Albrecht, Björn

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Grunitz, Juliane"],["dc.contributor.author","Stonawski, Valeska"],["dc.contributor.author","Frey, Stefan"],["dc.contributor.author","Wahl, Simone"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Goecke, Tamme W."],["dc.contributor.author","Beckmann, Matthias W."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fasching, Peter A."],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Eichler, Anna"],["dc.date.accessioned","2019-07-09T11:43:43Z"],["dc.date.available","2019-07-09T11:43:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1038/s41598-017-03326-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58960"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","990"],["dc.bibliographiccitation.journal","Frontiers in human neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Lütcke, Henry"],["dc.contributor.author","Auer, Tibor"],["dc.contributor.author","Dewiputri, Wan Ilma"],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Moll, Gunther"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2019-07-09T11:40:54Z"],["dc.date.available","2019-07-09T11:40:54Z"],["dc.date.issued","2014"],["dc.description.abstract","To elucidate basic mechanisms underlying neurofeedback we investigated neural mechanisms of training of slow cortical potentials (SCPs) by considering EEG- and fMRI. Additionally, we analyzed the feasibility of a double-blind, placebo-controlled design in NF research based on regulation performance during treatment sessions and self-assessment of the participants. Twenty healthy adults participated in 16 sessions of SCPs training: 9 participants received regular SCP training, 11 participants received sham feedback. At three time points (pre, intermediate, post) fMRI and EEG/ERP-measurements were conducted during a continuous performance test (CPT). Performance-data during the sessions (regulation performance) in the treatment group and the placebo group were analyzed. Analysis of EEG-activity revealed in the SCP group a strong enhancement of the CNV (electrode Cz) at the intermediate assessment, followed by a decrease back to baseline at the post-treatment assessment. In contrast, in the placebo group a continuous but smaller increase of the CNV could be obtained from pre to post assessment. The increase of the CNV in the SCP group at intermediate testing was superior to the enhancement in the placebo group. The changes of the CNV were accompanied by a continuous improvement in the test performance of the CPT from pre to intermediate to post assessment comparable in both groups. The change of the CNV in the SCP group is interpreted as an indicator of neural plasticity and efficiency while an increase of the CNV in the placebo group might reflect learning and improved timing due to the frequent task repetition. In the fMRI analysis evidence was obtained for neuronal plasticity. After regular SCP neurofeedback activation in the posterior parietal cortex decreased from the pre- to the intermediate measurement and increased again in the post measurement, inversely following the U-shaped increase and decrease of the tCNV EEG amplitude in the SCP-trained group. Furthermore, we found a localized increase of activity in the anterior cingulate cortex (ACC). Analyses of the estimation of treatment assignment by the participants indicate feasibility of blinding. Participants could not assess treatment assignment confidently. Participants of the SCP-group improved regulation capability during treatment sessions (in contrast to the participants of the placebo-group), although regulation capability appeared to be instable, presumably due to diminished confidence in the training (SCP- or sham-training). Our results indicate that SCP training in healthy adults might lead to functional changes in neuronal circuits serving cognitive preparation even after a limited number of sessions."],["dc.format.extent","13"],["dc.identifier.doi","10.3389/fnhum.2014.00990"],["dc.identifier.fs","607730"],["dc.identifier.pmid","25566020"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58291"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurofeedback of slow cortical potentials: neural mechanisms and feasibility of a placebo-controlled design in healthy adults."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","780"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","789"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Vogel, Claudia"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:28:14Z"],["dc.date.available","2018-11-07T08:28:14Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: For children with attention deficit/hyperactivity disorder (ADHD), a reduction of inattention, impulsivity and hyperactivity by neurofeedback (NF) has been reported in several studies. But so far, unspecific training effects have not been adequately controlled for and/or studies do not provide sufficient statistical power. To overcome these methodological shortcomings we evaluated the clinical efficacy of neurofeedback in children with ADHD in a multisite randomised controlled study using a computerised attention skills training as a control condition. Methods: 102 children with ADHD, aged 8 to 12 years, participated in the study. Children performed either 36 sessions of NF training or a computerised attention skills training within two blocks of about four weeks each (randomised group assignment). The combined NF treatment consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training. Pre-training, intermediate and post-training assessment encompassed several behaviour rating scales (e. g., the German ADHD rating scale, FBB-HKS) completed by parents and teachers. Evaluation ('placebo') scales were applied to control for parental expectations and satisfaction with the treatment. Results: For parent and teacher ratings, improvements in the NF group were superior to those of the control group. For the parent-rated FBB-HKS total score (primary outcome measure), the effect size was .60. Comparable effects were obtained for the two NF protocols (theta/beta training, SCP training). Parental attitude towards the treatment did not differ between NF and control group. Conclusions: Superiority of the combined NF training indicates clinical efficacy of NF in children with ADHD. Future studies should further address the specificity of effects and how to optimise the benefit of NF as treatment module for ADHD."