Albrecht, Björn

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Grunitz, Juliane"],["dc.contributor.author","Stonawski, Valeska"],["dc.contributor.author","Frey, Stefan"],["dc.contributor.author","Wahl, Simone"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Goecke, Tamme W."],["dc.contributor.author","Beckmann, Matthias W."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fasching, Peter A."],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Eichler, Anna"],["dc.date.accessioned","2019-07-09T11:43:43Z"],["dc.date.available","2019-07-09T11:43:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1038/s41598-017-03326-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58960"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","923"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel-von Sandersleben, Henrik"],["dc.contributor.author","Valko, Lilian"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Xu, X."],["dc.contributor.author","Drechsler, Renate"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T09:37:19Z"],["dc.date.available","2018-11-07T09:37:19Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Difficulties with performance and brain activity related to attentional orienting (Cue-P3), cognitive or response preparation (Cue-CNV) and inhibitory response control (Nogo-P3) during tasks tapping executive functions are familial in ADHD and may represent endophenotypes. The aim of this study was to clarify the impact of dopamine receptor D4 (DRD4) and dopamine transporter (DAT1) gene polymorphisms on these processes in ADHD and control children. Methods: Behavioural and electrophysiological parameters from cued continuous performance tests with low and high attentional load were assessed in boys with ADHD combined type (N = 94) and controls without family history of ADHD (N = 31). Both groups were split for the presence of at least one DRD4 7-repeat allele and the DAT1 10-6 haplotype. Results: Children with ADHD showed diminished performance and lower Cue-P3, CNV and Nogo-P3 amplitudes. Children with DRD4 7R showed similar performance problems and lower Cue-P3 and CNV, but Nogo-P3 was not reduced. Children with the DAT1 10-6 haplotype had no difficulties with performance or Cue-P3 and CNV, but contrary to expectations increased Nogo-P3. There were no Genotype by ADHD interactions. Conclusions: This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes."],["dc.identifier.doi","10.1111/jcpp.12212"],["dc.identifier.isi","000339384700009"],["dc.identifier.pmid","24521003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1469-7610"],["dc.relation.issn","0021-9630"],["dc.title","Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","990"],["dc.bibliographiccitation.journal","Frontiers in human neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Lütcke, Henry"],["dc.contributor.author","Auer, Tibor"],["dc.contributor.author","Dewiputri, Wan Ilma"],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Moll, Gunther"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2019-07-09T11:40:54Z"],["dc.date.available","2019-07-09T11:40:54Z"],["dc.date.issued","2014"],["dc.description.abstract","To elucidate basic mechanisms underlying neurofeedback we investigated neural mechanisms of training of slow cortical potentials (SCPs) by considering EEG- and fMRI. Additionally, we analyzed the feasibility of a double-blind, placebo-controlled design in NF research based on regulation performance during treatment sessions and self-assessment of the participants. Twenty healthy adults participated in 16 sessions of SCPs training: 9 participants received regular SCP training, 11 participants received sham feedback. At three time points (pre, intermediate, post) fMRI and EEG/ERP-measurements were conducted during a continuous performance test (CPT). Performance-data during the sessions (regulation performance) in the treatment group and the placebo group were analyzed. Analysis of EEG-activity revealed in the SCP group a strong enhancement of the CNV (electrode Cz) at the intermediate assessment, followed by a decrease back to baseline at the post-treatment assessment. In contrast, in the placebo group a continuous but smaller increase of the CNV could be obtained from pre to post assessment. The increase of the CNV in the SCP group at intermediate testing was superior to the enhancement in the placebo group. The changes of the CNV were accompanied by a continuous improvement in the test performance of the CPT from pre to intermediate to post assessment comparable in both groups. The change of the CNV in the SCP group is interpreted as an indicator of neural plasticity and efficiency while an increase of the CNV in the placebo group might reflect learning and improved timing due to the frequent task repetition. In the fMRI analysis evidence was obtained for neuronal plasticity. After regular SCP neurofeedback activation in the posterior parietal cortex decreased from the pre- to the intermediate measurement and increased again in the post measurement, inversely following the U-shaped increase and decrease of the tCNV EEG amplitude in the SCP-trained group. Furthermore, we found a localized increase of activity in the anterior cingulate cortex (ACC). Analyses of the estimation of treatment assignment by the participants indicate feasibility of blinding. Participants could not assess treatment assignment confidently. Participants of the SCP-group improved regulation capability during treatment sessions (in contrast to the participants of the placebo-group), although regulation capability appeared to be instable, presumably due to diminished confidence in the training (SCP- or sham-training). Our results indicate that SCP training in healthy adults might lead to functional changes in neuronal circuits serving cognitive preparation even after a limited number of sessions."],["dc.format.extent","13"],["dc.identifier.doi","10.3389/fnhum.2014.00990"],["dc.identifier.fs","607730"],["dc.identifier.pmid","25566020"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58291"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurofeedback of slow cortical potentials: neural mechanisms and feasibility of a placebo-controlled design in healthy adults."