Jung, Klaus

[["dc.bibliographiccitation.firstpage","747"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","754"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Gripp-Rudolph, Liliam"],["dc.contributor.author","Attin, Thomas"],["dc.contributor.author","Attin, Rengin"],["dc.contributor.author","Sadat-Khonsari, Reza"],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Bauss, Oskar"],["dc.date.accessioned","2018-11-07T08:27:55Z"],["dc.date.available","2018-11-07T08:27:55Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: To test the null hypothesis that third-order measurements are not correlated to lingual incisor features seen on radiographs. Material and Methods: The lateral headfilms of 38 untreated, norm-occlusion subjects without incisor abrasions or restorations were used for third-order measurements of upper and lower central incisors and assessment of the inclination of four sites suitable for lingual bracket placement with reference to the occlusal plane perpendicular. Lingual sections were determined by the tangents at the incisal fossa (S1), at the transition plateau between incisal fossa and the cingulum (S2), by a constructed line reaching from the incisal tip to the cingulum (S3), and by a tangent at the cingulum convexity (S4). Third-order angles were also assessed on corresponding dental casts using an incisor inclination gauge. Regression analysis was performed using the third-order measurements of both methods as the dependent variables and the inclination of the lingual enamel sections (S1, S2, S3, S4) as the independent variables. Results: The null hypothesis was rejected. For the most common bracket application sites located on the lingual shovel (S1 and S2), third-order inclination changes of 0.4-0.7 degrees are expected for each degree of change in the inclination of the lingual surface. The impact of bracket placement errors on third-order angulation is similar between sections S1 and S2 and the cingulum convexity (S4). Section S3 proved to be least affected by interindividual variation. Conclusion: The third-order measurements are correlated to lingual incisor features. Accordingly, third-order changes resulting from variation in lingual bracket placement can be individually predicted from radiographic assessments. (Angle Orthod. 2009;79:747-754.)"],["dc.identifier.doi","10.2319/072308-385.1"],["dc.identifier.isi","000267712600019"],["dc.identifier.pmid","19537870"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16306"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Changes in Incisor Third-Order Inclination Resulting from Vertical Variation in Lingual Bracket Placement"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","454"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","461"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Attin, Thomas"],["dc.contributor.author","Engelke, Wilfried G. H."],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Gripp-Rudolph, Liliam"],["dc.contributor.author","Attin, Rengin"],["dc.date.accessioned","2018-11-07T08:30:05Z"],["dc.date.available","2018-11-07T08:30:05Z"],["dc.date.issued","2009"],["dc.description.abstract","Objective: To evaluate the significance of crown-root angles (CRAs) by testing the null hypothesis that there are no significant differences in deviations of third-order angles to axial inclination values between Angle Class II division 2 incisors and a neutral occlusion control sample. Materials and Methods: The study group comprised n(total) = 130 whites with either Angle Class II division 2 (n(1) = 62; group A) or neutral (n(2) = 68; control group B) occlusal relationships. Upper central incisor inclination (U1) was assessed with reference to the cephalometric lines NA and palatal plane (U1NA/deg, U1PP/deg). Craniofacial sagittal and vertical relations were classified using angles SNA, SNB, ANB, and NSL-PP. Third-order angles were derived from corresponding dental cast pairs using an incisor inclination gauge. Welch's two-sample t-tests (alpha-level:.05) were used to test the null hypothesis. Single linear regression was applied to determine third-order angle values as a function of axial inclination values (U1NA, U1PP) or sagittal craniofacial structures (ANB angle), separately for group A and B. Results: The discrepancy between axial inclination (U1NA, U1PP) and third-order angles is significantly different (P <.001) between groups A and B. Regression analysis revealed a simply moderate correlation between third-order measurements and axial inclinations or sagittal craniofacial structures. Conclusion: The hypothesis is rejected. The results of this study warn against the use of identical third-order angles irrespective of diminished CRAs typical for Angle Class II division 2 subjects. Routine CRA assessment may be considered in orthodontic treatment planning of Angle Class II division 2 cases. (Angle Orthod. 