Schulz-Schaeffer, Walter Joachim

[["dc.bibliographiccitation.firstpage","698"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Neurology"],["dc.bibliographiccitation.lastpage","704"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Schirmer, Lucas"],["dc.contributor.author","Albert, Monika"],["dc.contributor.author","Buss, Armin"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2019-07-09T11:52:53Z"],["dc.date.available","2019-07-09T11:52:53Z"],["dc.date.issued","2009"],["dc.description.abstract","Research in multiple sclerosis (MS) has recently been focusing on the extent of neuroaxonal damage and its contribution to disease outcome. In the present study, we examined spinal cord tissue from 30 clinically well-characterized MS patients. MS, amyotrophic lateral sclerosis (ALS), and control spinal cord tissue were subjected to morphometric analysis and immunohistochemistry for markers of cell damage and regeneration. Data were related to disease duration and age at death. Here, we present evidence for substantial, nonprogressive neuronal loss on the cervical and lumbar levels early in the disease course of MS. Chromatolytic neurons and immunoreactivity for c-Jun and GAP43 were observed in the ventral gray matter in and adjacent to actively demyelinating lesions, pointing toward neuronal damage and regeneration as an early response to lesion formation."],["dc.identifier.doi","10.1002/ana.21799"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60301"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Substantial early, but nonprogressive neuronal loss in multiple sclerosis (ms) spinal cord"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0180665"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hollmann, Anne K."],["dc.contributor.author","Dammann, Insa"],["dc.contributor.author","Wemheuer, Wiebke M."],["dc.contributor.author","Wemheuer, Wilhelm E."],["dc.contributor.author","Chilla, Almuth"],["dc.contributor.author","Tipold, Andrea"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Beck, Julia"],["dc.contributor.author","Schütz, Ekkehard"],["dc.contributor.author","Brenig, Bertram"],["dc.date.accessioned","2019-07-09T11:43:31Z"],["dc.date.available","2019-07-09T11:43:31Z"],["dc.date.issued","2017"],["dc.description.abstract","To investigate the genetic basis of hereditary lens opacities we analyzed 31 cases of bilateral congenital cataract in Red Holstein Friesian cattle. A genome-wide association study revealed a significant association on bovine chromosome 7 at positions 6,166,179 and 12,429,691. Whole genome re-sequencing of one case and four relatives showed a nonsense mutation (g.5995966C>T) in the PZP-like, alpha-2-macroglobulin domain containing 8 (CPAMD8) gene leading to a premature stop codon (CPAMD8 p.Gln74 ) associated with cataract development in cattle. With immunohistochemistry we confirmed a physiological expression of CPAMD8 in the ciliary body epithelium of the eye in unaffected cattle, while the protein was not detectable in the ciliary body of cattle with cataracts. RNA expression of CPAMD8 was detected in healthy adult, fetal and cataractous lenses."],["dc.identifier.doi","10.1371/journal.pone.0180665"],["dc.identifier.pmid","28683140"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14551"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58902"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Morgagnian cataract resulting from a naturally occurring nonsense mutation elucidates a role of CPAMD8 in mammalian lens development."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]