Albrecht, Björn

[["dc.bibliographiccitation.firstpage","914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","923"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel-von Sandersleben, Henrik"],["dc.contributor.author","Valko, Lilian"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Xu, X."],["dc.contributor.author","Drechsler, Renate"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T09:37:19Z"],["dc.date.available","2018-11-07T09:37:19Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Difficulties with performance and brain activity related to attentional orienting (Cue-P3), cognitive or response preparation (Cue-CNV) and inhibitory response control (Nogo-P3) during tasks tapping executive functions are familial in ADHD and may represent endophenotypes. The aim of this study was to clarify the impact of dopamine receptor D4 (DRD4) and dopamine transporter (DAT1) gene polymorphisms on these processes in ADHD and control children. Methods: Behavioural and electrophysiological parameters from cued continuous performance tests with low and high attentional load were assessed in boys with ADHD combined type (N = 94) and controls without family history of ADHD (N = 31). Both groups were split for the presence of at least one DRD4 7-repeat allele and the DAT1 10-6 haplotype. Results: Children with ADHD showed diminished performance and lower Cue-P3, CNV and Nogo-P3 amplitudes. Children with DRD4 7R showed similar performance problems and lower Cue-P3 and CNV, but Nogo-P3 was not reduced. Children with the DAT1 10-6 haplotype had no difficulties with performance or Cue-P3 and CNV, but contrary to expectations increased Nogo-P3. There were no Genotype by ADHD interactions. Conclusions: This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes."],["dc.identifier.doi","10.1111/jcpp.12212"],["dc.identifier.isi","000339384700009"],["dc.identifier.pmid","24521003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1469-7610"],["dc.relation.issn","0021-9630"],["dc.title","Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","149"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","157"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Wangler, Susanne"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T11:22:46Z"],["dc.date.available","2018-11-07T11:22:46Z"],["dc.date.issued","2009"],["dc.description.abstract","In a randomized controlled trial, neurofeedback (NF) training was found to be superior to a computerised attention skills training concerning the reduction of ADHD symptomatology (Gevensleben et al., 2009). The aims of this investigation were to assess the impact of different NF protocols (theta/beta training and training of slow cortical potentials, SCPs) on the resting EEG and the association between distinct EEG measures and behavioral improvements. In 72 (of initially 102) children with ADHD, aged 8-12, EEG changes after either a NF training (n = 46) or the control training (n = 26) could be studied. The combined NF training consisted of one block of theta/beta training and one block of SCP training, each block comprising 18 units of 50 minutes (balanced order). Spontaneous EEG was recorded in a two-minute resting condition before the start of the training, between the two training blocks and after the end of the training. Activity in the different EEG frequency bands was analyzed. In contrast to the control condition, the combined NF training was accompanied by a reduction of theta activity. Protocol-specific EEG changes (theta/beta training: decrease of posterior-midline theta activity; SCP training: increase of central-midline alpha activity) were associated with improvements in the German ADHD rating scale. Related EEG-based predictors were obtained. Thus, differential EEG patterns for theta/beta and SCP training provide further evidence that distinct neuronal mechanisms may contribute to similar behavioral improvements in children with ADHD. (C) 2009 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1016/j.ijpsycho.2009.08.005"],["dc.identifier.isi","000271783100010"],["dc.identifier.pmid","19712709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56049"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-8760"],["dc.title","Distinct EEG effects related to neurofeedback training in children with ADHD: A randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","106"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Hoegl, Thomas"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Diruf, Martin"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Kratz, Oliver"],["dc.date.accessioned","2018-11-07T08:53:45Z"],["dc.date.available","2018-11-07T08:53:45Z"],["dc.date.issued","2011"],["dc.description.abstract","The neuronal processes underlying response inhibition are often studied using either event-related potentials (ERPs) or by applying transcranial magnetic stimulation (TMS) to investigate excitatory and inhibitory processes in the motor system. We performed a more refined analysis of response inhibition by combining both approaches with the aim of identifying an interplay between ERPs and TMS parameters. During a go/nogo task, motor system excitability was measured using TMS single and double pulses and brain electrical activity was recorded in healthy adults (n = 14). Each participant completed two testing sessions, once on placebo and once on methylphenidate (double-blind, crossover design). Studying the effects of methylphenidate served as an example application for this combined