2009;79:454-461.)"],["dc.identifier.doi","10.2319/042508-234"],["dc.identifier.isi","000266052200008"],["dc.identifier.pmid","19413389"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16807"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","On the Interaction between Incisor Crown-Root Morphology and Third-Order Angulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","532"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","539"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Knoesel, Michael"],["dc.contributor.author","Jung, Klaus"],["dc.date.accessioned","2018-11-07T08:56:38Z"],["dc.date.available","2018-11-07T08:56:38Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: To assess the informational value, intention, source, and bias of videos related to orthodontics screened by the video-sharing Internet platform You Tube. Methods: You Tube (www.youtube.com) was scanned in July 2010 for orthodontics-related videos using an adequately defined search term. Each of the first 30 search results of the scan was categorized with the system-generated sorts \"by relevance\" and \"most viewed\" (total: 60). These were rated independently by three assessors, who completed a questionnaire for each video. The data were analyzed statistically using Friedman's test for dependent samples, Kendall's tau, and Fleiss's kappa. Results: The You Tube scan produced 5140 results. There was a wide variety of information about orthodontics available on You Tube, and the highest proportion of videos was found to originate from orthodontic patients. These videos were also the most viewed ones. The informational content of most of the videos was generally judged to be low, with a rather poor to inadequate representation of the orthodontic profession, although a moderately pro-orthodontics stance prevailed. It was noticeable that the majority of contributions of orthodontists to You Tube constituted advertising. This tendency was not viewed positively by the majority of You Tube users, as was evident in the divergence in the proportions when sorting by \"relevance\" and \"most viewed.\" Conclusion: In the light of the very large number of people using the Internet as their primary source of information, orthodontists should recognize the importance of You Tube and similar social media Web sites in the opinion-forming process, especially in the case of adolescents. (Angle Orthod. 2011;81:532-539.)"],["dc.identifier.doi","10.2319/091710-541.1"],["dc.identifier.isi","000289761800025"],["dc.identifier.pmid","21261492"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23198"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Informational value and bias of videos related to orthodontics screened on a video-sharing Web site"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","27"],["dc.bibliographiccitation.journal","World Journal of Surgical Oncology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Rothe, Hilka"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Ghadimi, B. Michael"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Liersch, Torsten"],["dc.date.accessioned","2018-11-07T08:44:09Z"],["dc.date.available","2018-11-07T08:44:09Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Response to preoperative radiochemotherapy (RCT) in patients with locally advanced rectal cancer is very heterogeneous. Pathologic complete response (pCR) is accompanied by a favorable outcome. However, most patients show incomplete response. The aim of this investigation was to find indications for risk stratification in the group of intermediate responders to RCT. Methods: From a prospective database of 496 patients with rectal adenocarcinoma, 107 patients with stage II/III cancers and intermediate response to preoperative 5-FU based RCT (ypT2/3 and TRG 2/3), treated within the German Rectal Cancer Trials were studied. Surgical treatment comprised curative (R0) total mesorectal excision (TME) in all cases. In 95 patients available for statistical analyses, residual transmural infiltration of the mesorectal compartment, nodal involvement and histolologic tumor grading were investigated for their prognostic impact on disease-free (DFS) and overall survival ( OS). Results: Residual tumor transgression into the mesorectal compartment (ypT3) did not influence DFS and OS rates ( p = 0.619, p = 0.602, respectively). Nodal involvement after preoperative RCT (ypN1/2) turned out to be a valid prognostic factor with decreased DFS and OS (p = 0.0463, p = 0.0236, respectively). Persistent tumor infiltration of the mesorectum ( ypT3) and histologic tumor grading of residual tumor cell clusters were strongly correlated with lymph node metastases after neoadjuvant treatment (p < 0.001). Conclusions: Advanced transmural tumor invasion after RCT does not affect prognosis when curative ( R0) resection is achievable. Residual nodal status is the most important predictor of individual outcome in intermediate responders to preoperative RCT. Furthermore, ypT stage and tumor grading turn out to be additional auxiliary factors. Future clinical trials for risk-adapted adjuvant therapy should be based on a synopsis of clinicopathologic parameters."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.1186/1477-7819-8-27"],["dc.identifier.isi","000277431000001"],["dc.identifier.pmid","20388220"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5680"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20132"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1477-7819"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Stage II/III rectal cancer with intermediate response to preoperative radiochemotherapy: Do we have indications for individual risk stratification?