Streit, Frank

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Domke, I."],["dc.contributor.author","Shipkova, Maria"],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Kheradmand, M."],["dc.contributor.author","Luthe, Hilmar"],["dc.contributor.author","Pou, L."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Vukovich, T."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Wieland, Eberhard"],["dc.date.accessioned","2018-11-07T09:44:11Z"],["dc.date.available","2018-11-07T09:44:11Z"],["dc.date.issued","2006"],["dc.format.extent","A61"],["dc.identifier.isi","000237925900188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34335"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","58th Annual Meeting of the American-Association-of-Clinical-Chemistry"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0009-9147"],["dc.title","Cyclosporin determination with different immunoassays in four laboratories using routine patient samples from different transplant types: Performance of automated immunoassays and comparability to tandem mass spectrometry"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Barten, Markus J."],["dc.contributor.author","Shipkova, Maria"],["dc.contributor.author","Bartsch, P."],["dc.contributor.author","Dhein, S."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Tarnok, A."],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Mohr, F. W."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Gummert, J. E."],["dc.date.accessioned","2018-11-07T11:14:21Z"],["dc.date.available","2018-11-07T11:14:21Z"],["dc.date.issued","2005"],["dc.description.abstract","The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = 6 per group) were orally treated with 2.5 or 5 ing/kg of mycophenolate mofetil (MMF), either alone or in combination with 5 mg/kg CsA or 4 mg/kg TRL. Blood was obtained before and at different times after dosing. For both in vitro and in vivo studies, mitogen-stimulated whole blood was analyzed by flow cytometry to determine inhibition of expression of lymphocyte proliferation (proliferating cell nuclear antigen, PCNA) and T-cell activation (eg, CD25). Plasma MPA concentrations were measured by HPLC, and whole-blood CsA and TRL concentrations were quantified using LC-MS/MS. In vitro, low concentrations of 250 and 500 nM MPA acted additively with CsA and overadditively with TRL to suppress lymphocyte function, whereas higher MPA concentrations (1000 nM) in these combinations did not further increase inhibition compared with monotherapy with CsA or TRL alone. In vivo, the MPA AUC(O-24) showed a dose-dependent increase. CsA and TRL AUC(O-24) were not influenced by the MMF dose. Combination therapy increased inhibition of lymphocyte function compared with MMF monotherapy with a pronounced effect on PCNA compared with CD25. Significant differences between 2.5 and 5 mg/kg MMF in the combination groups were observed at 2 or 6 hours after dosing because of the maximal inhibitory effect oil PCNA and CD25 expression (P < 0.05, ANOVA), However, in combination with TRL no different effects on the inhibition of CD25 expression were found between the 2 MMF doses. These novel data indicate that measurement of pharmacodynamic parameters of lymphocyte function in whole blood may help to monitor drug combination therapy and provide a rationale for drug reduction to minimize toxicity without compromising efficacy."],["dc.identifier.doi","10.1097/01.ftd.0000146874.11480.8a"],["dc.identifier.isi","000228115500003"],["dc.identifier.pmid","15795640"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54104"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0163-4356"],["dc.title","Mycophenolic acid interaction with cyclosporine and tacrolimus in vitro and in vivo - Evaluation of additive effects on rat blood lymphocyte function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","955"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.lastpage","958"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T10:27:02Z"],["dc.date.available","2018-11-07T10:27:02Z"],["dc.date.issued","2002"],["dc.identifier.isi","000176035200026"],["dc.identifier.pmid","12029019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43166"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.relation.issn","0009-9147"],["dc.title","Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","438"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.lastpage","443"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wigger, M."],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Shipkova, Maria"],["dc.contributor.author","Wacke, R."],["dc.contributor.author","Nizze, H."