Weig, Michael

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwarz, A."],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Tangwattanachuleeporn, Marut"],["dc.contributor.author","Schmidt, P."],["dc.contributor.author","Jacobsen, Mette D."],["dc.contributor.author","Gross, U."],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T09:09:43Z"],["dc.date.available","2018-11-07T09:09:43Z"],["dc.date.issued","2012"],["dc.format.extent","143"],["dc.identifier.isi","000305069800445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Karyotypic and phenotypic plasticity of the Candida glabrata strain CBS138/ATCC2001"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","de Boer, Albert D."],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Gomez Molero, E."],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Sanchez Virosta, P."],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","de Groot, Piet W. J."],["dc.date.accessioned","2018-11-07T09:09:42Z"],["dc.date.available","2018-11-07T09:09:42Z"],["dc.date.issued","2012"],["dc.format.extent","26"],["dc.identifier.isi","000305069800087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26318"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","0933-7407"],["dc.title","Surface moieties involved in adhesion of the pathogenic yeast C. glabrata"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","394"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Mycoses"],["dc.bibliographiccitation.lastpage","395"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Wagener, Jeanette"],["dc.contributor.author","Weindl, Guenther"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","de Boer, A."],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Schaller, Martin"],["dc.date.accessioned","2018-11-07T11:20:25Z"],["dc.date.available","2018-11-07T11:20:25Z"],["dc.date.issued","2008"],["dc.identifier.isi","000258408900055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55531"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","0933-7407"],["dc.title","Multiple roles of Candida albicans-derived cell wall components in human keratinocytes activation of immune response and induction of apoptosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3129"],["dc.bibliographiccitation.journal","Microbiology"],["dc.bibliographiccitation.lastpage","3144"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Jansch, L."],["dc.contributor.author","Gross, U."],["dc.contributor.author","De Koster, C. G."],["dc.contributor.author","Klis, Frans M."],["dc.contributor.author","de Groot, Piet W. J."],["dc.date.accessioned","2018-11-07T10:45:19Z"],["dc.date.available","2018-11-07T10:45:19Z"],["dc.date.issued","2004"],["dc.description.abstract","Candida glabrata is an important cause of systemic candidiasis in humans. This paper reports a systematic analysis of the putative glycosylphosphatidylinositol-modified (GPI) proteins of C. glabrata, a large part of which are covalently bound to the cell wall glucan network and the remainder of which are retained in the plasma membrane, and of cell wall proteins (CWPs) which are covalently bound in a mild-alkali-sensitive manner. In silico genomic analysis revealed 106 putative GPI proteins. Fifty-one of these GPI proteins could be categorized as adhesive proteins, potentially implicated in fungus-host interactions or biofilm formation during the development of fungal infections. Eleven proteins belonged to well-known GPI protein families of glycoside hydrolases, probably involved in cell wall expansion and remodelling during growth. Other identified GPI proteins included phospholipases, aspartic proteases, homologues of ScEcm33p and ScKre1p, and structural CWPs. Interestingly, the GPI algorithm predicted three orthologues of an abundant CWP in S. cerevisiae, Cwp1p, which is absent in Candida albicans. To evaluate the in silico predictions, isolated cell walls were extracted using HF-pyridine, which specifically cleaves phosphodiester bonds, to release GPI-CWPs. Immunological analysis of the extract using one-dimensional SDS-PAGE and anti-ScCwp1p antiserum indicated the presence of a Cwp1p, homologue in C. glabrata cell walls. Further analysis by two-dimensional gel electrophoresis and electrospray ionization tandem mass spectrometry (ESI-MS/MS) confirmed the presence of two of the predicted Cwp1p proteins, Cwp1.1p and Cwp1.2p. Crh1p, a putative 1,3-beta-glucan remodelling enzyme, was also identified. In silico genomic analysis further revealed five putative Pir proteins (Pir1-5p) and five members of the Bgl2 glycoside hydrolase family 17, belonging to a class of putative CWPs that can be extracted with NaOH. Immunological analysis of mild-alkali-extracted CWPs showed the presence of a ScPir2p homologue. Together, these experimental data and in silico predictions represent the first systematic analysis of the C. glabrata cell wall proteome."],["dc.identifier.doi","10.1099/mic.0.27256-0"],["dc.identifier.isi","000224695800008"],["dc.identifier.pmid","15470094"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47476"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc General Microbiology"],["dc.relation.issn","1350-0872"],["dc.title","Systematic identification in silico of covalently bound cell wall proteins and analysis of protein-polysaccharide linkages of the human pathogen Candida glabrata"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","611"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Yeast"],["dc.bibliographiccitation.lastpage","624"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","de Boer, Albert D."],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Weindl, Guenther"],["dc.contributor.author","Schaller, Martin"],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Diez-Orejas, Rosalia"],["dc.contributor.author","Klis, Frans M."],["dc.contributor.author","de Koster, Chris G."],["dc.contributor.author","Dekker, Henk L."