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","127"],["dc.bibliographiccitation.journal","BMC Bioinformatics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Jung, Klaus"],["dc.date.accessioned","2018-11-07T08:56:54Z"],["dc.date.available","2018-11-07T08:56:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e. g. cancer. Frequently, microarray studies are performed to identify genes of which the expression levels in pretherapeutic tissue samples are correlated to survival times of patients. Typically, such a study can take several years until the full planned sample size is available. Therefore, interim analyses are desirable, offering the possibility of stopping the study earlier, or of performing additional laboratory experiments to validate the role of the detected genes. While many methods correcting the multiple testing bias introduced by interim analyses have been proposed for studies of one single feature, there are still open questions about interim analyses of multiple features, particularly of high-dimensional microarray data, where the number of features clearly exceeds the number of samples. Therefore, we examine false discovery rates and power rates in microarray experiments performed during interim analyses of survival studies. In addition, the early stopping based on interim results of such studies is evaluated. As stop criterion we employ the achieved average power rate, i.e. the proportion of detected true positives, for which a new estimator is derived and compared to existing estimators. Results: In a simulation study, pre-specified levels of the false discovery rate are maintained in each interim analysis, where reduced levels as used in classical group sequential designs of one single feature are not necessary. Average power rates increase with each interim analysis, and many studies can be stopped prior to their planned end when a certain pre-specified power rate is achieved. The new estimator for the power rate slightly deviates from the true power rate but is comparable to other estimators. Conclusions: Interim analyses of microarray experiments can provide evidence for early stopping of long-term survival studies. The developed simulation framework, which we also offer as a new R package 'SurvGenesInterim' available at http://survgenesinter.R-Forge.R-Project.org, can be used for sample size planning of the evaluated study design."],["dc.identifier.doi","10.1186/1471-2105-12-127"],["dc.identifier.isi","000290784600001"],["dc.identifier.pmid","21527044"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6343"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23260"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2105"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Sequential interim analyses of survival data in DNA microarray experiments"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","78"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Proteomics & Bioinformatics"],["dc.bibliographiccitation.lastpage","87"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Poschmann, Gereon"],["dc.contributor.author","Podwojski, Katharina"],["dc.contributor.author","Eisenacher, Martin"],["dc.contributor.author","Kohl, Michael"],["dc.contributor.author","Pfeiffer, Kathy"],["dc.contributor.author","Meyer, Helmut E."],["dc.contributor.author","Stühler, Kai"],["dc.contributor.author","Stephan, Christian"],["dc.date.accessioned","2019-07-09T11:52:47Z"],["dc.date.available","2019-07-09T11:52:47Z"],["dc.date.issued","2009"],["dc.description.abstract","Differential proteome analyses focus on the detection and quantification of expression changes between samples from different biological groups. While the significance of an expression change is detected by some statistical test, the strength of an expression change is usually quantified by some ratio estimate, e.g. the ‘fold change’. Due to its quantitative character, the fold change is more intuitively for biologists than the decision of a statistical test. However, strong expression changes are often misleading if this change is not significant. For this reason, we propose the employment of confidence intervals, adjusted for multiple hypotheses testing, which naturally comprise both, test decision and quantification. The adjusted confidence intervals can be used for making test decisions under the control of error rates typically considered in multiple hypotheses testing (e.g. the familywise error rate or the false discovery rate). For biologists, test decisions based on adjusted confidence intervals offer a more intuitive method for selecting proteins with a significant expression change between two groups. The length of the intervals can be used for sample size planning of upcoming experiments. Our approach is primarily addressed to protein expression data recorded by two-dimensional Difference Gel Electrophoresis."],["dc.identifier.doi","10.4172/jpb.1000064"],["dc.identifier.fs","550223"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5947"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60276"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0974-276X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Adjusted