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1111/j.1469-7610.2008.02033.x"],["dc.identifier.isi","000266980600003"],["dc.identifier.pmid","19207632"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16374"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0021-9630"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Is neurofeedback an efficacious treatment for ADHD? A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","615"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","625"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Hasselhorn, Marcus"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T11:10:20Z"],["dc.date.available","2018-11-07T11:10:20Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Attention-deficit/hyperactivity disorder (ADHD) is a very common and highly heritable child psychiatric disorder associated with dysfunctions in fronto-striatal networks that control attention and response organization. The aim of this study was to investigate whether features of action monitoring related to dopaminergic functions represent endophenotypes that are brain functions on the pathway from genes and environmental risk factors to behavior. Methods: Action monitoring and error processing as indicated by behavioral and electrophysiological parameters during a flanker task were examined in boys with ADHD combined type according to DSM-IV (n = 68), their nonaffected siblings (n = 18), and healthy control subjects with no known family history of ADHD (n = 22). Results: Boys with ADHD displayed slower and more variable reaction-times. Error negativity (Ne) was smaller in boys with ADHDcompared with healthy control subjects, whereas nonaffected siblings displayed intermediate amplitudes following a linear model predicted by genetic concordance. The three groups did not differ on error positivity (Pe). The N2 amplitude enhancement due to conflict (incongruent flankers) was reduced in the ADHD group. Nonaffected siblings also displayed intermediate N2 enhancement. Conclusions: Converging evidence from behavioral and event-related potential findings suggests that action monitoring and initial error processing, both related to dopaminergically modulated functions of anterior cingulate cortex, might be an endophenotype related to ADHD."],["dc.identifier.doi","10.1016/j.biopsych.2007.12.016"],["dc.identifier.isi","000259588600010"],["dc.identifier.pmid","18339358"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53190"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Action monitoring in boys with attention-deficit/hyperactivity disorder, their nonaffected siblings, and normal control subjects: Evidence for an endophenotype"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","715"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","European Child & Adolescent Psychiatry"],["dc.bibliographiccitation.lastpage","724"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:39:38Z"],["dc.date.available","2018-11-07T08:39:38Z"],["dc.date.issued","2010"],["dc.description.abstract","Neurofeedback (NF) could help to improve attentional and self-management capabilities in children with attention-deficit/hyperactivity disorder (ADHD). In a randomised controlled trial, NF training was found to be superior to a computerised attention skills training (AST) (Gevensleben et al. in J Child Psychol Psychiatry 50(7):780-789, 2009). In the present paper, treatment effects at 6-month follow-up were studied. 94 children with ADHD, aged 8-12 years, completed either 36 sessions of NF training (n = 59) or a computerised AST (n = 35). Pre-training, post-training and follow-up assessment encompassed several behaviour rating scales (e.g., the German ADHD rating scale, FBB-HKS) completed by parents. Follow-up information was analysed in 61 children (ca. 65%) on a per-protocol basis. 17 children (of 33 dropouts) had started a medication after the end of the training or early in the follow-up period. Improvements in the NF group (n = 38) at follow-up were superior to those of the control group (n = 23) and comparable to the effects at the end of the training. For the FBB-HKS total score (primary outcome measure), a medium effect size of 0.71 was obtained at follow-up. A reduction of at least 25% in the primary outcome measure (responder criterion) was observed in 50% of the children in the NF group. In conclusion, behavioural improvements induced by NF training in children with ADHD were maintained at a 6-month follow-up. Though treatment effects appear to be limited, the results confirm the notion that NF is a clinically efficacious module in the treatment of children with ADHD."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1007/s00787-010-0109-5"],["dc.identifier.isi","000281162600004"],["dc.identifier.pmid","20499120"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19045"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1018-8827"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Neurofeedback training in children with ADHD: 6-month follow-up of a randomised controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]