approach. Developing regression models, inhibition-related TMS measures (e.g., short intracortical inhibition) and the contingent negative variation explained about 85% of the variance of the nogo-P3 under both MPH and placebo medication. The smaller the inhibitory effect in the motor system, the more terminal response control was required and the more resources were allocated for the evaluation of the inhibitory process, respectively, as indicated by a larger P3. Thus, an interplay between processes in the motor system (cortex) and control processes with sources in the prefrontal cortex and the anterior cingulate cortex (ACC) may take place, acting complementarily to facilitate a correct nogo-response. While ERPs rather represent initiation and monitoring of inhibitory processes and response control, motor inhibition may be best analyzed using TMS. A combined ERP/TMS analysis may allow for the development of distinct models concerning the interplay of processes involved in response inhibition. (C) 2011 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.ijpsycho.2011.05.004"],["dc.identifier.isi","000293432800005"],["dc.identifier.pmid","21620906"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22497"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-8760"],["dc.title","Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","183"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","190"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Yordanova, Juliana"],["dc.contributor.author","Kolev, Vasil"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T08:34:59Z"],["dc.date.available","2018-11-07T08:34:59Z"],["dc.date.issued","2009"],["dc.description.abstract","Response processing may comprise multiple systems working in parallel at different functional levels of performance monitoring. In time-frequency decompositions of response-locked event-related potentials from adults, a subprocess operating in the delta frequency band was interpreted as an index of cognitive error monitoring, distinguishable from a process with theta frequency probably related to motor control. However, it remains unclear whether such subprocesses can also be distinguished in children. In the current study, error processing was assessed in 22 normal boys aged 8 to 15 years using an Erikson Flanker task. Performance data revealed the expected indices of conflicting task demands, such as increased reaction times and error rates. A clear error-negativity was found in the response-locked event-related potentials after incompatible stimuli, and correct responses show a slow negative deflection immediately preceding the button-press, which is absent in errors. Time-frequency decompositions disclosed that a subprocess in the lower delta band preceding correct responses may reflect a more general action monitoring process sensitive to conflicting task demands that, moreover, may prevent one from making an error if it is active early enough. Processes in the delta and theta bands are modulated specifically by errors and may index motor-related monitoring in children. Moreover, these processes occurred considerably earlier for correct responses compared to errors, suggesting that their timing reflects some performance capacity. These considerations may help to clarify response processing in tasks with conflicting demands."],["dc.identifier.doi","10.1027/0269-8803.23.4.183"],["dc.identifier.isi","000278323700004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hogrefe & Huber Publishers"],["dc.relation.issn","0269-8803"],["dc.title","Flanker-Task in Children Time-Frequency Analyses of Response Monitoring"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","942"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Wangler, Susanne"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:56:36Z"],["dc.date.available","2018-11-07T08:56:36Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: In a randomized controlled trial, we could demonstrate clinical efficacy of neurofeedback (NF) training for children with ADHD (Gevensleben et al., 2009a). The present investigation aimed at learning more about the neuronal mechanisms of NF training. Methods: Children with ADHD either completed a NF training or a computerized attention skills training (ratio 3: 2). NF training consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training, each comprising 18 training units. At three times (pre-training, between the two training blocks and at post-training), event-related potentials (ERP) were recorded during the Attention Network Test. ERP analysis focused on the P3, reflecting inter alia attentional resources for stimulus evaluation, and the contingent negative variation (CNV), primarily related to cognitive preparation. Results: After NF training, an increase of the CNV in cue trials could be observed, which was specific for the SCP training. A larger pre-training CNV was associated with a larger reduction of ADHD symptomatology for SCP training. Conclusions: CNV effects reflect neuronal circuits underlying resource allocation during cognitive preparation. These distinct ERP effects are closely related to a successful NF training in children with ADHD. In future studies, neurophysiological recordings could help to optimize and individualize NF training. Significance: The findings contribute to a better understanding of the mechanisms underlying NF training in children with ADHD. