Weig, Michael

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Schmidt, P."],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, U."],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2012"],["dc.format.extent","143"],["dc.identifier.isi","000305069800445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Karyotypic and phenotypic plasticity of the Candida glabrata strain CBS138/ATCC2001"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1035"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Infectious Diseases"],["dc.bibliographiccitation.lastpage","1036"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2018-11-07T09:11:58Z"],["dc.date.available","2018-11-07T09:11:58Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1093/cid/cir943"],["dc.identifier.isi","000301296200029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26841"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1058-4838"],["dc.title","A 32-Year-Old Man With Ulcerative Mucositis, Skin Lesions, and Nail Dystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Taverne-Ghadwal, Liliane"],["dc.contributor.author","Kuhns, Martin"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Schulze, Marco H."],["dc.contributor.author","Mbaitolum, Weina Joseph"],["dc.contributor.author","Kersch, Lydia"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Groß, U."],["dc.date.accessioned","2022-04-01T10:00:45Z"],["dc.date.available","2022-04-01T10:00:45Z"],["dc.date.issued","2022"],["dc.description.abstract","Oral candidiasis remains a common problem in HIV-infected individuals, especially in sub-Saharan Africa. Here, we performed the first study in Chad on the prevalence of oral yeasts carriage and oral candidiasis in HIV-positive subjects from southern Chad and analyzed the influence of HAART, CD4 + T-cell numbers, and antimycotics in 589 patients. These patients were recruited from a specialized medical center for HIV patients in Sarh and from a rural medical health dispensary in the vicinity, including a total of 384 HIV-positive and 205 HIV-negative individuals. Yeasts obtained from oral specimen were identified by MALDI-TOF MS and their antifungal susceptibility profiles determined. The overall prevalence of yeast colonization and symptomatic oral candidiasis in HIV-infected patients was 25.1%. The prevalence of oral candidiasis was higher in untreated than in HAART-treated HIV-positive patients (16% vs. 2%; p  < 0.01). Oral candidiasis was furthermore associated with high fungal burdens of Candida albicans and a CD4 + T-cell number <200/μl. A shift toward non -albicans Candida species was observed under nucleoside-based HAART therapy. Azole antifungal drug resistance was only observed for the intrinsically resistant species Candida krusei and Candida glabrata . Prevalence of oral candidiasis in the studied area was very low. The species distribution was similar to other countries around the world, with C. albicans being dominant. Candida dubliniensis was not isolated. Nucleoside-based HAART therapy significantly reduced oral colonization as well as occurrence of oral candidiasis caused by C. albicans and led to a species shift toward non- albicans species. Antifungal resistance was not yet a concern in Chad."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fmicb.2022.844069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105503"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1664-302X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Epidemiology and Prevalence of Oral Candidiasis in HIV Patients From Chad in the Post-HAART Era"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e70425"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Morais, Janne K. S."],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Oliveira, Jose Tadeu A."],["dc.contributor.author","Arantes, Mariana R."],["dc.contributor.author","Gomes, Valdirene M."],["dc.contributor.author","Da Cunha, Maura"],["dc.contributor.author","Oliveira, Hermogenes D."],["dc.contributor.author","Sousa, Daniele O. B."],["dc.contributor.author","Lourencao, Andre L."],["dc.contributor.author","Vasconcelos, Ilka M."],["dc.date.accessioned","2018-11-07T09:22:19Z"],["dc.date.available","2018-11-07T09:22:19Z"],["dc.date.issued","2013"],["dc.description.abstract","Soybean toxin (SBTX) is an antifungal protein from soybeans with broad inhibitory activity against the growth and filamentation of many fungi, including human and plant pathogenic species such as Candida albicans, Candida parapsilosis, Aspergillus niger, Penicillium herquei, Cercospora sojina and Cercospora kikuchii. Understanding the mechanism by which SBTX acts on fungi and yeasts may contribute to the design of novel antifungal drugs and/or the development of transgenic plants resistant to pathogens. To this end, the polymorphic yeast C. albicans was chosen as a model organism and changes in the gene expression profile of strain SC5314 upon exposure to SBTX were examined. Genes that were differentially regulated in the presence of SBTX were involved in glucose transport and starvation-associated stress responses as well as in the control of both the induction and repression of C. albicans hyphal formation. Transmission electron microscopy showed that C. albicans cells exposed to SBTX displayed severe signs of starvation and were heavily granulated. Our data were indicative of C. albicans cell starvation despite sufficient nutrient availability in the medium; therefore, it can be speculated that SBTX blocks nutrient uptake systems. Because neither the starvation signal nor the alkaline response pathway lead to the induction of hyphae, we hypothesise that conflicting signals are transmitted to the complex regulatory network controlling morphogenesis, eventually preventing the filamentation signal from reaching a significant threshold."],["dc.identifier.doi","10.1371/journal.pone.0070425"],["dc.identifier.isi","000322132100094"],["dc.identifier.pmid","23894655"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29314"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Soybean Toxin (SBTX) Impairs Fungal Growth by Interfering with Molecular