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","149"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","157"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Wangler, Susanne"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T11:22:46Z"],["dc.date.available","2018-11-07T11:22:46Z"],["dc.date.issued","2009"],["dc.description.abstract","In a randomized controlled trial, neurofeedback (NF) training was found to be superior to a computerised attention skills training concerning the reduction of ADHD symptomatology (Gevensleben et al., 2009). The aims of this investigation were to assess the impact of different NF protocols (theta/beta training and training of slow cortical potentials, SCPs) on the resting EEG and the association between distinct EEG measures and behavioral improvements. In 72 (of initially 102) children with ADHD, aged 8-12, EEG changes after either a NF training (n = 46) or the control training (n = 26) could be studied. The combined NF training consisted of one block of theta/beta training and one block of SCP training, each block comprising 18 units of 50 minutes (balanced order). Spontaneous EEG was recorded in a two-minute resting condition before the start of the training, between the two training blocks and after the end of the training. Activity in the different EEG frequency bands was analyzed. In contrast to the control condition, the combined NF training was accompanied by a reduction of theta activity. Protocol-specific EEG changes (theta/beta training: decrease of posterior-midline theta activity; SCP training: increase of central-midline alpha activity) were associated with improvements in the German ADHD rating scale. Related EEG-based predictors were obtained. Thus, differential EEG patterns for theta/beta and SCP training provide further evidence that distinct neuronal mechanisms may contribute to similar behavioral improvements in children with ADHD. (C) 2009 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1016/j.ijpsycho.2009.08.005"],["dc.identifier.isi","000271783100010"],["dc.identifier.pmid","19712709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56049"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-8760"],["dc.title","Distinct EEG effects related to neurofeedback training in children with ADHD: A randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","106"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Hoegl, Thomas"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Diruf, Martin"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Kratz, Oliver"],["dc.date.accessioned","2018-11-07T08:53:45Z"],["dc.date.available","2018-11-07T08:53:45Z"],["dc.date.issued","2011"],["dc.description.abstract","The neuronal processes underlying response inhibition are often studied using either event-related potentials (ERPs) or by applying transcranial magnetic stimulation (TMS) to investigate excitatory and inhibitory processes in the motor system. We performed a more refined analysis of response inhibition by combining both approaches with the aim of identifying an interplay between ERPs and TMS parameters. During a go/nogo task, motor system excitability was measured using TMS single and double pulses and brain electrical activity was recorded in healthy adults (n = 14). Each participant completed two testing sessions, once on placebo and once on methylphenidate (double-blind, crossover design). Studying the effects of methylphenidate served as an example application for this combined approach. Developing regression models, inhibition-related TMS measures (e.g., short intracortical inhibition) and the contingent negative variation explained about 85% of the variance of the nogo-P3 under both MPH and placebo medication. The smaller the inhibitory effect in the motor system, the more terminal response control was required and the more resources were allocated for the evaluation of the inhibitory process, respectively, as indicated by a larger P3. Thus, an interplay between processes in the motor system (cortex) and control processes with sources in the prefrontal cortex and the anterior cingulate cortex (ACC) may take place, acting complementarily to facilitate a correct nogo-response. While ERPs rather represent initiation and monitoring of inhibitory processes and response control, motor inhibition may be best analyzed using TMS. A combined ERP/TMS analysis may allow for the development of distinct models concerning the interplay of processes involved in response inhibition. (C) 2011 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.ijpsycho.2011.05.004"],["dc.identifier.isi","000293432800005"],["dc.identifier.pmid","21620906"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22497"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-8760"],["dc.title","Interplay of neuronal processes during response inhibition: Results from a combined event-related potentials (ERPs)/transcranial magnetic stimulation (TMS) study on