Lang, Christine

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","331"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Irle, Eva"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Weniger, Godehard"],["dc.date.accessioned","2018-11-07T08:30:49Z"],["dc.date.available","2018-11-07T08:30:49Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1111/j.1600-0447.2009.01351.x"],["dc.identifier.isi","000263855500012"],["dc.identifier.pmid","19207126"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0001-690X"],["dc.title","Further evidence that post-traumatic stress disorder but not dissociative disorders are related to amygdala and hippocampal size reduction in trauma-exposed individuals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","281"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Psychiatrica Scandinavica"],["dc.bibliographiccitation.lastpage","290"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Weniger, Godehard"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T11:10:09Z"],["dc.date.available","2018-11-07T11:10:09Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: Trauma-exposed individuals with post-traumatic stress disorder (PTSD) display reduced amygdala and hippocampal size and impaired cognition. However, studies on trauma-exposed individuals with dissociative amnesia (DA) or dissociative identity disorder (DID) are lacking. Method: Twenty-three young women who had experienced severe childhood sexual/physical abuse, diagnosed with DA/DID or PTSD, and 25 healthy control subjects were subjected to 3D structural magnetic resonance imaging of amygdala and hippocampus and a clinical and neuropsychological investigation. Results: Compared with controls, trauma-exposed subjects with PTSD (n = 10) displayed significantly reduced amygdala and hippocampal size and significantly impaired cognition. By contrast, trauma-exposed subjects with DA or DID (n = 13) displayed normal amygdala and hippocampal size and normal cognition. Conclusion: We report for the first time volumetric results in subjects with DA/DID without PTSD as comorbid diagnosis. Our results indicate preserved amygdala and hippocampal size and preserved cognition in subjects with these disorders."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [IR 15/8]"],["dc.identifier.doi","10.1111/j.1600-0447.2008.01246.x"],["dc.identifier.isi","000259207900004"],["dc.identifier.pmid","18759808"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53155"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0001-690X"],["dc.title","Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Psychiatry Research Neuroimaging"],["dc.bibliographiccitation.lastpage","126"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Kracht, L."],["dc.contributor.author","Herholz, K."],["dc.contributor.author","Sachsse, Ulrich"],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T08:29:15Z"],["dc.date.available","2018-11-07T08:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) often experience dissociative symptoms. Evidence is increasing that stress-related hyperglutamatergic states may contribute to dissociative symptoms and neurodegeneration in temporo-parietal cortical areas. Seventeen young women with BPD who had been exposed to severe childhood physical/sexual abuse and presented with pronounced dissociative symptoms underwent (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Nine healthy, matched volunteers served as comparison subjects. Borderline subjects displayed reduced FDG uptake (as analyzed by SPM) in the right temporal pole/anterior fusiform gyrus and in the left precuneus and posterior cingulate cortex. Impaired memory performance among borderline subjects was significantly correlated with metabolic activity in ventromedial and lateral temporal cortices. Our results demonstrate regional hypometabolism in temporal and medial parietal cortical regions known to be involved in episodic memory consolidation and retrieval. Currently, the precuneus/posterior cingulate cortex is modeled as part of a network of tonically active brain regions that continuously gather information about the world around and within us [Gusnard, D.A., Raichle, M.E., 2001. Searching for a baseline: functional imaging and the resting human brain. Nature Reviews Neuroscience 2, 685-694.]. Decreased resting metabolic rate of these regions may reflect dissociative symptoms and possibly also identity disturbances and interpersonal difficulties of individuals with BPD. (c) 2005 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.pscychresns.2005.05.003"],["dc.identifier.isi","000230807300004"],["dc.identifier.pmid","15978784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16602"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0925-4927"],["dc.title","Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","173"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Irle, Eva"],["dc.contributor.author","Lange, C."],["dc.contributor.author","Sachsse, Ulrich"],["dc.date.accessioned","2018-11-07T08:32:12Z"],["dc.date.available","2018-11-07T08:32:12Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Evidence is accumulating that suggests borderline personality disorder(BPD) and posttraumatic stress disorder(PTSD) are related to small hippocampal size. Psychotic symptoms are frequent in both disorders. Psychotic spectrum disorders are known to be related to abnormalities of temporoparietal cortices. Methods: Using structural magnetic resonance imaging (3D-MRI), parietal cortex and hippocampal volumes were associated in 30 young women with BPD who had been exposed to severe childhood sexual and physical abuse and in 25 healthy control subjects. Results: Compared with control subjects, BPD subjects had significantly smaller right parietal cortex (-11%) and hippocampal (17%) volumes. The parietal cortex of borderline subjects showed a significantly stronger leftward asymmetry when compared with control subjects. Stronger psychotic symptoms and schizoid personality traits in borderline subjects were significantly related to reduced leftward asymmetry. Stronger trauma-related clinical symptoms and neuropsychologic deficits were significantly related to smaller hippocampal size. Conclusions: Our results are consistent with previous findings of small hippocampal size in BPD and PTSD. Reduced right parietal cortex size in individuals with BPD may reflect a neurodevelopmental deficit of the right hemisphere."],["dc.identifier.doi","10.1016/j.bio[sych.2004.10.004"],["dc.identifier.isi","000226349600010"],["dc.identifier.pmid","15652877"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17281"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.title","Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]