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T08:41:15Z"],["dc.date.available","2018-11-07T08:41:15Z"],["dc.date.issued","2010"],["dc.description.abstract","The glycosylphosphatidylinositol-modified protein Rhd3/Pga29 of the human pathogen Candida albicans belongs to a family of cell wall proteins that are widespread among Candida species but are not found in other fungi. Pga29 is covalently linked to the beta-1,3-glucan framework of the cell wall via beta-1,6-glucan. It is a small and abundant O-glycosylated protein and requires the protein-O-mannosyl transferase Pmt1 for glycosylation. Furthermore, Pga29 is strongly expressed in yeast cells but is downregulated in hyphae. Removal of the PGA29 gene in C. albicans leads to a significant reduction of cell wall mannan; however, Pga29 does not seem to have a major role in maintaining cell wall integrity. In addition, adhesion capacity and hyphae formation appear normal in pga29 deletion mutants. Importantly, the pga29 deletion mutant is less virulent, and infection of reconstituted human epithelium with the pga29 mutant results in a diminished induction of proinfiammatory cytokines, such as GM-CSF, TNF, IL-6 and IL-8. We propose that the reduced virulence of the pga29 mutant is a consequence of altered surface properties, resulting in altered fungal recognition. (C) Copyright 2010 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/yea.1790"],["dc.identifier.isi","000281227000017"],["dc.identifier.pmid","20533408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19423"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0749-503X"],["dc.title","The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","UNSP fov098"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","FEMS Yeast Research"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gomez-Molero, Emilia"],["dc.contributor.author","de Boer, Albert D."],["dc.contributor.author","Dekker, Henk L."],["dc.contributor.author","Moreno-Martinez, Ana"],["dc.contributor.author","Kraneveld, Eefje A."],["dc.contributor.author","Ichsan, Ichsan"],["dc.contributor.author","Chauhan, Neeraj"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","de Soet, Johannes J."],["dc.contributor.author","de Koster, Chris G."],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","de Groot, Piet W. J."],["dc.date.accessioned","2018-11-07T09:48:08Z"],["dc.date.available","2018-11-07T09:48:08Z"],["dc.date.issued","2015"],["dc.description.abstract","Attachment to human host tissues or abiotic medical devices is a key step in the development of infections by Candida glabrata. The genome of this pathogenic yeast codes for a large number of adhesins, but proteomic work using reference strains has shown incorporation of only few adhesins in the cell wall. By making inventories of the wall proteomes of hyperadhesive clinical isolates and reference strain CBS138 using mass spectrometry, we describe the cell wall proteome of C. glabrata and tested the hypothesis that hyperadhesive isolates display differential incorporation of adhesins. Two clinical strains (PEU382 and PEU427) were selected, which both were hyperadhesive to polystyrene and showed high surface hydrophobicity. Cell wall proteome analysis under biofilm-forming conditions identified a core proteome of about 20 proteins present in all C. glabrata strains. In addition, 12 adhesin-like wall proteins were identified in the hyperadherent strains, including six novel adhesins (Awp8-13) of which only Awp12 was also present in CBS138. We conclude that the hyperadhesive capacity of these two clinical C. glabrata isolates is correlated with increased and differential incorporation of cell wall adhesins. Future studies should elucidate the role of the identified proteins in the establishment of C. glabrata infections."],["dc.identifier.doi","10.1093/femsyr/fov098"],["dc.identifier.isi","000367341100015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35247"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1567-1364"],["dc.relation.issn","1567-1356"],["dc.title","Proteomic analysis of hyperadhesive Candida glabrata clinical isolates reveals a core wall proteome and differential incorporation of adhesins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","1290"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","FEMS Yeast Research"],["dc.bibliographiccitation.lastpage","1294"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Kaplanek, Pia"],["dc.contributor.author","de Boer, Albert D."],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","Hube, Bernhard"],["dc.contributor.author","Weig, Michael S."],["dc.date.accessioned","2018-11-07T08:53:36Z"],["dc.date.available","2018-11-07T08:53:36Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1111/j.1567-1364.2006.00184.x"],["dc.identifier.isi","000242196100020"],["dc.identifier.pmid","17156027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22457"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","1567-1356"],["dc.title","Candida and Candidosis today: where are we, and where to go? The Interdisciplinary Forum on Candidosis (IFOCAN) 2005, Gottingen (Germany), 23-25 September 2005"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","84"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","85"],["dc.bibliographiccitation.volume","297"],["dc.contributor.author","Wagener, Jeanette"],["dc.contributor.author","Weindl, Guenther"],["dc.contributor.author","de Groot, Piet W. J."],["dc.contributor.author","de Boer, A."],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Schaller, Martin"],["dc.date.accessioned","2018-11-07T10:59:04Z"],["dc.date.available","2018-11-07T10:59:04Z"],["dc.date.issued","2007"],["dc.identifier.isi","000250104800220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50614"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","59th Annual Meeting of the Deutschen-Gesellschaft-fur-Hygiene-und-Mikrobiologie"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Candida albicans and Candida-derived cell wall components stimulate toll-like receptor and cytokine expression in human keratinocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]