methylphenidate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","780"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","789"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Vogel, Claudia"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:28:14Z"],["dc.date.available","2018-11-07T08:28:14Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: For children with attention deficit/hyperactivity disorder (ADHD), a reduction of inattention, impulsivity and hyperactivity by neurofeedback (NF) has been reported in several studies. But so far, unspecific training effects have not been adequately controlled for and/or studies do not provide sufficient statistical power. To overcome these methodological shortcomings we evaluated the clinical efficacy of neurofeedback in children with ADHD in a multisite randomised controlled study using a computerised attention skills training as a control condition. Methods: 102 children with ADHD, aged 8 to 12 years, participated in the study. Children performed either 36 sessions of NF training or a computerised attention skills training within two blocks of about four weeks each (randomised group assignment). The combined NF treatment consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training. Pre-training, intermediate and post-training assessment encompassed several behaviour rating scales (e. g., the German ADHD rating scale, FBB-HKS) completed by parents and teachers. Evaluation ('placebo') scales were applied to control for parental expectations and satisfaction with the treatment. Results: For parent and teacher ratings, improvements in the NF group were superior to those of the control group. For the parent-rated FBB-HKS total score (primary outcome measure), the effect size was .60. Comparable effects were obtained for the two NF protocols (theta/beta training, SCP training). Parental attitude towards the treatment did not differ between NF and control group. Conclusions: Superiority of the combined NF training indicates clinical efficacy of NF in children with ADHD. Future studies should further address the specificity of effects and how to optimise the benefit of NF as treatment module for ADHD."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1111/j.1469-7610.2008.02033.x"],["dc.identifier.isi","000266980600003"],["dc.identifier.pmid","19207632"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16374"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0021-9630"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Is neurofeedback an efficacious treatment for ADHD? A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","183"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","190"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Yordanova, Juliana"],["dc.contributor.author","Kolev, Vasil"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T08:34:59Z"],["dc.date.available","2018-11-07T08:34:59Z"],["dc.date.issued","2009"],["dc.description.abstract","Response processing may comprise multiple systems working in parallel at different functional levels of performance monitoring. In time-frequency decompositions of response-locked event-related potentials from adults, a subprocess operating in the delta frequency band was interpreted as an index of cognitive error monitoring, distinguishable from a process with theta frequency probably related to motor control. However, it remains unclear whether such subprocesses can also be distinguished in children. In the current study, error processing was assessed in 22 normal boys aged 8 to 15 years using an Erikson Flanker task. Performance data revealed the expected indices of conflicting task demands, such as increased reaction times and error rates. A clear error-negativity was found in the response-locked event-related potentials after incompatible stimuli, and correct responses show a slow negative deflection immediately preceding the button-press, which is absent in errors. Time-frequency decompositions disclosed that a subprocess in the lower delta band preceding correct responses may reflect a more general action monitoring process sensitive to conflicting task demands that, moreover, may prevent one from making an error if it is active early enough. Processes in the delta and theta bands are modulated specifically by errors and may index motor-related monitoring in children. Moreover, these processes occurred considerably earlier for correct responses compared to errors, suggesting that their timing reflects some performance capacity. These considerations may help to clarify response processing in tasks with conflicting demands."],["dc.identifier.doi","10.1027/0269-8803.23.4.183"],["dc.identifier.isi","000278323700004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17951"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hogrefe & Huber Publishers"],["dc.relation.issn","0269-8803"],["dc.title","Flanker-Task in Children Time-Frequency Analyses of Response Monitoring"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","942"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","950"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Wangler, Susanne"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:56:36Z"],["dc.date.available","2018-11-07T08:56:36Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: In a randomized controlled trial, we could demonstrate clinical efficacy of neurofeedback (NF) training for children with ADHD (Gevensleben et al., 2009a). The present investigation aimed at learning more about the neuronal mechanisms of NF training. Methods: Children with ADHD either completed a NF training or a computerized attention skills training (ratio 3: 2). NF training consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training, each comprising 18 training units. At three