Perske, Christina

[["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.contributor.author","Sievers, Denise"],["dc.contributor.author","Bunzendahl, Jens"],["dc.contributor.author","Frosch, Alice"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-06-01T10:48:53Z"],["dc.date.available","2021-06-01T10:48:53Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3892/mco.2017.1514"],["dc.identifier.eissn","2049-9469"],["dc.identifier.issn","2049-9450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86085"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14677"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Kling, Alexander"],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.date.accessioned","2018-06-25T07:26:32Z"],["dc.date.available","2018-06-25T07:26:32Z"],["dc.date.issued","2017"],["dc.description.abstract","This study evaluates the effects of tumour-associated mast cells on the prognosis of patients suffering from oral squamous cell carcinoma (OSCC). Tryptase-positive (MCT+) and CD117-positive (CD117+) mast cells were immunohistochemically evaluated in tissue samples of 118 OSCC patients. Besides, various clinicopathological parameters, the influence of the MCT+ and CD117+ mast cell density on overall survival and the incidence of first local recurrence was analysed by Cox regression and competing risk regression. Among all investigated parameters, multiple Cox regression revealed a significant influence of the MCT+ (cut-off at 14.87 mast cells/mm2 stroma; p = 0.0027) and CD117+ mast cell density (cut-off at 33.19 mast cells/mm2 stroma; p = 0.004), the age at primary diagnosis, and the T and N stage (all p-values < 0.05) on overall survival. Patients with a low mast cell density showed a significantly poorer overall survival rate compared to those with a high mast cell density in the tumour-associated stroma. Competing risk regression revealed a significant influence of the resection status (R) on the incidence of first local recurrence (p = 0.0023). A high mast cell density in the tumour-associated stroma of oral squamous cell carcinoma indicates a longer patient survival."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1038/s41598-017-15406-5"],["dc.identifier.pmid","29116177"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14831"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15131"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High mast cell density indicates a longer overall survival in oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","273"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Oncology"],["dc.bibliographiccitation.lastpage","281"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Hemmerlein, Bernhard"],["dc.date.accessioned","2018-11-07T09:38:40Z"],["dc.date.available","2018-11-07T09:38:40Z"],["dc.date.issued","2014"],["dc.description.abstract","The aim of the present study was to evaluate the expression and localization of connexin (Cx) 26, -43 and -45 in a group of 35 patients with primary oral squamous cell carcinoma (OSCC) with the objective of making a more accurate disease prognosis. We analysed the expression of connexins in tissue samples of primary OSCC, matching oral mucosa free of dysplasia, and its associated lymph node metastases (LNM) by semi-quantitative immunohistochemistry of membrane, cytoplasmic and nuclear connexin expression. The levels of expression were correlated with the overall survival time (OS). Cx43 was overexpressed in tumour cells compared to epithelia in dysplasia-free mucosa. High membrane expression of Cx43 on tumour cells was the only statistically significant and independent prognostic factor of short OS (P=0.0088). Membrane expression of Cx43 in matching dysplasia-free mucosa acted similarly, but did not reach statistical significance (P=0.059). No correlation was found between the Cx26, Cx45 expression and OS. We conclude that Cx43 expression in dysplasia-free mucosa may indicate a very early stage of tumour promotion. Although overexpression of Cx43 is found in invasive tumours we only found membrane Cx43 expression to correlate with OS. This observation suggests that cytoplasmic Cx43 serves as storage and only membrane translocation may promote the formation of gap junctions and gap junctional intercellular communication (GJIC) with prognostic relevance."],["dc.identifier.doi","10.3892/ijo.2014.2394"],["dc.identifier.isi","000336881600030"],["dc.identifier.pmid","24788723"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33114"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Spandidos Publ Ltd"],["dc.relation.issn","1791-2423"],["dc.relation.issn","1019-6439"],["dc.title","Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","820"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal Of Clinical Periodontology"],["dc.bibliographiccitation.lastpage","826"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Mauth, Corinna"],["dc.contributor.author","Dard, Michel"],["dc.contributor.author","Molenberg, Aart"],["dc.contributor.author","Lange, Katharina"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-11-07T09:37:06Z"],["dc.date.available","2018-11-07T09:37:06Z"],["dc.date.issued","2014"],["dc.description.abstract","Aim: To test the hypothesis that a synthetic hydroxyapatite/beta-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone. Material and Methods: Bilateral mandibular partial thickness 20 x 8 x 8 mm (L x W x H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP-2 (105 mu g/defect) in contra-lateral sites using a split-mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4-week healing interval when the animals were killed for histometric analysis. Results: Bone morphogenetic proteins-2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP-2 induced bone formation. Conclusion: Polyethylene glycol compromises the osteogenic effect of BMP-2."],["dc.identifier.doi","10.1111/jcpe.12264"],["dc.identifier.isi","000340542600011"],["dc.identifier.pmid","24738890"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32762"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1600-051X"],["dc.relation.issn","0303-6979"],["dc.title","Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]