Lang, Christine

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Psychiatry Research"],["dc.bibliographiccitation.lastpage","146"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Weniger, Godehard"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T10:45:28Z"],["dc.date.available","2018-11-07T10:45:28Z"],["dc.date.issued","2004"],["dc.description.abstract","The goal of this study was to assess facial affect recognition abilities in subjects with various schizophrenia subtypes and subjects with major depression. A total of six disorganized, 21 paranoid and 18 residual subjects with schizophrenia (DSM-IV criteria) were compared with 21 subjects with major depression (DSM-1V criteria) and 30 matched healthy control subjects. Two experimental tasks requiring the sorting and rating of emotional facial expressions were applied. Disorganized and paranoid subjects showed strong impairments in the sorting of emotional facial expressions. Depressive subjects displayed only minor deficits, and residual subjects were unimpaired. Subjects with disorganized schizophrenia rated emotional facial expressions as more aroused, and depressive subjects rated them as less aroused, than the other study groups. Our study demonstrates strong deficits in facial affect recognition in subjects with schizophrenia and pronounced disorganized or psychotic symptoms. Deficits in facial affect recognition are specific to schizophrenia. They may be considered as a state marker of schizophrenia. (C) 2004 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.psychres.2003.12.027"],["dc.identifier.isi","000224994600004"],["dc.identifier.pmid","15488956"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","0165-1781"],["dc.title","Differential impairments of facial affect recognition in schizophrenia subtypes and major depression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","331"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Irle, Eva"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Weniger, Godehard"],["dc.date.accessioned","2018-11-07T08:30:49Z"],["dc.date.available","2018-11-07T08:30:49Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1111/j.1600-0447.2009.01351.x"],["dc.identifier.isi","000263855500012"],["dc.identifier.pmid","19207126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0001-690X"],["dc.title","Further evidence that post-traumatic stress disorder but not dissociative disorders are related to amygdala and hippocampal size reduction in trauma-exposed individuals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Seizure"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Exner, C."],["dc.contributor.author","Boucsein, K."],["dc.contributor.author","Lange, C."],["dc.contributor.author","Winter, H."],["dc.contributor.author","Weniger, Godehard"],["dc.contributor.author","Steinhoff, B. J."],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T10:33:47Z"],["dc.date.available","2018-11-07T10:33:47Z"],["dc.date.issued","2002"],["dc.description.abstract","The search for a special neuropsychological profile of frontal lobe epilepsy subjects (FLE) has so far led to inconclusive results. In this paper we compared the preoperative neuropsychological performance of FLE and temporal lobe epilepsy (TLE) subjects. We further investigated whether frontal lobe lesions of epileptogenic cause produce the same type of cognitive dysfunction as do tumours of the frontal lobe. Sixteen FLE subjects were compared to 16 TLE subjects as well as to a group of 10 subjects after the removal of frontal lobe tumors (TUM) and a healthy control group, A set of neuropsychological test measures routinely used for presurgical evaluation, an emotional conceptualization task and two associative learning tasks were administered. We found that subjects with frontal lobe damage were significantly impaired relative to controls on a wide range of cognitive functions independent of neurological cause. FLE subjects could hardly be discriminated from TLE subjects as both groups showed a similarly reduced level of neuropsychological performance. Our results demonstrate the devastating effect that frontal lobe epilepsy can have on cognitive functioning. Routinely used neuropsychological test measures lack the specificity to distinguish between frontal and temporal lobe epilepsy. Highly specialized measures are necessary to reveal differences. (C) 2002 BEA Trading Ltd."],["dc.identifier.doi","10.1053/seiz.2001.0572"],["dc.identifier.isi","000174109800004"],["dc.identifier.pmid","11888256"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44700"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.relation.issn","1059-1311"],["dc.title","Neuropsychological performance in frontal lobe epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1059"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Psychological Medicine"],["dc.bibliographiccitation.lastpage","1064"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T10:47:04Z"],["dc.date.available","2018-11-07T10:47:04Z"],["dc.date.issued","2004"],["dc.description.abstract","Background. Evidence is increasing that amygdala and hippocampus show significant structural abnormalities in affective disorders. Two previous studies found enlarged amygdala size in subjects with recent-onset major depression. Method. Amygdala and hippocampal volumes were assessed in 17 young women with major depressive disorder and 17 healthy matched control subjects by use of three-dimensional structural magnetic resonance imaging. The severity of depressive symptoms was assessed using the Hamilton Depression Scale and the Beck Depression Inventory. Results. Compared with control subjects, depressive subjects had significantly larger (+13%) amygdala volumes and significantly smaller (-12%) hippocampal volumes. Amygdala and hippocampal volumes were not significantly correlated with disorder-related variables. Conclusions. Our results are consistent with previous findings of structural abnormalities of amygdala and hippocampus in subjects with recent-onset major depression. It may be suggested that the size of the amygdala is enlarged in the first years of the disorder, and may decrease