times (pre-training, between the two training blocks and at post-training), event-related potentials (ERP) were recorded during the Attention Network Test. ERP analysis focused on the P3, reflecting inter alia attentional resources for stimulus evaluation, and the contingent negative variation (CNV), primarily related to cognitive preparation. Results: After NF training, an increase of the CNV in cue trials could be observed, which was specific for the SCP training. A larger pre-training CNV was associated with a larger reduction of ADHD symptomatology for SCP training. Conclusions: CNV effects reflect neuronal circuits underlying resource allocation during cognitive preparation. These distinct ERP effects are closely related to a successful NF training in children with ADHD. In future studies, neurophysiological recordings could help to optimize and individualize NF training. Significance: The findings contribute to a better understanding of the mechanisms underlying NF training in children with ADHD. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.clinph.2010.06.036"],["dc.identifier.isi","000290098700014"],["dc.identifier.pmid","20843737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","Neurofeedback in children with ADHD: Specific event-related potential findings of a randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","615"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","625"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Hasselhorn, Marcus"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T11:10:20Z"],["dc.date.available","2018-11-07T11:10:20Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Attention-deficit/hyperactivity disorder (ADHD) is a very common and highly heritable child psychiatric disorder associated with dysfunctions in fronto-striatal networks that control attention and response organization. The aim of this study was to investigate whether features of action monitoring related to dopaminergic functions represent endophenotypes that are brain functions on the pathway from genes and environmental risk factors to behavior. Methods: Action monitoring and error processing as indicated by behavioral and electrophysiological parameters during a flanker task were examined in boys with ADHD combined type according to DSM-IV (n = 68), their nonaffected siblings (n = 18), and healthy control subjects with no known family history of ADHD (n = 22). Results: Boys with ADHD displayed slower and more variable reaction-times. Error negativity (Ne) was smaller in boys with ADHDcompared with healthy control subjects, whereas nonaffected siblings displayed intermediate amplitudes following a linear model predicted by genetic concordance. The three groups did not differ on error positivity (Pe). The N2 amplitude enhancement due to conflict (incongruent flankers) was reduced in the ADHD group. Nonaffected siblings also displayed intermediate N2 enhancement. Conclusions: Converging evidence from behavioral and event-related potential findings suggests that action monitoring and initial error processing, both related to dopaminergically modulated functions of anterior cingulate cortex, might be an endophenotype related to ADHD."],["dc.identifier.doi","10.1016/j.biopsych.2007.12.016"],["dc.identifier.isi","000259588600010"],["dc.identifier.pmid","18339358"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53190"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Action monitoring in boys with attention-deficit/hyperactivity disorder, their nonaffected siblings, and normal control subjects: Evidence for an endophenotype"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1171"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neuropsychologia"],["dc.bibliographiccitation.lastpage","1177"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Hasselhorn, Marcus"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T08:45:39Z"],["dc.date.available","2018-11-07T08:45:39Z"],["dc.date.issued","2010"],["dc.description.abstract","Attention-deficit/hyperactivity disorder (ADHD) is a frequent and highly heritable disorder over-represented in boys. In a recent study investigating boys only, we found that action monitoring deficits as reflected by certain behavioral and electrophysiological parameters were familially driven. As gender may also have an important impact, this was examined in the current study with nonaffected children aged 8-15 years having relatives suffering from ADHD (N=37, 21 female) and with age-matched controls without family history of ADHD (N = 33, female). Extending our previous findings that action monitoring is a potential endophenotype for boys with ADHD, familially driven deficits were confirmed independently of gender. Thus, despite sharing the phenotype with controls, nonaffected siblings showed ADHD-like impairments albeit of smaller magnitude. However, girls performed generally more accurately, which in turn may have produced the differences between nonaffected siblings and controls in affective error processing that were not present in our boys-only assessment. (C) 2009 Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","NIMH [R01MH062873]; Swiss National Science Foundation [32-109591]"],["dc.identifier.doi","10.1016/j.neuropsychologia.2009.12.018"],["dc.identifier.isi","000275933500037"],["dc.identifier.pmid","20026087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20499"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0028-3932"],["dc.title","Action monitoring in children with or without a family history of ADHD - Effects of gender on an endophenotype parameter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]