic vascular resistance index (SVRI), total body oxygen uptake (VO2) and electric dermal response were measured and compared between the groups. Results: 62 patients were studied (study group 32, control group 30). Systolic and mean arterial blood pressures, SVRI, VO2 and skin conductance increased during sternotomy and sternal spread in the control group but not in the study group. Systolic blood pressure increase: 7.5 +/- 19 mmHg vs. -3.4 +/- 8.9 (p = 0.005); VO2 increase: 31 +/- 46% vs. -0.4 +/- 32%; incidence of systolic blood pressure increase greater than 15 percent: 20% vs. 3% (p = 0.035) (control vs. study group). Conclusion: High-dose remifentanil added to sevoflurane-sufentanil anesthesia suppresses the sympathoadrenergic response to sternotomy and sternal spread better than high-dose sufentanil alone."],["dc.identifier.doi","10.1186/1471-2253-15-3"],["dc.identifier.isi","000348943000001"],["dc.identifier.pmid","25670917"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38162"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2253"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Remifentanil added to sufentanil-sevoflurane anesthesia suppresses hemodynamic and metabolic stress responses to intense surgical stimuli more effectively than high-dose sufentanil-sevoflurane alone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e6046"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Büttner, Benedikt"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Bergmann, Ingo"],["dc.date.accessioned","2020-12-10T18:20:03Z"],["dc.date.available","2020-12-10T18:20:03Z"],["dc.date.issued","2017"],["dc.description.abstract","Background: Effective methods for postoperative pain relief are an important concern in outpatient surgery. For arthroscopies we combine a single-shot peripheral nerve block using low-volume, low-concentration ropivacaine with general anesthesia. We hypothesized that the patients would have less postoperative pain and be more rapidly home ready than after general anesthesia alone. Methods: Patients (American Society of Anesthesiologists I-III, 18-80 years old) scheduled for outpatient arthroscopy on the upper or lower extremity were randomized to have either a combination of peripheral nerve block and general anesthesia (NB + GA, study group) or general anesthesia alone (GA, control group). The relevant nerve was localized by ultrasound and 10 mL ropivacaine 0.2% was injected. General anesthesia was with propofol and remifentanil. Numeric rating scales were used to assess pain and patient satisfaction in the recovery room, on the evening of surgery, and on the following 2 days. Results: A total of 120 patients participated in the study (NB+ GA: 61; GA: 59). The percentage of patients reporting relevant pain in the recovery room were 0% versus 44% (P<0.001), on the evening after surgery 3% versus 80% (P<0.001), and on days 1 and 2 postsurgery 12% versus 73% and 12% versus 64% (NB+ GA vs GA, respectively). Median time to home discharge was NB+ GA 34.5min (range 15-90) versus GA 55min (20-115) (P<0.001). Conclusions: The combination of a peripheral nerve block with low-dose ropivacaine and general anesthesia reduced postoperative pain compared with general anesthesia alone for several days after outpatient arthroscopy. It also shortened the time to home discharge."],["dc.identifier.doi","10.1097/MD.0000000000006046"],["dc.identifier.isi","000394391200030"],["dc.identifier.issn","0025-7974"],["dc.identifier.pmid","28178149"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14948"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75448"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Combination of general anesthesia and peripheral nerve block with low-dose ropivacaine reduces postoperative pain for several days after outpatient arthroscopy"],["dc.title.subtitle","A randomized controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","10539"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Mulwande, Evelyn"],["dc.contributor.author","Steinau, Maximilian"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:57:04Z"],["dc.date.available","2018-11-07T09:57:04Z"],["dc.date.issued","2015"],["dc.description.abstract","According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 perpendicular to 4.0 and 6.5 perpendicular to 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions."],["dc.description.sponsorship","Open Access Publikationsfonds 2015"],["dc.identifier.doi","10.1038/srep10539"],["dc.identifier.isi","000355509300001"],["dc.identifier.pmid","25995131"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11870"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37088"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","177"],["dc.bibliographiccitation.journal","Journal of Translational Medicine"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","von Gruben, Luisa"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Steinau, Maximilian"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Ross, Daniel"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, José Maria"],["dc.date.accessioned","2018-11-07T09:38:51Z"],["dc.date.available","2018-11-07T09:38:51Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS plays a major role in sepsis pathogenesis. A single nucleotide polymorphism, rs11536889, in the 3'-untranslated region of the TLR4 gene is thought to affect TLR4 translation. This study aimed to investigate whether organ failure in sepsis patients is related to the TLR4 rs11536889 genotype. Methods: Adult Caucasian patients with sepsis from the intensive care unit of a university medical center were followed up for 90 days, and organ failure was recorded as the primary outcome variable. Blood samples were collected at enrollment for TLR4 rs11536889 genotyping. Sepsis-related organ failure assessment (SOFA) scores were quantified at sepsis onset and throughout the observational period to monitor organ failure. Results: A total of 210 critically ill patients with sepsis were enrolled into this study. Wild-type GG was compared to GC/CC. During their stay in the intensive care unit, GG patients presented significantly higher SOFA scores than did C allele carriers (7.9 +/- 4.5 and 6.8 +/- 4.2, respectively; p = 0.0005). Analysis of organ-specific SOFA sub-scores revealed significant differences in three organ systems: renal, coagulation and hepatic (p = 0.0005, p = 0.0245 and p < 0.0001, respectively). Additionally, the rs11536889 polymorphism was associated with a higher incidence of gram-negative infections. Conclusions: These results offer the first evidence that TLR4 rs11536889 is a useful marker of organ failure in patients with sepsis."],["dc.identifier.doi","10.1186/1479-5876-12-177"],["dc.identifier.isi","000339026200001"],["dc.identifier.pmid","24950711"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10433"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33149"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1479-5876"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]