with prolonged disorder duration."],["dc.identifier.doi","10.1017/S0033291703001806"],["dc.identifier.isi","000224104300010"],["dc.identifier.pmid","15554576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47886"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0033-2917"],["dc.title","Enlarged amygdala volume and reduced hippocampal volume in young women with major depression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","281"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","290"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Weniger, Godehard"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T11:10:09Z"],["dc.date.available","2018-11-07T11:10:09Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: Trauma-exposed individuals with post-traumatic stress disorder (PTSD) display reduced amygdala and hippocampal size and impaired cognition. However, studies on trauma-exposed individuals with dissociative amnesia (DA) or dissociative identity disorder (DID) are lacking. Method: Twenty-three young women who had experienced severe childhood sexual/physical abuse, diagnosed with DA/DID or PTSD, and 25 healthy control subjects were subjected to 3D structural magnetic resonance imaging of amygdala and hippocampus and a clinical and neuropsychological investigation. Results: Compared with controls, trauma-exposed subjects with PTSD (n = 10) displayed significantly reduced amygdala and hippocampal size and significantly impaired cognition. By contrast, trauma-exposed subjects with DA or DID (n = 13) displayed normal amygdala and hippocampal size and normal cognition. Conclusion: We report for the first time volumetric results in subjects with DA/DID without PTSD as comorbid diagnosis. Our results indicate preserved amygdala and hippocampal size and preserved cognition in subjects with these disorders."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [IR 15/8]"],["dc.identifier.doi","10.1111/j.1600-0447.2008.01246.x"],["dc.identifier.isi","000259207900004"],["dc.identifier.pmid","18759808"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53155"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0001-690X"],["dc.title","Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Psychiatry Research Neuroimaging"],["dc.bibliographiccitation.lastpage","126"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Kracht, L."],["dc.contributor.author","Herholz, K."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T08:29:15Z"],["dc.date.available","2018-11-07T08:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) often experience dissociative symptoms. Evidence is increasing that stress-related hyperglutamatergic states may contribute to dissociative symptoms and neurodegeneration in temporo-parietal cortical areas. Seventeen young women with BPD who had been exposed to severe childhood physical/sexual abuse and presented with pronounced dissociative symptoms underwent (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Nine healthy, matched volunteers served as comparison subjects. Borderline subjects displayed reduced FDG uptake (as analyzed by SPM) in the right temporal pole/anterior fusiform gyrus and in the left precuneus and posterior cingulate cortex. Impaired memory performance among borderline subjects was significantly correlated with metabolic activity in ventromedial and lateral temporal cortices. Our results demonstrate regional hypometabolism in temporal and medial parietal cortical regions known to be involved in episodic memory consolidation and retrieval. Currently, the precuneus/posterior cingulate cortex is modeled as part of a network of tonically active brain regions that continuously gather information about the world around and within us [Gusnard, D.A., Raichle, M.E., 2001. Searching for a baseline: functional imaging and the resting human brain. Nature Reviews Neuroscience 2, 685-694.]. Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD. (c) 2005 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.pscychresns.2005.05.003"],["dc.identifier.isi","000230807300004"],["dc.identifier.pmid","15978784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16602"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0925-4927"],["dc.title","Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","173"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Irle, Eva"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.date.accessioned","2018-11-07T08:32:12Z"],["dc.date.available","2018-11-07T08:32:12Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Evidence is accumulating that suggests borderline personality disorder(BPD) and posttraumatic stress disorder(PTSD) are related to small hippocampal size. Psychotic symptoms are frequent in both disorders. Psychotic spectrum disorders are known to be related to abnormalities of temporoparietal cortices. Methods: Using structural magnetic resonance imaging (3D-MRI), parietal cortex and hippocampal volumes were associated in 30 young women with BPD who had been exposed to severe childhood sexual and physical abuse and in 25 healthy control subjects. Results: Compared with control subjects, BPD subjects had significantly smaller right parietal cortex (-11%) and hippocampal (17%) volumes. The parietal cortex of borderline subjects showed a significantly stronger leftward asymmetry when compared with control subjects. Stronger psychotic symptoms and schizoid personality traits in borderline subjects were significantly related to reduced leftward asymmetry. Stronger trauma-related clinical symptoms and neuropsychologic deficits were significantly related to smaller hippocampal size. Conclusions: Our results are consistent with previous findings of small hippocampal size in BPD and PTSD. Reduced right parietal cortex size in individuals with BPD may reflect a neurodevelopmental deficit of the right hemisphere."],["dc.identifier.doi","10.1016/j.bio[sych.2004.10.004"],["dc.identifier.isi","000226349600010"],["dc.identifier.pmid","15652877"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17281"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.title","Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]