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.clinph.2010.06.036"],["dc.identifier.isi","000290098700014"],["dc.identifier.pmid","20843737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","Neurofeedback in children with ADHD: Specific event-related potential findings of a randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1171"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neuropsychologia"],["dc.bibliographiccitation.lastpage","1177"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Hasselhorn, Marcus"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T08:45:39Z"],["dc.date.available","2018-11-07T08:45:39Z"],["dc.date.issued","2010"],["dc.description.abstract","Attention-deficit/hyperactivity disorder (ADHD) is a frequent and highly heritable disorder over-represented in boys. In a recent study investigating boys only, we found that action monitoring deficits as reflected by certain behavioral and electrophysiological parameters were familially driven. As gender may also have an important impact, this was examined in the current study with nonaffected children aged 8-15 years having relatives suffering from ADHD (N=37, 21 female) and with age-matched controls without family history of ADHD (N = 33, female). Extending our previous findings that action monitoring is a potential endophenotype for boys with ADHD, familially driven deficits were confirmed independently of gender. Thus, despite sharing the phenotype with controls, nonaffected siblings showed ADHD-like impairments albeit of smaller magnitude. However, girls performed generally more accurately, which in turn may have produced the differences between nonaffected siblings and controls in affective error processing that were not present in our boys-only assessment. (C) 2009 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","NIMH [R01MH062873]; Swiss National Science Foundation [32-109591]"],["dc.identifier.doi","10.1016/j.neuropsychologia.2009.12.018"],["dc.identifier.isi","000275933500037"],["dc.identifier.pmid","20026087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20499"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0028-3932"],["dc.title","Action monitoring in children with or without a family history of ADHD - Effects of gender on an endophenotype parameter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","22"],["dc.bibliographiccitation.journal","Behavioral and Brain Functions"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2018-11-07T08:34:58Z"],["dc.date.available","2018-11-07T08:34:58Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Evidence from behavioural studies suggests that impaired motor response inhibition may be common to several externalizing child psychiatric disorders, although it has been proposed to be the core-deficit in AD/HD. Since similar overt behaviour may be accompanied by different covert brain activity, the aim of this study was to investigate both brain-electric-activity and performance measures in three groups of children with externalizing child psychiatric disorders and a group of normal controls. Methods: A Stop-task was used to measure specific aspects of response inhibition in 10 children with attention-deficit hyperactivity disorder (AD/HD), 8 children with oppositional defiant disorder/conduct disorder (ODD/CD), 11 children with comorbid AD/HD+ODD/CD and 11 normal controls. All children were between 8 and 14 years old. Event-related potentials and behavioural responses were recorded. An initial go-signal related microstate, a subsequent Stop-signal related N200, and performance measures were analyzed using ANCOVA with age as covariate. Results: Groups did not differ in accuracy or reaction time to the Go-stimuli. However, all clinical groups displayed reduced map strength in a microstate related to initial processing of the Go-stimulus compared to normal controls, whereas topography did not differ. Concerning motor response inhibition, the AD/HD-only and the ODD/CD-only groups displayed slower Stop-signal reaction times (SSRT) and Stop-failure reaction time compared to normal controls. In children with comorbid AD/HD+ODD/CD, Stop-failure reaction-time was longer than in controls, but their SSRT was not slowed. Moreover, SSRT in AD/HD+ODD/CD was faster than in AD/HD-only or ODD/CD-only. The AD/HD-only and ODD/CD-only groups displayed reduced Stop-N200 mean amplitude over right-frontal electrodes. This effect reached only a trend for comorbid AD/HD+ODD/CD. Conclusion: Following similar attenuations in initial processing of the Go-signal in all clinical groups compared to controls, distinct Stop-signal related deficits became evident in the clinical groups. Both children with AD/HD and ODD/CD showed deficits in behavioural response-inhibition accompanied by decreased central conflict signalling or inhibition processes. Neither behavioural nor neural markers of inhibitory deficits as found in AD/HD-only and ODD/CD-only were additive. Instead, children with comorbid AD/HD+ODD/CD showed similar or even less prominent inhibition deficits than the other clinical groups. Hence, the AD/HD+ODD/CD-group may represent a separate clinical entity."],["dc.identifier.doi","10.1186/1744-9081-1-22"],["dc.identifier.isi","000209751900022"],["dc.identifier.pmid","16336676"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17947"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1744-9081"],["dc.title","Response inhibition deficits in externalizing child psychiatric disorders: An ERP-study with the Stop-task"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]