Transport, Carbohydrate/Amino Acid Metabolism and Drug/Stress Responses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Folba, Claudia"],["dc.contributor.author","Ichsan, Ichsan"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2018-11-07T09:20:59Z"],["dc.date.available","2018-11-07T09:20:59Z"],["dc.date.issued","2013"],["dc.format.extent","5"],["dc.identifier.isi","000322918300017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29007"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Mass Spectrometry as a new Tool for Subtyping in Fungi"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4356"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Antimicrobial Agents and Chemotherapy"],["dc.bibliographiccitation.lastpage","4359"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Tuennermann, Jana"],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, Uwe"],["dc.date.accessioned","2018-11-07T09:54:53Z"],["dc.date.available","2018-11-07T09:54:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters."],["dc.description.sponsorship","Pfizer Pharma Germany [WS2275398]"],["dc.identifier.doi","10.1128/AAC.00100-15"],["dc.identifier.isi","000360896000088"],["dc.identifier.pmid","25941229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36631"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","1098-6596"],["dc.relation.issn","0066-4804"],["dc.title","Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","301"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","de Groot, P."],["dc.contributor.author","Schwarzmueller, T."],["dc.contributor.author","Kuchler, K."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T08:51:56Z"],["dc.date.available","2018-11-07T08:51:56Z"],["dc.date.issued","2011"],["dc.format.extent","10"],["dc.identifier.isi","000296990800037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22052"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.eventlocation","Essen, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Ecm33 and Pst1 of Candida glabrata contribute to cell wall organization"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","myw130"],["dc.bibliographiccitation.journal","Medical Mycology"],["dc.contributor.author","Worasilchai, Navaporn"],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Meesilpavikkai, Kornvalee"],["dc.contributor.author","Folba, Claudia"],["dc.contributor.author","Kangogo, Mourine"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Chindamporn, Ariya"],["dc.date.accessioned","2020-12-10T18:19:22Z"],["dc.date.available","2020-12-10T18:19:22Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1093/mmy/myw130"],["dc.identifier.eissn","1460-2709"],["dc.identifier.issn","1369-3786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75224"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Diversity and Antifungal Drug Susceptibility of Cryptococcus Isolates in Thailand: Table 1."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Kuhns, Martin"],["dc.contributor.author","Reichard, Utz"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T08:52:29Z"],["dc.date.available","2018-11-07T08:52:29Z"],["dc.date.issued","2011"],["dc.format.extent","403"],["dc.identifier.isi","000294878900056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22171"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","0933-7407"],["dc.title","Azole antifungal drug resistance in clinical Aspergillus fumigatus isolates as a consequence of azole use in agriculture in Germany?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Cellular and Infection Microbiology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Bernhard, Mareike"],["dc.contributor.author","Worasilchai, Navaporn"],["dc.contributor.author","Kangogo, Mourine"],["dc.contributor.author","Bii, Christine"],["dc.contributor.author","Trzaska, Wioleta J."],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Chindamporn, Ariya"],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2021-06-01T09:42:23Z"],["dc.date.available","2021-06-01T09:42:23Z"],["dc.date.issued","2021"],["dc.description.abstract","Yeasts of the Cryptococcus neoformans / gattii species complexes are human pathogens mostly in immune compromised individuals, and can cause infections from dermal lesions to fungal meningitis. Differences in virulence and antifungal drug susceptibility of species in these complexes indicate the value of full differentiation to species level in diagnostic procedures. MALDI-TOF MS has been reported to sufficiently discriminate these species. Here, we sought to re-evaluate sample pre-processing procedures and create a set of publicly available references for use with the MALDI Biotyper system. Peak content using four different pre-processing protocols was assessed, and database entries for 13 reference strains created. These were evaluated against a collection of 153 clinical isolates, typed by conventional means. The use of decapsulating protocols or mechanical disruption did not sufficiently increase the information content to justify the extra hands-on-time. Using the set of 13 reference entries created with the standard formic acid extraction, we were able to correctly classify 143/153 (93.5%) of our test isolates. The majority of the remaining ten isolates still gave correct top matches; only two isolates did not give reproducible identifications. This indicates that the log score cut-off can be lowered also in this context. Ease to identify cryptococcal isolates to the species level is improved by the workflow evaluated here. The database references are freely available from https://github.com/oliverbader/BioTyper-libraries for incorporation into local diagnostic systems."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3389/fcimb.2021.634382"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85236"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2235-2988"],["dc.relation.orgunit","Institut für Medizinische Mikrobiologie"],["dc.rights","CC BY 4.0"],["dc.title","CryptoType – Public Datasets for MALDI-TOF-MS Based Differentiation of Cryptococcus neoformans/gattii Complexes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]