Hafner, Georg

[["dc.bibliographiccitation.firstpage","5353"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","5368"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Zhou, Xiaojuan"],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2019-02-14T16:30:29Z"],["dc.date.available","2019-02-14T16:30:29Z"],["dc.date.issued","2017"],["dc.description.abstract","Neocortical vasoactive intestinal polypeptide (VIP) expressing cells are a diverse subpopulation of GABAergic interneurons issuing distinct axonal projections. They are known to inhibit other types of interneurons as well as excitatory principal neurons and possess a disinhibitory net effect in cortical circuits. In order to elucidate their targeting specificity, the output connectivity of VIP interneurons was studied at the subcellular level in barrel cortex of interneuron-specific Cre-driver mice, using pre- and postembedding electron microscopy. Systematically sampling VIP boutons across all layers, we found a substantial proportion of the innervated subcellular structures were dendrites (80%), with somata (13%), and spines (7%) being much less targeted. In layer VI, a high proportion of axosomatic synapses was found (39%). GABA-immunopositive ratio was quantified among the targets using statistically validated thresholds: only 37% of the dendrites, 7% of the spines, and 26% of the somata showed above-threshold immunogold labeling. For the main target structure \"dendrite\", a higher proportion of GABAergic subcellular profiles existed in deep than in superficial layers. In conclusion, VIP interneurons innervate non-GABAergic excitatory neurons and interneurons at their subcellular domains with layer-dependent specificity. This suggests a diverse output of VIP interneurons, which predicts multiple functionality in cortical circuitry beyond disinhibition."],["dc.identifier.doi","10.1093/cercor/bhx220"],["dc.identifier.pmid","28968722"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16876"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57564"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1460-2199"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Subcellular Targeting of VIP Boutons in Mouse Barrel Cortex is Layer-Dependent and not Restricted to Interneurons"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3450"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","3461.e8"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Hafner, Georg"],["dc.contributor.author","Witte, Mirko"],["dc.contributor.author","Guy, Julien"],["dc.contributor.author","Subhashini, Nidhi"],["dc.contributor.author","Fenno, Lief E."],["dc.contributor.author","Ramakrishnan, Charu"],["dc.contributor.author","Kim, Yoon Seok"],["dc.contributor.author","Deisseroth, Karl"],["dc.contributor.author","Callaway, Edward M."],["dc.contributor.author","Oberhuber, Martina"],["dc.contributor.author","Conzelmann, Karl-Klaus"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2020-12-10T14:23:02Z"],["dc.date.available","2020-12-10T14:23:02Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.celrep.2019.08.064"],["dc.identifier.issn","2211-1247"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16830"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71810"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Mapping Brain-Wide Afferent Inputs of Parvalbumin-Expressing GABAergic Neurons in Barrel Cortex Reveals Local and Long-Range Circuit Motifs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]