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Muscheites, J."],["dc.contributor.author","Glasenapp, S."],["dc.contributor.author","Stolpe, H. J."],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T10:29:47Z"],["dc.date.available","2018-11-07T10:29:47Z"],["dc.date.issued","2002"],["dc.description.abstract","A juvenile, female renal transplant recipient suffered two acute rejection episodes: the first on posttransplant day 31 while taking cyclosporine, prednisone, and mycophenolate mofetil (MMF); and the second on posttransplant clay 67, when she was taking tacrolimus, prednisone, and MMF. Dosage of MMF was initially started at 2 g/d (corresponding to 600 mg MMF/m(2) twice daily) but was reduced to 250 mg/d to 500 mg/d after severe diarrhea and a paralytic ileus on posttransplant day 16. During therapy with tacrolimus, prednisone, and MMF, predose plasma mycophenolic acid (MPA) concentrations varied from 1.1 mg/L to 8.2 mg/L (median 3.0 mg/L). On posttransplant day 91, a 12-hour pharmacokinetic profile was obtained. The concentrations of MPA and its metabolites were determined with a validated high-performance liquid chromatography (HPLC) procedure. After oral MMIF (250 mg) administration, the MPA concentration showed an atypical decline front a predose concentration of 6.0 mg/L to a value of 3.8 mg/L at 75 minutes postdose, and 3.4 mg/L at 6 hours postdose, before returning to 6.0 mg/L after 12 hours. The 12-hour area under the concentration-time curve (AUC) values for MPA and its major metabolite the phenolic glucuronide MPAG were 55.1 mg.h/L and 800 mg.h/L, respectively. An unusually high concentration (12-h AUC, 165 mg.h/L) of the phenolic glucose conjugate of MPA was found. The apparent renal clearance of MPAG was only 2.2 mL/min. Her creatinine clearance was 30 mL/min. MPAG clearances have been reported to range from approximately. 5.5 m:/min to 35 mL/min at a creatinine clearance of approximately 30 mL/min in renal transplant recipients. The authors' findings suggest that conjugation and clearance of MPA through the kidney is strongly impaired in this patient. The relatively high preclose MPA concentrations could result from an enhanced enterohepatic circulation of MPA and its metabolites."],["dc.identifier.doi","10.1097/00007691-200206000-00019"],["dc.identifier.isi","000175866900019"],["dc.identifier.pmid","12021639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43715"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0163-4356"],["dc.title","Atypical pharmacokinetics and metabolism of mycophenolic acid in a young kidney transplant recipient with impaired renal function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Engelmayer, U."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Boyd, J."],["dc.contributor.author","Arabshahi, L."],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T11:14:27Z"],["dc.date.available","2018-11-07T11:14:27Z"],["dc.date.issued","2005"],["dc.format.extent","217"],["dc.identifier.isi","000228115500044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54126"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","9th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology"],["dc.relation.eventlocation","Louisville, KY"],["dc.relation.issn","0163-4356"],["dc.title","Comparison of the seradyn Innofluor((R)) Certican((R)) assay on TDXFLX (R) system with LC/MS-MS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Dresing, Klaus"],["dc.contributor.author","Leip, C. L."],["dc.contributor.author","Burchardi, Hilmar"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T10:38:28Z"],["dc.date.available","2018-11-07T10:38:28Z"],["dc.date.issued","2003"],["dc.format.extent","A52"],["dc.identifier.isi","000183088700162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45817"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","55th Annual Meeting of the American-Association-for-Clinical-Chemiatry"],["dc.relation.eventlocation","PHILADELPHIA, PENNSYLVANIA"],["dc.relation.issn","0009-9147"],["dc.title","Real-time assessment of hepatic function is related to clinical outcome in critically ill patients after polytrauma."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Domke, I."],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Langmann, T."],["dc.contributor.author","Liebisch, Gerhard"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Luthe, Hilmar"],["dc.contributor.author","Dorn, A."],["dc.contributor.author","Schmitz, G."],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T08:35:50Z"],["dc.date.available","2018-11-07T08:35:50Z"],["dc.date.issued","2005"],["dc.format.extent","A148"],["dc.identifier.isi","000229452500479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18169"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","57th Annual Meeting of the American-Association-for-Clinical-Chemistry"],["dc.relation.eventlocation","Orlando, FL"],["dc.relation.issn","0009-9147"],["dc.title","Measurement of total and free mycophenolic acid with new enzyme receptor methods on COBAS INTEGRA