Confidence Intervals for the Expression Change of Proteins observed in 2-Dimensional Difference Gel Electrophoresis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1057"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Angle Orthodontist"],["dc.bibliographiccitation.lastpage","1063"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Hahn, Wolfram"],["dc.contributor.author","Engelke, Benjamin"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Dathe, Henning"],["dc.contributor.author","Kramer, Franz-Joseph"],["dc.contributor.author","Roedig, Tina"],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-11-07T08:50:19Z"],["dc.date.available","2018-11-07T08:50:19Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: To determine the forces and moments delivered to a maxillary central incisor during rotation with aligners when a simulated occlusal force generated during swallowing acts on the appliance. Materials and Methods: Five identical appliances were manufactured from four different starting materials (Erkodur 0.8 mm and 1.0 mm; Biolon 0.75 mm and 1.0 mm). An upper central incisor fixed in a measuring device was rotated around its central axis in 0.5-degree steps up to +/- 10 degrees with the appliance fixed in place. An occlusal force of 30 N generated during swallowing was simulated with a weight positioned on the appliance. For statistical analysis, the moments Tz (rotation) and forces Fz (intrusion) at a deflection of +/- 0.34 mm to the incisor edge (+/- 5 degrees rotation) were tested. Means and standard deviations for Tz and median and 25% and 75% quartiles for Fz were calculated. An analysis of variance was performed. Results: The simulated occlusal force increased the measured intrusive force Fz (maximum with a weight, -3.7 N [-3.7, -2.4]; minimum without a weight, -1.3 N [-1.4, -1.1]) and the rotary moment Tz (maximum with a weight, -50.8 Nmm [+/- 0.8]; minimum without a weight, 18.2 Nmm [+/- 0.9]) significantly in all cases (P < .01). This was found for all materials measured and for both directions of rotation. Conclusion: During rotation with aligners, a simulated occlusal force increases the intrusive force and the rotary moment. The biological adverse side effects of these phenomena remain unclear, especially in patients with periods of bruxism. (Angle Orthod. 2011;81:1057-1063.)"],["dc.identifier.doi","10.2319/013111-62.1"],["dc.identifier.isi","000296484900019"],["dc.identifier.pmid","21612314"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8018"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21669"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","E H Angle Education Research Foundation, Inc"],["dc.relation.issn","0003-3219"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The influence of occlusal forces on force delivery properties of aligners during rotation of an upper central incisor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","731"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Heart Rhythm"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:42:45Z"],["dc.date.available","2018-11-07T08:42:45Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND Idiopathic ventricular tachycardia (VT) in children with a structurally normal heart can cause significant morbidity, and although rare, mortality. Conventional activation and pace mapping may be limited by nonsustained tachycardia or unstable hemodynamics. OBJECTIVE The aim of this study was to assess feasibility of catheter ablation of idiopathic VT in the pediatric population guided by noncontact mapping. METHODS Twenty consecutive pediatric patients with idiopathic VT underwent electrophysiologic study with the intention to use the noncontact mapping system EnSite 3000 (EnSite Array, St. Jude Medical Inc., Minneapolis, Minnesota). The multielectrode balloon array was introduced into the left or right ventricle, respectively, and tachycardia was analyzed using color-coded isopotential maps as well as reconstructed unipolar electrograms on the virtual geometry. The region of origin was identified in all of them, and the site of earliest activation with a QS pattern of the unipolar electrograms was guided for sites of ablation. RESULTS Idiopathic VT originated from the right ventricular outflow tract in 6 patients, from the left ventricle in 8, and from the aortic sinus cusp in 6 in this cohort with a median age of 14.4 (range: 4.8 to 20.9) years. Ablation was attempted in 18 of 20 children, and was acutely successful in 17 of these 18 (94%). During a mean follow-up of 2.3 +/- 1.7 years, VT recurred in 3, 2 of them have been treated with a second procedure, resulting in an overall intermediate-term success in 16 of 18 (89%) children with idiopathic VT. CONCLUSION Noncontact mapping can safely and effectively be used to map and guide catheter ablation of the tachycardia substrate of idiopathic VT in pediatric patients."],["dc.identifier.doi","10.1016/j.hrthm.2010.02.031"],["dc.identifier.isi","000278608300002"],["dc.identifier.pmid","20193776"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19771"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1547-5271"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Catheter