Eckardstein, Kajetan L. von

[["dc.bibliographiccitation.firstpage","1376"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","1383"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Engelhorn, Tobias"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Steighardt, Jörg"],["dc.contributor.author","Richter, Michael"],["dc.contributor.author","Barker, Fred G."],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2020-12-10T18:44:04Z"],["dc.date.available","2020-12-10T18:44:04Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3171/2016.8.JNS16626"],["dc.identifier.eissn","1933-0693"],["dc.identifier.issn","0022-3085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78314"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Prophylactic nimodipine treatment and improvement in hearing outcome after vestibular schwannoma surgery: a combined analysis of a randomized, multicenter, Phase III trial and its pilot study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","733"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","738"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Scheller, Konstanze"],["dc.contributor.author","Prell, Julian"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Barker, Fred G., II"],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2018-11-07T10:25:39Z"],["dc.date.available","2018-11-07T10:25:39Z"],["dc.date.issued","2017"],["dc.description.abstract","Background Evidence of a high interobserver variability of the subjective House-Brackmann facial nerve grading system (HBGS) would justify cost- and time-consuming technological enhancements of objective classifications for facial nerve paresis. Method A total of 112 patients were recruited for a randomized multi-center trial to investigate the efficacy of prophylactic nimodipine treatment in vestibular schwannoma (VS) surgery. For the present investigation both treatment groups were pooled for the assessment of facial nerve function preoperatively, in the early postoperative course and 1 year after the surgery. Facial nerve function was documented photographically at rest and in motion and classified according to the HBGS by three independent observers (neurosurgeon, neurologist, ENT) and by the investigator of each center. Result Interobserver variability was considerably different with respect to the three time points depending upon the severity of facial nerve paresis. Preoperative facial nerve function was normal or only mildly impaired (HB grade I or II) and was assessed consistently in 97%. Facial nerve function deteriorated during the early postoperative course and was subsequently documented without dissent in only 36%, with one grade difference in 45%, two grade difference in 17% and three grade difference in 2%. One year after surgery, facial nerve function predominantly improved resulting in a consistent assessment in 66%. Differing ratings were observed in 34% with one grade deviation in 88% and of two grades in 12%. Patients with differing ratings of two or more grades exhibited considerably worse facial nerve function (p < 0.001). Conclusions The HBGS produced comparable results between different observers in patients with normal or only mildly impaired facial nerve function. Interobserver variability increased depending on the severity of facial nerve paresis. The results suggest that the HBGS does not promote uniformity of reporting and comparison of outcomes in patients with moderate or severe facial nerve paresis."],["dc.identifier.doi","10.1007/s00701-017-3109-0"],["dc.identifier.isi","000398164500021"],["dc.identifier.pmid","28188418"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42898"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Interobserver variability of the House-Brackmann facial nerve grading system for the analysis of a randomized multi-center phase III trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","249"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","256"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Rampp, Stefan"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2021-04-14T08:23:53Z"],["dc.date.available","2021-04-14T08:23:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3171/2019.1.JNS181784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81083"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","A critical comparison between the semisitting and the supine positioning in vestibular schwannoma surgery: subgroup analysis of a randomized, multicenter trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","657"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","664"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Engelhorn, Tobias"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Kornhuber, Malte"],["dc.contributor.author","Steighardt, Jörg"],["dc.contributor.author","Richter, Michael"],["dc.contributor.author","Barker, Fred G."],["dc.contributor.author","Strauss, Christian"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.date.accessioned","2020-12-10T18:44:03Z"],["dc.date.available","2020-12-10T18:44:03Z"],["dc.date.issued","2016"],["dc.description.abstract","OBJECTIVE A pilot study of prophylactic nimodipine and hydroxyethyl starch treatment showed a beneficial effect on facial and cochlear nerve preservation following vestibular schwannoma (VS) surgery. A prospective Phase III trial was undertaken to confirm these results. METHODS An open-label, 2-arm, randomized parallel group and multicenter Phase III trial with blinded expert review was performed and included 112 patients who underwent VS surgery between January 2010 and February 2013 at 7 departments of neurosurgery to investigate the efficacy and safety of the prophylaxis. The was performed after the patients were randomly assigned to one of 2 groups using online randomization. The treatment group (n = 56) received parenteral nimodipine (1-2 mg/hr) and hydroxyethyl starch (hematocrit 30%-35%) from the day before surgery until the 7th postoperative day. The control group (n = 56) was not treated prophylactically. RESULTS Intent-to-treat analysis showed no statistically significant effects of the treatment on either preservation of facial nerve function (35 [67.3%] of 52 [treatment group] compared with 34 [72.3%] of 47 [control group]) (p = 0.745) or hearing preservation (11 [23.4%] of 47 [treatment group] compared with 15 [31.2%] of 48 [control group]) (p = 0.530) 12 months after surgery. Since tumor sizes were significantly larger in the treatment group than in the control group, logistic regression analysis