systems"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Shipkova, Maria"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T10:37:33Z"],["dc.date.available","2018-11-07T10:37:33Z"],["dc.date.issued","2003"],["dc.format.extent","506"],["dc.identifier.isi","000184445500093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45592"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","8th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology"],["dc.relation.eventlocation","BASEL, SWITZERLAND"],["dc.relation.issn","0163-4356"],["dc.title","Quantification of plasma total MPA and free MPA 80 mass interferences in quantification of using liquid chromatography tandem mass cyclosporine using tandem mass spectrometry spectrometry"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3154"],["dc.bibliographiccitation.issue","7-8"],["dc.bibliographiccitation.journal","Transplantation Proceedings"],["dc.bibliographiccitation.lastpage","3155"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Braun, F."],["dc.contributor.author","Kassuhn, M."],["dc.contributor.author","Laabs, S. O."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Ringe, B."],["dc.date.accessioned","2018-11-07T08:31:04Z"],["dc.date.available","2018-11-07T08:31:04Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1016/S0041-1345(01)02343-0"],["dc.identifier.isi","000173143600047"],["dc.identifier.pmid","11750354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17034"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","2001: A Transplant Odyssey Congress"],["dc.relation.eventlocation","ISTANBUL, TURKEY"],["dc.relation.issn","0041-1345"],["dc.title","Intestinal biotransformation of cyclosporine A in an extracorporeal pig intestine perfusion model"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","697"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Acta Anaesthesiologica Scandinavica"],["dc.bibliographiccitation.lastpage","703"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Braun, J. P."],["dc.contributor.author","Schroeder, T."],["dc.contributor.author","Buehner, S."],["dc.contributor.author","Dohmen, P."],["dc.contributor.author","Moshirzadeh, M."],["dc.contributor.author","Grosse, J."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Schlaefke, A."],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Lochs, H."],["dc.contributor.author","Konertz, W."],["dc.contributor.author","Kox, W. J."],["dc.contributor.author","Spies, C."],["dc.date.accessioned","2018-11-07T10:47:23Z"],["dc.date.available","2018-11-07T10:47:23Z"],["dc.date.issued","2004"],["dc.description.abstract","Background: The effect of non-pulsatile, normothermic cardiopulmonary-bypass (CPB) on the splanchnic blood-flow and oxygen-transport, the hepatic function and the gastrointestinal barrier were observed in a prospective observational study in 31 adults undergoing cardiac valve replacement surgery. Methods: The splanchnic (i.e. hepatic) blood-flow (HBF) was measured by the constant infusion of indocyanine-green (ICG) using a hepatic-venous catheter. Liver function was examined by calculation of lactate uptake, ICG extraction and the monoethylglycinexylidide (MEGX) test. A day before and after surgery the gastrioduodenal and intestinal permeability was measured by determination of sucrose and lactulose/mannitol excretion. Results: Splanchnic blood flow and oxygen delivery did not decrease during and after surgery while splanchnic oxygen consumption (P < 0.0125) and arterial lactate concentrations increased. The splanchnic lactate uptake paralleled the lactate concentration. After but not during CPB an increase of systemic oxygen consumption was observed. The MEGX test values decreased on the first day after surgery. The ICG extraction was attenuated during the operation. The gastroduodenal and the intestinal permeability increased significantly postoperatively (P < 0.002, respectively, P < 0.001). There was no correlation between these findings and the duration of CPB. There was a significant correlation of the intestinal permeability but not of the gastroduodenal permeability between the prior and after surgery values (P < 0.001). Conclusion: Increased oxygen consumption during CPB may indicate an inflammatory reaction due to the pump beginning in the splanchnic area or a redistribution of the splanchinc blood flow during the CPB. Normothermic CPB does not lead to a significant or prolonged reduction of liver function. Normothermic CPB causes an increase of gastrointestinal permeability. The intestinal barrier function prior to surgery was accountable for the degree of loss of intestinal barrier function following surgery."],["dc.identifier.doi","10.1111/j.1399-6576.2004.00392.x"],["dc.identifier.isi","000221967500005"],["dc.identifier.pmid","15196101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0001-5172"],["dc.title","Splanchnic oxygen transport, hepatic function and gastrointestinal barrier after normothermic cardiopulmonary bypass"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]