ablation of idiopathic left and right ventricular tachycardias in the pediatric population using noncontact mapping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","563"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Clinical and Experimental Nephrology"],["dc.bibliographiccitation.lastpage","568"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Ratliff, Brian B."],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Gauczinski, Sarah"],["dc.contributor.author","Koziolek, Michael Johann"],["dc.date.accessioned","2018-11-07T09:21:45Z"],["dc.date.available","2018-11-07T09:21:45Z"],["dc.date.issued","2013"],["dc.description.abstract","The assessment of hydration status remains a challenging task in hemodialysis (HD) management. There are only limited data available on the relevance of clinical decisions in the estimation of dialysis overhydration (OH). The objective of this study was to examine the significance of clinical judgment in the assessment of pre-dialysis OH. We compared the performance of three methods of OH assessment: (1) clinical judgment guided by a single clinical examination with (2) multifrequency bioimpedance analysis (BIA) and (3) complex systematic clinical approach. We additionally studied the associations of these methods with selected laboratory and imaging parameters. Any of the single parameters alone reached a sufficient level of accuracy for reliable prediction of OH. Clinical judgment was the single most important factor in OH estimation, and also had the highest contribution when in combination with other parameters. BIA reliably measured extracellular fluid, but the automatically calculated OHBIA exhibited a substantial degree of inaccuracy that precludes the use of BIA as a standard at present. The combination of clinical judgment with additional clinical parameters had the highest prediction accuracy for OH. Among the parameters studied, vena cava collapsibility index and calf circumference showed the strongest association with OH. Echocardiography, cardiothoracic index, atrial natriuretic peptide levels and spirometry did not have acceptable sensitivity. The systematic clinical approach combining physician and patient inputs, laboratory and imaging data enables an individualized decision and a superior accuracy in OH assessment."],["dc.identifier.doi","10.1007/s10157-012-0745-9"],["dc.identifier.isi","000323511000012"],["dc.identifier.pmid","23192771"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10331"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29183"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1342-1751"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Clinical judgment is the most important element in overhydration assessment of chronic hemodialysis patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1811"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","1819"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Xyda, Argyro"],["dc.contributor.author","Haberland, Ulrike"],["dc.contributor.author","Klotz, Ernst"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Schramm, Ramona"],["dc.contributor.author","Psychogios, Marios Nikos"],["dc.contributor.author","Erb, Gunter"],["dc.contributor.author","Schramm, Peter"],["dc.date.accessioned","2018-11-07T08:52:58Z"],["dc.date.available","2018-11-07T08:52:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Validation of the feasibility and efficacy of volume perfusion computed tomography (VPCT) in the preoperative assessment of cerebral gliomas by applying a 128-slice CT covering the entire tumour. Forty-six patients (25 men, 21 women; mean age 52.8 years) with cerebral gliomas were evaluated with VPCT. Two readers independently evaluated VPCT data, drawing volumes of interest (VOIs) around the tumour according to maximum intensity projection volumes, which were mapped automatically onto the cerebral blood volume (CBV), flow (CBF) and permeability (Ktrans) perfusion datasets. As control, a second VOI was placed in the contralateral healthy cortex. Correlation among perfusion parameters, tumour grade, hemisphere and VOIs was assessed. The diagnostic power of perfusion parameters was analysed by receiver operating characteristics curve analyses. VPCT was feasible in the assessment of the entire tumour extent. Mean values of Ktrans, CBV, CBF in high-grade gliomas were significantly higher compared with low-grade (p < 0.01). Ktrans demonstrated the highest diagnostic (97% sensitivity), positive (100%) and negative (94%) prognostic values. VPCT was feasible in all subjects. All areas of different perfusion characteristics are depicted and quantified in colour-coded 3D maps. The derived parameters correlate well with tumour histopathology, differentiating low- from high-grade gliomas."],["dc.identifier.doi","10.1007/s00330-011-2150-2"],["dc.identifier.isi","000293640500002"],["dc.identifier.pmid","21573969"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22293"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0938-7994"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]