was required. The risk for deterioration of facial nerve function was adjusted nearly the same in both groups (OR 1.07 [95% CI 0.34-3.43], p = 0.91). In contrast, the risk for postoperative hearing loss was adjusted 2 times lower in the treatment group compared with the control group (OR 0.49 [95% CI 0.18-1.30], p = 0.15). Apart from dose dependent hypotension (p < 0.001), no clinically relevant adverse reactions were observed. CONCLUSIONS There were no statistically significant effects of the treatment. Despite the width of the confidence intervals, the odds ratios may suggest but do not prove a clinically relevant effect of the safe study medication on the preservation of cochlear nerve function after VS surgery. Further study is needed before prophylactic nimodipine can be recommended in VS surgery."],["dc.identifier.doi","10.3171/2015.1.JNS142001"],["dc.identifier.eissn","1933-0693"],["dc.identifier.isi","000370915200008"],["dc.identifier.issn","0022-3085"],["dc.identifier.pmid","26274985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78311"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Prophylactic nimodipine treatment for cochlear and facial nerve preservation after vestibular schwannoma surgery: a randomized multicenter Phase III trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1277"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","1282"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Bischoff, Barbara"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria Teresa"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Kretschmer, Thomas"],["dc.contributor.author","Zenk, Johannes"],["dc.contributor.author","Strauss, Christian"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.date.accessioned","2020-12-10T18:44:03Z"],["dc.date.available","2020-12-10T18:44:03Z"],["dc.date.issued","2016"],["dc.description.abstract","OBJECTIVE The purpose of this research was to examine the stability of long-term hearing preservation and the regeneration capacity of the cochlear nerve following vestibular schwannoma (VS) surgery in a prospective study. METHODS A total of 112 patients were recruited for a randomized multicenter trial between January 2010 and April 2012 to investigate the efficacy of prophylactic nimodipine treatment versus no prophylactic nimodipine treatment in VS surgery. For the present investigation, both groups were pooled to compare hearing abilities in the early postoperative course and 1 year after the surgery. Hearing was examined using pure-tone audiometry with speech discrimination, which was performed preoperatively, in the early postoperative course, and 12 months after surgery and was subsequently classified by an independent otorhinolaryngologist using the Gardner-Robertson classification system. RESULTS Hearing abilities at 2 time points were compared by evaluation in the early postoperative course and 1 year after surgery in 102 patients. The chi-square test showed a very strong association between the 2 measurements in all 102 patients (p < 0.001) and in the subgroup of 66 patients with a preserved cochlear nerve (p < 0.001). CONCLUSIONS There is no significant change in cochlear nerve function between the early postoperative course and 1 year after VS surgery. The result of hearing performance, as evaluated by early postoperative audiometry after VS surgery, seems to be a reliable prognosticator for future hearing ability."],["dc.identifier.doi","10.3171/2015.10.JNS15926"],["dc.identifier.eissn","1933-0693"],["dc.identifier.isi","000386106100028"],["dc.identifier.issn","0022-3085"],["dc.identifier.pmid","26824379"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78310"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Stability of hearing preservation and regeneration capacity of the cochlear nerve following vestibular schwannoma surgery via a retrosigmoid approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Scheller, Christian"],["dc.contributor.author","Rampp, Stefan"],["dc.contributor.author","Leisz, Sandra"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Ramina, Kristofer F."],["dc.contributor.author","Ganslandt, Oliver"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Antoniadis, Gregor"],["dc.contributor.author","Pedro, Maria T."],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Scheller, Konstanze"],["dc.contributor.author","Strauss, Christian"],["dc.date.accessioned","2021-04-14T08:24:42Z"],["dc.date.available","2021-04-14T08:24:42Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s10143-020-01368-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81394"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1437-2320"],["dc.relation.issn","0344-5607"],["dc.title","Prophylactic nimodipine treatment improves hearing outcome after vestibular schwannoma surgery in men: a subgroup analysis of a randomized multicenter phase III trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3"],["dc.bibliographiccitation.journal","Parkinsonism & Related Disorders"],["dc.bibliographiccitation.lastpage","9"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Haas, Kirsten"],["dc.contributor.author","Stangl, Stephanie"],["dc.contributor.author","Steigerwald, Frank"],["dc.contributor.author","Matthies, Cordula"],["dc.contributor.author","Gruber, Doreen"],["dc.contributor.author","Kühn, Andrea A."],["dc.contributor.author","Krauss, Joachim K."],["dc.contributor.author","Sixel-Döring, Friederike"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Deuschl, Günther"],["dc.contributor.author","Classen, Joseph"],["dc.contributor.author","Winkler, Dirk"],["dc.contributor.author","Voges, Jürgen"],["dc.contributor.author","Galazky, Imke"],["dc.contributor.author","Oertel, Wolfgang"],["dc.contributor.author","Ceballos-Baumann, Andres O."],["dc.contributor.author","Lange, Max"],["dc.contributor.author","Gharabaghi, Alireza"],["dc.contributor.author","Weiss, Daniel T."],["dc.contributor.author","Volkmann, Jens"],["dc.contributor.author","Heuschmann, Peter U."],["dc.date.accessioned","2020-12-10T15:20:41Z"],["dc.date.available","2020-12-10T15:20:41Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.parkreldis.2019.01.016"],["dc.identifier.issn","1353-8020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72762"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Development of evidence-based quality indicators for deep brain stimulation in patients with Parkinson's disease and first year experience of implementation of a nation-wide registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]